PI3K/AKT/mTOR - vitamin D3 signaling (Homo sapiens)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="PI3K/AKT/mTOR - vitamin D3 signaling" Version="20170307" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Pathway representation of the model proposed by Ferreira et al. in the Figure 7 C of their article: "Proposed model for the mechanism of action of 1,25(OH)2D3 in human-monocyte-derived DCs. We hypothesize that VDR-bound 1,25(OH)2D3 activates the PI3K-Akt-mTOR pathway via either forming a complex and phosphorylating the regulatory subunit of PI3K, or by other unknown mechanisms. This releases and activates the catalytic subunit, which unleashes the PI3K downstream pathway. Among other functions, activation of this pathway promotes the expression of different key glycolytic enzymes, which induces glycolysis. Control of surface marker expression and cytokine production by 1,25(OH)2D3 might arise from its impact on the PI3K pathway, which can control essential transcription factors (e.g., GSK-3β and NF-κB nuclear translocation) or from the direct regulation of transcription factors, key metabolic bifunctional enzymes, and RNA binding proteins. In the absence of glucose or glycolysis, an increase in the AMP/ATP ratio will be sensed by AMPK, which, in turn, phosphorylates TSC2 and blocks activation of the mTOR complex and its downstream processes. We further consider that the increase in OXPHOS also seen in 1,25D3-DCs is derived from the excess pyruvate generated during induced glycolysis, in addition to the control of metabolic enzymes from the oxidative branch by 1,25(OH)2D3". Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4141 CPTAC Assay Portal]</Comment> <Comment/> <BiopaxRef>ca5</BiopaxRef> <Graphics BoardWidth="1295.5310621242486" BoardHeight="871.6833667334665"/> <DataNode TextLabel="TCA Cycle" GraphId="a100d" Type="Pathway"> <Graphics CenterX="411.36773547094174" CenterY="719.283256763526" Width="99.10821643286602" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Oval" Color="14961e"/> <Xref Database="WikiPathways" ID="WP78"/> </DataNode> <DataNode TextLabel="mTOR " GraphId="a2fa6" Type="GeneProduct"> <Graphics CenterX="676.2124407506417" CenterY="546.3026052104207" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000198793"/> </DataNode> <DataNode TextLabel="PDHA1" GraphId="ad7ae" Type="GeneProduct"> <Graphics CenterX="396.66332665330617" CenterY="651.7535070140283" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000131828"/> </DataNode> <DataNode TextLabel="Glucose-6-P" GraphId="afc8d" Type="Metabolite"> <Graphics CenterX="316.17735470942006" CenterY="251.50300601202431" Width="98.10621242484974" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:4170"/> </DataNode> <DataNode TextLabel="HLA-DRA" GraphId="b0348" Type="GeneProduct" GroupRef="e348d"> <Graphics CenterX="676.2124407506418" CenterY="774.4488977955912" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000204287"/> </DataNode> <DataNode TextLabel="Pyruvate" GraphId="b13c5" Type="Metabolite"> <Graphics CenterX="316.17735470942" CenterY="549.0981963927859" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15361"/> </DataNode> <DataNode TextLabel="AMP" GraphId="b1738" Type="Metabolite" GroupRef="d42ee"> <Graphics CenterX="510.4084654947278" CenterY="446.06712773701867" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="HMDB" ID="HMDB0003540"/> </DataNode> <DataNode TextLabel="HK3" GraphId="b227e" Type="GeneProduct"> <Graphics CenterX="316.17735470942" CenterY="314.25851703406886" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000160883"/> </DataNode> <DataNode TextLabel="AKT" GraphId="b60df" Type="GeneProduct"> <Graphics CenterX="676.2124407506418" CenterY="345.96192384769455" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000142208"/> </DataNode> <DataNode TextLabel="PI3K" GraphId="c01d0" Type="GeneProduct"> <Graphics CenterX="676.2124407506417" CenterY="251.59318637274487" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000121879"/> </DataNode> <DataNode TextLabel="Fructose Bisphosphate " GraphId="c141f" Type="Metabolite"> <Graphics CenterX="316.1773547094208" CenterY="478.95791583166397" Width="156.22244488977964" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:65056"/> </DataNode> <DataNode