Familial hyperlipidemia type 3 (Homo sapiens)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Familial hyperlipidemia type 3" Version="20210520" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Familial hyperlipidemias are classified according to the Fredrickson classification. Type III is also known is familial dysbetalipoproteinemia. It is mainly linked to an increase of IDL. This is caused by APOE. APOE has multiple types, and is part of LDL, IDL, VLDL and chylomicrons. APOE also binds to LDLR, which is required for normal catabolism of triglycerid-rich proteins. Specifically APOE2 is linked with to IDL and because of this, mutations in APOE2 will lead to dysbetalipoproteinemia. </Comment> <Graphics BoardWidth="1236.4452756938044" BoardHeight="711.7115129098631"/> <DataNode TextLabel="VLDLR" GraphId="d39aa" Type="GeneProduct"> <Graphics CenterX="961.6227266296611" CenterY="193.74799247182114" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000147852"/> </DataNode> <DataNode TextLabel="VLDL" GraphId="a6511" Type="Metabolite"> <Graphics CenterX="996.112332951286" CenterY="418.70931148129137" Width="90.0" Height="25.0" ZOrder="32951" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:39027"/> </DataNode> <DataNode TextLabel="APOA2" GraphId="cbe11" Type="GeneProduct" GroupRef="ce31d"> <Graphics CenterX="1073.8419532779872" CenterY="575.9020499967515" Width="90.0" Height="25.0" ZOrder="32953" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000158874"/> </DataNode> <DataNode TextLabel="Cholesterol" GraphId="c68ae" Type="Metabolite"> <Graphics CenterX="858.5151124371122" CenterY="669.2115129098631" Width="90.0" Height="25.0" ZOrder="32956" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16113"/> </DataNode> <DataNode TextLabel="HDL" GraphId="ba0ef" Type="Metabolite"> <Graphics CenterX="910.6838813246985" CenterY="495.4640704913092" Width="90.0" Height="25.0" ZOrder="32958" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:47775"/> </DataNode> <DataNode TextLabel="LDL" GraphId="d6717" Type="Metabolite"> <Graphics CenterX="617.0361424750917" CenterY="418.70931148129137" Width="90.0" Height="25.0" ZOrder="32960" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:47774"/> </DataNode> <DataNode TextLabel="Familial dysbetalipoproteinemia" GraphId="fb919"> <Graphics CenterX="455.6029103143571" CenterY="280.87429223587293" Width="183.29308454676345" Height="24.999999999999982" ZOrder="32962" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="Wikidata" ID="Q2069207"/> </DataNode> <DataNode TextLabel="APOA4" GraphId="c99af" Type="GeneProduct" GroupRef="ce31d"> <Graphics CenterX="1073.8419532779872" CenterY="600.9020499967517" Width="90.0" Height="25.0" ZOrder="32979" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000110244"/> </DataNode> <DataNode TextLabel="Familial hyperlipidemia" GraphId="d33d9"> <Graphics CenterX="80.68314596891788" CenterY="280.87429223587293" Width="136.4433506614415" Height="25.0" ZOrder="32983" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="Wikidata" ID="Q18554145"/> </DataNode> <DataNode TextLabel="Lipoprotein" GraphId="c4aed" Type="Metabolite"> <Graphics CenterX="967.9047188901376" CenterY="669.2115129098631" Width="90.0" Height="25.0" ZOrder="32986" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:6495"/> </DataNode> <DataNode TextLabel="IDL" GraphId="d7759" Type="Metabolite"> <Graphics CenterX="828.3349716414269" CenterY="418.70931148129137" Width="90.0" Height="25.0" ZOrder="32989" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:132933"/> </DataNode> <DataNode TextLabel="APOE" GraphId="acaf7" Type="GeneProduct"> <Graphics CenterX="722.8770162786778" CenterY="280.87429223587293" Width="90.0" Height="25.0" ZOrder="33014" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000130203"/> </DataNode> <DataNode TextLabel="CETP" GraphId="a97d1" Type="GeneProduct"> <Graphics CenterX="707.6357518842766" CenterY="484.2637264449895" Width="90.0" Height="25.0" ZOrder="33016" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000087237"/> </DataNode> <DataNode TextLabel="LIPC" GraphId="ef11c" Type="GeneProduct"> <Graphics CenterX="734.8157563622316" CenterY="340.83447052989135" Width="90.0" Height="25.0" ZOrder="33018" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000166035"/> </DataNode> <DataNode TextLabel="APOA1" GraphId="c565e" Type="GeneProduct" GroupRef="ce31d"> <Graphics CenterX="1073.8419532779872" CenterY="550.9020499967515" Width="90.0" Height="25.0" ZOrder="33020" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000118137"/> </DataNode> <DataNode TextLabel="SCARB1" GraphId="d8c7c" Type="GeneProduct"> <Graphics CenterX="1088.6059849929345" CenterY="193.74799247182108" Width="90.0" Height="25.0" ZOrder="33022" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000073060"/> </DataNode> <DataNode TextLabel="LCAT" GraphId="aed48" Type="GeneProduct"> <Graphics CenterX="793.1511888341978" CenterY="589.2190481039219" Width="90.0" Height="25.0" ZOrder="33024" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000213398"/> </DataNode> <DataNode TextLabel="LPL" GraphId="bf3f2" Type="GeneProduct"> <Graphics CenterX="920.0015595848876" CenterY="340.83447052989135" Width="90.0" Height="25.0" ZOrder="33026" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000175445"/> </DataNode> <DataNode