Metabolic pathway of LDL, HDL and TG, including diseases (Homo sapiens)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Metabolic pathway of LDL, HDL and TG, including diseases" Version="20161102" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">This pathway shows genetic disorders related to lipoprotein metabolism. Two plasmalipoproteins, LDL and HDL, and one plasma lipid, triglyceride (TG), play an important role in this pathway. Hydrophobic lipids and fat-soluble vitamins are normally transported to the site of their uptake by transporters called lipoproteins, and any deregulation of the plasma concentrations of these proteins can cause dyslipidemias. Disorders resulting from an enzyme deficiency are highlighted in pink. More details on the composition of the various lipoproteins in this pathway are visualised in [https://www.wikipathways.org/index.php/Pathway:WP3601]. This pathway was inspired by Chapter 43 of the book of Blau (ISBN 3642403360 (978-3642403361)). </Comment> <BiopaxRef>e64</BiopaxRef> <Graphics BoardWidth="1727.0" BoardHeight="1126.3721657952603" /> <DataNode TextLabel="LPL" GraphId="a2fe4" Type="GeneProduct"> <Graphics CenterX="883.5311609390255" CenterY="944.0823456467372" Width="49.888657676684815" Height="29.395077873879263" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000175445" /> </DataNode> <DataNode TextLabel="Cholesterol" GraphId="a7196" Type="Metabolite" GroupRef="c112d"> <Graphics CenterX="1289.97867803838" CenterY="508.80110958255284" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16113" /> </DataNode> <DataNode TextLabel="Oxysterols" GraphId="aa2cd" Type="Pathway" GroupRef="b2e01"> <Comment>"Oxysterols are oxygenated derivatives of cholesterol or its sterol precursors, e.g. 7-dehydrocholesterol (7-DHC) or desmosterol" [ PubMed 27068984].</Comment> <Comment>See https://www.wikipathways.org/index.php/Pathway:WP4346 for mouse version (Human will be created at some point).</Comment> <BiopaxRef>a5e</BiopaxRef> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1573.5129902804786" CenterY="545.3991092840008" Width="90.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP4545"/> </DataNode> <DataNode TextLabel="LDLR" GraphId="abfde" Type="Protein"> <Graphics CenterX="501.4598799126639" CenterY="974.1179039301308" Width="113.87500000000023" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000130164" /> </DataNode> <DataNode TextLabel="SR-B1" GraphId="b15ec" Type="Protein"> <Comment>AKA SCARB1; Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux.</Comment> <BiopaxRef>e62</BiopaxRef> <Graphics CenterX="560.8537557515897" CenterY="744.6577181208054" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WTV0" /> </DataNode> <DataNode TextLabel="LCAT" GraphId="b485e" Type="GeneProduct"> <Comment>AKA Lecithin-cholesterol acyl transferase</Comment> <Graphics CenterX="852.659409917145" CenterY="593.027222385584" Width="79.91607949456875" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000213398" /> </DataNode> <DataNode TextLabel="LDLRAP1" GraphId="c3d61" Type="Protein"> <Comment>AKA Low density lipoprotein receptor adapter protein 1; ARH1</Comment> <Comment>"Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members." [https://www.uniprot.org/uniprot/Q5SW96]</Comment> <BiopaxRef>a69</BiopaxRef> <Graphics CenterX="473.4002042602858" CenterY="913.5652860502227" Width="76.21749429272745" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q5SW96" /> </DataNode> <DataNode TextLabel="Nuclear hormone receptors&#xA;(involved in sterol metabolism)" GraphId="c7e11" Type="Pathway"> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1573.5129902804786" CenterY="673.6509649555392" Width="223.81216963423367" Height="36.66488983653148" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP299"/> </DataNode> <DataNode TextLabel="Vit. D pathway" GraphId="cf557" Type="Pathway"> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1268.48933901919" CenterY="420.6551176434593" Width="112.97867803838017" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP1531"/> </DataNode> <DataNode TextLabel="Steroid Biosynthesis&#xA;(general overview)" GraphId="d4389" Type="Pathway" GroupRef="e793e"> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1427.3354231974922" CenterY="325.5692313979645" Width="210.05205922163623" Height="32.08509142053447" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP496" /> </DataNode> <DataNode TextLabel="HL " GraphId="d6f30" Type="GeneProduct"> <Comment>EC 3.1.1.3</Comment> <Graphics CenterX="1119.6580041580041" CenterY="951.9133749133747" Width="49.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P11150" /> </DataNode> <DataNode TextLabel="HL" GraphId="d820d" Type="GeneProduct"> <Comment>EC 3.1.1.3 aka LIPC</Comment> <Graphics CenterX="864.034484746023" CenterY="434.13404544173807" Width="55.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y5X9" /> </DataNode> <DataNode TextLabel="CETP" GraphId="db111" Type="GeneProduct"> <Graphics CenterX="901.4838663209448" CenterY="740.6666666666666" Width="74.30106597522344" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000087237" /> </DataNode> <DataNode TextLabel="Annexin A2" GraphId="dd4e5" Type="Protein"> <BiopaxRef>caa</BiopaxRef> <Graphics CenterX="562.4006706016245" CenterY="1039.327919499606" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="H0YKN4" /> </DataNode> <DataNode TextLabel="LDL-receptor" GraphId="e84e1" Type="Protein"> <Graphics CenterX="1277.896233120114" CenterY="608.2562521411444" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P01130" /> </DataNode> <DataNode TextLabel="MTP" GraphId="efd64" Type="GeneProduct"> <Comment>"Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B." [https://www.uniprot.org/uniprot/P55157]</Comment> <Graphics CenterX="1041.4201183431946" CenterY="140.53254437869828" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P55157" /> </DataNode> <DataNode TextLabel="C-II" GraphId="f4600" Type="Protein" GroupRef="dc6a8"> <Comment>AKA Apolipoprotein C2; cofactor for lipoprotein lipase (LPL) enzyme.</Comment> <Graphics CenterX="740.7522517526618" CenterY="145.65708256084145" Width="48.47222222222217" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02655" /> </DataNode> <DataNode TextLabel="PCSK9" GraphId="f5c32" Type="GeneProduct"> <BiopaxRef>ca1</BiopaxRef> <Graphics CenterX="694.7790044521824" CenterY="1039.3279194996062" Width="90.0" Height="29.24445559715999" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000169174" /> </DataNode> <DataNode TextLabel="Cyclic fatty acids" GraphId="f6188" Type="Metabolite"> <Graphics CenterX="832.1881038502859" CenterY="125.38376602686739" Width="107.75" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:59238" /> </DataNode> <DataNode TextLabel="ABCA1" GraphId="f63e5" Type="GeneProduct"> <Graphics CenterX="1143.2560583451284" CenterY="581.925851703407" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000165029" /> </DataNode> <DataNode TextLabel="Remnant receptor" GraphId="f9700" Type="Protein"> <Graphics CenterX="495.66002265328365" CenterY="676.6362153344212" Width="104.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="LPL" GraphId="fb57d" Type="GeneProduct"> <Graphics CenterX="558.0528052805262" CenterY="113.68646864686411" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000175445" /> </DataNode> <DataNode TextLabel="Cholesterol" GraphId="f8747" Type="Metabolite" GroupRef="c112d"> <Graphics CenterX="1317.9937304075238" CenterY="553.2838682032435" Width="90.0" Height="25.0" ZOrder="32791" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16113" /> </DataNode> <DataNode TextLabel="Cholesterol" GraphId="db79a" Type="Metabolite" GroupRef="c112d"> <Graphics CenterX="1428.3072100313477" CenterY="557.7979747863159" Width="90.0" Height="25.0" ZOrder="32792" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16113" /> </DataNode> <DataNode TextLabel="Cholesterol" GraphId="cd187" Type="Metabolite" GroupRef="c112d"> <Graphics CenterX="1427.3354231974924" CenterY="473.7540876389808" Width="90.0" Height="25.0" ZOrder="32793" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16113" /> </DataNode> <DataNode TextLabel="Classical steroidogenesis&#xA;(including diseases)" GraphId="e10f4" Type="Pathway" GroupRef="e793e"> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1427.3354231974922" CenterY="357.65432281849894" Width="210.05205922163623" Height="32.08509142053447" ZOrder="32794" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP4523"/> </DataNode> <DataNode TextLabel="Alternative steroidogenesis&#xA;(including diseases)" GraphId="d862d" Type="Pathway" GroupRef="e793e"> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1427.3354231974922" CenterY="389.7394142390334" Width="210.05205922163623" Height="32.08509142053447" ZOrder="32795" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP4524"/> </DataNode> <DataNode TextLabel="Bile Acids" GraphId="d0127" Type="Pathway" GroupRef="b2e01"> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1573.5129902804786" CenterY="570.3991092840008" Width="90.0" Height="25.0" ZOrder="32798" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP4389"/> </DataNode> <DataNode TextLabel="B48" GraphId="fbfee" Type="Protein" GroupRef="dc6a8"> <Comment>"Apolipoprotein B(apo B) occurs in the plasma in 2 main isoforms, ApoB48 and ApoB100. ApoB48 is generated when a stop codon (UAA) is created by RNA editing. As a result of the RNA editing, ApoB48 and ApoB100 share a common N-terminal sequence, but ApoB48 lacks ApoB100's C-terminal LDL receptor binding region. In fact, ApoB48 is so called because it constitutes 48% of the sequence for ApoB100. ApoB 48 is a unique protein to chylomicrons from the small intestine. After most of the lipids in the chylomicron have been absorbed, ApoB48 returns to the liver as part of the chylomicron remnant, where it is endocytosed and degraded." [https://en.wikipedia.org/wiki/Apolipoprotein_B]</Comment> <Comment>Synthesized in small intestine.