BMP signaling pathway (Danio rerio)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="BMP signaling pathway" Organism="Danio rerio"> <Comment Source="WikiPathways-description">The bone morphogenetic protein (BMP) signalling pathway play critical roles in germ layer induction and patterning in early zebrafish embryos. Smad2/3 and Smad1/5/8 are intracellular effectors of BMPs. These Smads regulate, in cooperation with other factors, transcription of hundreds of target genes in the nucleus. The activity and stability of Smads are regulated by phosphorylation modifications.</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <BiopaxRef>b36</BiopaxRef> <Graphics BoardWidth="1436.7253333333333" BoardHeight="840.8336333333333" /> <DataNode TextLabel="bmp1b" GraphId="a0d" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp1b" /> <Graphics CenterX="1180.0" CenterY="130.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="559877" /> </DataNode> <DataNode TextLabel="msx a" GraphId="a14" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000017825</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000017825" /> <Graphics CenterX="1030.0" CenterY="636.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30528" /> </DataNode> <DataNode TextLabel="vent" GraphId="a25" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000017456</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000017456" /> <Graphics CenterX="1336.6666666666667" CenterY="706.6666666666666" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="64810" /> </DataNode> <DataNode TextLabel="bmp6" GraphId="a3c" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp6" /> <Graphics CenterX="1270.0" CenterY="113.33333333333333" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.85164" /> </DataNode> <DataNode TextLabel="tbx2a" GraphId="a59" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="tbx2a" /> <Graphics CenterX="1336.6666666666667" CenterY="646.6666666666666" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30247" /> </DataNode> <DataNode TextLabel="bmp5l" GraphId="a69" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp5l" /> <Graphics CenterX="1180.0" CenterY="270.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="337711" /> </DataNode> <DataNode TextLabel="bmp1l" GraphId="a7f" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp1l" /> <Graphics CenterX="1180.0" CenterY="150.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30204" /> </DataNode> <DataNode TextLabel="bmpr1a" GraphId="a94" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000026768</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000026768" /> <Graphics CenterX="250.0" CenterY="370.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="58145" /> </DataNode> <DataNode TextLabel="bambi" GraphId="aa8" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000078899</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000078899" /> <Graphics CenterX="950.0" CenterY="390.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="431736" /> </DataNode> <DataNode TextLabel="hrb" GraphId="aa9" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000043960</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000043960" /> <Graphics CenterX="877.8991596638656" CenterY="736.6666666666666" Width="123.2444" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.1483" /> </DataNode> <DataNode TextLabel="smad1" GraphId="aac" Type="GeneProduct" GroupRef="d7fbb"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000033566</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000033566" /> <Graphics CenterX="273.3333333333333" CenterY="510.05145167217927" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30628" /> </DataNode> <DataNode TextLabel="snai2" GraphId="ab5" Type="GeneProduct" GroupRef="bdcfa"> <Graphics CenterX="653.3333333333334" CenterY="686.6666666666666" Width="66.84446666666666" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.75349" /> </DataNode> <DataNode TextLabel="acvr2b" GraphId="ad2" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="acvr2b" /> <Graphics CenterX="720.0" CenterY="390.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000044422" /> </DataNode> <DataNode TextLabel="bmper" GraphId="ad8" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmper" /> <Graphics CenterX="1270.0" CenterY="206.66666666666666" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.38460" /> </DataNode> <DataNode TextLabel="bmp5" GraphId="aeb" Type="GeneProduct" GroupRef="b2dc5"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000019239</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000019239" /> <Graphics CenterX="400.0" CenterY="203.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="394026" /> </DataNode> <DataNode TextLabel="tbx2b" GraphId="b04" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="tbx2b" /> <Graphics CenterX="1336.6666666666667" CenterY="666.6666666666666" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30253" /> </DataNode> <DataNode TextLabel="bmp5" GraphId="b18" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp5" /> <Graphics CenterX="1180.0" CenterY="250.