TextLabel="LDLR" GraphId="a3cc3" Type="GeneProduct"> <Graphics CenterX="617.2198423768403" CenterY="193.74799247182108" Width="90.0" Height="25.0" ZOrder="33028" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000130164"/> </DataNode> <DataNode TextLabel="PLTP" GraphId="d8f64" Type="GeneProduct" GroupRef="ce31d"> <Graphics CenterX="1073.8419532779872" CenterY="625.9020499967517" Width="90.0" Height="25.0" ZOrder="33030" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000100979"/> </DataNode> <DataNode TextLabel="CETP" GraphId="bc88b" Type="GeneProduct"> <Graphics CenterX="1161.4452756938044" CenterY="483.2990695755909" Width="90.0" Height="25.0" ZOrder="33171" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000087237"/> </DataNode> <DataNode TextLabel="LRP1" GraphId="df009" Type="GeneProduct"> <Graphics CenterX="828.3349716414269" CenterY="193.74799247182105" Width="90.0" Height="25.0" ZOrder="33175" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000123384"/> </DataNode> <DataNode TextLabel="CETP" GraphId="ad747" Type="GeneProduct"> <Graphics CenterX="911.7961528867879" CenterY="456.4569643124326" Width="90.0" Height="25.0" ZOrder="33181" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000087237"/> </DataNode> <DataNode TextLabel="Cholesterol" GraphId="cbf3c" Type="Metabolite" GroupRef="b05b0"> <Graphics CenterX="828.334971641427" CenterY="102.82002251219961" Width="90.0" Height="25.0" ZOrder="33371" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16113"/> </DataNode> <DataNode TextLabel="Triglyceride" GraphId="a94ee" Type="Metabolite" GroupRef="b05b0"> <Graphics CenterX="828.334971641427" CenterY="77.82002251219998" Width="90.0" Height="25.0" ZOrder="33372" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17855"/> </DataNode> <DataNode TextLabel="Phospholipid" GraphId="a89dd" Type="Metabolite" GroupRef="b05b0"> <Graphics CenterX="828.334971641427" CenterY="52.82002251220041" Width="90.0" Height="25.0" ZOrder="33373" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16247"/> </DataNode> <Interaction GraphId="idd6b32ab2"> <BiopaxRef>fe9</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="767.8770162786778" Y="280.87429223587293" GraphRef="acaf7" RelX="1.0" RelY="0.0"/> <Point X="973.6123329512861" Y="406.20931148129137" GraphRef="a6511" RelX="-0.5" RelY="-1.0" ArrowHead="mim-binding"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id5043522a"> <BiopaxRef>ff2</BiopaxRef> <Graphics ZOrder="12290" LineThickness="1.0"> <Point X="828.3349716414269" Y="181.24799247182105" GraphRef="df009" RelX="0.0" RelY="-1.0"/> <Point X="828.334971641427" Y="123.32002251219961" GraphRef="bc143" RelX="0.0" RelY="1.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id3366baaa"> <BiopaxRef>e5a</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12292" LineStyle="Broken" LineThickness="1.0"> <Point X="996.1123329512861" Y="406.20931148129137" GraphRef="a6511" RelX="0.0" RelY="-1.0"/> <Point X="978.8675297904736" Y="250.47619047619045"/> <Point X="961.6227266296611" Y="206.24799247182114" GraphRef="d39aa" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ideac42eb3"> <BiopaxRef>fe9</BiopaxRef> <BiopaxRef>c0f</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12294" LineThickness="1.0"> <Point X="700.3770162786778" Y="268.37429223587293" GraphRef="acaf7" RelX="-0.5" RelY="-1.0"/> <Point X="662.2198423768403" Y="193.74799247182108" GraphRef="a3cc3" RelX="1.0" RelY="0.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ide04fef6f"> <BiopaxRef>fe9</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="12296" LineThickness="1.0"> <Point X="745.3770162786778" Y="293.37429223587293" GraphRef="acaf7" RelX="0.5" RelY="1.0"/> <Point X="805.8349716414269" Y="406.20931148129137" GraphRef="d7759" RelX="-0.5" RelY="-1.0" ArrowHead="mim-binding"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c82f3"> <BiopaxRef>b79</BiopaxRef> <Graphics ZOrder="32887" LineThickness="1.0"> <Point X="838.1511888341978" Y="589.2190481039219" GraphRef="aed48" RelX="1.0" RelY="0.0"/> <Point X="888.1838813246985" Y="589.2190342940688" GraphRef="ad16d" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="fada6"> <BiopaxRef>f2e</BiopaxRef> <BiopaxRef>b34</BiopaxRef> <Graphics ZOrder="32893" LineThickness="1.0"> <Point X="752.6357518842766" Y="484.2637264449895" GraphRef="a97d1" RelX="1.0" RelY="0.0"/> <Point X="828.3349716414269" Y="484.26373815755915" GraphRef="e1d72" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="aa022"> <BiopaxRef>e79</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="32896" LineThickness="1.0"> <Point X="1088.6059849929345" Y="181.24799247182108" GraphRef="d8c7c" RelX="0.0" RelY="-1.0"/> <Point X="828.334971641427" Y="123.32002251219961" GraphRef="bc143" RelX="0.0" RelY="1.