</Comment> <Comment>Transcript ID: ENST00000233242.4</Comment> <Graphics CenterX="830.6160482637899" CenterY="190.3981025831841" Width="48.47222222222217" Height="25.0" ZOrder="32800" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="A8MUN2" /> </DataNode> <DataNode TextLabel="E" GraphId="dda82" Type="Protein" GroupRef="dc6a8"> <Comment>AKA APo E, a ligand for receptor mediated endocytosis.</Comment> <Graphics CenterX="719.0318770856525" CenterY="242.0996794500743" Width="48.47222222222217" Height="25.0" ZOrder="32801" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02649" /> </DataNode> <DataNode TextLabel="VLDL" GraphId="ea312" Type="Metabolite" GroupRef="d4ee4"> <Comment>Very low-density lipoprotein (VLDL) is one of the two main TG (triglyceride or triacylglycerol) carrying lipoproteins, which are spheroidal macromolecular complexes responsible for transporting lipids through plasma.</Comment> <Graphics CenterX="759.7463488083893" CenterY="965.3135698208508" Width="90.0" Height="25.0" ZOrder="32803" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:39027" /> </DataNode> <DataNode TextLabel="B100" GraphId="a7aed" Type="Protein" GroupRef="d4ee4"> <Comment>"Apoprotein B100 (ApoB-100) is embedded in the outer phospholipid layer of LDL particles." [https://en.wikipedia.org/wiki/LDL_receptor]</Comment> <Comment>Synthesized in liver.</Comment> <Graphics CenterX="702.039003593381" CenterY="856.5362206080595" Width="48.47222222222217" Height="25.0" ZOrder="32805" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P04114" /> </DataNode> <DataNode TextLabel="B48" GraphId="f94ed" Type="Protein" GroupRef="f6a07"> <Comment>"Apolipoprotein B(apo B) occurs in the plasma in 2 main isoforms, ApoB48 and ApoB100. ApoB48 is generated when a stop codon (UAA) is created by RNA editing. As a result of the RNA editing, ApoB48 and ApoB100 share a common N-terminal sequence, but ApoB48 lacks ApoB100's C-terminal LDL receptor binding region. In fact, ApoB48 is so called because it constitutes 48% of the sequence for ApoB100. ApoB 48 is a unique protein to chylomicrons from the small intestine. After most of the lipids in the chylomicron have been absorbed, ApoB48 returns to the liver as part of the chylomicron remnant, where it is endocytosed and degraded." [https://en.wikipedia.org/wiki/Apolipoprotein_B]</Comment> <Comment>Synthesized in small intestine.</Comment> <Graphics CenterX="534.5666023758358" CenterY="198.41193572919445" Width="48.47222222222217" Height="25.0" ZOrder="32811" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="A8MUN2" /> </DataNode> <DataNode TextLabel="E" GraphId="b1def" Type="Protein" GroupRef="f6a07"> <Comment>AKA APo E, a ligand for receptor mediated endocytosis.</Comment> <Graphics CenterX="447.34438015361616" CenterY="235.0323060995649" Width="48.47222222222217" Height="25.0" ZOrder="32812" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02649" /> </DataNode> <DataNode TextLabel="A-I" GraphId="c0ca0" Type="Protein" GroupRef="a45d1"> <Comment>AKA Apo A-I; activator of lecithin-cholesterol acyl transferase (LCAT).</Comment> <Graphics CenterX="983.4414128226152" CenterY="472.7710639444007" Width="39.98290241868209" Height="32.726855713094324" ZOrder="32816" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02647" /> </DataNode> <DataNode TextLabel="A-II" GraphId="c3dbf" Type="Protein" GroupRef="a45d1"> <Comment>AKA Apolipoprotein A-II</Comment> <Graphics CenterX="1030.7141400953417" CenterY="546.7355609858205" Width="39.98290241868209" Height="32.726855713094324" ZOrder="32817" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02652" /> </DataNode> <DataNode TextLabel="A-I" GraphId="e2d25" Type="Protein" GroupRef="b0c05"> <Comment>AKA Apo A-I; activator of lecithin-cholesterol acyl transferase (LCAT).</Comment> <Graphics CenterX="725.5192299263268" CenterY="472.7710639444007" Width="39.98290241868209" Height="32.726855713094324" ZOrder="32821" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02647" /> </DataNode> <DataNode TextLabel="IDL" GraphId="fdfe8" Type="Metabolite" GroupRef="f503f"> <Comment>Itermediate-density lipoprotein (IDL), physiologically a short lived species, containd around equimolar amounts of cholesterol and Triglycerides (TG).</Comment> <Graphics CenterX="995.9397491796203" CenterY="966.0113773907606" Width="90.0" Height="25.0" ZOrder="32824" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:132933" /> </DataNode> <DataNode TextLabel="B100" GraphId="a05f3" Type="Protein" GroupRef="f503f"> <Comment>"Apoprotein B100 (ApoB-100) is embedded in the outer phospholipid layer of LDL particles." [https://en.wikipedia.org/wiki/LDL_receptor]</Comment> <Comment>Synthesized in liver.</Comment> <Graphics CenterX="941.886484354381" CenterY="858.4520549745587" Width="48.47222222222217" Height="25.0" ZOrder="32826" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P04114" /> </DataNode> <DataNode TextLabel="LDL" GraphId="f04bd" Type="Metabolite" GroupRef="f29db"> <Comment>Low-density lipoprotein (LDL) is one of the two main cholesterol carrying lipoproteins, which are spheroidal macromolecular complexes responsible for transporting lipids through plasma.</Comment> <Graphics CenterX="1240.162954890032" CenterY="964.3188662835835" Width="90.0" Height="25.0" ZOrder="32830" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:39026" /> </DataNode> <DataNode TextLabel="B100" GraphId="d572e" Type="Protein" GroupRef="f29db"> <Comment>"Apoprotein B100 (ApoB-100) is embedded in the outer phospholipid layer of LDL particles." [https://en.wikipedia.org/wiki/LDL_receptor]</Comment> <Comment>Synthesized in liver.</Comment> <Graphics CenterX="1177.666193408669" CenterY="866.3320873667612" Width="48.47222222222217" Height="25.0" ZOrder="32831" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P04114" /> </DataNode> <DataNode TextLabel="C-II" GraphId="e94ad" Type="Protein" GroupRef="d4ee4"> <Comment>AKA Apolipoprotein C2; cofactor for lipoprotein lipase (LPL) enzyme.</Comment> <Graphics CenterX="812.6307047913349" CenterY="841.8449278647089" Width="48.47222222222217" Height="25.0" ZOrder="32836" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02655" /> </DataNode> <DataNode TextLabel="E" GraphId="caa9a" Type="Protein" GroupRef="d4ee4"> <Comment>AKA APo E, a ligand for receptor mediated endocytosis.</Comment> <Graphics CenterX="809.694860511067" CenterY="922.8179114942751" Width="48.47222222222217" Height="25.0" ZOrder="32837" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02649" /> </DataNode> <DataNode TextLabel="E" GraphId="bbbcf" Type="Protein" GroupRef="f503f"> <Comment>AKA APo E, a ligand for receptor mediated endocytosis.</Comment> <Graphics CenterX="1048.8942325675823" CenterY="917.3480268054802" Width="48.47222222222217" Height="25.0" ZOrder="32838" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P02649" /> </DataNode> <DataNode TextLabel="MTP" GraphId="c741d" Type="GeneProduct"> <Comment>"Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B." [https://www.uniprot.org/uniprot/P55157]</Comment> <Graphics CenterX="626.4437120976992" CenterY="984.7084438254893" Width="61.504409958692634" Height="25.0" ZOrder="32847" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P55157" /> </DataNode> <Interaction GraphId="id100161b9"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="694.7790044521824" Y="1053.950147298186" GraphRef="f5c32" RelX="0.0" RelY="1.0" /> <Point X="735.9480912248268" Y="1080.1221657952601" GraphRef="e42eb" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id444e240b"> <BiopaxRef>a67</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="924.7378892592549" Y="489.94893683897226" GraphRef="a3d29" RelX="-1.0" RelY="-0.5" /> <Point X="789.2184841407442" Y="489.94893683897226" GraphRef="a3424" RelX="1.0" RelY="-0.5" ArrowHead="mim-conversion" /> <Anchor Position="0.4367816091954018" Shape="None" GraphId="b78b2" /> </Graphics> <Xref Database="Rhea" ID="RHEA:38497" /> </Interaction> <Interaction GraphId="id44587cee"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="883.5311609390255" Y="929.3848067097975" GraphRef="a2fe4" RelX="0.0" RelY="-1.0" /> <Point X="881.2715793056515" Y="896.761810173181" GraphRef="eff88" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id486de70c"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="624.2105263157895" Y="941.2309998487943" GraphRef="e463c" RelX="0.0" RelY="0.0" /> <Point X="626.4437120976993" Y="867.1151241300252" GraphRef="ed33b" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id5498245e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="864.333333333333" Y="740.6666666666666" GraphRef="db111" RelX="-1.0" RelY="0.0" /> <Point X="758.8385068628429" Y="749.9811913791826" GraphRef="a582b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id56204ee1"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="686.7957659745414" Y="211.07745507953192" GraphRef="e14d8" RelX="-1.0" RelY="0.0" /> <Point X="566.8027134869469" Y="211.8387511909449" GraphRef="b3f75" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4776320411384771" Shape="None" GraphId="c7033" /> <Anchor Position="0.483067829139724" Shape="None" GraphId="d380b" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id7417e119"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="1229.9723631918828" Y="984.8188662835835" GraphRef="ab814" RelX="0.0" RelY="1.0" /> <Point X="865.7161215522733" Y="1129.113924050633" /> <Point X="501.45987991266395" Y="986.6179039301308" GraphRef="abfde" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id76d8bd1c"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1235.289267945985" Y="530.9586330935258" GraphRef="fddb5" RelX="-1.0" RelY="0.0" /> <Point X="1058.7055913046827" Y="531.490237590091" GraphRef="a3d29" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> <Anchor Position="0.5207814686147749" Shape="None" GraphId="be1d6" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id7a3039f6"> <Comment>Oxysterols and Bile acids are activators of nuclear hormone receptors, which are involved in sterol metabolism.