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="394026" /> </DataNode> <DataNode TextLabel="follistatin" GraphId="b26" Type="GeneProduct" GroupRef="fddaa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000051065</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000051065" /> <Graphics CenterX="122.25182863113892" CenterY="115.07105538140023" Width="106.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30235" /> </DataNode> <DataNode TextLabel="bmp1a" GraphId="b49" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp1a" /> <Graphics CenterX="1180.0" CenterY="110.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.76758" /> </DataNode> <DataNode TextLabel="gata5" GraphId="b58" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="gata5" /> <Graphics CenterX="1153.3333333333333" CenterY="746.6666666666666" Width="58.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30482" /> </DataNode> <DataNode TextLabel="twsg1a" GraphId="b59" Type="GeneProduct" GroupRef="a2323"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000049963</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000049963" /> <Graphics CenterX="723.6666666666666" CenterY="268.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.45891" /> </DataNode> <DataNode TextLabel="snai1a" GraphId="b64" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Snai1" /> <Graphics CenterX="653.3333333333334" CenterY="646.6666666666666" Width="66.84446666666666" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.75079" /> </DataNode> <DataNode TextLabel="smad6a" GraphId="b65" Type="GeneProduct" GroupRef="c9fd0"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000014508</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000014508" /> <Graphics CenterX="88.94957983193277" CenterY="520.8879551820721" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000053209" /> </DataNode> <DataNode TextLabel="id3" GraphId="b8d" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000021064</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000021064" /> <Graphics CenterX="880.0" CenterY="656.6666666666666" Width="123.2444" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="246093" /> </DataNode> <DataNode TextLabel="bmpr1bb" GraphId="b8e" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmpr1b" /> <Graphics CenterX="346.6666666666667" CenterY="370.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000075729" /> </DataNode> <DataNode TextLabel="bmp2b/swirl(swr)" GraphId="b9d" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000060734</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000060734" /> <Graphics CenterX="400.0" CenterY="156.66666666666666" Width="115.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O93369" /> </DataNode> <DataNode TextLabel="msx c" GraphId="ba4" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000014176</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000014176" /> <Graphics CenterX="1030.0" CenterY="676.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30526" /> </DataNode> <DataNode TextLabel="smurf-1(WWP1)" GraphId="ba7" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000004923</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000004923" /> <Graphics CenterX="413.3333333333333" CenterY="456.6666666666667" Width="106.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.76814" /> </DataNode> <DataNode TextLabel="bmp2b" GraphId="bbb" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp2b" /> <Graphics CenterX="1180.0" CenterY="190.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O93369" /> </DataNode> <DataNode TextLabel="rack1 (gnb2l1)" GraphId="bbc" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000061001</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000061001" /> <Graphics CenterX="880.0" CenterY="636.6666666666666" Width="123.2444" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30722" /> </DataNode> <DataNode TextLabel="smad1" GraphId="bc2" Type="GeneProduct" GroupRef="d7fbb"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="smad1" /> <Graphics CenterX="273.3333333333333" CenterY="470.0514516721793" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30628" /> </DataNode> <DataNode TextLabel="smad6" GraphId="bc8" Type="GeneProduct" GroupRef="c9fd0"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="smad6" /> <Graphics CenterX="88.94957983193277" CenterY="500.8879551820726" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000031763" /> </DataNode> <DataNode TextLabel="bmp4" GraphId="bcd" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp4" /> <Graphics CenterX="1180.0" CenterY="230.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30612" /> </DataNode> <DataNode TextLabel="gata6" GraphId="bd9" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="gata6" /> <Graphics CenterX="1153.3333333333333" CenterY="766.6666666666666" Width="58.