Cohesin complex - Cornelia de Lange syndrome (Homo sapiens)

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Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Securin" GraphId="e2a27" Type="Protein"> <Graphics CenterX="2771.2630725253593" CenterY="3357.1388867884725" Width="90.0" Height="25.0" ZOrder="33555" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95997" /> </DataNode> <DataNode TextLabel="HDAC8" GraphId="be183" Type="GeneProduct"> <Graphics CenterX="1823.1750185218941" CenterY="2048.0706581887384" Width="90.0" Height="25.0" ZOrder="33556" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000147099" /> </DataNode> <DataNode TextLabel="ESCO1" GraphId="d4d19" Type="GeneProduct" GroupRef="c7f98"> <Graphics CenterX="1297.0217503281656" CenterY="2010.152257835823" Width="90.0" Height="25.0" ZOrder="33557" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000141446" /> </DataNode> <DataNode TextLabel="REC8" GraphId="ea232" Type="GeneProduct"> <Graphics CenterX="604.8800696677747" CenterY="3188.8996101924236" Width="90.0" Height="25.0" ZOrder="33558" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000100918" /> </DataNode> <DataNode TextLabel="SMC3" GraphId="a8972" Type="GeneProduct" GroupRef="c7754"> <Graphics CenterX="290.1574664754696" CenterY="2126.8258258108085" Width="90.0" Height="25.0" ZOrder="33562" FontSize="12" Valign="Middle" Color="ff3333" /> <Xref Database="Ensembl" ID="ENSG00000108055" /> </DataNode> <DataNode TextLabel="SMC1B" GraphId="c8ac9" Type="GeneProduct" GroupRef="c7754"> <Graphics CenterX="200.15746647546916" CenterY="2126.8258258108085" Width="90.0" Height="25.0" ZOrder="33563" FontSize="12" Valign="Middle" Color="00cc33" /> <Xref Database="Ensembl" ID="ENSG00000077935" /> </DataNode> <DataNode TextLabel="STAG3" GraphId="bdbbb" Type="GeneProduct" GroupRef="c7754"> <Graphics CenterX="247.2255670820727" CenterY="2365.7397447584726" Width="90.0" Height="25.0" ZOrder="33564" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000066923" /> </DataNode> <DataNode TextLabel="REC8" GraphId="acbf6" Type="GeneProduct" GroupRef="c7754"> <Graphics CenterX="247.2255670820727" CenterY="2340.7397447584726" Width="90.0" Height="25.0" ZOrder="33565" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000100918" /> </DataNode> <DataNode TextLabel="SMC3" GraphId="b107b" Type="GeneProduct" GroupRef="f2edf"> <Graphics CenterX="1132.158636851195" CenterY="2139.688082914816" Width="90.0" Height="25.0" ZOrder="33572" FontSize="12" Valign="Middle" Color="ff3333" /> <Xref Database="Ensembl" ID="ENSG00000108055" /> </DataNode> <DataNode TextLabel="SMC1B" GraphId="bc9b6" Type="GeneProduct" GroupRef="f2edf"> <Graphics CenterX="1042.1586368511946" CenterY="2139.688082914816" Width="90.0" Height="25.0" ZOrder="33573" FontSize="12" Valign="Middle" Color="00cc33" /> <Xref Database="Ensembl" ID="ENSG00000077935" /> </DataNode> <DataNode TextLabel="STAG3" GraphId="b3dd7" Type="GeneProduct" GroupRef="f2edf"> <Graphics CenterX="1089.226737457798" CenterY="2378.60200186248" Width="90.0" Height="25.0" ZOrder="33575" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000066923" /> </DataNode> <DataNode TextLabel="REC8" GraphId="d0242" Type="GeneProduct" GroupRef="f2edf"> <Comment>Phosphorylation of REC8 makes it more susceptible to separase cleavage</Comment> <Graphics CenterX="1089.226737457798" CenterY="2353.60200186248" Width="90.0" Height="25.0" ZOrder="33576" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000100918" /> </DataNode> <DataNode TextLabel="SMC3" GraphId="b67ca" Type="GeneProduct"> <Graphics CenterX="1702.2969267596172" CenterY="2137.1990328876354" Width="90.0" Height="25.0" ZOrder="33586" FontSize="12" Valign="Middle" Color="ff3333" /> <Xref Database="Ensembl" ID="ENSG00000108055" /> </DataNode> <DataNode TextLabel="SMC1B" GraphId="f0748" Type="GeneProduct"> <Graphics CenterX="1612.2969267596065" CenterY="2137.1990328876354" Width="90.0" Height="25.0" ZOrder="33587" FontSize="12" Valign="Middle" Color="00cc33" /> <Xref Database="Ensembl" ID="ENSG00000077935" /> </DataNode> <DataNode TextLabel="STAG3" GraphId="d796a" Type="GeneProduct"> <Graphics CenterX="1659.365027366212" CenterY="2376.1129518352996" Width="90.0" Height="25.0" ZOrder="33588" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000066923" /> </DataNode> <DataNode TextLabel="REC8" GraphId="b5dd0" Type="GeneProduct"> <Graphics CenterX="1659.365027366212" CenterY="2351.1129518352996" Width="90.0" Height="25.0" ZOrder="33589" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000100918" /> </DataNode> <DataNode TextLabel="SMC3" GraphId="c5e71" Type="GeneProduct" GroupRef="fe592"> <Graphics CenterX="1132.9589486951381" CenterY="2974.884245054807" Width="90.0" Height="25.0" ZOrder="33594" FontSize="12" Valign="Middle" Color="ff3333" /> <Xref Database="Ensembl" ID="ENSG00000108055" /> 