TextLabel="PFKFB4" GraphId="c6b34" Type="GeneProduct"> <Graphics CenterX="316.17735470941994" CenterY="422.41482965931914" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000114268"/> </DataNode> <DataNode TextLabel="LDHA" GraphId="caedf" Type="GeneProduct"> <Graphics CenterX="224.3266533066132" CenterY="622.7535070140275" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000134333"/> </DataNode> <DataNode TextLabel="CD80" GraphId="cb91c" Type="GeneProduct" GroupRef="e348d"> <Graphics CenterX="676.2124407506418" CenterY="724.4488977955912" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000121594"/> </DataNode> <DataNode TextLabel="GSK-3b" GraphId="cc138" Type="GeneProduct"> <Graphics CenterX="801.4328657314634" CenterY="383.917835671342" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000082701"/> </DataNode> <DataNode TextLabel="TSC1" GraphId="d67d3" Type="GeneProduct" GroupRef="e788b"> <Graphics CenterX="676.2124407506418" CenterY="433.12875751503003" Width="61.03206412825625" Height="19.514028056112075" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000165699"/> </DataNode> <DataNode TextLabel="GLUT3" GraphId="dbf39" Type="GeneProduct"> <Graphics CenterX="316.17735470941994" CenterY="190.130260521042" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000059804"/> </DataNode> <DataNode TextLabel="VDR" GraphId="dc73e" Type="GeneProduct"> <Graphics CenterX="1076.0220440881785" CenterY="250.5911823647288" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000111424"/> </DataNode> <DataNode TextLabel="ROS" GraphId="e6675" Type="Metabolite"> <Comment>Reactive oxygen species</Comment> <Graphics CenterX="526.0971943887761" CenterY="666.5706412825645" Width="66.04208416833636" Height="18.512024048096237" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q424361"/> </DataNode> <DataNode TextLabel="RXR" GraphId="eb3c9" Type="GeneProduct"> <Graphics CenterX="1194.2585170340653" CenterY="254.53907815631015" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000186350"/> </DataNode> <DataNode TextLabel="Lactate" GraphId="ec800" Type="Metabolite"> <Graphics CenterX="195.39078156312664" CenterY="698.3967935871746" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:24996"/> </DataNode> <DataNode TextLabel="AMPK" GraphId="f15dc" Type="GeneProduct"> <Graphics CenterX="536.948992685562" CenterY="542.495369539843" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000162409"/> </DataNode> <DataNode TextLabel="Fructose-6-P" GraphId="f815b" Type="Metabolite"> <Graphics CenterX="316.17735470941994" CenterY="363.99048096192354" Width="97.10420841683121" Height="17.51002004008017" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16084"/> </DataNode> <DataNode TextLabel="C-MYC" GraphId="fafbc" Type="GeneProduct"> <Graphics CenterX="189.2484969939879" CenterY="264.2184368737471" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000136997"/> </DataNode> <DataNode TextLabel="1,25-(OH)2-D3" GraphId="fd735" Type="Metabolite"> <Graphics CenterX="1074.694388777558" CenterY="166.59569138276547" Width="123.1563126252463" Height="23.522044088176393" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17823"/> </DataNode> <DataNode TextLabel="CD86" GraphId="fe4a4" Type="GeneProduct" GroupRef="e348d"> <Graphics CenterX="676.2124407506418" CenterY="749.4488977955912" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000114013"/> </DataNode> <DataNode TextLabel="CYP24A1" GraphId="ffe0d" Type="GeneProduct" GroupRef="f35d6"> <Graphics CenterX="936.5699482925327" CenterY="652.0025632861674" Width="80.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000019186"/> </DataNode> <DataNode TextLabel="C-MYC" GraphId="cf82e" Type="GeneProduct"> <Graphics CenterX="170.1903807615227" CenterY="552.7755511022052" Width="80.0" Height="20.0" ZOrder="32770" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000136997"/> </DataNode> <DataNode TextLabel="C-MYC" GraphId="adfbf" Type="GeneProduct"> <Graphics CenterX="801.4328657314635" CenterY="500.6513026052119" Width="80.0" Height="20.0" ZOrder="32771" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000136997"/> </DataNode> <DataNode TextLabel="C-MYC" GraphId="dc82e" Type="GeneProduct" GroupRef="f35d6"> <Graphics