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="58076" /> </DataNode> <DataNode TextLabel="deltaNP63/tp73l" GraphId="be2" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065137</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000065137" /> <Graphics CenterX="676.6666666666666" CenterY="733.3333333333334" Width="113.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="325581" /> </DataNode> <DataNode TextLabel="crim1" GraphId="bf3" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="crim1" /> <Graphics CenterX="1266.6666666666667" CenterY="273.3333333333333" Width="43.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="404210" /> </DataNode> <DataNode TextLabel="deltaNP63/tp73l" GraphId="bf5" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065137</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000065137" /> <Graphics CenterX="674.5658263305322" CenterY="793.3333333333334" Width="113.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="335185" /> </DataNode> <DataNode TextLabel="rpl15" GraphId="bf9" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000034837</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000034837" /> <Graphics CenterX="880.0" CenterY="696.6666666666666" Width="123.2444" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000009285" /> </DataNode> <DataNode TextLabel="smad8" GraphId="bff" Type="GeneProduct" GroupRef="d7fbb"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000028618</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000028618" /> <Graphics CenterX="273.3333333333333" CenterY="563.3847850055126" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.75542" /> </DataNode> <DataNode TextLabel="bmp15" GraphId="c1f" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp15" /> <Graphics CenterX="1270.0" CenterY="173.33333333333334" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.7003" /> </DataNode> <DataNode TextLabel="deltaNP63/tp73l" GraphId="c2d" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065285</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000065285" /> <Graphics CenterX="676.6666666666666" CenterY="773.3333333333334" Width="113.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="325581" /> </DataNode> <DataNode TextLabel="bmp3" GraphId="c31" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp3" /> <Graphics CenterX="1180.0" CenterY="210.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="335252" /> </DataNode> <DataNode TextLabel="bmp1b/tolloid" GraphId="c33" Type="GeneProduct" GroupRef="cd619"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000059795</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000059795" /> <Graphics CenterX="846.6666666666666" CenterY="200.0" Width="175.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="335826" /> </DataNode> <DataNode TextLabel="gata2" GraphId="c45" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="gata2" /> <Graphics CenterX="1153.3333333333333" CenterY="666.6666666666666" Width="58.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30480" /> </DataNode> <DataNode TextLabel="smad4" GraphId="c47" Type="GeneProduct" GroupRef="beeca"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="smad4" /> <Graphics CenterX="458.8202866593165" CenterY="568.8717383314957" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000045094" /> </DataNode> <DataNode TextLabel="gata3" GraphId="c58" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="gata3" /> <Graphics CenterX="1153.3333333333333" CenterY="706.6666666666666" Width="58.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30458" /> </DataNode> <DataNode TextLabel="follistatin-like 1" GraphId="c71" Type="GeneProduct" GroupRef="fddaa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="325423" /> <Graphics CenterX="122.25182863113892" CenterY="175.07105538140004" Width="106.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.4964" /> </DataNode> <DataNode TextLabel="smad7" GraphId="c74" Type="GeneProduct" GroupRef="c9fd0"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000024277</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000024277" /> <Graphics CenterX="88.94957983193277" CenterY="560.8879551820731" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000016858" /> </DataNode> <DataNode TextLabel="bmp1b/tolloid" GraphId="c85" Type="GeneProduct" GroupRef="cd619"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000059795</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000059795" /> <Graphics CenterX="846.6666666666666" CenterY="180.0" Width="175.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="559877" /> </DataNode> <DataNode TextLabel="bmp1a/tolloid" GraphId="c89" Type="GeneProduct" GroupRef="cd619"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000033284</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000033284" /> <Graphics CenterX="846.6666666666666" CenterY="220.0" Width="175.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Wikidata" ID="Q29772966" /> </DataNode> <DataNode TextLabel="prdc" GraphId="c93" Type="GeneProduct" GroupRef="a798e"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000024960</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000024960" /> <Graphics CenterX="276.6666666666667" CenterY="120.