Initiation of transcription and translation elongation at the HIV-1 LTR (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Initiation of transcription and translation elongation at the HIV-1 LTR" Version="20150827" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Following cellular activation or drug treatment, NFAT and NF-kB translocate to the nucleus and bind sites at the HIV-1 LTR. NFAT and NF-kB recruit p300/CBP to the LTR, resulting in acetylation of histone tails and transcriptional activation. In the case of NF-kB, proteosomal degradation of IkBa permits NF-kB translocation and displacement of the p50 homodimers. This is followed by Tat- dependent elongation in which Tat recruits the P-TEFb complex to TAR. Cdk9 phosphorylates the CTD of RNA Pol II, resulting in increased processivity. P-TEFb phosphorylates DSIF and NELF, resulting in removal of NELF from Pol II and converting DSIF into a positive elongation factor, thereby promoting productive elongation. Data nodes in blue represent HIV proteins. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3414 CPTAC Assay Portal]</Comment> <BiopaxRef>ff9</BiopaxRef> <Graphics BoardWidth="1111.0" BoardHeight="867.0"/> <DataNode TextLabel="NFATC4" GraphId="b244e" Type="GeneProduct" GroupRef="ed121"> <Graphics CenterX="58.5" CenterY="138.0" Width="57.0" Height="20.0" ZOrder="-10" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000100968"/> </DataNode> <DataNode TextLabel="NFATC3" GraphId="d84be" Type="GeneProduct" GroupRef="ed121"> <Graphics CenterX="58.5" CenterY="118.0" Width="57.0" Height="20.0" ZOrder="-8" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000072736"/> </DataNode> <DataNode TextLabel="NFATC2" GraphId="e99f2" Type="GeneProduct" GroupRef="ed121"> <Graphics CenterX="58.5" CenterY="98.0" Width="57.0" Height="20.0" ZOrder="-6" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000101096"/> </DataNode> 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