</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1573.5129902804786" Y="590.8991092840008" GraphRef="e6032" RelX="0.0" RelY="1.0" /> <Point X="1573.5129902804786" Y="655.3185200372734" GraphRef="c7e11" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id87db2526"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="473.4002042602858" Y="926.0652860502227" GraphRef="c3d61" RelX="0.0" RelY="1.0" /> <Point X="472.9911299126639" Y="961.6179039301308" GraphRef="abfde" RelX="-0.5" RelY="-1.0" ArrowHead="mim-stimulation" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id90f3ee49"> <BiopaxRef>d07</BiopaxRef> <BiopaxRef>eae</BiopaxRef> <BiopaxRef>abb</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>fb8</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1041.4201183431946" Y="153.03254437869828" GraphRef="efd64" RelX="0.0" RelY="1.0" /> <Point X="1023.0762728986409" Y="211.22662498685497" GraphRef="ded1b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id9179eec7"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="728.0170952518553" Y="614.5728390923286" GraphRef="a3424" RelX="0.0" RelY="1.0" /> <Point X="713.568873337314" Y="807.4832899326252" GraphRef="da60c" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id91aacfc3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="490.955491264726" Y="289.9304542477127" GraphRef="b3f75" RelX="0.0" RelY="1.0" /> <Point X="495.6600226532837" Y="664.1362153344212" GraphRef="f9700" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id91c1e8bf"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="558.0528052805262" Y="126.18646864686411" GraphRef="fb57d" RelX="0.0" RelY="1.0" /> <Point X="629.4832393924552" Y="211.4410744951369" GraphRef="c7033" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id94bd6c4"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="560.8537557515897" Y="732.1577181208054" GraphRef="b15ec" RelX="0.0" RelY="-1.0" /> <Point X="759.5417852611008" Y="387.91946308724835" /> <Point X="958.2298147706118" Y="448.40763608785346" GraphRef="a3d29" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id9d374fe4"> <Comment>Transport of cholesterol-rich LDL into cell.</Comment> <Graphics ConnectorType="Elbow" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="1277.896233120114" Y="813.6981104367148" GraphRef="bf5f3" RelX="0.0" RelY="0.0" /> <Point X="1372.257053291536" Y="719.8010935876621" /> <Point X="1369.7274310524183" Y="611.8752997601918" /> <Point X="1367.1978088133005" Y="591.8752997601919" GraphRef="cbbd7" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idaa974573"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="558.3973799126641" Y="974.1179039301308" GraphRef="abfde" RelX="1.0" RelY="0.0" /> <Point X="669.80289248227" Y="941.2309998487943" GraphRef="da60c" RelX="-1.0" RelY="0.5" ArrowHead="mim-conversion" /> <Anchor Position="0.6840279813403296" Shape="None" GraphId="e463c" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idaebe7fca"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="864.034484746023" Y="446.63404544173807" GraphRef="d820d" RelX="0.0" RelY="1.0" /> <Point X="865.5455054143882" Y="489.94893683897226" GraphRef="b78b2" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Rhea" ID="RHEA:38497" /> </Interaction> <Interaction GraphId="idafce192"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1114.4720741304898" Y="211.3117151951865" GraphRef="e7489" RelX="-1.0" RelY="0.0" /> <Point X="862.852159374901" Y="211.07745507953192" GraphRef="e14d8" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> <Anchor Position="0.3632296009663078" Shape="None" GraphId="ded1b" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idcc399a35"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="844.866815902446" Y="896.648429876738" GraphRef="da60c" RelX="1.0" RelY="0.0" /> <Point X="909.6503732432698" Y="896.8501941034294" GraphRef="e2a67" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> <Anchor Position="0.5709232722655543" Shape="None" GraphId="aa5ce" /> <Anchor Position="0.5619444948304005" Shape="None" GraphId="eff88" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idce5366f8"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="852.659409917145" Y="580.527222385584" GraphRef="b485e" RelX="0.0" RelY="-1.0" /> <Point X="853.6912751677852" Y="531.490237590091" GraphRef="b6414" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idcebb4f45"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="666.8157063629664" Y="531.490237590091" GraphRef="a3424" RelX="-1.0" RelY="0.0" /> <Point X="644.2953020134228" Y="638.0739778554482" /> <Point X="605.8537557515897" Y="744.6577181208054" GraphRef="b15ec" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idd9cbf02b"> <BiopaxRef>ca1</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="694.7790044521824" Y="1053.950147298186" GraphRef="f5c32" RelX="0.0" RelY="1.0" /> <Point X="529.9286299126641" Y="986.6179039301308" GraphRef="abfde" RelX="0.5" RelY="1.0" ArrowHead="mim-binding" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="iddcf88dc3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="758.9452760343984" Y="815.4832899326252" GraphRef="bf0f8" RelX="0.0" RelY="-1.0" /> <Point X="758.6177896962997" Y="614.5728390923286" GraphRef="a3424" RelX="0.5" RelY="1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.32602633800025693" Shape="None" GraphId="a582b" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ide5250c6b"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1143.2560583451284" Y="594.425851703407" GraphRef="f63e5" RelX="0.0" RelY="1.0" /> <Point X="1143.327761491331" Y="531.2354828639693" GraphRef="be1d6" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ide571e679"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="789.2184841407442" Y="531.490237590091" GraphRef="a3424" RelX="1.0" RelY="0.0" /> <Point X="924.7378892592549" Y="531.490237590091" GraphRef="a3d29" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4757458237856051" Shape="None" GraphId="b6414" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ide60b483a"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="1143.327761491331" Y="531.2354828639693" GraphRef="be1d6" RelX="0.0" RelY="0.0" /> <Point X="1143.2560583451282" Y="453.60113857756613" GraphRef="e932c" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ideb2222c1"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="1114.4720741304898" Y="225.6867151951865" GraphRef="e7489" RelX="-1.0" RelY="0.5" /> <Point X="991.7217402819688" Y="448.40763608785346" GraphRef="a3d29" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idf0c2e3ad"> <BiopaxRef>b5a</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="694.7790044521824" Y="1024.7056917010264" GraphRef="f5c32" RelX="0.0" RelY="-1.0" /> <Point X="714.7463488083893" Y="965.3135698208508" GraphRef="ea312" RelX="-1.0" RelY="0.0" ArrowHead="mim-modification" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="a02a4"> <BiopaxRef>e4a</BiopaxRef> <Graphics ZOrder="32773" LineThickness="1.0"> <Point X="1081.1303436786934" Y="896.8501941034294" GraphRef="e2a67" RelX="1.0" RelY="0.0" /> <Point X="1145.4300822975579" Y="895.9660574547426" GraphRef="ab814" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> <Anchor Position="0.7407407407407409" Shape="None" GraphId="bdde7" /> </Graphics> <Xref Database="Rhea" ID="RHEA:12046" /> </Interaction> <Interaction GraphId="deee1"> <Graphics ZOrder="32774" LineThickness="1.0"> <Point X="1119.6580041580041" Y="939.4133749133747" GraphRef="d6f30" RelX="0.0" RelY="-1.0" /> <Point X="1128.759779692667" Y="896.195278067365" GraphRef="bdde7" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ida765c91"> <BiopaxRef>caa</BiopaxRef> <Graphics ZOrder="32790" LineThickness="1.0"> <Point X="607.4006706016245" Y="1039.327919499606" GraphRef="dd4e5" RelX="1.0" RelY="0.0" /> <Point X="649.7790044521824" Y="1039.3279194996062" GraphRef="f5c32" RelX="-1.0" RelY="0.0" ArrowHead="mim-inhibition" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id10ce9d03"> <Comment>Cholesterol is the precursor for steroid hormones.</Comment> <Graphics ZOrder="32796" LineStyle="Broken" LineThickness="1.0"> <Point X="1427.3354231974924" Y="461.2540876389808" GraphRef="cd187" RelX="0.0" RelY="-1.0" /> <Point X="1427.3354231974922" Y="413.78195994930064" GraphRef="ab550" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f16ca"> <Comment>Cholesterol is the precursor for Vitamin D.</Comment> <Graphics ZOrder="32797" LineStyle="Broken" LineThickness="1.0"> <Point X="1289.97867803838" Y="496.30110958255284" GraphRef="a7196" RelX="0.0" RelY="-1.0" /> <Point X="1268.48933901919" Y="433.1551176434593" GraphRef="cf557" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f4a63"> <Comment>Cholesterol is the precursor for Oxysterols and Bile acids.</Comment> <Graphics ZOrder="32799" LineStyle="Broken" LineThickness="1.0"> <Point X="1473.3072100313477" Y="557.7979747863159" GraphRef="db79a" RelX="1.0" RelY="0.0" /> <Point X="1520.5129902804786" Y="557.8991092840008" GraphRef="e6032" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id9b79643f"> <Graphics ConnectorType="Elbow" ZOrder="32834" LineThickness="1.0"> <Point X="1201.90230451978" Y="866.3320873667612" GraphRef="d572e" RelX="1.0" RelY="0.0" /> <Point X="1277.896233120114" Y="620.7562521411444" GraphRef="e84e1" RelX="0.0" RelY="1.0" ArrowHead="mim-binding" /> <Anchor Position="0.4" Shape="None" GraphId="bf5f3" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id8c6ae5bf"> <Graphics ZOrder="32835" LineStyle="Broken" LineThickness="1.0"> <Point X="1189.7842489642244" Y="853.8320873667612" GraphRef="d572e" RelX="0.5" RelY="-1.0" /> <Point X="1209.7004403270694" Y="775.1120524962967" GraphRef="ce526" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f1eb8"> <BiopaxRef>b5a</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="32845" LineThickness="1.0"> <Point X="739.7790044521824" Y="1039.3279194996062" GraphRef="f5c32" RelX="1.0" RelY="0.0" /> <Point X="809.694860511067" Y="935.3179114942751" GraphRef="caa9a" RelX="0.0" RelY="1.0" ArrowHead="mim-modification" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f8ceb"> <BiopaxRef>b5a</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="32846" LineThickness="1.0"> <Point X="739.7790044521824" Y="1046.6390333988961" GraphRef="f5c32" RelX="1.0" RelY="0.5" /> <Point X="1698.205546492659" Y="654.6408870093991" /> <Point