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="378455" /> </DataNode> <DataNode TextLabel="bambi" GraphId="cb5" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bambi" /> <Graphics CenterX="950.0" CenterY="410.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="83496" /> </DataNode> <DataNode TextLabel="smurf2" GraphId="cc7" Type="GeneProduct" GroupRef="c9fd0"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="smurf2" /> <Graphics CenterX="88.94957983193277" CenterY="579.8375350140059" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.77630" /> </DataNode> <DataNode TextLabel="msx d" GraphId="cce" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000003441</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000003441" /> <Graphics CenterX="1030.0" CenterY="696.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30531" /> </DataNode> <DataNode TextLabel="acvr1/lost a fin (laf)" GraphId="cd5" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000017977</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000017977" /> <Graphics CenterX="123.33333333333333" CenterY="370.0" Width="130.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30615" /> </DataNode> <DataNode TextLabel="acvr2b" GraphId="ce3" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="acvr2b" /> <Graphics CenterX="720.0" CenterY="370.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000044422" /> </DataNode> <DataNode TextLabel="gata4" GraphId="d02" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="gata4" /> <Graphics CenterX="1153.3333333333333" CenterY="726.6666666666666" Width="58.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30483" /> </DataNode> <DataNode TextLabel="pcca" GraphId="d0b" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000034097</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000034097" /> <Graphics CenterX="880.0" CenterY="676.6666666666666" Width="123.2444" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="437019" /> </DataNode> <DataNode TextLabel="Nucleoporin like protein RAB" GraphId="d1c" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000021158</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000021158" /> <Graphics CenterX="913.3333333333334" CenterY="776.6666666666666" Width="193.33333333333334" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="393560" /> </DataNode> <DataNode TextLabel="follistatin" GraphId="d36" Type="GeneProduct" GroupRef="fddaa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000034851</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000034851" /> <Graphics CenterX="122.25182863113892" CenterY="135.07105538140013" Width="106.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="557352" /> </DataNode> <DataNode TextLabel="bambi" GraphId="d48" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000077732</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000077732" /> <Graphics CenterX="950.0" CenterY="370.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="83496" /> </DataNode> <DataNode TextLabel="Ubiquitin carrier protein" GraphId="d52" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000047452</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000047452" /> <Graphics CenterX="913.3333333333334" CenterY="756.6666666666666" Width="193.33333333333334" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="565498" /> </DataNode> <DataNode TextLabel="smad4" GraphId="d53" Type="GeneProduct" GroupRef="beeca"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000035478</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000035478" /> <Graphics CenterX="458.8202866593165" CenterY="528.8717383314957" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30640" /> </DataNode> <DataNode TextLabel="msx e" GraphId="d58" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000002232</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000002232" /> <Graphics CenterX="1030.0" CenterY="736.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q90455" /> </DataNode> <DataNode TextLabel="chordin/dino(din)" GraphId="d62" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000045110</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000045110" /> <Graphics CenterX="622.3333333333334" CenterY="191.0" Width="120.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.75804" /> </DataNode> <DataNode TextLabel="noggin2" GraphId="d71" Type="GeneProduct" GroupRef="fddaa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000063231</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000063231" /> <Graphics CenterX="102.25182863113898" CenterY="248.4043887147334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.8123" /> </DataNode> <DataNode TextLabel="deltaNP63/tp73l" GraphId="d75" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065137</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000065137" /> <Graphics CenterX="676.6666666666666" CenterY="713.3333333333334" Width="113.