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a57cf"> <BiopaxRef>b79</BiopaxRef> <BiopaxRef>d68</BiopaxRef> <BiopaxRef>c97</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="32900" LineThickness="1.0"> <Point X="967.9047188901376" Y="656.7115129098631" GraphRef="c4aed" RelX="0.0" RelY="-1.0"/> <Point X="950.544300107418" Y="613.7605231143389"/> <Point X="933.1838813246985" Y="507.9640704913092" GraphRef="ba0ef" RelX="0.5" RelY="1.0" ArrowHead="mim-conversion"/> <Anchor Position="0.559830983300454" Shape="None" GraphId="ef4f1"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c2498"> <BiopaxRef>f2e</BiopaxRef> <Graphics ZOrder="32903" LineThickness="1.0"> <Point X="951.1123329512861" Y="418.70931148129137" GraphRef="a6511" RelX="-1.0" RelY="0.0"/> <Point X="873.3349716414269" Y="418.70931148129137" GraphRef="d7759" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion"/> <Anchor Position="0.4" Shape="None" GraphId="e0108"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a78b8"> <BiopaxRef>f89</BiopaxRef> <Graphics ZOrder="32905" LineStyle="Broken" LineThickness="1.0"> <Point X="828.3349716414269" Y="406.20931148129137" GraphRef="d7759" RelX="0.0" RelY="-1.0"/> <Point X="828.3349716414269" Y="206.24799247182105" GraphRef="df009" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="bd53f"> <BiopaxRef>b79</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="32907" LineThickness="1.0"> <Point X="858.5151124371122" Y="656.7115129098631" GraphRef="c68ae" RelX="0.0" RelY="-1.0"/> <Point X="873.3494968809053" Y="616.5470960128274"/> <Point X="888.1838813246985" Y="507.9640704913092" GraphRef="ba0ef" RelX="-0.5" RelY="1.0" ArrowHead="mim-conversion"/> <Anchor Position="0.5445763408609989" Shape="None" GraphId="ad16d"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="dd119"> <BiopaxRef>b79</BiopaxRef> <BiopaxRef>d41</BiopaxRef> <BiopaxRef>d68</BiopaxRef> <BiopaxRef>f43</BiopaxRef> <Graphics ZOrder="32914" LineThickness="1.0"> <Point X="1016.8419532779872" Y="588.4020499967517" GraphRef="e10ad" RelX="-1.0" RelY="0.0"/> <Point X="933.1838813246985" Y="588.7211228874204" GraphRef="ef4f1" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c27d8"> <BiopaxRef>f2e</BiopaxRef> <BiopaxRef>eef</BiopaxRef> <Graphics ZOrder="32916" LineThickness="1.0"> <Point X="920.0015595848876" Y="353.33447052989135" GraphRef="bf3f2" RelX="0.0" RelY="1.0"/> <Point X="920.0013884273425" Y="418.70931148129137" GraphRef="e0108" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="bb41c"> <BiopaxRef>f2e</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="32923" LineThickness="1.0"> <Point X="865.6838813246985" Y="495.4640704913092" GraphRef="ba0ef" RelX="-1.0" RelY="0.0"/> <Point X="828.3349716414269" Y="431.20931148129137" GraphRef="d7759" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion"/> <Anchor Position="0.47782961620782677" Shape="None" GraphId="e1d72"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d7ded"> <BiopaxRef>ff2</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="32925" LineThickness="1.0"> <Point X="617.2198423768403" Y="181.24799247182108" GraphRef="a3cc3" RelX="0.0" RelY="-1.0"/> <Point X="828.334971641427" Y="123.32002251219961" GraphRef="bc143" RelX="0.0" RelY="1.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ec09c"> <BiopaxRef>f89</BiopaxRef> <BiopaxRef>c81</BiopaxRef> <BiopaxRef>e79</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="32927" LineStyle="Broken" LineThickness="1.0"> <Point X="955.6838813246985" Y="501.7140704913092" GraphRef="ba0ef" RelX="1.0" RelY="0.5"/> <Point X="1088.6059849929345" Y="206.24799247182108" GraphRef="d8c7c" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="cda05"> <BiopaxRef>f2e</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="32930" LineThickness="1.0"> <Point X="955.6838813246985" Y="495.4640704913092" GraphRef="ba0ef" RelX="1.0" RelY="0.0"/> <Point X="996.1123329512861" Y="431.20931148129137" GraphRef="a6511" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion"/> <Anchor Position="0.5024060810356783" Shape="None" GraphId="b83e5"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c9a18"> <BiopaxRef>f89</BiopaxRef> <BiopaxRef>ff2</BiopaxRef> <Graphics ZOrder="32934" LineStyle="Broken" LineThickness="1.0"> <Point X="617.0361424750917" Y="406.20931148129137" GraphRef="d6717" RelX="0.0" RelY="-1.0"/> <Point X="617.2198423768403" Y="206.24799247182108" GraphRef="a3cc3" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e5620"> <BiopaxRef>f2e</BiopaxRef> <Graphics ZOrder="32941" LineThickness="1.0"> <Point X="783.3349716414269" Y="418.70931148129137" GraphRef="d7759" RelX="-1.0" RelY="0.0"/> <Point X="662.0361424750917" Y="418.70931148129137" GraphRef="d6717" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion"/> <Anchor Position="0.4" Shape="None" GraphId="ae037"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d5860"> <BiopaxRef>afd</BiopaxRef> <Graphics ZOrder="32943" LineThickness="1.0"> <Point X="734.8157563622316" Y="353.33447052989135" GraphRef="ef11c" RelX="0.0" RelY="1.0"/> <Point X="734.8154399748928" Y="418.70931148129137" GraphRef="ae037" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f3030"> <BiopaxRef>e5a</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="32946" LineThickness="1.0"> <Point X="961.6227266296611" Y="181.24799247182114" GraphRef="d39aa" RelX="0.0" RelY="-1.0"/> <Point X="828.334971641427" Y="123.32002251219961" GraphRef="bc143" RelX="0.0" RelY="1.