COVID-19, thrombosis and anticoagulation (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="COVID-19, thrombosis and anticoagulation" Version="20200513" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Several hospitals and researchers have reported links between thrombosis and anticoagulation quite regularly for Covid-19 patients. This pathways combines this information, including biological mechanisms involved, in one graphical overview. The D-dimer is one of the protein fragments produced when a blood clot dissolves within the (human) body; when not properly degraded could lead to thrombosis. The graphical visualisation of (crosslinked) fibrin mesh leading to D-dimers is inspired by [https://en.wikipedia.org/wiki/D-dimer Wikipedia].</Comment> <BiopaxRef>bfd</BiopaxRef> <BiopaxRef>ba8</BiopaxRef> <Graphics BoardWidth="1677.6003406241853" BoardHeight="1181.0526315789473" /> <DataNode TextLabel="Leupeptin" GraphId="aa25f" Type="Metabolite" GroupRef="bc97b"> <Graphics CenterX="529.4605561522851" CenterY="1048.2500895094877" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:6426" /> </DataNode> <DataNode TextLabel="Chloroquine" GraphId="aa6bf" Type="Metabolite" GroupRef="bc97b"> <Graphics CenterX="529.4605561522851" CenterY="998.2500895094878" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:3638" /> </DataNode> <DataNode TextLabel="NH4Cl" GraphId="c8acb" Type="Metabolite" GroupRef="bc97b"> <Graphics CenterX="529.4605561522851" CenterY="1023.2500895094877" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:31206" /> </DataNode> <DataNode TextLabel="FGB (Bβ)" GraphId="e5d3d" Type="Protein" GroupRef="d3ccd"> <Comment>"FGB is not alternatively spliced"</Comment> <Graphics CenterX="1584.1287937403151" CenterY="357.69110235323166" Width="90.0" Height="25.0" ZOrder="32996" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02675" /> </DataNode> <DataNode TextLabel="FGA" GraphId="a4aba" Type="GeneProduct"> <Graphics CenterX="677.0" CenterY="138.45051698670602" Width="90.0" Height="25.0" ZOrder="33044" FontSize="12" Valign="Middle" /> <Xref Database="Entrez Gene" ID="2243" /> </DataNode> <DataNode TextLabel="Fibrinogen" GraphId="d0b3d" Type="Metabolite"> <Comment>Fibrinogen is a so-called Acute Phase Reactant, a class of proteins whose plasma concentrations increase or decrease at least 25 percent during inflammation.</Comment> <Graphics CenterX="789.1842475386776" CenterY="876.3853727144867" Width="90.0" Height="25.0" ZOrder="33045" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q381899" /> </DataNode> <DataNode TextLabel="Plasmin" GraphId="f1440" Type="Protein"> <Graphics CenterX="344.75479744136464" CenterY="675.72565742715" Width="90.0" Height="25.0" ZOrder="33046" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P00747" /> </DataNode> <DataNode TextLabel="FGG (γ)" GraphId="e46f4" Type="Protein" GroupRef="f349a"> <Comment>"fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene"</Comment> <Graphics CenterX="1326.6930288418623" CenterY="382.69110235323194" Width="90.0" Height="25.0" ZOrder="33047" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02679" /> </DataNode> <DataNode TextLabel="FGB (Bβ)" GraphId="d9a72" Type="Protein" GroupRef="f349a"> <Comment>"the fibrinogen beta chain (also termed the Bβ or β chain) encoded by the FGB gene"</Comment> <Graphics CenterX="1326.6930288418623" CenterY="357.69110235323166" Width="90.0" Height="25.0" ZOrder="33048" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02675" /> </DataNode> <DataNode TextLabel="Fibrinogen" GraphId="f3c75" Type="Metabolite"> <Graphics CenterX="342.47972478893917" CenterY="133.83577079040055" Width="90.0" Height="25.0" ZOrder="33049" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q381899" /> </DataNode> <DataNode TextLabel="FGA (Aα)" GraphId="f7650" Type="Protein" GroupRef="f349a"> <Comment>"fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene"</Comment> <Graphics CenterX="1356.4831439400334" CenterY="332.6911023532314" Width="90.0" Height="25.0" ZOrder="33053" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02671" /> </DataNode> <DataNode TextLabel="Formation of Fibrin Clot &#xA;(Clotting Cascade)" GraphId="ef4b2" Type="Pathway" GroupRef="d9a5a"> <Graphics CenterX="1463.5837337325102" CenterY="619.745274284257" Width="277.24489795918305" Height="36.07142857142816" ZOrder="33054" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP1818" /> </DataNode> <DataNode TextLabel="Blood Clotting &#xA;Cascade" GraphId="a5c4c" Type="Pathway" GroupRef="d9a5a"> <Graphics CenterX="1463.583733732512" CenterY="691.888131427114" Width="277.2448979591831" Height="36.07142857142816" ZOrder="33055" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP272" /> </DataNode> <DataNode TextLabel="FGA (AαE)" GraphId="d3c11" Type="Protein" GroupRef="d3ccd"> <Comment>"Alternate splicing of the FGA gene produces a minor expanded isoform of Aα termed AαE which replaces Aα in 1–3% of circulating fibrinogen"</Comment> <Graphics CenterX="1551.6304863604921" CenterY="332.6911023532314" Width="90.0" Height="25.0" ZOrder="33056" FontSize="12" Valign="Middle" /> <Xref Database="NCBI Protein" ID="NP_000499.1" /> </DataNode> <DataNode TextLabel="Blood clotting &#xA;and drug effects" GraphId="baa0a" Type="Pathway" GroupRef="d9a5a"> <Graphics CenterX="1463.5837337325117" CenterY="727.9595599985411" Width="277.2448979591831" Height="36.07142857142816" ZOrder="33058" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP4580" /> </DataNode> <DataNode TextLabel="Factor XIII A chain" GraphId="c1095" Type="Protein" GroupRef="aef85"> <Comment>Catalytically active</Comment> <Graphics CenterX="448.51713975492777" CenterY="379.70311772917626" Width="128.80952380952385" Height="25.0" ZOrder="33059" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P00488" /> </DataNode> <DataNode TextLabel="Complement and &#xA;Coagulation Cascades" GraphId="fe491" Type="Pathway" GroupRef="d9a5a"> <Graphics CenterX="1463.5837337325117" CenterY="764.0309885699681" Width="277.2448979591831" Height="36.07142857142816" ZOrder="33060" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP558" /> </DataNode> <DataNode TextLabel="Platelet-mediated interactions with &#xA;vascular and circulating cells" GraphId="f1370" Type="Pathway" GroupRef="d9a5a"> <Graphics CenterX="1463.5837337325102" CenterY="655.8167028556859" Width="277.24489795918305" Height="36.07142857142816" ZOrder="33061" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP4462" /> </DataNode> <DataNode TextLabel="Fibrin" GraphId="b71c1" Type="Metabolite" GroupRef="bc8f1"> <Graphics CenterX="299.8279430731174" CenterY="236.94385728518705" Width="90.0" Height="25.0" ZOrder="33062" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q27205" /> </DataNode> <DataNode TextLabel="fibrin degradation &#xA;products (FDPs)" GraphId="b02e2" Type="Metabolite"> <Graphics CenterX="232.2257383966245" CenterY="625.1958509142053" Width="129.38818565400845" Height="39.22292545710275" ZOrder="33066" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q2162109" /> </DataNode> <DataNode TextLabel="Fibrin" GraphId="a868a" Type="Metabolite" GroupRef="bc8f1"> <Graphics CenterX="429.7259022567932" CenterY="236.943857285187" Width="90.0" Height="25.0" ZOrder="33067" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q27205" /> </DataNode> <DataNode TextLabel="Thrombin" GraphId="af109" Type="Protein"> <Graphics CenterX="448.51713975492777" CenterY="177.79835582441416" Width="90.0" Height="25.0" ZOrder="33071" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P00734" /> </DataNode> <DataNode TextLabel="Fibrin" GraphId="d46df" Type="Metabolite" GroupRef="bc8f1"> <Graphics