FAS pathway and stress induction of HSP regulation (Danio rerio)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="FAS pathway and Stress induction of HSP regulation" Last-Modified="4/18/2012" Organism="Danio rerio" License="CC BY 2.0"> <Comment Source="GenMAPP remarks">Converted to human by GenMAPP.org.</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP314&amp;oldid=45253 WP314(r45253)] with a 86% conversion rate.</Comment> <BiopaxRef>ed8</BiopaxRef> <Graphics BoardWidth="1282.0" BoardHeight="860.0" /> <DataNode TextLabel="spna2" GraphId="a16" Type="GeneProduct"> <Comment Source="GenMAPP remarks">Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SPTAN1 | spectrin alpha non-erythrocytic 1 (a..." /> <Graphics CenterX="225.33333333333334" CenterY="418.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="553383" /> </DataNode> <DataNode TextLabel="Phosphate" GraphId="a2bf6" Type="Metabolite"> <Graphics CenterX="816.0" CenterY="334.0" Width="53.333333333333336" Height="14.666666666666666" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0001429" /> </DataNode> <DataNode TextLabel="IL1A" GraphId="a2d" Type="GeneProduct" GroupRef="af542"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL1A | interleukin 1 alpha" /> <Graphics CenterX="701.3333333333334" CenterY="74.0" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="faf1" GraphId="a4f" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FAF1 | Fas (TNFRSF6) associated factor 1" /> <Graphics CenterX="210.33333333333331" CenterY="161.33333333333334" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="406243" /> </DataNode> <DataNode TextLabel="casp7" GraphId="a6f" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP7 | caspase 7 apoptosis-related cysteine p..." /> <Graphics CenterX="415.3333333333333" CenterY="313.3333333333333" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="553634" /> </DataNode> <DataNode TextLabel="hspb1" GraphId="a84" Type="GeneProduct" GroupRef="a0cef"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HSPB1 | heat shock 27kDa protein 1" /> <Graphics CenterX="756.0" CenterY="296.0" Width="53.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="368243" /> </DataNode> <DataNode TextLabel="ripk2" GraphId="a8a" Type="GeneProduct" GroupRef="f83c9"> <Comment Source="GenMAPP remarks">receptor (TNFRSF)-interacting serine-threonine kinase 2</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RIPK2 | receptor-interacting serine-threonine k..." /> <Graphics CenterX="422.0" CenterY="230.66666666666666" Width="46.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="373874" /> </DataNode> <DataNode TextLabel="dffb" GraphId="ae2" Type="GeneProduct" GroupRef="cf372"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DFFB | DNA fragmentation factor 40kDa beta po..." /> <Graphics CenterX="334.66666666666663" CenterY="406.6666666666667" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="373130" /> </DataNode> <DataNode TextLabel="pak1" GraphId="aea" Type="GeneProduct" GroupRef="cd34f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PAK1 | p21/Cdc42/Rac1-activated kinase 1 (STE20..." /> <Graphics CenterX="322.0" CenterY="338.6666666666667" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="373103" /> </DataNode> <DataNode TextLabel="apaf1" GraphId="b2c" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="APAF1 | apoptotic protease activating factor" /> <Graphics CenterX="1139.6666666666667" CenterY="486.3333333333333" Width="46.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="58131" /> </DataNode> <DataNode TextLabel="Glutathione" GraphId="b8214" Type="Metabolite"> <Graphics CenterX="828.3333333333334" CenterY="196.33333333333334" Width="63.333333333333336" Height="15.333333333333334" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0000125" /> </DataNode> <DataNode TextLabel="daxx" GraphId="bc0" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DAXX | death-associated protein 6" /> <Graphics CenterX="555.3333333333334" CenterY="161.0" Width="46.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="561006" /> </DataNode> <DataNode TextLabel="mapkapk2a" GraphId="bc2" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPKAPK2 | mitogen-activated protein kinase-act..." /> <Graphics CenterX="690.0" CenterY="216.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="327321" /> </DataNode> <DataNode TextLabel="casp8" GraphId="bcc" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP8 | caspase 8 apoptosis-related cysteine p..." /> <Graphics CenterX="325.3333333333334" CenterY="240.0" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="58022" /> </DataNode> <DataNode TextLabel="parp1" GraphId="bd4" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PARP1 | poly (ADP-ribose) polymerase family me..." /> <Graphics CenterX="282.0" CenterY="620.0" Width="53.