Nod-like receptor (NLR) signaling pathway (Bos taurus)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Nod-like receptor (NLR) signaling pathway" Organism="Bos taurus"> <Comment Source="WikiPathways-description">Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-category">Molecular Function</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP288_r80026 WP288(80026)] with a 64.0% conversion rate.</Comment> <BiopaxRef>d56</BiopaxRef> <BiopaxRef>b56</BiopaxRef> <BiopaxRef>f81</BiopaxRef> <BiopaxRef>f78</BiopaxRef> <BiopaxRef>b26</BiopaxRef> <BiopaxRef>c28</BiopaxRef> <Graphics BoardWidth="1616.0" BoardHeight="866.0"/> <DataNode TextLabel="MAP3K7" GraphId="ce469" Type="GeneProduct" GroupRef="f2631"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885</Comment> <Graphics CenterX="514.0" CenterY="353.0" Width="50.0" Height="24.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002625"/> </DataNode> <DataNode TextLabel="CARD" GraphId="dba17" Type="GeneProduct" GroupRef="fe1ee"> <Graphics CenterX="366.5" CenterY="170.0" Width="55.0" Height="22.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="ERBB2IP" GraphId="a8040" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55914</Comment> <Graphics CenterX="842.0" CenterY="248.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000415"/> </DataNode> <DataNode TextLabel="TriDAP" GraphId="bf8e1" Type="Metabolite"> <Graphics CenterX="374.2416666666667" CenterY="55.99166666666667" Width="49.516666666666666" Height="20.016666666666666" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0033"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="MDP" GraphId="dd316" Type="Metabolite"> <Graphics CenterX="706.9833333333333" CenterY="27.483333333333334" Width="40.0333333333333" Height="20.016666666666666" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0033"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="DAMPS" GraphId="aff40" Type="Metabolite"> <Graphics CenterX="1486.4833333333333" CenterY="196.48333333333332" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CARD" GraphId="b34c1" Type="GeneProduct" GroupRef="fc942"> <Graphics CenterX="715.5" CenterY="166.0" Width="55.0" Height="22.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CARD" GraphId="b3290" Type="GeneProduct" GroupRef="fc942"> <Graphics CenterX="651.5" CenterY="166.0" Width="55.0" Height="22.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CARD" GraphId="c116a" Type="GeneProduct" GroupRef="bf51a"> <Graphics CenterX="474.5" CenterY="284.0" Width="55.0" Height="22.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="EPHB2" GraphId="ca822" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2048</Comment> <Graphics CenterX="646.4833333333333" CenterY="423.48333333333335" Width="49.03333333333337" Height="21.03333333333336" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000045902"/> </DataNode> <DataNode TextLabel="MAPK" GraphId="c87f4" Type="GeneProduct"> <Graphics CenterX="387.48333333333335" CenterY="413.48333333333335" Width="49.03333333333337" Height="21.03333333333336" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="MAPK8" GraphId="ca07c" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599</Comment> <Graphics CenterX="588.4833333333333" CenterY="464.48333333333335" Width="49.03333333333337" Height="21.03333333333336" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000007876"/> </DataNode> <DataNode TextLabel="IKBKG" GraphId="baa78" Type="GeneProduct" GroupRef="c95c4"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517</Comment> <Graphics CenterX="468.98333333333335" CenterY="530.9833333333333" Width="48.03333333333333" Height="16.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006268"/> </DataNode> <DataNode TextLabel="CHUK" GraphId="b2366" Type="GeneProduct" GroupRef="c95c4"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147</Comment> <Graphics CenterX="441.0" CenterY="548.9833333333333" Width="54.0" Height="16.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000007591"/> </DataNode> <DataNode TextLabel="IKBKB" GraphId="ddac9" Type="GeneProduct" GroupRef="c95c4"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551</Comment> <Graphics CenterX="495.98333333333335" CenterY="548.9833333333333" Width="52.03333333333333" Height="16.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000007599"/> </DataNode> <DataNode TextLabel="RELA" GraphId="c7084" Type="GeneProduct" GroupRef="e69a7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970</Comment> <Graphics CenterX="486.0504201680672" CenterY="649.9495798319327" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000013895"/> </DataNode> <DataNode TextLabel="CD40" GraphId="e68ae" Type="GeneProduct" GroupRef="e69a7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:958</Comment> <Graphics CenterX="485.0" CenterY="671.