CenterX="936.5699482925329" CenterY="672.0025632861673" Width="79.99999999999991" Height="20.000000000000036" ZOrder="32772" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000136997"/> </DataNode> <DataNode TextLabel="ATP" GraphId="bffcb" Type="Metabolite"> <Graphics CenterX="518.0410821643278" CenterY="762.7229458917818" Width="66.04208416833636" Height="18.512024048096237" ZOrder="32780" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15422"/> </DataNode> <DataNode TextLabel="PFKFB4" GraphId="e681a" Type="GeneProduct" GroupRef="f35d6"> <Graphics CenterX="936.5699482925329" CenterY="692.0025632861673" Width="79.99999999999991" Height="20.000000000000036" ZOrder="32785" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000114268"/> </DataNode> <DataNode TextLabel="VDR" GraphId="a43fe" Type="GeneProduct" GroupRef="f840f"> <Graphics CenterX="1079.8325491107605" CenterY="683.5557949755304" Width="80.0" Height="20.0" ZOrder="32786" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000111424"/> </DataNode> <DataNode TextLabel="1,25-(OH)2-D3" GraphId="b47a4" Type="Metabolite" GroupRef="f840f"> <Graphics CenterX="1120.0980801728865" CenterY="662.7466767390571" Width="100.13026052103675" Height="23.522044088176393" ZOrder="32787" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17823"/> </DataNode> <DataNode TextLabel="RXR" Type="GeneProduct" GroupRef="f840f"> <Graphics CenterX="1159.8325491107612" CenterY="683.5557949755304" Width="80.00000000000003" Height="20.000000000000036" ZOrder="32788" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000186350"/> </DataNode> <DataNode TextLabel="TSC2" GraphId="a0320" Type="GeneProduct" GroupRef="e788b"> <Graphics CenterX="676.2124407506418" CenterY="452.64278557114216" Width="61.03206412825625" Height="19.514028056112075" ZOrder="32798" FontSize="12" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000103197"/> </DataNode> <DataNode TextLabel="Cell cycle" GraphId="a80b7" Type="Pathway"> <Graphics CenterX="826.1873747495005" CenterY="563.1262525050099" Width="73.07615230460668" Height="24.04809619238467" ZOrder="32803" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Oval" Color="14961e"/> <Xref Database="WikiPathways" ID="WP179"/> </DataNode> <DataNode TextLabel="p65" GraphId="d8229" Type="GeneProduct"> <Graphics CenterX="918.3921039273044" CenterY="459.7616731280158" Width="59.24913771433292" Height="18.512024048096237" ZOrder="32810" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Ensembl" ID="ENSG00000173039"/> </DataNode> <DataNode TextLabel="IL10" GraphId="e1453" Type="GeneProduct" GroupRef="e4ff8"> <Graphics CenterX="977.9509018036051" CenterY="511.1598196392817" Width="44.0981963927884" Height="18.512024048096237" ZOrder="32813" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Ensembl" ID="ENSG00000136634"/> </DataNode> <DataNode TextLabel="IL12A" GraphId="d477f" Type="GeneProduct" GroupRef="e4ff8"> <Graphics CenterX="916.3176352705401" CenterY="511.1598196392816" Width="47.12424849699602" Height="18.512024048096237" ZOrder="32815" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Ensembl" ID="ENSG00000168811"/> </DataNode> <DataNode TextLabel="ATP" GraphId="cc02d" Type="Metabolite" GroupRef="d42ee"> <Graphics CenterX="510.4084654947277" CenterY="471.0671277370186" Width="90.0" Height="25.0" ZOrder="32823" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15422"/> </DataNode> <Interaction GraphId="id108edcb2"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="1076.0220440881785" Y="260.5911823647288" GraphRef="dc73e" RelX="0.0" RelY="1.0"/> <Point X="1119.8325491107607" Y="638.9856546949688" GraphRef="a7de9" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id2b5bda84"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="316.17735470942" Y="372.7454909819637" GraphRef="f815b" RelX="0.0" RelY="1.0"/> <Point X="316.17735470941994" Y="412.41482965931914" GraphRef="c6b34" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id33c80641"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="676.2124407506418" Y="355.96192384769455" GraphRef="b60df" RelX="0.0" RelY="1.0"/> <Point X="761.4328657314634" Y="383.917835671342" GraphRef="cc138" RelX="-1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id6d26fc8e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="316.17735470941994" Y="432.41482965931914" GraphRef="c6b34" RelX="0.0" RelY="1.0"/> <Point