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c4d49"> <BiopaxRef>c9f</BiopaxRef> <BiopaxRef>c0f</BiopaxRef> <Graphics ZOrder="32993" LineThickness="1.0" Color="ff0000"> <Point X="677.8770162786778" Y="280.87429223587293" GraphRef="acaf7" RelX="-1.0" RelY="0.0"/> <Point X="547.2494525877388" Y="280.87429223587293" GraphRef="fb919" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a2279"> <BiopaxRef>f2e</BiopaxRef> <BiopaxRef>b34</BiopaxRef> <Graphics ZOrder="33173" LineThickness="1.0"> <Point X="1116.4452756938044" Y="483.2990695755909" GraphRef="bc88b" RelX="-1.0" RelY="0.0"/> <Point X="996.1123329512861" Y="483.2990405117274" GraphRef="b83e5" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e3a0d"> <BiopaxRef>f2e</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="33177" LineThickness="1.0"> <Point X="850.8349716414269" Y="431.20931148129137" GraphRef="d7759" RelX="0.5" RelY="1.0"/> <Point X="865.6838813246985" Y="489.2140704913092" GraphRef="ba0ef" RelX="-1.0" RelY="-0.5" ArrowHead="mim-conversion"/> <Anchor Position="0.34587827037097996" Shape="None" GraphId="a44c1"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="bcfbc"> <BiopaxRef>f2e</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="33179" LineThickness="1.0"> <Point X="973.6123329512861" Y="431.20931148129137" GraphRef="a6511" RelX="-0.5" RelY="1.0"/> <Point X="955.6838813246985" Y="489.2140704913092" GraphRef="ba0ef" RelX="1.0" RelY="-0.5" ArrowHead="mim-conversion"/> <Anchor Position="0.3327218481637752" Shape="None" GraphId="c515a"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="cc688"> <BiopaxRef>f2e</BiopaxRef> <BiopaxRef>b34</BiopaxRef> <Graphics ZOrder="33183" LineThickness="1.0"> <Point X="956.7961528867879" Y="456.4569643124326" GraphRef="ad747" RelX="1.0" RelY="0.0"/> <Point X="973.6123329512861" Y="456.47394966131196" GraphRef="c515a" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c2799"> <BiopaxRef>f2e</BiopaxRef> <BiopaxRef>b34</BiopaxRef> <Graphics ZOrder="33185" LineThickness="1.0"> <Point X="866.7961528867879" Y="456.4569643124326" GraphRef="ad747" RelX="-1.0" RelY="0.0"/> <Point X="850.8349716414269" Y="456.4078123991067" GraphRef="a44c1" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f7123"> <BiopaxRef>fe9</BiopaxRef> <BiopaxRef>c0f</BiopaxRef> <Graphics ConnectorType="Elbow" ZOrder="33374" LineThickness="1.0"> <Point X="700.3770162786778" Y="293.37429223587293" GraphRef="acaf7" RelX="-0.5" RelY="1.0"/> <Point X="639.5361424750917" Y="406.20931148129137" GraphRef="d6717" RelX="0.5" RelY="-1.0" ArrowHead="mim-binding"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <GraphicalLine GraphId="e7e44"> <Graphics ZOrder="33035" LineThickness="1.0"> <Point X="148.90482129963863" Y="280.87429223587293" GraphRef="d33d9" RelX="1.0" RelY="0.0"/> <Point X="215.94360633197505" Y="280.87429223587293" GraphRef="fc112" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="be17a"> <Graphics ZOrder="33040" LineThickness="1.0"> <Point X="305.94360633197505" Y="280.87429223587293" GraphRef="fc112" RelX="1.0" RelY="0.0"/> <Point X="363.95636804097535" Y="280.87429223587293" GraphRef="fb919" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="bc6b4"> <Graphics ZOrder="33131" LineStyle="Broken" LineThickness="1.0"> <Point X="35.248745062030125" Y="200.819"/> <Point X="105.61521249224157" Y="200.8187740531717" GraphRef="c34b9" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="c9451"> <Graphics ZOrder="33137" LineThickness="1.0"> <Point X="212.12002127959957" Y="198.783"/> <Point X="274.2139224326873" Y="198.78296035947957" GraphRef="a5208" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="c5c02"> <Graphics ZOrder="33139" LineThickness="1.0"> <Point X="212.33435977536914" Y="79.879"/> <Point X="274.2139224326873" Y="79.87867293443375" GraphRef="e6c2e" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="e6700"> <Graphics ZOrder="33141" LineThickness="1.0"> <Point X="213.07240223198053" Y="116.043"/> <Point X="274.2139224326873" Y="116.04323576814897" GraphRef="f0936" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="de3da"> <Graphics ZOrder="33145" LineThickness="1.0"> <Point X="212.6624976544817" Y="160.899"/> <Point X="274.2139224326873" Y="160.89904137154915" GraphRef="d55d5" RelX="-1.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="b4bfa"> <Graphics ZOrder="33161" LineThickness="1.0" Color="ff0000"> <Point X="35.10219355057089" Y="169.615"/> <Point X="105.61521249224143" Y="169.6152853834621" GraphRef="ff33e" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> </GraphicalLine> <Label TextLabel="Liver" GraphId="dd661"> <Graphics CenterX="550.4761904761904" CenterY="45.71428571428571" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Plasma&#10;" GraphId="fd0e0"> <Graphics CenterX="543.8095238095242" CenterY="220.0" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Type III&#10;" GraphId="fc112"> <Graphics CenterX="260.94360633197505" CenterY="280.87429223587293" Width="90.0" Height="25.0" ZOrder="33006" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Transport&#10;" GraphId="c34b9"> <Graphics CenterX="150.61521249224157" CenterY="200.8187740531717" Width="90.0" Height="25.0" ZOrder="33135" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Binding" GraphId="a5208"> <Graphics CenterX="319.2139224326873" CenterY="198.78296035947957" Width="90.0" Height="25.0" ZOrder="33147" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Conversion" GraphId="e6c2e"> <Graphics CenterX="319.2139224326873" CenterY="79.87867293443375" Width="90.0" Height="25.0" ZOrder="33151" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Gene/protein" GraphId="d68e3"> <Graphics