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020736"/> </DataNode> <Interaction GraphId="a584f"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="802.0" Y="248.0" GraphRef="a8040" RelX="-1.0" RelY="0.0"/> <Point X="755.5" Y="185.01666666666665" GraphRef="ee356" RelX="0.0" RelY="1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d723a"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="706.9833333333333" Y="37.49166666666667" GraphRef="dd316" RelX="0.0" RelY="1.0"/> <Point X="714.0" Y="131.0" GraphRef="a6a99" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a9aaf"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="1446.4833333333333" Y="196.48333333333332" GraphRef="aff40" RelX="-1.0" RelY="0.0"/> <Point X="1361.0" Y="320.9820885558939" GraphRef="afb65" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c9d2a" GroupRef="fe1ee"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="394.0" Y="170.0" GraphRef="dba17" RelX="1.0" RelY="0.0"/> <Point X="406.9666666666667" Y="169.4833333333333" GraphRef="d5df5" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e508b" GroupRef="fe1ee"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="459.0" Y="169.4833333333333" GraphRef="d5df5" RelX="1.0" RelY="0.0"/> <Point X="468.9666666666667" Y="168.9833333333333" GraphRef="aab26" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="efd57"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="374.2416666666667" Y="66.0" GraphRef="bf8e1" RelX="0.0" RelY="1.0"/> <Point X="434.0" Y="132.0" GraphRef="e15d2" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e40a8" GroupRef="fc942"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="743.0" Y="166.0" GraphRef="b34c1" RelX="1.0" RelY="0.0"/> <Point X="753.9666666666667" Y="165.4833333333333" GraphRef="efb4d" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f7b3e" GroupRef="fc942"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="806.0" Y="165.4833333333333" GraphRef="efb4d" RelX="1.0" RelY="0.0"/> <Point X="815.9666666666667" Y="164.9833333333333" GraphRef="dac44" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ef9ad" GroupRef="fc942"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="679.0" Y="166.0" GraphRef="b3290" RelX="1.0" RelY="0.0"/> <Point X="688.0" Y="166.0" GraphRef="b34c1" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e518e" GroupRef="bf51a"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="502.0" Y="284.0" GraphRef="c116a" RelX="1.0" RelY="0.0"/> <Point X="528.9666666666667" Y="284.98333333333335" GraphRef="cbfc8" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f4de8"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="439.5" Y="189.01666666666665" GraphRef="fe33c" RelX="0.0" RelY="1.0"/> <Point X="478.25" Y="260.98333333333335" GraphRef="faa76" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="fc609"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="685.75" Y="185.01666666666665" GraphRef="ee356" RelX="-0.5" RelY="1.0"/> <Point X="564.75" Y="260.98333333333335" GraphRef="faa76" RelX="0.5" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="fac29"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="521.5" Y="308.0" GraphRef="faa76" RelX="0.0" RelY="1.0"/> <Point X="514.0" Y="333.0" GraphRef="a1cd1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c418f"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="476.0" Y="383.25" GraphRef="a1cd1" RelX="-1.0" RelY="0.5"/> <Point X="412.0" Y="413.48333333333335" GraphRef="c87f4" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ee4e2"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="552.0" Y="383.25" GraphRef="a1cd1" RelX="1.0" RelY="0.5"/> <Point X="621.9666666666667" Y="423.48333333333335" GraphRef="ca822" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c65d7"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="533.0" Y="400.0" GraphRef="a1cd1" RelX="0.5" RelY="1.0"/> <Point X="588.4833333333333" Y="453.9666666666667" GraphRef="ca07c" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="dcc1b"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="514.0" Y="400.0" GraphRef="a1cd1" RelX="0.0" RelY="1.0"/> <Point X="485.0" Y="491.0" GraphRef="a2900" RelX="0.5" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="bafdc"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="485.0" Y="565.0" GraphRef="a2900" RelX="0.5" RelY="1.0"/> <Point X="485.5252100840336" Y="599.0" GraphRef="d2edd" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a5062"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="538.0504201680671" Y="646.0" GraphRef="d2edd" RelX="1.0" RelY="0.0"/> <Point