X="1364.4598432940004" Y="262.6427406199021" /> <Point X="1030.7141400953417" Y="530.3721331292734" GraphRef="c3dbf" RelX="0.0" RelY="-1.0" ArrowHead="mim-modification" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="eddd3"> <BiopaxRef>d07</BiopaxRef> <BiopaxRef>eae</BiopaxRef> <BiopaxRef>abb</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>fb8</BiopaxRef> <Graphics ZOrder="32848" LineThickness="1.0"> <Point X="626.4437120976993" Y="972.2084438254893" GraphRef="c741d" RelX="0.0" RelY="-1.0" /> <Point X="624.2105263157895" Y="941.2309998487943" GraphRef="e463c" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="c6e2a"> <Graphics ZOrder="32849" LineStyle="Broken" LineThickness="1.0"> <Point X="677.80289248227" Y="850.2862206080595" GraphRef="a7aed" RelX="-1.0" RelY="-0.5" /> <Point X="661.7443122326117" Y="822.9892881311873" GraphRef="e1132" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <GraphicalLine GraphId="a6710"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="472.9911299126639" Y="986.6179039301308" GraphRef="abfde" RelX="-0.5" RelY="1.0" /> <Point X="383.20323786909773" Y="1030.2168850072783" GraphRef="a6b6b" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="aced1"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="758.8385068628429" Y="749.9811913791826" GraphRef="a582b" RelX="0.0" RelY="0.0" /> <Point X="857.5207100591715" Y="791.5" GraphRef="cb2e7" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="b5cf8"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="983.4414128226153" Y="456.4076360878535" GraphRef="c0ca0" RelX="0.0" RelY="-1.0" /> <Point X="950.3743837842876" Y="356.75155714354673" GraphRef="bd09a" RelX="0.5" RelY="1.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="c8487"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="1023.0762728986409" Y="211.22662498685497" GraphRef="ded1b" RelX="0.0" RelY="0.0" /> <Point X="935.2435116292695" Y="100.33819594977054" GraphRef="a72da" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="d1cb3"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="629.4832393924552" Y="211.4410744951369" GraphRef="c7033" RelX="0.0" RelY="0.0" /> <Point X="653.7286887576588" Y="80.13300570640368" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="e9b02"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="435.2263245980606" Y="247.5323060995649" GraphRef="b1def" RelX="-0.5" RelY="1.0" /> <Point X="383.1858866695951" Y="305.3704684633475" GraphRef="a0bf7" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="efcd3"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="853.6912751677852" Y="531.490237590091" GraphRef="b6414" RelX="0.0" RelY="0.0" /> <Point X="941.8756987713148" Y="618.5437609710549" GraphRef="a1ae8" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="f66be"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="605.8537557515897" Y="750.9077181208054" GraphRef="b15ec" RelX="1.0" RelY="0.5" /> <Point X="651.6778523489932" Y="773.7549488870438" GraphRef="c49bb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="fb97c"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="1128.759779692667" Y="896.195278067365" GraphRef="bdde7" RelX="0.0" RelY="0.0" /> <Point X="1109.2298684152775" Y="855.1254054017967" GraphRef="e941a" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="d7069"> <Graphics ZOrder="32839" LineStyle="Broken" LineThickness="1.0"> <Point X="740.7522517526618" Y="133.15708256084145" GraphRef="f4600" RelX="0.0" RelY="-1.0" /> <Point X="726.9238493223157" Y="81.15667434545735" GraphRef="ec9f4" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="db8bd"> <Graphics ZOrder="32840" LineStyle="Broken" LineThickness="1.0"> <Point X="854.852159374901" Y="190.3981025831841" GraphRef="fbfee" RelX="1.0" RelY="0.0" /> <Point X="871.3154256254019" Y="166.84756478606255" GraphRef="e7e8d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="c4a1f"> <Graphics ZOrder="32842" LineStyle="Broken" LineThickness="1.0"> <Point X="865.5455054143882" Y="489.94893683897226" GraphRef="b78b2" RelX="0.0" RelY="0.0" /> <Point X="780.3254566374201" Y="438.45651264890796" GraphRef="b792f" RelX="0.5" RelY="1.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <GraphicalLine GraphId="d3934"> <Graphics ZOrder="32844" LineStyle="Broken" LineThickness="1.0"> <Point X="454.34583068710396" Y="901.0652860502227" GraphRef="c3d61" RelX="-0.5" RelY="-1.0" /> <Point X="383.1858866695951" Y="872.5705331576728" GraphRef="a891c" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> </GraphicalLine> <Label TextLabel="43.2.1" GraphId="a72da" Href="https://www.omim.org/entry/200100"> <Comment>Abetalipoproteinemia (MTP)</Comment> <BiopaxRef>cbd</BiopaxRef> <BiopaxRef>afb</BiopaxRef> <Graphics CenterX="935.2435116292696" CenterY="85.08819594977058" Width="92.38051438279822" Height="30.499999999999915" ZOrder="28672" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="Chyclomicron" GraphId="bcd5d" GroupRef="dc6a8"> <Comment>Chyclomicron (CM) is one of the two main TG (triglyceride or triacylglycerol) carrying lipoproteins, which are spheroidal macromolecular complexes responsible for transporting lipids through plasma. </Comment> <Comment>See also [https://en.wikipedia.org/wiki/Chylomicron]</Comment> <Graphics CenterX="766.1054892709225" CenterY="276.4978275982224" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" /> </Label> <Label TextLabel="Endocytosis" GraphId="ce2e5"> <Graphics CenterX="1333.0721003134804" CenterY="808.7774294670845" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" /> </Label> <Label TextLabel="Cholesterol is the precursor &#xA;for steroid hormones." GraphId="e68bd"> <Graphics CenterX="1518.3670931058996" CenterY="429.65372904235267" Width="177.19616204690894" Height="26.003909026296977" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" /> </Label> <Label TextLabel="43.2.2" GraphId="e7e8d" Href="https://www.omim.org/entry/605019"> <Comment>Hypobetalipoproteinemia (APOB)</Comment> <BiopaxRef>cb2</BiopaxRef> <Graphics CenterX="903.1133341144761" CenterY="166.84756478606255" Width="63.5958169781484" Height="30.833333333333144" ZOrder="32769" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.5.1&#xA;" GraphId="b2b1c" Href="https://www.omim.org/entry/238600"> <Comment>Lipoprotein lipase deficiency (LPL)</Comment> <BiopaxRef>eff</BiopaxRef> <BiopaxRef>dbe</BiopaxRef> <Graphics CenterX="582.1302832223251" CenterY="59.63300570640368" Width="78.34298385120799" Height="25.0" ZOrder="32770" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.5.2" GraphId="ec9f4" Href="https://www.omim.org/entry/207750"> <Comment>Apolipoprotein C2 deficiency (APOC2)</Comment> <BiopaxRef>e53</BiopaxRef> <Graphics CenterX="726.9238493223157" CenterY="66.57334101212408" Width="86.98379331918778" Height="29.166666666666544" ZOrder="32771" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.6.2" GraphId="a0bf7" Href="https://www.omim.org/entry/107741"> <Comment>Dysbetalipoproteinemia (APOE)</Comment> <BiopaxRef>c29</BiopaxRef> <Graphics CenterX="343.95980724012304" CenterY="305.3704684633475" Width="78.45215885894422" Height="28.5" ZOrder="32772" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.3.2" GraphId="e941a" Href="https://www.omim.org/entry/614025"> <Comment>Hepatic lipase deficiency (LIPC)</Comment> <BiopaxRef>ac6</BiopaxRef> <Graphics CenterX="1109.2298684152772" CenterY="838.8754054017967" Width="61.82329824852572" Height="32.5" ZOrder="32775" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.1.1" GraphId="dfcc9" Href="https://www.omim.org/entry/143890" GroupRef="e92a0"> <Comment>Familial hypercholesterolemia heterozygous (LDLR)</Comment> <BiopaxRef>cda</BiopaxRef> <Graphics CenterX="343.959807240123" CenterY="1013.9668850072784" Width="62.486861257949435" Height="32.5" ZOrder="32776" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.1.2" GraphId="b6a77" Href="https://www.omim.org/entry/143890" GroupRef="e92a0"> <Comment>Familial hypercholesterolemia homozygous (LDLR)</Comment> <BiopaxRef>cda</BiopaxRef> <Graphics CenterX="343.959807240123" CenterY="1046.4668850072783" Width="62.486861257949435" Height="32.5" ZOrder="32777" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.3.1" GraphId="cb2e7" Href="https://www.omim.org/entry/143470"> <Comment>Cholesteryl ester transfer protein deficiency (CETP)</Comment> <BiopaxRef>d51</BiopaxRef> <BiopaxRef>a02</BiopaxRef> <Graphics CenterX="895.8744489893172" CenterY="791.5" Width="76.70747786029153" Height="32.5" ZOrder="32779" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.4.1" GraphId="e932c" Href="https://www.omim.org/entry/205400"> <Comment>Tangier disease (ABCA1)</Comment> <BiopaxRef>cea</BiopaxRef> <BiopaxRef>aa3</BiopaxRef> <Graphics CenterX="1143.2560583451282" CenterY="437.35113857756613" Width="59.407493541163376" Height="32.5" ZOrder="32780" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.4.4" GraphId="f13c8" Href="https://www.omim.org/entry/136120" GroupRef="ab98e"> <Comment>Familial LCAT deficiency (partial)</Comment> <BiopaxRef>c91</BiopaxRef> <Graphics CenterX="963.4697052211451" CenterY="675.2937609710549" Width="70.37602579932077" Height="32.50000000000004" ZOrder="32781" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.4.3" GraphId="f1373" Href="https://www.omim.org/entry/245900" GroupRef="ab98e"> <Comment>Familial LCAT deficiency (complete)</Comment> <BiopaxRef>a07</BiopaxRef> <BiopaxRef>f5b</BiopaxRef> <Graphics CenterX="963.4697052211449" CenterY="642.7937609710549" Width="70.37602579932084" Height="32.5" ZOrder="32782" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.4.2" GraphId="bd09a" Href="https://www.omim.org/entry/107680"> <Comment>Apolipoprotein A-1 deficiency (APOA1)</Comment> <BiopaxRef>ab5</BiopaxRef> <Graphics CenterX="930.6746451179366" CenterY="342.1682238102135" Width="78.79895466540415" Height="29.166666666666536" ZOrder="32783" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.3.3" GraphId="c49bb" Href="https://www.omim.org/entry/601040"> <Comment>Scavenger receptor B1 deficiency (SCARB1)</Comment> <BiopaxRef>a25</BiopaxRef> <Graphics