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CenterY="3331.9546544085833" Width="90.0" Height="25.0" ZOrder="33600" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000105568" /> </DataNode> <DataNode TextLabel="PPP2R5C" GraphId="d94aa" Type="GeneProduct" GroupRef="ee4e7"> <Graphics CenterX="808.9036227467758" CenterY="3456.954654408574" Width="90.0" Height="25.0" ZOrder="33601" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000078304" /> </DataNode> <DataNode TextLabel="PPP2R5B" GraphId="c599f" Type="GeneProduct" GroupRef="ee4e7"> <Graphics CenterX="808.9036227467758" CenterY="3431.954654408575" Width="90.0" Height="25.0" ZOrder="33602" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="PPP2R5B" /> </DataNode> <DataNode TextLabel="PPP2R5A" GraphId="b285f" Type="GeneProduct" GroupRef="ee4e7"> <Graphics CenterX="808.9036227467758" CenterY="3406.954654408578" Width="90.0" Height="25.0" ZOrder="33603" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000066027" /> </DataNode> <DataNode TextLabel="PPP2CB" GraphId="caab1" Type="GeneProduct" GroupRef="ee4e7"> <Graphics CenterX="808.9036227467758" CenterY="3556.9546544085615" Width="90.0" Height="25.0" ZOrder="33604" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000104695" /> </DataNode> <DataNode TextLabel="PPP2CA" GraphId="f7db5" Type="GeneProduct" GroupRef="ee4e7"> <Graphics CenterX="808.9036227467758" CenterY="3531.954654408566" Width="90.0" Height="25.0" ZOrder="33605" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000113575" /> </DataNode> <DataNode TextLabel="PPP2R5E" GraphId="be6ff" Type="GeneProduct" GroupRef="ee4e7"> <Graphics CenterX="808.9036227467758" CenterY="3506.954654408569" Width="90.0" Height="25.0" ZOrder="33606" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000154001" /> </DataNode> <DataNode TextLabel="PTPA" GraphId="f1c09" Type="GeneProduct" GroupRef="ee4e7"> <Graphics CenterX="808.9036227467758" CenterY="3381.954654408579" Width="90.0" Height="25.0" ZOrder="33607" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000119383" /> </DataNode> <DataNode TextLabel="PPP2R1B" GraphId="ca9a6" Type="GeneProduct" GroupRef="ee4e7"> <Graphics CenterX="808.9036227467758" CenterY="3356.9546544085824" Width="90.0" Height="25.0" ZOrder="33608" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000137713" /> </DataNode> <DataNode TextLabel="PPP2R5D" GraphId="c069a" Type="GeneProduct" GroupRef="ee4e7"> <Graphics CenterX="808.9036227467758" CenterY="3481.9546544085733" Width="90.0" Height="25.0" ZOrder="33609" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000112640" /> </DataNode> <DataNode TextLabel="SMC3" GraphId="bc976" Type="GeneProduct"> <Graphics CenterX="2443.297904086454" CenterY="3143.5848221747624" Width="90.0" Height="25.0" ZOrder="33611" FontSize="12" Valign="Middle" Color="ff3333" /> <Xref Database="Ensembl" ID="ENSG00000108055" /> </DataNode> <DataNode TextLabel="SMC1B" GraphId="e3fd8" Type="GeneProduct"> <Graphics CenterX="2353.2979040864534" CenterY="3143.5848221747624" Width="90.0" Height="25.0" ZOrder="33612" FontSize="12" Valign="Middle" Color="00cc33" /> <Xref Database="Ensembl" ID="ENSG00000077935" /> </DataNode> <DataNode TextLabel="STAG3" GraphId="dbbbb" Type="GeneProduct"> <Graphics CenterX="2400.3660046930563" CenterY="3382.4987411224265" Width="90.0" Height="25.0" ZOrder="33613" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000066923" /> </DataNode> <DataNode TextLabel="REC8" GraphId="fe741" Type="GeneProduct"> <Graphics CenterX="2400.3660046930563" CenterY="3357.4987411224265" Width="90.0" Height="25.0" ZOrder="33614" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000100918" /> </DataNode> <DataNode TextLabel="SMC3" GraphId="c3e87" Type="GeneProduct" GroupRef="f521f"> <Graphics CenterX="1917.995350493685" CenterY="2988.0514074901093" Width="90.0" Height="25.0" ZOrder="33629" FontSize="12" Valign="Middle" Color="ff3333" /> <Xref Database="Ensembl" ID="ENSG00000108055" /> </DataNode> <DataNode TextLabel="SMC1B" GraphId="bbca6" Type="GeneProduct" GroupRef="f521f"> <Graphics CenterX="1827.9953504936805" CenterY="2988.0514074901093" Width="90.0" Height="25.0" ZOrder="33630" FontSize="12" Valign="Middle" Color="00cc33" /> <Xref Database="Ensembl" ID="ENSG00000077935" /> </DataNode> <DataNode TextLabel="STAG3" GraphId="eaa82" Type="GeneProduct" GroupRef="f521f"> <Graphics CenterX="1875.0634511002872" CenterY="3226.965326437775" Width="90.0" Height="25.0" ZOrder="33631" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000066923" /> </DataNode> <DataNode TextLabel="REC8" GraphId="b4c66" Type="GeneProduct" GroupRef="f521f"> <Comment>Phosphorylation of REC8 makes it more susceptible to separase cleavage</Comment> <Graphics CenterX="1875.0634511002872" CenterY="3201.965326437774" Width="90.0" Height="25.0" 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