X="642.0" Y="686.0" GraphRef="ceaec" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a7940"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="433.0" Y="646.0" GraphRef="d2edd" RelX="-1.0" RelY="0.0"/> <Point X="330.0" Y="666.0" GraphRef="c62c6" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a2676" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1266.0" Y="302.48333333333335" GraphRef="afa1b" RelX="1.0" RelY="0.0"/> <Point X="1278.9666666666667" Y="275.98333333333335" GraphRef="ac2b5" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d5e7f" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1266.0" Y="324.48333333333335" GraphRef="d1487" RelX="1.0" RelY="0.0"/> <Point X="1297.9666666666667" Y="321.98333333333335" GraphRef="eb477" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="de367" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1266.0" Y="346.48333333333335" GraphRef="ef05f" RelX="1.0" RelY="0.0"/> <Point X="1292.9666666666667" Y="363.98333333333335" GraphRef="a8865" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a5a9b" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1213.9666666666667" Y="302.48333333333335" GraphRef="afa1b" RelX="-1.0" RelY="0.0"/> <Point X="1204.0" Y="280.48333333333335" GraphRef="e19ef" RelX="1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c8ab8" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1213.9666666666667" Y="324.48333333333335" GraphRef="d1487" RelX="-1.0" RelY="0.0"/> <Point X="1204.0" Y="324.48333333333335" GraphRef="f71fc" RelX="1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c90a6" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1213.9666666666667" Y="346.48333333333335" GraphRef="ef05f" RelX="-1.0" RelY="0.0"/> <Point X="1204.0" Y="368.48333333333335" GraphRef="c3716" RelX="1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f03a6" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1161.0" Y="302.48333333333335" GraphRef="ba45a" RelX="1.0" RelY="0.0"/> <Point X="1170.9666666666667" Y="302.48333333333335" GraphRef="f1122" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="cd2de" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1160.0" Y="345.48333333333335" GraphRef="c4ac3" RelX="1.0" RelY="0.0"/> <Point X="1170.9666666666667" Y="346.48333333333335" GraphRef="a039f" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d3ca2" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1001.0" Y="324.48333333333335" GraphRef="afcd2" RelX="1.0" RelY="0.0"/> <Point X="1009.9666666666667" Y="323.98333333333335" GraphRef="c3a01" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f7913" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1067.0" Y="323.98333333333335" GraphRef="c3a01" RelX="1.0" RelY="0.0"/> <Point X="1077.0" Y="324.48333333333335" GraphRef="d3781" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="b7ccd" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1001.0" Y="366.48333333333335" GraphRef="ff033" RelX="1.0" RelY="0.0"/> <Point X="1009.9666666666667" Y="365.98333333333335" GraphRef="f71ca" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c600c" GroupRef="f9f72"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1067.0" Y="365.98333333333335" GraphRef="f71ca" RelX="1.0" RelY="0.0"/> <Point X="1077.0" Y="366.48333333333335" GraphRef="f5acb" RelX="-1.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="cf88f"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="1066.225" Y="385.00000000000006" GraphRef="afb65" RelX="-0.5" RelY="1.0"/> <Point X="1045.0" Y="485.0" GraphRef="a9ecd" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Label TextLabel="NACHT" GraphId="eaba4" GroupRef="fe1ee"> <Graphics CenterX="434.0" CenterY="168.0" Width="80.0" Height="22.033333333333335" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="NACHT" GraphId="d2272" GroupRef="fc942"> <Graphics CenterX="781.0" CenterY="164.0" Width="80.0" Height="22.033333333333335" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="Nod2" GraphId="a6a99"> <Graphics CenterX="714.0" CenterY="141.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Nod1" GraphId="e15d2"> <Graphics CenterX="434.0" CenterY="142.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="KD" GraphId="b5e06" GroupRef="bf51a"> <Comment>Kinase domain of RIP2</Comment> <Graphics CenterX="562.0" CenterY="282.0" Width="28.0" Height="14.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="RIP2" GraphId="a39ce"> <Graphics CenterX="629.0" CenterY="284.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="TAB1" GraphId="bd9bd" GroupRef="f2631"> <Graphics CenterX="499.0" CenterY="378.0" Width="30.0" Height="18.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="TAB2" GraphId="f202e" GroupRef="f2631"> <Graphics CenterX="529.0" CenterY="378.0" Width="30.0" Height="18.