CenterX="254.66314622149508" CenterY="298.59079309115333" Width="90.0" Height="25.0" ZOrder="33072" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q27205" /> </DataNode> <DataNode TextLabel="Fibrin" GraphId="ddd67" Type="Metabolite" GroupRef="bc8f1"> <Graphics CenterX="389.1240548827713" CenterY="298.59079309115333" Width="90.0" Height="25.0" ZOrder="33076" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q27205" /> </DataNode> <DataNode TextLabel="Fibrin" GraphId="c2cf1" Type="Metabolite" GroupRef="a6456"> <Graphics CenterX="300.3041335493078" CenterY="458.37242871375946" Width="90.0" Height="25.0" ZOrder="33096" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q27205" /> </DataNode> <DataNode TextLabel="Fibrin" GraphId="ccbe8" Type="Metabolite" GroupRef="a6456"> <Graphics CenterX="430.20209273298354" CenterY="458.37242871375946" Width="90.0" Height="25.0" ZOrder="33100" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q27205" /> </DataNode> <DataNode TextLabel="Fibrin" GraphId="bacfd" Type="Metabolite" GroupRef="a6456"> <Graphics CenterX="255.1393366976855" CenterY="520.0193645197272" Width="90.0" Height="25.0" ZOrder="33104" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q27205" /> </DataNode> <DataNode TextLabel="Fibrin" GraphId="eeb61" Type="Metabolite" GroupRef="a6456"> <Graphics CenterX="389.6002453589617" CenterY="520.0193645197272" Width="90.0" Height="25.0" ZOrder="33108" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q27205" /> </DataNode> <DataNode TextLabel="Factor XIII B chain" GraphId="a3bd1" Type="Protein" GroupRef="aef85"> <Comment>Not catalytically active, believed to stabilise A chain</Comment> <Graphics CenterX="448.5171397549291" CenterY="404.7031177291764" Width="128.8095238095239" Height="25.0" ZOrder="33126" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P05160" /> </DataNode> <DataNode TextLabel="D-Dimer" GraphId="fc137" Type="Metabolite"> <BiopaxRef>c2a</BiopaxRef> <BiopaxRef>bfd</BiopaxRef> <Graphics CenterX="466.4090584364315" CenterY="625.1958509142053" Width="129.38818565400842" Height="39.22292545710275" ZOrder="33130" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q198526" /> </DataNode> <DataNode TextLabel="FGG (γ')" GraphId="bde6b" Type="Protein" GroupRef="d3ccd"> <Comment>"alternate splicing of FGG produces a minor isoform of γ termed γ' which replaces γ in 8–10% of circulating fibrinogen"</Comment> <Graphics CenterX="1584.1287937403151" CenterY="382.69110235323194" Width="90.0" Height="25.0" ZOrder="33145" FontSize="12" Valign="Middle" /> <Xref Database="NCBI Protein" ID="NP_068656.2" /> </DataNode> <DataNode TextLabel="FGG (γ)" GraphId="c5467" Type="Protein"> <Comment>"fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene"</Comment> <Graphics CenterX="789.4271499644617" CenterY="214.68719076069328" Width="90.0" Height="25.0" ZOrder="33148" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02679" /> </DataNode> <DataNode TextLabel="FGB (Bβ)" GraphId="d8eb7" Type="Protein"> <Comment>"the fibrinogen beta chain (also termed the Bβ or β chain) encoded by the FGB gene"</Comment> <Graphics CenterX="905.4271499644617" CenterY="214.68719076069328" Width="90.0" Height="25.0" ZOrder="33149" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02675" /> </DataNode> <DataNode TextLabel="FGA (Aα)" GraphId="f5a20" Type="Protein"> <Comment>"fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene"</Comment> <Graphics CenterX="677.0" CenterY="214.68719076069328" Width="90.0" Height="25.0" ZOrder="33150" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02671" /> </DataNode> <DataNode TextLabel="FGB" GraphId="dd369" Type="GeneProduct"> <Graphics CenterX="905.4271499644617" CenterY="138.45051698670602" Width="90.0" Height="25.0" ZOrder="33151" FontSize="12" Valign="Middle" /> <Xref Database="Entrez Gene" ID="2244" /> </DataNode> <DataNode