Methionine metabolism leading to sulfur amino acids and related disorders (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Methionine metabolism leading to Sulphur Amino Acids and related disorders" Version="20180309" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">This pathway visualises the conversion of methionine to inorganic sulphates (involving the formation of homocysteine, a toxic intermediate also related to MTHFR deficiency [https://www.wikipathways.org/index.php/Pathway:WP4288]). Methionine, an essential amino acid, is taken in from diet and can be created from breaking down proteins. This pathway was inspired by Chapter 3 of the book of Blau (ISBN 3642403360 (978-3642403361)).</Comment> <BiopaxRef>c47</BiopaxRef> <Graphics BoardWidth="1195.3272762523216" BoardHeight="898.5799482583783" /> <DataNode TextLabel="Methionine" GraphId="af11a" Type="Metabolite"> <Graphics CenterX="601.014163311703" CenterY="101.83299571761097" Width="170.0" Height="25.0" ZOrder="32980" FontSize="12" Valign="Middle" Color="009999" /> <Xref Database="ChEBI" ID="CHEBI:16643" /> </DataNode> <DataNode TextLabel="Sulphocysteine" GraphId="e0e45" Type="Metabolite"> <Graphics CenterX="543.1017377630958" CenterY="759.5239454411226" Width="99.98721227621513" Height="24.008951406649672" ZOrder="32981" FontSize="12" Valign="Middle" Color="009999" /> <Xref Database="ChEBI" ID="CHEBI:27891" /> </DataNode> <DataNode TextLabel="Cystathionine" GraphId="df1ad" Type="Metabolite"> <Graphics CenterX="494.40192290158654" CenterY="529.0644771990919" Width="170.0" Height="25.0" ZOrder="32982" FontSize="12" Valign="Middle" Color="009999" /> <Xref Database="ChEBI" ID="CHEBI:17482" /> </DataNode> <DataNode TextLabel="ADKD" GraphId="be549" Type="GeneProduct"> <Comment>aka Adenosine kinase</Comment> <Graphics CenterX="704.7250459635693" CenterY="436.0212212565828" Width="62.164179104476716" Height="25.0" ZOrder="32983" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000156110" /> </DataNode> <DataNode TextLabel="Sulfate" GraphId="ae60c" Type="Metabolite"> <Graphics CenterX="740.6196020414034" CenterY="856.0799482583783" Width="90.0" Height="25.0" ZOrder="32984" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0001448" /> </DataNode> <DataNode TextLabel="Taurine" GraphId="e55e3" Type="Metabolite"> <Graphics CenterX="1111.2216752242339" CenterY="630.5851056295388" Width="90.0" Height="25.0" ZOrder="32985" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15891" /> </DataNode> <DataNode TextLabel="Sulfite" GraphId="f17b4" Type="Metabolite"> <Graphics CenterX="740.6196020414034" CenterY="759.5239454411225" Width="90.0" Height="25.0" ZOrder="32986" FontSize="12" Valign="Middle" Color="009999" /> <Xref Database="ChEBI" ID="CHEBI:26823" /> </DataNode> <DataNode TextLabel="S-Adenosylmethionine" GraphId="ef5a1" Type="Metabolite"> <Graphics CenterX="601.014163311703" CenterY="198.89781053242615" Width="170.0" Height="20.5" ZOrder="32987" FontSize="12" Valign="Middle" Color="009999" /> <Xref Database="ChEBI" ID="CHEBI:67040" /> </DataNode> <DataNode TextLabel="Cysteine" GraphId="b96ed" Type="Metabolite"> <Graphics CenterX="494.40192290158234" CenterY="630.5851056295387" Width="169.99999999999997" Height="25.000000000000025" ZOrder="32988" FontSize="12" Valign="Middle" Color="009999" /> <Xref Database="ChEBI" ID="CHEBI:15356" /> </DataNode> <DataNode TextLabel="CSAT" GraphId="a67b9" Type="Protein"> <Comment>cysteine sulphinate alpha-oxoglutarate aminotransferase</Comment> <Comment>Not available in Uniprot (yet) 2021-01-17</Comment> <Graphics CenterX="857.3786569566248" CenterY="662.5958907661753" Width="90.0" Height="25.0" ZOrder="32989" FontSize="12" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="2.6.1.-" /> </DataNode> <DataNode TextLabel="Methionine adenosyltransferase I/III" GraphId="d9679" Type="Protein" GroupRef="cbec3"> <Graphics CenterX="927.5452648486295" CenterY="132.45641767160976" Width="213.42104692898238" Height="25.000000000000025" ZOrder="32990" FontSize="12" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="2.5.1.6" /> </DataNode> <DataNode TextLabel="X-MT" GraphId="b5879" Type="Protein"> <Comment>S-adenosylmethionine-dependent transmethylation enzymes</Comment> <Graphics CenterX="648.9265868863484" CenterY="262.16903921791277" Width="62.164179104476666" Height="25.0" ZOrder="32991" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Vit. B12&#xA;pathway" GraphId="be2aa" Type="Pathway"> <Graphics CenterX="566.5006075334143" CenterY="462.00486026731454" Width="90.0" Height="25.0" ZOrder="32992" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e" /> <Xref Database="WikiPathways" ID="WP4271" /> </DataNode> <DataNode TextLabel="CyD" GraphId="eac39" Type="Protein"> <Comment>Cysteine dioxygenase type 1</Comment> <Graphics CenterX="610.8930603740371" CenterY="579.4807288505314" Width="72.96049797227313" Height="24.02786614235265" ZOrder="32993" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16878" /> </DataNode> <DataNode TextLabel="CySD" GraphId="ca778" Type="Protein"> <Comment>Cysteine sulfinic acid decarboxylase</Comment> <Graphics