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="K63-linked Ub" GraphId="edd3c" GroupRef="c95c4"> <Graphics CenterX="398.0" CenterY="509.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="Iأژآ؛Bأژآ±" GraphId="df5a8" GroupRef="e69a7"> <Graphics CenterX="484.5" CenterY="626.0" Width="31.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="transcription" GraphId="ceaec"> <Graphics CenterX="662.0" CenterY="696.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="degradation" GraphId="c62c6"> <Graphics CenterX="330.0" CenterY="676.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="NACHT" GraphId="b73d5" GroupRef="f9f72"> <Graphics CenterX="1247.0" CenterY="323.0" Width="40.0" Height="22.033333333333335" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="NACHT" GraphId="d0088" GroupRef="f9f72"> <Graphics CenterX="1243.0" CenterY="345.0" Width="40.0" Height="22.033333333333335" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="NACHT" GraphId="c49c0" GroupRef="f9f72"> <Graphics CenterX="1243.5" CenterY="300.0" Width="43.0" Height="22.033333333333335" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="PYD" GraphId="c4445" GroupRef="f9f72"> <Graphics CenterX="1187.0" CenterY="279.0" Width="32.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="PYD" GraphId="e80ca" GroupRef="f9f72"> <Graphics CenterX="1187.0" CenterY="323.0" Width="32.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="PYD" GraphId="bcfd1" GroupRef="f9f72"> <Graphics CenterX="1187.0" CenterY="367.0" Width="32.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="PYD" GraphId="d972c" GroupRef="f9f72"> <Graphics CenterX="1187.0" CenterY="301.0" Width="32.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="PYD" GraphId="c814a" GroupRef="f9f72"> <Graphics CenterX="1187.0" CenterY="344.0" Width="32.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="CARD" GraphId="bd5df" GroupRef="f9f72"> <Graphics CenterX="1133.5" CenterY="301.0" Width="50.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="CARD" GraphId="b8ae6" GroupRef="f9f72"> <Graphics CenterX="1132.5" CenterY="344.0" Width="50.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="CARD" GraphId="adc4b" GroupRef="f9f72"> <Graphics CenterX="1101.0" CenterY="365.0" Width="50.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="CARD" GraphId="cc4fd" GroupRef="f9f72"> <Graphics CenterX="1103.5" CenterY="323.0" Width="50.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="p10" GraphId="bb2a7" GroupRef="f9f72"> <Graphics CenterX="988.5" CenterY="323.0" Width="25.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="p20" GraphId="e6ddd" GroupRef="f9f72"> <Graphics CenterX="1036.0" CenterY="323.0" Width="58.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="p10" GraphId="b464b" GroupRef="f9f72"> <Graphics CenterX="988.5" CenterY="365.0" Width="25.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="p20" GraphId="a6b1d" GroupRef="f9f72"> <Graphics CenterX="1036.0" CenterY="365.0" Width="58.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="IL-1أ¯آ؟آ½ and IL-18&#10;" GraphId="a9ecd"> <Graphics CenterX="1045.0" CenterY="495.0" Width="98.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="NALP3" GraphId="d79e2"> <Graphics CenterX="1255.0" CenterY="226.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="ASC" GraphId="ac15e"> <Graphics CenterX="1160.0" CenterY="415.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Caspase-1" GraphId="f8b50"> <Graphics CenterX="1053.0" CenterY="221.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Inflammasome pathway" GraphId="ac763"> <Graphics CenterX="1318.5" CenterY="530.0" Width="145.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Shape GraphId="dfec9"> <Graphics CenterX="801.0" CenterY="453.0" Width="1570.0" Height="766.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="aab26" GroupRef="fe1ee"> <Graphics CenterX="472.48333333333335" CenterY="168.98333333333332" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="e626f" GroupRef="fe1ee"> <Graphics CenterX="480.48333333333335" CenterY="168.98333333333332" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="ee569" GroupRef="fe1ee"> <Graphics CenterX="488.48333333333335" CenterY="168.98333333333332" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="aa9a2" GroupRef="fe1ee"> <Graphics CenterX="496.48333333333335" CenterY="168.98333333333332" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="f60c3" GroupRef="fe1ee"> <Graphics CenterX="504.48333333333335" CenterY="170.0" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="cc724" GroupRef="fe1ee"> <Graphics CenterX="512.4833333333333" CenterY="168.98333333333332" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="cc88e" GroupRef="fe1ee"> <Graphics