TextLabel="FGG" GraphId="b0c94" Type="GeneProduct"> <Graphics CenterX="789.4271499644617" CenterY="138.45051698670602" Width="90.0" Height="25.0" ZOrder="33152" FontSize="12" Valign="Middle" /> <Xref Database="Entrez Gene" ID="2266" /> </DataNode> <DataNode TextLabel="FGG (γ)" GraphId="c1685" Type="Protein"> <Comment>"fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene"</Comment> <Graphics CenterX="789.4271499644617" CenterY="282.700516986706" Width="90.0" Height="25.0" ZOrder="33155" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02679" /> </DataNode> <DataNode TextLabel="FGB (Bβ)" GraphId="bd1cb" Type="Protein"> <Comment>"the fibrinogen beta chain (also termed the Bβ or β chain) encoded by the FGB gene"</Comment> <Graphics CenterX="905.4271499644617" CenterY="282.700516986706" Width="90.0" Height="25.0" ZOrder="33156" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02675" /> </DataNode> <DataNode TextLabel="FGA (Aα)" GraphId="d7d71" Type="Protein"> <Comment>"fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene"</Comment> <Graphics CenterX="677.0" CenterY="282.700516986706" Width="90.0" Height="25.0" ZOrder="33157" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02671" /> </DataNode> <DataNode TextLabel="FGA (Aα)" GraphId="b033d" Type="Protein" GroupRef="dfeb4"> <Comment>"fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene"</Comment> <Graphics CenterX="723.0" CenterY="364.70051698670636" Width="90.0" Height="25.0" ZOrder="33162" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02671" /> </DataNode> <DataNode TextLabel="FGG (γ)" GraphId="f865f" Type="Protein" GroupRef="dfeb4"> <Comment>"fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene"</Comment> <Graphics CenterX="723.0" CenterY="389.70051698670636" Width="90.0" Height="25.0" ZOrder="33163" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02679" /> </DataNode> <DataNode TextLabel="FGB (Bβ)" GraphId="c852c" Type="Protein" GroupRef="fe361"> <Comment>"the fibrinogen beta chain (also termed the Bβ or β chain) encoded by the FGB gene"</Comment> <Graphics CenterX="855.0" CenterY="364.70051698670636" Width="90.0" Height="25.0" ZOrder="33164" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02675" /> </DataNode> <DataNode TextLabel="FGG (γ)" GraphId="e7b86" Type="Protein" GroupRef="fe361"> <Comment>"fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene"</Comment> <Graphics CenterX="855.0" CenterY="389.70051698670636" Width="90.0" Height="25.0" ZOrder="33165" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02679" /> </DataNode> <DataNode TextLabel="FGA (Aα)" GraphId="ed893" Type="Protein" GroupRef="e856d"> <Comment>"fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene"</Comment> <Graphics CenterX="723.0" CenterY="499.70051698670636" Width="90.0" Height="25.0" ZOrder="33172" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02671" /> </DataNode> <DataNode TextLabel="FGG (γ)" GraphId="a482a" Type="Protein" GroupRef="e856d"> <Comment>"fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene"</Comment> <Graphics CenterX="723.0" CenterY="549.7005169867064" Width="90.0" Height="25.0" ZOrder="33173" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02679" /> </DataNode> <DataNode TextLabel="FGB (Bβ)" GraphId="e0508" Type="Protein" GroupRef="e856d"> <Comment>"the fibrinogen beta chain (also termed the Bβ or β chain) encoded by the FGB gene"</Comment> <Graphics CenterX="723.0" CenterY="524.7005169867064" Width="90.0" Height="25.0" ZOrder="33174" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02675" /> </DataNode> <DataNode TextLabel="FGA (Aα)" GraphId="c897a" Type="Protein" GroupRef="d2319"> <Comment>"fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene"</Comment> <Graphics CenterX="855.0" CenterY="499.70051698670636" Width="90.0" Height="25.0" ZOrder="33175" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02671" /> </DataNode> <DataNode