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="260407" /> </DataNode> <DataNode TextLabel="bmp8" GraphId="d78" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp8" /> <Graphics CenterX="1270.0" CenterY="153.33333333333334" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="378445" /> </DataNode> <DataNode TextLabel="bmp2a" GraphId="d79" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmp2a" /> <Graphics CenterX="1180.0" CenterY="170.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30631" /> </DataNode> <DataNode TextLabel="goosecoid" GraphId="da7" Type="GeneProduct" GroupRef="bdcfa"> <Graphics CenterX="1336.6666666666667" CenterY="726.6666666666666" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.289" /> </DataNode> <DataNode TextLabel="gremlin 1" GraphId="dac" Type="GeneProduct" GroupRef="dc233"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000043382</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000043382" /> <Graphics CenterX="580.0" CenterY="112.33333333333333" Width="70.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="405778" /> </DataNode> <DataNode TextLabel="smad1" GraphId="db5" Type="GeneProduct" GroupRef="d7fbb"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000033566</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000033566" /> <Graphics CenterX="273.3333333333333" CenterY="490.0514516721793" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="323405" /> </DataNode> <DataNode TextLabel="twsg1b" GraphId="dbe" Type="GeneProduct" GroupRef="a2323"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000059299</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000059299" /> <Graphics CenterX="723.6666666666666" CenterY="288.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="259304" /> </DataNode> <DataNode TextLabel="bmpr2" GraphId="dea" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000056764</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000056764" /> <Graphics CenterX="843.3333333333334" CenterY="390.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="562822" /> </DataNode> <DataNode TextLabel="crim1" GraphId="df2" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Crim" /> <Graphics CenterX="1053.3333333333333" CenterY="370.0" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000029668" /> </DataNode> <DataNode TextLabel="bmp4" GraphId="e0c" Type="GeneProduct" GroupRef="b2dc5"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000075150</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000075150" /> <Graphics CenterX="400.0" CenterY="180.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30612" /> </DataNode> <DataNode TextLabel="gremlin 1" GraphId="e12" Type="GeneProduct" GroupRef="dc233"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000076092</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000076092" /> <Graphics CenterX="580.0" CenterY="132.33333333333334" Width="70.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="405778" /> </DataNode> <DataNode TextLabel="admp" GraphId="e1e" Type="GeneProduct" GroupRef="c5f55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="admp" /> <Graphics CenterX="1270.0" CenterY="226.66666666666666" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="140619" /> </DataNode> <DataNode TextLabel="msx e" GraphId="e47" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000002232</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000002232" /> <Graphics CenterX="1030.0" CenterY="716.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30527" /> </DataNode> <DataNode TextLabel="bmp7/snailhouse (snh)" GraphId="e5f" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000016472</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000016472" /> <Graphics CenterX="400.0" CenterY="226.66666666666666" Width="150.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30584" /> </DataNode> <DataNode TextLabel="acvrl1/violet beauregarde (vbg)" GraphId="e65" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000043462</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000043462" /> <Graphics CenterX="530.0" CenterY="370.0" Width="226.66666666666666" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="266753" /> </DataNode> <DataNode TextLabel="noggin1" GraphId="e8f" Type="GeneProduct" GroupRef="fddaa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000081766</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000081766" /> <Graphics CenterX="102.25182863113898" CenterY="228.4043887147334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.78473" /> </DataNode> <DataNode TextLabel="bmpr1ba" GraphId="e97" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="bmpr1b" /> <Graphics CenterX="346.6666666666667" CenterY="390.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000104100" /> </DataNode> <DataNode TextLabel="gata2" GraphId="e9d" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="gata2" /> <Graphics CenterX="1153.3333333333333" CenterY="686.6666666666666" Width="58.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30480" /> </DataNode> <DataNode TextLabel="bmpr2" GraphId="eaa" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000002334</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000002334" /> <Graphics CenterX="843.3333333333334" CenterY="370.