CenterX="852.5065497702667" CenterY="579.4807288505314" Width="79.56950675620477" Height="25.488801602952464" ZOrder="32994" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y600" /> </DataNode> <DataNode TextLabel="SUOX" GraphId="d12ea" Type="GeneProduct"> <Comment>Sulfite oxidase</Comment> <Graphics CenterX="857.3786569566247" CenterY="774.6769739399805" Width="90.0" Height="25.0" ZOrder="32995" FontSize="12" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="1.8.3.1" /> </DataNode> <DataNode TextLabel="HTOx" GraphId="f3c97" Type="Protein"> <Comment>hypothaurine:NAD+ oxidoreductase</Comment> <Comment>Two known cofactors: heme,Molybdenum</Comment> <Graphics CenterX="1037.513075875906" CenterY="579.4807288505315" Width="90.0" Height="25.0" ZOrder="32996" FontSize="12" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="1.8.1.3" /> </DataNode> <DataNode TextLabel="Adenosine" GraphId="f06ef" Type="Metabolite"> <Graphics CenterX="672.1785132912025" CenterY="386.0838112723331" Width="90.0" Height="25.0" ZOrder="32997" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16335" /> </DataNode> <DataNode TextLabel="S-Adenosylhomocysteine" GraphId="da433" 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CenterX="439.0937579591445" CenterY="209.54595868057407" Width="90.0" Height="25.0" ZOrder="33003" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0000123" /> </DataNode> <DataNode TextLabel="BMT" GraphId="b5b47" Type="Protein"> <Comment>aka Betaine--homocysteine S-methyltransferase 1</Comment> <Graphics CenterX="109.52256944892098" CenterY="185.1132936148914" Width="53.037811920717786" Height="30.80977457581018" ZOrder="33004" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="E5RJH0" /> </DataNode> <DataNode TextLabel="Betaine" GraphId="ced92" Type="Metabolite"> <Graphics CenterX="109.52256944892098" CenterY="236.39781053242598" Width="90.0" Height="25.0" ZOrder="33005" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17750" /> </DataNode> <DataNode TextLabel="MAT2A" GraphId="ce53e" Type="Protein" GroupRef="cbec3"> <Graphics CenterX="928.1472297407779" CenterY="156.14735203366575" 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Href="http://omim.org/272300"> <Comment>DISEASE</Comment> <Comment>aka isolated sulphite oxidase deficiency</Comment> <Graphics CenterX="857.3786569566248" CenterY="829.1166690167717" Width="113.0" Height="29.5" ZOrder="33031" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="MAT deficiency" GraphId="d9ead" Href="http://omim.org/250850"> <Comment>DISEASE</Comment> <Comment>aka HYPERMETHIONINEMIA</Comment> <Graphics CenterX="816.7557348799385" CenterY="93.95231733693211" Width="113.0" Height="29.5" ZOrder="33032" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="Disease" GraphId="b5c85"> <Graphics CenterX="972.7772870502456" CenterY="231.62632573023666" Width="90.0" Height="25.0" ZOrder="33041" FillColor="ffcccc" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="Catalysis" GraphId="ec7cb"> <Graphics CenterX="1096.1513489172987" CenterY="458.16842321915465" Width="90.0" Height="25.0" ZOrder="33042" FillColor="ffffff" FontSize="12" Valign="Middle" /> </Label> <Label TextLabel="Pathway" GraphId="f7bd5"> <Graphics CenterX="972.7772870502456" CenterY="352.8536084043419" Width="90.0" Height="25.0" ZOrder="33043" FillColor="cccccc" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="009933" /> </Label> <Label TextLabel="Stimulation" GraphId="a866e"> <Graphics CenterX="1096.1513489172987" CenterY="422.1680417494291" Width="90.0" Height="25.0" ZOrder="33044" FillColor="ffffff" FontSize="12" Valign="Middle" /> </Label> <Label TextLabel="Protein" GraphId="a0db3"> <Graphics CenterX="972.7772870502456" CenterY="323.48323803397216" Width="90.0" Height="25.0" ZOrder="33045" FillColor="ffffff" FontSize="12" Valign="Middle" ShapeType="Rectangle" /> </Label> <Label TextLabel="Metabolite" GraphId="ca703"> <Graphics CenterX="972.7772870502456" CenterY="260.62632573023643" Width="90.0" Height="25.0" ZOrder="33046" FillColor="ffffff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="Conversion" GraphId="d467f"> <Graphics CenterX="1096.1513489172987" CenterY="385.16804174942945" Width="90.0" Height="25.0" ZOrder="33047" FillColor="ffffff" FontSize="12" Valign="Middle" /> </Label> <Label TextLabel="Connection &#xA;to disease&#xA;" GraphId="dbbaf"> <Graphics CenterX="1096.1513489172987" CenterY="498.1680417494272" Width="90.0" Height="25.0" ZOrder="33048" FillColor="ffffff" FontSize="12" Valign="Middle" /> </Label> <Label TextLabel="Legend" GraphId="e7a68"> <Graphics CenterX="1027.1513489172912" CenterY="196.55191556689783" Width="90.0" Height="25.0" ZOrder="33049" FillColor="ffffff" FontWeight="Bold" FontSize="16" Valign="Middle" /> </Label> <Label TextLabel="Biomarker" GraphId="a0943"> <Graphics CenterX="972.7772870502456" CenterY="291.45965906356935" Width="90.0" Height="25.0" ZOrder="33050" FillColor="ffffff" FontSize="12" Valign="Middle" ShapeType="Rectangle" Color="009999" /> </Label> <Label TextLabel="Cofactor" GraphId="e3500" GroupRef="bc6d5"> <Graphics