TextLabel="FGG (γ)" GraphId="e3160" Type="Protein" GroupRef="d2319"> <Comment>"fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene"</Comment> <Graphics CenterX="855.0" CenterY="549.7005169867064" Width="90.0" Height="25.0" ZOrder="33176" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02679" /> </DataNode> <DataNode TextLabel="FGB (Bβ)" GraphId="d9ab7" Type="Protein" GroupRef="d2319"> <Comment>"the fibrinogen beta chain (also termed the Bβ or β chain) encoded by the FGB gene"</Comment> <Graphics CenterX="855.0" CenterY="524.7005169867064" Width="90.0" Height="25.0" ZOrder="33177" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02675" /> </DataNode> <DataNode TextLabel="FGA (Aα)" GraphId="f8b3b" Type="Protein" GroupRef="f912e"> <Comment>"fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene"</Comment> <Graphics CenterX="723.0" CenterY="639.7005169867064" Width="90.0" Height="25.0" ZOrder="33185" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02671" /> </DataNode> <DataNode TextLabel="FGG (γ)" GraphId="dcbc5" Type="Protein" GroupRef="f912e"> <Comment>"fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene"</Comment> <Graphics CenterX="723.0" CenterY="689.7005169867064" Width="90.0" Height="25.0" ZOrder="33186" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02679" /> </DataNode> <DataNode TextLabel="FGB (Bβ)" GraphId="f0fc7" Type="Protein" GroupRef="f912e"> <Comment>"the fibrinogen beta chain (also termed the Bβ or β chain) encoded by the FGB gene"</Comment> <Graphics CenterX="723.0" CenterY="664.7005169867064" Width="90.0" Height="25.0" ZOrder="33187" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02675" /> </DataNode> <DataNode TextLabel="FGA (Aα)" GraphId="da2b6" Type="Protein" GroupRef="f912e"> <Comment>"fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene"</Comment> <Graphics CenterX="855.0" CenterY="640.7005169867064" Width="90.0" Height="25.0" ZOrder="33188" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02671" /> </DataNode> <DataNode TextLabel="FGG (γ)" GraphId="a1272" Type="Protein" GroupRef="f912e"> <Comment>"fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene"</Comment> <Graphics CenterX="855.0" CenterY="690.7005169867064" Width="90.0" Height="25.0" ZOrder="33189" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02679" /> </DataNode> <DataNode TextLabel="FGB (Bβ)" GraphId="f16bc" Type="Protein" GroupRef="f912e"> <Comment>"the fibrinogen beta chain (also termed the Bβ or β chain) encoded by the FGB gene"</Comment> <Graphics CenterX="855.0" CenterY="665.7005169867064" Width="90.0" Height="25.0" ZOrder="33190" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02675" /> </DataNode> <DataNode TextLabel="FGA (Aα)" GraphId="eb717" Type="Protein" GroupRef="f7bfa"> <Comment>"fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene"</Comment> <Graphics CenterX="723.0" CenterY="760.8116280978177" Width="90.0" Height="25.0" ZOrder="33194" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02671" /> </DataNode> <DataNode TextLabel="FGG (γ)" GraphId="e6f92" Type="Protein" GroupRef="f7bfa"> <Comment>"fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene"</Comment> <Graphics CenterX="723.0" CenterY="810.8116280978177" Width="90.0" Height="25.0" ZOrder="33195" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02679" /> </DataNode> <DataNode TextLabel="FGB (Bβ)" GraphId="da513" Type="Protein" GroupRef="f7bfa"> <Comment>"the fibrinogen beta chain (also termed the Bβ or β chain) encoded by the FGB gene"</Comment> <Graphics CenterX="723.0" CenterY="785.8116280978177" Width="90.0" Height="25.0" ZOrder="33196" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02675" /> </DataNode> <DataNode TextLabel="FGA (Aα)" 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