CenterX="150.6152124922414" CenterY="100.4680429710351" Width="89.99999999999999" Height="24.999999999999993" ZOrder="33153" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Metabolite" GraphId="ffbb5"> <Graphics CenterX="150.6152124922414" CenterY="130.61877791561582" Width="89.99999999999999" Height="24.999999999999993" ZOrder="33155" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Catalysis" GraphId="d55d5"> <Graphics CenterX="319.2139224326873" CenterY="160.89904137154915" Width="90.0" Height="25.0" ZOrder="33157" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Stimulation" GraphId="f0936"> <Graphics CenterX="319.2139224326873" CenterY="116.04323576814897" Width="90.0" Height="25.0" ZOrder="33159" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Mutations" GraphId="ff33e"> <Graphics CenterX="150.61521249224143" CenterY="169.6152853834621" Width="89.99999999999999" Height="25.00000000000001" ZOrder="33165" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Legend" GraphId="e85a8"> <Graphics CenterX="43.94793425247404" CenterY="67.27046031036737" Width="50.05263157894808" Height="25.0" ZOrder="33167" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Shape GraphId="d9dc8"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell"/> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/> <Graphics CenterX="846.8928571428567" CenterY="112.70238095238095" Width="647.1666666666674" Height="170.97619047619045" ZOrder="-2" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/> </Shape> <Shape TextLabel="x" GraphId="c474e"> <Graphics CenterX="69.19797872669449" CenterY="98.16432457393057" Width="80.30214005481258" Height="23.858371768964034" ZOrder="33133" FontSize="12" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape GraphId="b9074"> <Graphics CenterX="194.92257309255905" CenterY="136.37793509267547" Width="368.7715544468414" Height="174.96750668032092" ZOrder="33163" FontSize="12" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Shape TextLabel="x" GraphId="f74ad"> <Graphics CenterX="69.19797872669449" CenterY="132.02269634289533" Width="80.30214005481258" Height="23.858371768964034" ZOrder="33169" FontSize="12" Valign="Middle" ShapeType="Rectangle" Color="0000ff" Rotation="0.0"/> </Shape> <Group GroupId="b05b0" GraphId="bc143" Style="Group"/> <Group GroupId="ce31d" GraphId="e10ad" Style="Complex"/> <InfoBox CenterX="0.0" CenterY="0.0"/> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b37"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30333156</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Genetic and secondary causes of severe HDL deficiency and cardiovascular disease.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2018</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Geller AS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Polisecki EY</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Diffenderfer MR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Asztalos BF</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Karathanasis SK</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hegele RA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schaefer EJ</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e51"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20301485</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Familial Lipoprotein Lipase Deficiency</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1993</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Burnett JR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hooper AJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hegele RA</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d5e"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24426196</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Indian J Clin Biochem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2013</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Todur SP</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ashavaid TF</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="edb"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23055695</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug Des Devel Ther</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Goldberg AS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hegele RA</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b79"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28766509</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">High-density lipoprotein metabolism and reverse cholesterol transport: strategies for raising HDL cholesterol.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Anatol J Cardiol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tosheska Trajkovska K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Topuzovska S</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e5a"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29057873</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Commun</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shin KC</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hwang I</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Choe SS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Park J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ji Y</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim JI</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee GY</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Choi SH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ching J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kovalik JP</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim JB</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c97"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30333156</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Genetic and secondary causes of severe HDL deficiency and cardiovascular disease.