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="555655" /> </DataNode> <DataNode TextLabel="bmpr1ab" GraphId="eaf" Type="GeneProduct"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000066309</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000066309" /> <Graphics CenterX="256.6666666666667" CenterY="393.3333333333333" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.7989" /> </DataNode> <DataNode TextLabel="snip1" GraphId="eda" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="snip1" /> <Graphics CenterX="280.0" CenterY="730.0" Width="56.5778" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="474374" /> </DataNode> <DataNode TextLabel="kheper/zfhx1" GraphId="ee8" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000047724</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000047724" /> <Graphics CenterX="666.6666666666666" CenterY="616.6666666666666" Width="93.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.78569" /> </DataNode> <DataNode TextLabel="follistatin like" GraphId="efc" Type="GeneProduct" GroupRef="fddaa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000080772</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000080772" /> <Graphics CenterX="122.25182863113892" CenterY="155.07105538140004" Width="106.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.4964" /> </DataNode> <DataNode TextLabel="smad5/somitabun (sbn)" GraphId="f32" Type="GeneProduct" GroupRef="d7fbb"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000054175</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000054175" /> <Graphics CenterX="273.3333333333333" CenterY="536.718118338846" Width="153.33333333333334" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30641" /> </DataNode> <DataNode TextLabel="msx b" GraphId="f68" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000008486</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000008486" /> <Graphics CenterX="1030.0" CenterY="656.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30511" /> </DataNode> <DataNode TextLabel="bmp7" GraphId="f79" Type="GeneProduct" GroupRef="c5f55"> <Graphics CenterX="1270.783699059561" CenterY="132.5496342737722" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.77644" /> </DataNode> <DataNode TextLabel="follistatin 2" GraphId="f8a" Type="GeneProduct" GroupRef="fddaa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000080772</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000080772" /> <Graphics CenterX="122.25182863113892" CenterY="195.07105538140004" Width="106.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q2PMI4" /> </DataNode> <DataNode TextLabel="snai1b" GraphId="f94" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="snai1b" /> <Graphics CenterX="653.3333333333334" CenterY="666.6666666666666" Width="66.84446666666666" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000046019" /> </DataNode> <DataNode TextLabel="smad4" GraphId="f9a" Type="GeneProduct" GroupRef="beeca"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="smad4" /> <Graphics CenterX="458.8202866593165" CenterY="548.8717383314957" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.8327" /> </DataNode> <DataNode TextLabel="prdc" GraphId="fa6" Type="GeneProduct" GroupRef="a798e"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000024960</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000024960" /> <Graphics CenterX="276.6666666666667" CenterY="100.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="550399" /> </DataNode> <DataNode TextLabel="tolloid-like 1/mini fin (mfn)" GraphId="fa7" Type="GeneProduct" GroupRef="cd619"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000054472</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000054472" /> <Graphics CenterX="846.6666666666666" CenterY="160.0" Width="175.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="474335" /> </DataNode> <DataNode TextLabel="noggin3" GraphId="fad" Type="GeneProduct" GroupRef="fddaa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="noggin3" /> <Graphics CenterX="102.25182863113898" CenterY="268.4043887147334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="30173" /> </DataNode> <DataNode TextLabel="deltaNP63/tp73l" GraphId="fc0" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065285</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000065285" /> <Graphics CenterX="676.6666666666666" CenterY="753.3333333333334" Width="113.