CenterX="520.4833333333333" CenterY="168.98333333333332" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="b76a6" GroupRef="fe1ee"> <Graphics CenterX="528.4833333333333" CenterY="168.98333333333332" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="f6757" GroupRef="fe1ee"> <Graphics CenterX="536.4833333333333" CenterY="168.98333333333332" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="d5df5" GroupRef="fe1ee"> <Comment>Type your comment here</Comment> <Graphics CenterX="432.98333333333335" CenterY="169.48333333333332" Width="52.03333333333337" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="dee02" GroupRef="fc942"> <Graphics CenterX="875.4833333333333" CenterY="164.98333333333332" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="ce23c" GroupRef="fc942"> <Graphics CenterX="827.4833333333333" CenterY="164.98333333333332" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="efb4d" GroupRef="fc942"> <Comment>Type your comment here</Comment> <Graphics CenterX="779.9833333333333" CenterY="165.48333333333332" Width="52.0333333333333" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="e90a2" GroupRef="fc942"> <Graphics CenterX="843.4833333333333" CenterY="164.98333333333332" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="dac44" GroupRef="fc942"> <Graphics CenterX="819.4833333333333" CenterY="164.98333333333332" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="f3060" GroupRef="fc942"> <Graphics CenterX="867.4833333333333" CenterY="164.98333333333332" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="fb123" GroupRef="fc942"> <Graphics CenterX="835.4833333333333" CenterY="164.98333333333332" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="a7688" GroupRef="fc942"> <Graphics CenterX="883.4833333333333" CenterY="164.98333333333332" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="ff892" GroupRef="fc942"> <Graphics CenterX="851.4833333333333" CenterY="166.0" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="e5a3e" GroupRef="fc942"> <Graphics CenterX="859.4833333333333" CenterY="164.98333333333332" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="cbfc8" GroupRef="bf51a"> <Graphics CenterX="562.4833333333333" CenterY="284.98333333333335" Width="67.03333333333333" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="f6978" GroupRef="f2631"> <Graphics CenterX="528.9833333333333" CenterY="379.48333333333335" Width="28.033333333333335" Height="25.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="ab7a5" GroupRef="f2631"> <Graphics CenterX="500.48333333333335" CenterY="379.48333333333335" Width="27.033333333333335" Height="25.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="a819a" GroupRef="c95c4"> <Graphics CenterX="441.48333333333335" CenterY="515.4833333333333" Width="13.033333333333333" Height="11.033333333333333" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="a04b7" GroupRef="e69a7"> <Graphics CenterX="484.98333333333335" CenterY="628.4833333333333" Width="50.03333333333333" Height="13.033333333333333" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="be79d" GroupRef="e69a7"> <Graphics CenterX="509.5" CenterY="617.5" Width="11.0" Height="13.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="mim-phosphorylated" Rotation="0.0"/> </Shape> <Shape GraphId="d7184"> <Graphics CenterX="725.4833333333333" CenterY="699.0" Width="333.03333333333336" Height="174.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" LineStyle="Broken" Rotation="0.0"/> </Shape> <Shape GraphId="d1487" GroupRef="f9f72"> <Comment>Type your comment here</Comment> <Graphics CenterX="1239.9833333333333" CenterY="324.48333333333335" Width="52.0333333333333" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="ef05f" GroupRef="f9f72"> <Comment>Type your comment here</Comment> <Graphics CenterX="1239.9833333333333" CenterY="346.48333333333335" Width="52.0333333333333" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="afa1b" GroupRef="f9f72"> <Comment>Type your comment here</Comment> <Graphics CenterX="1239.9833333333333" CenterY="302.48333333333335" Width="52.0333333333333" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="e49c6" GroupRef="f9f72"> <Graphics CenterX="1298.4833333333333" CenterY="275.98333333333335" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="d6b3d" GroupRef="f9f72"> <Graphics CenterX="1306.4833333333333" CenterY="275.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="d9aaf" GroupRef="f9f72"> <Graphics CenterX="1314.4833333333333" CenterY="277.0" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="ac2b5" GroupRef="f9f72"> <Graphics CenterX="1282.4833333333333" CenterY="275.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="cacea" GroupRef="f9f72"> <Graphics CenterX="1322.4833333333333" CenterY="275.