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2018</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Geller AS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Polisecki EY</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Diffenderfer MR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Asztalos BF</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Karathanasis SK</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hegele RA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schaefer EJ</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f4b"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28882953</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">&lt;i&gt;SCARB1&lt;/i&gt;Gene Polymorphisms and HDL Subfractions in Coronary Artery Disease.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">In Vivo</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ayhan H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gormus U</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Isbir S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yilmaz SG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Isbir T</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c9f"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28098593</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Familial dysbetalipoproteinemia: an underdiagnosed lipid disorder.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Curr Opin Endocrinol Diabetes Obes</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Koopal C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Marais AD</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Visseren FL</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c65"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30249788</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-terminal mutation of apoA-I and interaction with ABCA1 reveal mechanisms of nascent HDL biogenesis.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2019</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mei X</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Herscovitz H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Atkinson D</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bbc"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">32120838</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Association between the&lt;i&gt;APOA2&lt;/i&gt;rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biomedicines</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2020</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Boughanem H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bandera-Merchán B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hernández-Alonso P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moreno-Morales N</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tinahones FJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lozano J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morcillo S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Macias-Gonzalez M</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c72"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22474067</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Constitutive inhibition of plasma CETP by apolipoprotein C1 is blunted indyslipidemic patients with coronary artery disease.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pillois X</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gautier T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bouillet B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pais de Barros JP</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jeannin A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vergès B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bonnet J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lagrost L</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b52"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">31462513</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2019</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Obinata H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kuo A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wada Y</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Swendeman S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu CH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Blaho VA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nagumo R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Satoh K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Izumi T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hla