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="325581" /> </DataNode> <DataNode TextLabel="vox" GraphId="fc9" Type="GeneProduct" GroupRef="bdcfa"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000008176</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000008176" /> <Graphics CenterX="1336.6666666666667" CenterY="686.6666666666666" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="64807" /> </DataNode> <DataNode TextLabel="gata1/vlad tepes (vlt)" GraphId="fef" Type="GeneProduct" GroupRef="bdcfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="gata1" /> <Graphics CenterX="1206.6666666666667" CenterY="646.6666666666666" Width="161.9112" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="UniGene" ID="Dr.355" /> </DataNode> <DataNode TextLabel="smad6b" GraphId="c7a53" Type="GeneProduct" GroupRef="c9fd0"> <Comment Source="GenMAPP remarks">http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000014508</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ENSDART00000014508" /> <Graphics CenterX="88.94957983193277" CenterY="540.8879551820731" Width="60.0" Height="20.0" ZOrder="32769" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSDARG00000031763" /> </DataNode> <Interaction GraphId="a2f11"> <Graphics ZOrder="12288" LineThickness="1.0" Color="ff0000"> <Point X="723.6666666666666" Y="250.0" GraphRef="c5ac8" RelX="0.0" RelY="-1.0" /> <Point X="723.6333333333333" Y="190.4" GraphRef="cdacb" RelX="0.0" RelY="0.0" ArrowHead="TBar" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="a45d4"> <Graphics ZOrder="12288" LineThickness="1.0" Color="ff0000"> <Point X="314.6666666666667" Y="124.0" GraphRef="c1040" RelX="1.0" RelY="0.5" /> <Point X="342.5" Y="156.66666666666666" GraphRef="b9d" RelX="-1.0" RelY="0.0" ArrowHead="TBar" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="b8cb9"> <Graphics ZOrder="12288" LineThickness="1.0" Color="ff0000"> <Point X="183.58516196447226" Y="191.73772204806681" GraphRef="b7678" RelX="1.0" RelY="0.0" /> <Point X="362.0" Y="191.66666666666669" GraphRef="ea27d" RelX="-1.0" RelY="0.0" ArrowHead="TBar" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ba16a"> <Graphics ZOrder="12288" LineThickness="1.0" Color="ff0000"> <Point X="537.0" Y="122.33333333333334" GraphRef="eaddc" RelX="-1.0" RelY="0.0" /> <Point X="457.5" Y="156.66666666666666" GraphRef="b9d" RelX="1.0" RelY="0.0" ArrowHead="TBar" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="bace8"> <Graphics ZOrder="12288" LineThickness="1.0" Color="ff0000"> <Point X="413.33333333333337" Y="466.6666666666667" GraphRef="ba7" RelX="0.0" RelY="1.0" /> <Point X="358.0" Y="516.718118338846" GraphRef="b3b7d" RelX="1.0" RelY="0.0" ArrowHead="TBar" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="c5f6e"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="539.4355016538037" Y="748.8717383314957" GraphRef="a30" RelX="1.0" RelY="0.0" /> <Point X="605.2746666666667" Y="620.5831833333333" GraphRef="be1e7" RelX="-1.0" RelY="-0.5" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e09b7"> <Graphics ZOrder="12288" LineThickness="1.0" Color="ff0000"> <Point X="562.3333333333334" Y="191.0" GraphRef="d62" RelX="-1.0" RelY="0.0" /> <Point X="438.0" Y="191.66666666666669" GraphRef="ea27d" RelX="1.0" RelY="0.0" ArrowHead="TBar" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e32a0"> <Graphics ZOrder="12288" LineThickness="1.0" Color="ff0000"> <Point X="126.94957983193277" Y="540.3627450980392" GraphRef="af023" RelX="1.0" RelY="0.0" /> <Point X="180.0" Y="540.0" ArrowHead="TBar" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e80bc"> <Graphics ZOrder="12288" LineThickness="1.0" Color="ff0000"> <Point X="751.1666666666666" Y="190.0" GraphRef="b7212" RelX="-1.0" RelY="0.0" /> <Point X="682.3333333333334" Y="191.0" GraphRef="d62" RelX="1.0" RelY="0.0" ArrowHead="TBar" /> <Anchor Position="0.4" Shape="None" GraphId="cdacb" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <GraphicalLine GraphId="a4449" GroupRef="bdcfa"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="1106.6666666666667" Y="586.6666666666666" /> <Point X="1106.6666666666667" Y="796.6666666666666" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="a674b" GroupRef="bdcfa"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="803.3333333333334" Y="583.3333333333334" /> <Point X="803.3333333333334" Y="800.0" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="a9364"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="303.3333333333333" Y="756.6666666666666" /> <Point X="486.6666666666667" Y="756.6666666666666" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="id2e2d3a8d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="420.8202866593165" Y="548.8717383314957" GraphRef="cca07" RelX="-1.0" RelY="0.0" /> <Point X="395.8103638368247" Y="581.0363836824697" /> <Point X="395.8103638368247" Y="719.9558985667034" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="id7f464822"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="28.0" Y="366.0" /> <Point X="1100.0" Y="368.0" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="idcaa5226c"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="384.78500551267894" Y="738.6990077177512" /> <Point X="429.9889746416758" Y="739.8015435501652" ArrowHead="mim-transcription-translation" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="b0373"> <Graphics ConnectorType="Segmented" ZOrder="32770" LineThickness="1.0"> <Point X="358.0" Y="549.0514516721794" GraphRef="b3b7d" RelX="1.0" RelY="0.5" /> <Point X="386.9900771775083" Y="579.9338478500551" /> <Point X="385.8875413450937" Y="719.9558985667034" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <Label TextLabel="BMP target genes" GraphId="a30"> <Graphics CenterX="478.76883498713704" CenterY="748.8717383314957" Width="121.33333333333333" Height="16.