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="c4d92" GroupRef="f9f72"> <Graphics CenterX="1330.4833333333333" CenterY="275.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="7.087171031703404E-4"/> </Shape> <Shape GraphId="f69a9" GroupRef="f9f72"> <Graphics CenterX="1290.4833333333333" CenterY="275.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="be6c2" GroupRef="f9f72"> <Graphics CenterX="1325.4833333333333" CenterY="321.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="a942e" GroupRef="f9f72"> <Graphics CenterX="1341.4833333333333" CenterY="321.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="bd0d0" GroupRef="f9f72"> <Graphics CenterX="1309.4833333333333" CenterY="321.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="fdcb4" GroupRef="f9f72"> <Graphics CenterX="1333.4833333333333" CenterY="323.0" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="bb797" GroupRef="f9f72"> <Graphics CenterX="1317.4833333333333" CenterY="321.98333333333335" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="fc6b1" GroupRef="f9f72"> <Graphics CenterX="1349.4833333333333" CenterY="321.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="eb477" GroupRef="f9f72"> <Graphics CenterX="1301.4833333333333" CenterY="321.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="f9b0a" GroupRef="f9f72"> <Graphics CenterX="1320.4833333333333" CenterY="363.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="ef747" GroupRef="f9f72"> <Graphics CenterX="1336.4833333333333" CenterY="363.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="f3a63" GroupRef="f9f72"> <Graphics CenterX="1304.4833333333333" CenterY="363.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="eaa86" GroupRef="f9f72"> <Graphics CenterX="1328.4833333333333" CenterY="365.0" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="e6429" GroupRef="f9f72"> <Graphics CenterX="1312.4833333333333" CenterY="363.98333333333335" Width="7.03333333333336" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="ccc00" GroupRef="f9f72"> <Graphics CenterX="1344.4833333333333" CenterY="363.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="a8865" GroupRef="f9f72"> <Graphics CenterX="1296.4833333333333" CenterY="363.98333333333335" Width="7.033333333333303" Height="22.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Shape GraphId="e19ef" GroupRef="f9f72"> <Graphics CenterX="1187.4833333333333" CenterY="280.48333333333335" Width="33.03333333333333" Height="17.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="f71fc" GroupRef="f9f72"> <Graphics CenterX="1187.4833333333333" CenterY="324.48333333333335" Width="33.03333333333333" Height="17.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="c3716" GroupRef="f9f72"> <Graphics CenterX="1187.4833333333333" CenterY="368.48333333333335" Width="33.03333333333333" Height="17.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="f1122" GroupRef="f9f72"> <Graphics CenterX="1187.4833333333333" CenterY="302.48333333333335" Width="33.03333333333333" Height="17.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="a039f" GroupRef="f9f72"> <Graphics CenterX="1187.4833333333333" CenterY="346.48333333333335" Width="33.03333333333333" Height="17.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="ba45a" GroupRef="f9f72"> <Graphics CenterX="1136.0" CenterY="302.48333333333335" Width="50.0" Height="17.03333333333333" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="c4ac3" GroupRef="f9f72"> <Graphics CenterX="1135.0" CenterY="345.48333333333335" Width="50.0" Height="17.03333333333336" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="f5acb" GroupRef="f9f72"> <Graphics CenterX="1102.0" CenterY="366.48333333333335" Width="50.0" Height="17.03333333333336" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="d3781" GroupRef="f9f72"> <Graphics CenterX="1102.0" CenterY="324.48333333333335" Width="50.0" Height="17.03333333333336" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="afcd2" GroupRef="f9f72"> <Graphics CenterX="988.4833333333333" CenterY="324.48333333333335" Width="25.033333333333335" Height="17.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="c3a01" GroupRef="f9f72"> <Graphics CenterX="1038.4833333333333" CenterY="323.98333333333335" Width="57.03333333333333" Height="16.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="f71ca" GroupRef="f9f72"> <Graphics CenterX="1038.4833333333333" CenterY="365.98333333333335" Width="57.03333333333333" Height="16.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="ff033" GroupRef="f9f72"> <Graphics CenterX="988.4833333333333" CenterY="366.48333333333335" Width="25.033333333333335" Height="17.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="cceeb"> <Graphics CenterX="1252.5" CenterY="250.48333333333332" Width="161.0" Height="19.