T</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f43"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">31462513</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2019</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Obinata H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kuo A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wada Y</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Swendeman S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu CH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Blaho VA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nagumo R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Satoh K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Izumi T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hla T</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bab"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28766509</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">High-density lipoprotein metabolism and reverse cholesterol transport: strategies for raising HDL cholesterol.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Anatol J Cardiol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tosheska Trajkovska K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Topuzovska S</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="afd"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24426196</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Indian J Clin Biochem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2013</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Todur SP</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ashavaid TF</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eef"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29100061</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Atherosclerosis</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wolska A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dunbar RL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Freeman LA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ueda M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Amar MJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sviridov DO</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Remaley AT</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f89"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">31676439</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Interleukin 10 promotes macrophage uptake of HDL and LDL bystimulating fluid-phase endocytosis.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochim Biophys Acta Mol Cell Biol Lipids</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2020</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lucero D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Islam P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Freeman LA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jin X</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pryor M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tang J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kruth HS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Remaley AT</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d68"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30249788</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">N-terminal mutation of apoA-I and interaction with ABCA1 reveal mechanisms of nascent HDL biogenesis.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2019</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mei X</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Herscovitz H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Atkinson D</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ff2"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22461740</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yale J Biol Med</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Go GW</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mani A</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e79"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">14592533</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid traders.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Int J Biochem Cell Biol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2004</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rhainds D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brissette L</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d41"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">32120838</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Association between the&lt;i&gt;APOA2&lt;/i&gt;rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biomedicines</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2020</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Boughanem H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bandera-Merchán B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hernández-Alonso P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moreno-Morales N</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tinahones FJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lozano J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morcillo S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Macias-Gonzalez M</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c81"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28882953</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">&lt;i&gt;SCARB1&lt;/i&gt;Gene Polymorphisms and HDL Subfractions in Coronary Artery Disease.