CenterX="1098.7173614292235" CenterY="291.578676133761" Width="69.17086578103631" Height="16.70064131928527" ZOrder="33070" FillColor="ffffff" FontSize="12" Valign="Middle" ShapeType="Rectangle" Color="0000cc" /> </Label> <Shape GraphId="b3fce"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Extracellular region" /> <Graphics CenterX="1040.489312584802" CenterY="347.0121679165185" Width="249.67592733503912" Height="338.3125106053168" ZOrder="33040" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineStyle="Broken" Color="c0c0c0" Rotation="0.0" /> </Shape> <Group GroupId="bc6d5" Style="Group" /> <Group GroupId="a7fae" GraphId="b1016" Style="Complex" /> <Group GroupId="cbec3" GraphId="c27f3" Style="Group" /> <Group GroupId="f799d" GraphId="cbbaa" Style="Group" /> <Group GroupId="db9d5" GraphId="ee4bd" Style="Group" /> <InfoBox CenterX="0.0" CenterY="0.0" /> <Biopax> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0111039</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">homocystinuria pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001841</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">homocystinuria</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:9263</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hypermethioninemia pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002471</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">isolated sulfite oxidase deficiency</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0111270</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sulfite oxidase deficiency pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001647</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cysteine and methionine metabolic pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001078</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eac"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16435220</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Methionine adenosyltransferase (MAT) I/III deficiency with concurrent hyperhomocysteinaemia: two novel cases.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Inherit Metab Dis</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2005</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Linnebank M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lagler F</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Muntau AC</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Röschinger W</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Olgemöller B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fowler B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Koch HG</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cystathioninuria pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002561</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c47"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">'Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases'</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Springer-Verlag Berlin Heidelberg</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nenad Blau</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Marinus Duran K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Michael Gibson</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carlo Dionisi-Vici</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hypermethioninemia pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001868</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">altered metal homeostasis pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001832</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000013</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f2b"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6822523</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cysteinesulfinate metabolism. altered partitioning between transamination and decarboxylation following administration of beta-methyleneaspartate.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1983</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Griffith OW</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hypermethioninemia</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0050544</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cystathioninuria</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0090142</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">glycine N-methyltransferase deficiency pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002299</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">glycine N-methyltransferase deficiency</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0111037</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">methionine degradation pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001302</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hypermethioninemia due to adenosine kinase deficiency</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0111038</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> </Biopax> </Pathway>

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