X="316.1773547094208" Y="466.45791583166397" GraphRef="c141f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id73d49e6a"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1027.8325491107603" Y="672.2707248352497" GraphRef="a7de9" RelX="-1.0" RelY="0.0"/> <Point X="984.5699482925327" Y="672.0025632861673" GraphRef="e69fe" RelX="1.0" RelY="0.0" ArrowHead="mim-transcription-translation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id832cef87"> <Comment>Glucose-6-P intake</Comment> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="316.17735470941994" Y="200.130260521042" GraphRef="dbf39" RelX="0.0" RelY="1.0"/> <Point X="316.17735470942" Y="239.00300601202434" GraphRef="afc8d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id96359a5e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="189.2484969939879" Y="254.21843687374712" GraphRef="fafbc" RelX="0.0" RelY="-1.0"/> <Point X="276.17735470941994" Y="190.130260521042" GraphRef="dbf39" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ida7b944da"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="316.1773547094208" Y="491.45791583166397" GraphRef="c141f" RelX="0.0" RelY="1.0"/> <Point X="316.17735470942" Y="536.5981963927859" GraphRef="b13c5" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idbc141426"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="396.66332665330617" Y="661.7535070140283" GraphRef="ad7ae" RelX="0.0" RelY="1.0"/> <Point X="411.36773547094174" Y="706.783256763526" GraphRef="a100d" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idea4d7e61"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="316.17735470942" Y="561.5981963927859" GraphRef="b13c5" RelX="0.0" RelY="1.0"/> <Point X="240.39078156312664" Y="692.1467935871746" GraphRef="ec800" RelX="1.0" RelY="-0.5" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idfb3f136b"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="170.1903807615227" Y="562.7755511022052" GraphRef="cf82e" RelX="0.0" RelY="1.0"/> <Point X="224.3266533066132" Y="612.7535070140275" GraphRef="caedf" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idfea26355"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="716.2124407506417" Y="546.3026052104207" GraphRef="a2fa6" RelX="1.0" RelY="0.0"/> <Point X="770.0" Y="647.8757515030059"/> <Point X="729.2124407506418" Y="749.4488977955912" GraphRef="c5732" RelX="1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c58c1"> <Graphics ZOrder="32769" LineThickness="1.0"> <Point X="316.17735470942" Y="264.00300601202434" GraphRef="afc8d" RelX="0.0" RelY="1.0"/> <Point X="316.17735470942" Y="304.25851703406886" GraphRef="b227e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="b03bc"> <Graphics ZOrder="32773" LineThickness="1.0"> <Point X="316.17735470942" Y="561.5981963927859" GraphRef="b13c5" RelX="0.0" RelY="1.0"/> <Point X="396.66332665330617" Y="641.7535070140283" GraphRef="ad7ae" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d106a"> <Graphics ZOrder="32776" LineThickness="1.0"> <Point X="316.17735470942" Y="324.25851703406886" GraphRef="b227e" RelX="0.0" RelY="1.0"/> <Point X="316.17735470942" Y="355.2354709418835" GraphRef="f815b" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ac106"> <Graphics ZOrder="32777" LineThickness="1.0"> <Point X="189.2484969939879" Y="274.2184368737471" GraphRef="fafbc" RelX="0.0" RelY="1.0"/> <Point X="276.17735470942" Y="314.25851703406886" GraphRef="b227e" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d7aa9"> <Graphics ZOrder="32778" LineThickness="1.0"> <Point X="1074.694388777558" Y="178.35671342685362" GraphRef="fd735" RelX="0.0" RelY="1.0"/> <Point X="1076.0220440881785" Y="240.5911823647288" GraphRef="dc73e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d58e5"> <Graphics ZOrder="32789" LineStyle="Broken" LineThickness="1.0"> <Point X="1194.2585170340653" Y="264.53907815631015" GraphRef="eb3c9" RelX="0.0" RelY="1.0"/> <Point X="1119.8325491107607" Y="638.9856546949688" GraphRef="a7de9" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c6a2c"> <Graphics ZOrder="32790" LineThickness="1.0"> <Point X="636.2124407506418" Y="345.96192384769455" GraphRef="b60df" RelX="-1.0" RelY="0.0"/> <Point X="356.17735470941994" Y="190.130260521042" GraphRef="dbf39" RelX="1.0" RelY="0.