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="560788" /> </DataNode> <DataNode TextLabel="dffa" GraphId="c05" Type="GeneProduct" GroupRef="cf372"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DFFA | DNA fragmentation factor 45kDa alpha p..." /> <Graphics CenterX="324.66666666666663" CenterY="386.0" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="436904" /> </DataNode> <DataNode TextLabel="Phosphate" GraphId="c09d3" Type="Metabolite"> <Graphics CenterX="769.0" CenterY="260.3333333333333" Width="55.333333333333336" Height="15.333333333333334" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0001429" /> </DataNode> <DataNode TextLabel="arhgdig" GraphId="c3d" Type="GeneProduct"> <Comment Source="GenMAPP remarks">Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARHGDIB | Rho GDP dissociation inhibitor (GDI) ..." /> <Graphics CenterX="218.66666666666669" CenterY="362.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="394132" /> </DataNode> <DataNode TextLabel="cycsb" GraphId="c4e" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CYCS | cytochrome c somatic" /> <Graphics CenterX="1081.3333333333337" CenterY="316.6666666666667" Width="93.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="415158" /> </DataNode> <DataNode TextLabel="faslg" GraphId="c5b" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FASLG | Fas ligand (TNF superfamily member 6)" /> <Graphics CenterX="434.0" CenterY="51.333333333333336" Width="53.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="735295" /> </DataNode> <DataNode TextLabel="casp8" GraphId="c69" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP8 | caspase 8 apoptosis-related cysteine p..." /> <Graphics CenterX="324.00000000000006" CenterY="186.0" Width="93.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="58022" /> </DataNode> <DataNode TextLabel="fadd" GraphId="c81" Type="GeneProduct" GroupRef="d8cbe"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FADD | Fas (TNFRSF6)-associated via death domai..." /> <Graphics CenterX="428.6666666666667" CenterY="171.0" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="562317" /> </DataNode> <DataNode TextLabel="hspb1" GraphId="c92" Type="GeneProduct" GroupRef="fa0db"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HSPB1 | heat shock 27kDa protein 1" /> <Graphics CenterX="880.6666666666666" CenterY="293.3333333333333" Width="53.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="368243" /> </DataNode> <DataNode TextLabel="Apoptosis" GraphId="c9cf5" Type="Pathway"> <Graphics CenterX="576.0" CenterY="783.0" Width="80.0" Height="20.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e" /> <Xref Database="WikiPathways" ID="WP254" /> </DataNode> <DataNode TextLabel="casp8l2" GraphId="caa" Type="GeneProduct" GroupRef="d8cbe"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP10 | caspase 10 apoptosis-related cysteine..." /> <Graphics CenterX="462.0" CenterY="187.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="557302" /> </DataNode> <DataNode TextLabel="rb1" GraphId="cd0" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RB1 | retinoblastoma 1 (including osteosarcoma)..." /> <Graphics CenterX="227.33333333333334" CenterY="559.3333333333334" Width="40.0" 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Database="Entrez Gene" ID="266749" /> </DataNode> <DataNode TextLabel="map3k7" GraphId="dd0" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP3K7 | mitogen-activated protein kinase kinas..." /> <Graphics CenterX="538.0" CenterY="340.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="553788" /> </DataNode> <DataNode TextLabel="lmnb1" GraphId="dd6" Type="GeneProduct" GroupRef="b09cd"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LMNB1 | lamin B1" /> <Graphics CenterX="156.0" CenterY="652.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="195816" /> </DataNode> <DataNode TextLabel="lmnb2" GraphId="de5" Type="GeneProduct" GroupRef="b09cd"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LMNB2 | lamin B2" /> <Graphics CenterX="156.0" CenterY="672.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30196" /> </DataNode> <DataNode TextLabel="casp9" GraphId="dee" Type="GeneProduct" GroupRef="b0a88"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP9 | caspase 9 apoptosis-related cysteine p..." /> <Graphics CenterX="1055.3333333333335" CenterY="429.0" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="492763" /> </DataNode> <DataNode TextLabel="Phosphate" GraphId="df073" Type="Metabolite"> <Graphics CenterX="555.6666666666667" CenterY="373.3333333333333" Width="54.0" Height="14.666666666666666" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0001429" /> </DataNode> <DataNode TextLabel="daxx" GraphId="df6" Type="GeneProduct" GroupRef="d8cbe"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DAXX | death-associated protein 6" /> <Graphics CenterX="465.3333333333333" CenterY="151.0" 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