CenterX="651.6778523489932" CenterY="787.3434218527212" Width="68.45637583892591" Height="27.17694593135508" ZOrder="32784" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.1.4" GraphId="f0f87" Href="https://www.omim.org/entry/603776" GroupRef="e944e"> <Comment>Autosomal dominant hypercholesterolemia</Comment> <BiopaxRef>b1e</BiopaxRef> <Graphics CenterX="774.206147932188" CenterY="1080.1221657952603" Width="60.516113414721964" Height="32.5" ZOrder="32785" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.2.3" GraphId="df921" Href="https://www.omim.org/entry/607786" GroupRef="e944e"> <Comment>PCSK9 deficiency with low LDL</Comment> <BiopaxRef>b1e</BiopaxRef> <BiopaxRef>bf2</BiopaxRef> <Graphics CenterX="834.7222613469098" CenterY="1080.1221657952601" Width="60.51611341472195" Height="32.5" ZOrder="32786" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.2.1" GraphId="ed33b" Href="https://www.omim.org/entry/200100"> <Comment>Abetalipoproteinemia (MTP)</Comment> <BiopaxRef>cbd</BiopaxRef> <BiopaxRef>afb</BiopaxRef> <Graphics CenterX="626.4437120976993" CenterY="883.3651241300252" Width="64.50640527127669" Height="32.49999999999998" ZOrder="32787" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.2.2" GraphId="e1132" Href="https://www.omim.org/entry/144010"> <Comment>Hypobetalipoproteinemia (APOB)</Comment> <BiopaxRef>f3f</BiopaxRef> <Graphics CenterX="629.4911095969734" CenterY="822.9892881311873" Width="64.50640527127666" Height="32.5" ZOrder="32788" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.1.3" GraphId="ce526" Href="https://www.omim.org/entry/144010"> <Comment>Familial defective apolipoprotein B (APOB)</Comment> <BiopaxRef>ef6</BiopaxRef> <Graphics CenterX="1209.7004403270694" CenterY="758.8620524962967" Width="85.13333204165777" Height="32.5" ZOrder="32789" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="Remnant" GraphId="afe1e" GroupRef="f6a07"> <Comment></Comment> <Graphics CenterX="488.61752830176295" CenterY="269.4304542477127" Width="90.0" Height="25.0" ZOrder="32809" FillColor="ffffff" FontSize="12" Valign="Middle" /> </Label> <Label TextLabel="HDL3" GraphId="edc2b" GroupRef="a45d1"> <Comment>High-density lipoprotein (HDL) is one of the two main cholesterol carrying lipoproteins, which are spheroidal macromolecular complexes responsible for transporting lipids through plasma.</Comment> <Graphics CenterX="988.7934448148092" CenterY="594.0728390923286" Width="90.0" Height="25.0" ZOrder="32815" FillColor="ffffff" FontSize="12" Valign="Middle" /> </Label> <Label TextLabel="HDL2" GraphId="b8bd1" GroupRef="b0c05"> <Comment>High-density lipoprotein (HDL) is one of the two main cholesterol carrying lipoproteins, which are spheroidal macromolecular complexes responsible for transporting lipids through plasma.</Comment> <Graphics CenterX="730.8712619185209" CenterY="594.0728390923286" Width="90.0" Height="25.0" ZOrder="32820" FillColor="ffffff" FontSize="12" Valign="Middle" /> </Label> <Label TextLabel="43.3.2" GraphId="b792f" Href="https://www.omim.org/entry/614025"> <Comment>Hepatic lipase deficiency (LIPC)</Comment> <Graphics CenterX="762.7314501875899" CenterY="422.2065126489079" Width="70.37602579932077" Height="32.50000000000004" ZOrder="32841" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Label TextLabel="43.1.5" GraphId="a891c" Href="https://www.omim.org/entry/603813"> <Comment>Autosomal recessive hypercholesterolemia (ARH)</Comment> <BiopaxRef>a69</BiopaxRef> <BiopaxRef>c7b</BiopaxRef> <Graphics CenterX="343.959807240123" CenterY="872.5705331576728" Width="78.45215885894422" Height="28.5" ZOrder="32843" FillColor="ffccff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> </Label> <Shape GraphId="bf0f8" GroupRef="d4ee4"> <Graphics CenterX="758.9452760343984" CenterY="882.3903247087163" Width="130.29085965535057" Height="133.81406955218222" ZOrder="-4" FillColor="cccccc" FontSize="12" Valign="Middle" ShapeType="Oval" Rotation="0.0" /> </Shape> <Shape GraphId="a462e" GroupRef="f503f"> <Graphics CenterX="998.1230781418078" CenterY="882.0960455921893" Width="130.29085965535057" Height="133.81406955218222" ZOrder="-2" FillColor="cccccc" FontSize="12" Valign="Middle" ShapeType="Oval" Rotation="0.0" /> </Shape> <Shape TextLabel="Liver" GraphId="c2a08"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" /> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="502.18340611353716" CenterY="825.3333333333333" Width="174.6724890829695" Height="299.3333333333335" ZOrder="16384" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> </Shape> <Shape GraphId="cf0ce" GroupRef="dc6a8"> <Graphics CenterX="768.2976889868338" CenterY="201.7505690459947" Width="138.07338607990818" Height="131.66789588858256" ZOrder="16384" FontSize="12" Valign="Middle" ShapeType="Oval" Rotation="0.0" /> </Shape> <Shape TextLabel="Intestine&#xA;" GraphId="e7489"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" /> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1177.2220741304898" CenterY="211.3117151951865" Width="125.5" Height="57.5" ZOrder="16384" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> </Shape> <Shape TextLabel="Cholesterol pool" GraphId="e881e" GroupRef="c112d"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Sarcoplasmic Reticulum" /> <Graphics CenterX="1399.9393220461607" CenterY="519.6662227804146" Width="99.21330183366317" Height="163.06061932331795" ZOrder="16384" FontSize="12" Valign="Middle" ShapeType="Sarcoplasmic Reticulum" LineThickness="3.0" Color="c0c0c0" Rotation="4.521010195100263" /> </Shape> <Shape TextLabel="Cell" GraphId="fddb5"> <Comment>~ 80% of circulation cholesterol is produces endogenously by liver and extrahepatic tissues.</Comment> <BiopaxRef>edc</BiopaxRef> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" /> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1361.9559346126523" CenterY="530.9586330935258" Width="253.33333333333377" Height="161.83333333333297" ZOrder="16384" FontSize="12" Align="Left" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> </Shape> <Shape GraphId="c4e24" GroupRef="f6a07"> <Graphics CenterX="485.76336163509734" CenterY="194.94843702306588" Width="106.40277777777787" Height="106.40277777777763" ZOrder="32808" FontSize="12" Valign="Middle" ShapeType="Oval" Rotation="0.0" /> </Shape> <Shape GraphId="e4f87" GroupRef="a45d1"> <Graphics CenterX="985.9392781481439" CenterY="523.0669219325667" Width="106.40277777777787" Height="106.40277777777763" ZOrder="32814" FillColor="999999" FontSize="12" Valign="Middle" ShapeType="Oval" Rotation="0.0" /> </Shape> <Shape GraphId="ff771" GroupRef="b0c05"> <Graphics CenterX="728.0170952518553" CenterY="523.0669219325667" Width="106.40277777777787" Height="106.40277777777763" ZOrder="32819" FillColor="999999" FontSize="12" Valign="Middle" ShapeType="Oval" Rotation="0.0" /> </Shape> <Shape GraphId="bd933" GroupRef="f29db"> <Graphics CenterX="1241.3692142585326" CenterY="882.0202834019927" Width="130.29085965535057" Height="133.81406955218222" ZOrder="32829" FillColor="cccccc" FontSize="12" Valign="Middle" ShapeType="Oval" Rotation="0.0" /> </Shape> <Group GroupId="c95e7" Style="Group" /> <Group GroupId="b4fd5" Style="Group" /> <Group GroupId="e919d" Style="Group" /> <Group GroupId="a99e0" GraphId="a1239" Style="Group" /> <Group GroupId="ab98e" GraphId="a1ae8" Style="Group" /> <Group GroupId="b0c05" GraphId="a3424" Style="Group" /> <Group GroupId="a45d1" GraphId="a3d29" Style="Group" /> <Group GroupId="e92a0" GraphId="a6b6b" Style="Group" /> <Group GroupId="e793e" GraphId="ab550" Style="Group" /> <Group GroupId="f29db" GraphId="ab814" Style="Group" /> <Group GroupId="f6a07" GraphId="b3f75" Style="Group" /> <Group GroupId="c112d" GraphId="cbbd7" Style="Group" /> <Group GroupId="d4ee4" GraphId="da60c" Style="Group" /> <Group GroupId="dc6a8" GraphId="e14d8" Style="Group" /> <Group GroupId="f503f" GraphId="e2a67" Style="Group" /> <Group GroupId="e944e" GraphId="e42eb" Style="Group" /> <Group GroupId="b2e01" GraphId="e6032" Style="Group" /> <Group GroupId="bd323" GraphId="ec9af" Style="Group" /> <InfoBox CenterX="0.0" CenterY="0.0" /> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a69"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15728179</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2005</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mishra SK</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Keyel PA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Edeling MA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dupin AL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Owen DJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Traub LM</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a25"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21480869</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Clin Genet</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brunham LR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tietjen I</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bochem AE</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Singaraja RR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Franchini PL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Radomski C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mattice M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Legendre A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hovingh GK</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kastelein JJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hayden MR</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dbe"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3630977</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An incomplete form of familial lipoprotein lipase deficiency presenting with type I hyperlipoproteinemia.