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">In Vivo</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ayhan H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gormus U</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Isbir S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yilmaz SG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Isbir T</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e47"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30420806</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sexually Dimorphic Regulation of EET Synthesis and Metabolism: Roles of Estrogen.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Front Pharmacol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2018</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huang A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sun D</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fdd"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29100061</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Atherosclerosis</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wolska A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dunbar RL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Freeman LA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ueda M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Amar MJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sviridov DO</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Remaley AT</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d2a"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22461740</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yale J Biol Med</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Go GW</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mani A</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f2e"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26247089</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Introduction to Lipids and Lipoproteins</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2000</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Feingold KR</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cbc"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">31676439</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Interleukin 10 promotes macrophage uptake of HDL and LDL by stimulating fluid-phase endocytosis.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochim Biophys Acta Mol Cell Biol Lipids</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2020</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lucero D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Islam P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Freeman LA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jin X</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pryor M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tang J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kruth HS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Remaley AT</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b34"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23055695</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Drug Des Devel Ther</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Goldberg AS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hegele RA</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dd8"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">14592533</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid traders.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Int J Biochem Cell Biol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2004</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rhainds D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brissette L</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c0f"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25328986</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Apolipoprotein E isoforms and lipoprotein metabolism.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">IUBMB Life</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Phillips MC</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fe9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27457486</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">APOE genotype and stress response - a mini review.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lipids Health Dis</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dose J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huebbe P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nebel A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rimbach G</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>familial hyperlipidemia</bp:TERM><bp:ID>DOID:1168</bp:ID><bp:Ontology>Disease</bp:Ontology></bp:openControlledVocabulary></Biopax> </Pathway>

• Template:AuthorInfo
• Template:CheckAvailable (protected)
• Template:Help:LiteratureReferences (protected)
• Template:PathwayPage:History
• Template:PathwayPage:Xrefs

Return to Familial hyperlipidemia type 3 (Homo sapiens).