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" Color="0000ff" /> </Label> <Label TextLabel="ZF marker genes" GraphId="ade" GroupRef="bdcfa"> <Graphics CenterX="1340.0" CenterY="586.6666666666666" Width="116.0" Height="16.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" /> </Label> <Label TextLabel="degradation of Smad1 and Smad5" GraphId="b52"> <Graphics CenterX="486.8333333333333" CenterY="496.6666666666667" Width="165.66666666666663" Height="14.666666666666666" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="9" Valign="Middle" Color="008000" /> </Label> <Label TextLabel="danio rerio bmp targets" GraphId="ba6" GroupRef="bdcfa"> <Graphics CenterX="706.6666666666666" CenterY="586.6666666666666" Width="157.33333333333334" Height="16.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" /> </Label> <Label TextLabel="BMP ligands" GraphId="bd3" GroupRef="c5f55"> <Graphics CenterX="1230.0" CenterY="80.0" Width="88.0" Height="16.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" /> </Label> <Label TextLabel="binds BMP-2 and BMP-4" GraphId="c92"> <Graphics CenterX="373.3333333333333" CenterY="110.0" Width="126.66666666666667" Height="13.333333333333334" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle" Color="008000" /> </Label> <Label TextLabel="putative Xenopus direct bmp targets" GraphId="cc6" GroupRef="bdcfa"> <Graphics CenterX="946.6666666666666" CenterY="586.6666666666666" Width="242.66666666666666" Height="16.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" /> </Label> <Label TextLabel="binds BMP-2 and BMP-4" GraphId="e11"> <Graphics CenterX="543.3333333333334" CenterY="153.33333333333334" Width="126.66666666666667" Height="13.333333333333334" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle" Color="008000" /> </Label> <Label TextLabel="?" GraphId="e90"> <Graphics CenterX="713.6666666666666" CenterY="231.0" Width="14.666666666666666" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" Color="008000" /> </Label> <Label TextLabel="Gata genes" GraphId="f98" GroupRef="bdcfa"> <Graphics CenterX="1176.6666666666667" CenterY="586.6666666666666" Width="80.0" Height="16.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" /> </Label> <Shape GraphId="b2c" GroupRef="bdcfa"> <Graphics CenterX="1010.0" CenterY="686.6666666666666" Width="793.4506666666667" Height="248.33393333333333" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" /> </Shape> <Shape GraphId="b3a" GroupRef="c5f55"> <Graphics CenterX="1236.6666666666667" CenterY="186.66666666666666" Width="190.06813333333332" Height="235.20893333333333" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" /> </Shape> <Shape GraphId="fb0ba"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Nucleus" /> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="377.5" CenterY="736.5" Width="301.0" Height="135.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> </Shape> <Group GroupId="c9fd0" GraphId="af023" Style="Group"> <BiopaxRef>b64</BiopaxRef> </Group> <Group GroupId="d7fbb" GraphId="b3b7d" Style="Group"> <BiopaxRef>b64</BiopaxRef> </Group> <Group GroupId="cd619" GraphId="b7212" Style="Group" /> <Group GroupId="fddaa" GraphId="b7678" Style="Group" /> <Group GroupId="bdcfa" GraphId="be1e7" Style="Group" /> <Group GroupId="a798e" GraphId="c1040" Style="Group" /> <Group GroupId="a2323" GraphId="c5ac8" Style="Group" /> <Group GroupId="c5f55" GraphId="c98f2" Style="Group" /> <Group GroupId="beeca" GraphId="cca07" Style="Group"> <BiopaxRef>b64</BiopaxRef> </Group> <Group GroupId="b2dc5" GraphId="ea27d" Style="Group" /> <Group GroupId="dc233" GraphId="eaddc" Style="Group" /> <InfoBox CenterX="1160.0" CenterY="20.0" /> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b36"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18442396</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BMC Genomics</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Krens SF</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Corredor-Adamez M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">He S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Snaar-Jagalska BE</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Spaink HP</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bone morphogenetic proteins signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000330</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b64"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26520131</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Detection of Smad Signaling in Zebrafish Embryos.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Methods Mol Biol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu X</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang Q</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Meng A</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

Return to BMP signaling pathway (Danio rerio).