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Brace" Rotation="0.0"/> </Shape> <Shape GraphId="c82b2"> <Graphics CenterX="1158.4990882689658" CenterY="392.00349512118106" Width="92.91691611096819" Height="19.973222825713005" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Brace" Rotation="3.1416460149612266"/> </Shape> <Shape GraphId="b4d3a"> <Graphics CenterX="1053.0" CenterY="246.48333333333332" Width="152.0" Height="19.033333333333335" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Brace" Rotation="0.0"/> </Shape> <Shape GraphId="e61e7"> <Comment>Inflammasome pathway</Comment> <BiopaxRef>c28</BiopaxRef> <Graphics CenterX="1158.9833333333333" CenterY="374.0" Width="438.03333333333336" Height="328.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" LineStyle="Broken" Rotation="0.0"/> </Shape> <Group GroupId="f9f72" GraphId="afb65" Style="Group" TextLabel="NALP3 inflammasome"/> <Group GroupId="fe1ee" GraphId="fe33c" Style="Group" TextLabel="Nod1"/> <Group GroupId="fc942" GraphId="ee356" Style="Group" TextLabel="Nod2"/> <Group GroupId="e69a7" GraphId="d2edd" Style="Complex"/> <Group GroupId="c95c4" GraphId="a2900" Style="Group"/> <Group GroupId="f2631" GraphId="a1cd1" Style="Group"/> <Group GroupId="bf51a" GraphId="faa76" Style="Complex"/> <InfoBox CenterX="0.0" CenterY="0.0"/> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b56"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17110941</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nod-like proteins in immunity, inflammation and disease.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Immunol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fritz JH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ferrero RL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Philpott DJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Girardin SE</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b3c"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">kufer t</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c28"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17186029</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Rev Immunol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mariathasan S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Monack DM</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b26"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18161746</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nod-like proteins in inflammation and disease.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Pathol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carneiro LA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Magalhaes JG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tattoli I</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Philpott DJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Travassos LH</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NOD-like receptor signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000817</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f81"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16823444</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Intracellular pattern recognition receptors in the host response.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nature</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Meylan E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tschopp J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Karin M</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d56"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18414735</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Signal transduction pathways used by NLR-type innate immune receptors.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Biosyst</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kufer TA</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f78"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18585455</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NOD-like receptors (NLRs): bona fide intracellular microbial sensors.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Curr Opin Immunol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shaw MH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reimer T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim YG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nu&amp;amp;#xfffd;ez G</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

• Template:AuthorInfo
• Template:CheckAvailable (protected)
• Template:Help:LiteratureReferences (protected)
• Template:PathwayPage:History
• Template:PathwayPage:Xrefs

Return to Nod-like receptor (NLR) signaling pathway (Bos taurus).