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Am J Clin Pathol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1987</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Berger GM</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e62"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26965621</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Science</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zanoni P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Khetarpal SA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Larach DB</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hancock-Cerutti WF</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Millar JS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cuchel M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DerOhannessian S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kontush A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Surendran P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Saleheen D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Trompet S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jukema JW</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">De Craen A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Deloukas P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sattar N</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ford I</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Packard C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Majumder Aa</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Alam DS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Di Angelantonio E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Abecasis G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chowdhury R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Erdmann J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nordestgaard BG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nielsen SF</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tybjærg-Hansen A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schmidt RF</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kuulasmaa K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu DJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Perola M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Blankenberg S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Salomaa V</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Männistö S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Amouyel P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arveiler D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ferrieres J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Müller-Nurasyid M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ferrario M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kee F</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Willer CJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Samani N</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schunkert H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Butterworth AS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Howson JM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peloso GM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stitziel NO</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Danesh J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kathiresan S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rader DJ</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ef6"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3477815</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Proc Natl Acad Sci U S A</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1987</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Innerarity TL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Weisgraber KH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arnold KS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mahley RW</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Krauss RM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vega GL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Grundy SM</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a07"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7327552</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Familial lecithin-cholesterol acyltransferase: identification of heterozygotes with half-normal enzyme activity and mass.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hum Genet</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1981</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Albers JJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Adolphson JL</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cea"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">194920</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Isolation and characterization of an abnormal high density lipoprotein in Tangier Diesase.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Invest</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1977</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Assmann G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Herbert PN</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fredrickson DS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Forte T</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c29"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3004475</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ApoE deficiency: markedly decreased levels of cellular ApoE mRNA.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochem Biophys Res Commun</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1986</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Anchors JM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gregg RE</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Law SW</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brewer HB Jr</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b7c"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25108285</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Novel missense MTTP gene mutations causing abetalipoproteinemia.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochim Biophys Acta</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Miller SA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Burnett JR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Leonis MA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McKnight CJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">van Bockxmeer FM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hooper AJ</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d07"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23475612</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2013</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Khatun I</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Walsh MT</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hussain MM</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b5a"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18039658</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Poirier S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mayer G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Benjannet S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bergeron E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Marcinkiewicz J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nassoury N</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mayer H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nimpf J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prat A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Seidah NG</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lipoprotein metabolic pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000482</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eae"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8939939</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triglyceride transfer protein that prevents complex formation with protein disulfide isomerase.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1996</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rehberg EF</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Samson-Bouma ME</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kienzle B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Blinderman L</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jamil H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wetterau JR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Aggerbeck LP</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gordon DA</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">altered lipoprotein metabolic pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000484</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d51"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15071125</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N Engl J Med</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2004</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brousseau ME</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schaefer EJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wolfe ML</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bloedon LT</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Digenio AG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Clark RW</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mancuso JP</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rader DJ</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a67"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23066022</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Eichmann TO</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kumari M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Haas JT</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Farese RV Jr</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zimmermann R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lass A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zechner R</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">triacylglycerol metabolic pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000153</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e53"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3944267</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Invest</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1986</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Baggio G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Manzato E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gabelli C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fellin R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Martini S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Enzi GB</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Verlato F</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Baiocchi MR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sprecher DL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kashyap ML</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fb8"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22236406</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Di Filippo M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Créhalet H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Samson-Bouma ME</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bonnet V</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Aggerbeck LP</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rabès JP</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gottrand F</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Luc G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bozon D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sassolas A</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">familial combined hyperlipidemia</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:13809</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="caa"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24808179</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ly K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Saavedra YG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Canuel M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Routhier S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Desjardins R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hamelin J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mayne J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lazure C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Seidah NG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Day R</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e64"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN 978-3-64240337, 2014</bp:YEAR> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN 978-3-64240337</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Blau Nenad</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Duran Marinus</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gibson, K, Michael</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dionisi-Vici, Carlo</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="afb"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6403642</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1983</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brunzell JD</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Albers JJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chait A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Grundy SM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Groszek E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McDonald GB</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ac6"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6961921</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lipoprotein abnormalities associated with a familial deficiency of hepatic lipase.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Atherosclerosis</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1982</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Breckenridge WC</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Little JA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Alaupovic P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang CS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kuksis A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kakis G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lindgren F</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gardiner G</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a5e"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27068984</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Current trends in oxysterol research.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochem Soc Trans</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Griffiths WJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Abdel-Khalik J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hearn T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yutuc E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morgan AH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang Y</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cbd"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24288038</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Abetalipoproteinemia and homozygous hypobetalipoproteinemia: a framework for diagnosis and management.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Inherit Metab Dis</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hegele RA</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca1"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17215125</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molecular biology of PCSK9: its role in LDL metabolism.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Trends Biochem Sci</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Horton JD</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cohen JC</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hobbs HH</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="abb"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26224785</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Circ Cardiovasc Genet</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Walsh MT</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iqbal J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Josekutty J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Soh J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Di Leo E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Özaydin E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gündüz M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tarugi P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hussain MM</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f3f"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">52771</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A new type of familial hypercholesterolaemia.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lancet</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1975</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Higgins MJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lecamwasam DS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Galton DJ</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">familial combined hyperlipidemia pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000175</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ab5"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16452169</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Crystal structure of human apolipoprotein A-I: insights into its protective effect against cardiovascular diseases.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Proc Natl Acad Sci U S A</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ajees AA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Anantharamaiah GM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mishra VK</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hussain MM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Murthy HM</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e4a"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11717312</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Haemmerle G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zimmermann R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hayn M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Theussl C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Waeg G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wagner E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sattler W</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Magin TM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wagner EF</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zechner R</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eff"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2511019</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Defective enzyme protein in lipoprotein lipase deficiency.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Eur J Clin Invest</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1989</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Auwerx JH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Babirak SP</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fujimoto WY</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iverius PH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brunzell JD</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">autosomal recessive hypercholesterolemia</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0090105</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b1e"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">12730697</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Genet</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2003</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Abifadel M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Varret M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rabès</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Allard D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ouguerram K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Devillers M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cruaud C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Benjannet S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wickham L</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Erlich D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Derré A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Villéger L</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Farnier M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beucler I</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bruckert E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chambaz J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chanu B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lecerf JM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Luc G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moulin P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Weissenbach J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prat A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Krempf M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Junien C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Seidah NG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Boileau C</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000013</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tangier disease</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:1388</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f5b"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6805319</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Detection of heterozygotes for familial lecithin: cholesterol acyltransferase (LCAT) deficiency.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Am J Hum Genet</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1982</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Frohlich J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hon K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McLeod R</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a02"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">168823</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Familial hyperalphalipoproteinemia.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arch Intern Med</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1975</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glueck CJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fallat RW</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Millett F</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Steiner PM</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb2"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28538136</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N Engl J Med</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dewey FE</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gusarova V</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dunbar RL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">O'Dushlaine C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schurmann C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gottesman O</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McCarthy S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Hout CV</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bruse S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dansky HM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Leader JB</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Murray MF</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ritchie MD</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kirchner HL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Habegger L</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lopez A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Penn J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhao A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shao W</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stahl N</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Murphy AJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hamon S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bouzelmat A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shumel B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pordy R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gipe D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Herman GA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sheu WHH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee IT</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liang KW</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guo X</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rotter JI</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen YI</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kraus WE</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shah SH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Damrauer S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Small A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rader DJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wulff AB</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nordestgaard BG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tybjærg-Hansen A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">van den Hoek AM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Princen HMG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ledbetter DH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carey DJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Overton JD</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reid JG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sasiela WJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Banerjee P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shuldiner AR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Borecki IB</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Teslovich TM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yancopoulos GD</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mellis SJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gromada J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Baras A</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c7b"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">12016260</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mutation in the ARH gene and a chromosome 13q locus influence cholesterol levels in a new form of digenic-recessive familial hypercholesterolemia.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Circ Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Al-Kateb H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bähring D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hoffmann K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Strauch K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Busjahn A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nürnberg G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jouma M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bautz EK</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dresel HA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Luft FC</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hypobetalipoproteinemia</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:1390</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bf2"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18499582</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N Engl J Med</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kathiresan S</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="aa3"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">190272</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The lipoprotein abnormality in Tangier disease: quantitation of A apoproteins.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Invest</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1977</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Assmann G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Smootz E</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Adler K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Capurso A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oette K</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="edc"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19139765</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Plasma lipoproteins: geneticinfluences and clinical implications.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Rev Genet</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hegele RA</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cda"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7426196</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cadiovascular complications of homozygous familial hypercholesterolaemia.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Br Heart J</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1980</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Allen JM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thompson GR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Myant NB</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Steiner R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oakley CM</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c91"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">4061122</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Evidence for deficiency of high density lipoprotein lecithin: cholesterol acyltransferase activity (alpha-LCAT) in fish eye disease.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Acta Med Scand</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1985</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carlson LA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Holmquist L</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

• Template:AuthorInfo
• Template:CheckAvailable (protected)
• Template:Help:LiteratureReferences (protected)
• Template:PathwayPage:History
• Template:PathwayPage:Xrefs

Return to Metabolic pathway of LDL, HDL and TG, including diseases (Homo sapiens).