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f7000"> <Graphics ZOrder="32791" LineThickness="1.0"> <Point X="636.2124407506418" Y="345.96192384769455" GraphRef="b60df" RelX="-1.0" RelY="0.0"/> <Point X="356.17735470942" Y="314.25851703406886" GraphRef="b227e" RelX="1.0" RelY="0.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e7f1c"> <Graphics ZOrder="32792" LineThickness="1.0"> <Point X="636.2124407506418" Y="345.96192384769455" GraphRef="b60df" RelX="-1.0" RelY="0.0"/> <Point X="356.17735470941994" Y="422.41482965931914" GraphRef="c6b34" RelX="1.0" RelY="0.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d7fbc"> <Graphics ZOrder="32793" LineThickness="1.0"> <Point X="676.2124407506417" Y="261.59318637274487" GraphRef="c01d0" RelX="0.0" RelY="1.0"/> <Point X="676.2124407506418" Y="335.96192384769455" GraphRef="b60df" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c1560"> <Graphics ZOrder="32794" LineThickness="1.0"> <Point X="1036.0220440881785" Y="250.5911823647288" GraphRef="dc73e" RelX="-1.0" RelY="0.0"/> <Point X="716.2124407506417" Y="251.59318637274487" GraphRef="c01d0" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c39c7"> <Graphics ZOrder="32795" LineThickness="1.0"> <Point X="676.2124407506418" Y="355.96192384769455" GraphRef="b60df" RelX="0.0" RelY="1.0"/> <Point X="676.2124407506418" Y="423.37174348697397" GraphRef="d67d3" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f81ed"> <Graphics ZOrder="32796" LineThickness="1.0"> <Point X="676.2124407506418" Y="462.3997995991981" GraphRef="a0320" RelX="0.0" RelY="1.0"/> <Point X="676.2124407506417" Y="536.3026052104207" GraphRef="a2fa6" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="efa14"> <Graphics ZOrder="32797" LineThickness="1.0"> <Point X="801.4328657314634" Y="393.917835671342" GraphRef="cc138" RelX="0.0" RelY="1.0"/> <Point X="801.4328657314635" Y="490.6513026052119" GraphRef="adfbf" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f1ea4"> <Graphics ZOrder="32801" LineThickness="1.0"> <Point X="676.2124407506417" Y="556.3026052104207" GraphRef="a2fa6" RelX="0.0" RelY="1.0"/> <Point X="677.1102422009101" Y="601.5932742950948" GraphRef="e238c" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f022f"> <Graphics ZOrder="32802" LineStyle="Broken" LineThickness="1.0"> <Point X="677.1102422009101" Y="626.5932742950948" GraphRef="e238c" RelX="0.0" RelY="1.0"/> <Point X="676.2124407506418" Y="703.9488977955912" GraphRef="c5732" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d6da6"> <Graphics ZOrder="32805" LineThickness="1.0"> <Point X="801.4328657314635" Y="510.6513026052119" GraphRef="adfbf" RelX="0.0" RelY="1.0"/> <Point X="826.1873747495005" Y="551.1022044088176" GraphRef="a80b7" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="b2aa3"> <Graphics ZOrder="32806" LineThickness="1.0"> <Point X="510.40846549472775" Y="491.5671277370186" GraphRef="cdb28" RelX="0.0" RelY="1.0"/> <Point X="536.948992685562" Y="532.495369539843" GraphRef="f15dc" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e035f"> <Graphics ZOrder="32807" LineThickness="1.0"> <Point X="576.948992685562" Y="542.495369539843" GraphRef="f15dc" RelX="1.0" RelY="0.0"/> <Point X="633.6964086865137" Y="442.8857715430861" GraphRef="e3cd1" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c7118"> <Graphics ZOrder="32808" LineThickness="1.0"> <Point X="841.4328657314634" Y="383.917835671342" GraphRef="cc138" RelX="1.0" RelY="0.0"/> <Point X="918.3921039273046" Y="450.50566110396767" GraphRef="d8229" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <GraphicalLine GraphId="id4aec5e4d"> <Graphics ZOrder="12288" LineThickness="1.0" Color="0033ff"> <Point X="140.0" Y="709.0"/> <Point X="140.0" Y="686.0" ArrowHead="mim-binding"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="cbc97"> <Graphics ZOrder="32799" LineThickness="1.0" Color="3366ff"> <Point X="615.8404071392314" Y="621.1022044088186"/> <Point X="615.8404071392322" Y="604.068136272546" ArrowHead="mim-binding"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="bd057"> <Graphics ZOrder="32811" LineThickness="1.0"> <Point X="918.3921039273046" Y="469.0176851520639" GraphRef="d8229" RelX="0.0" RelY="1.0"/> <Point X="946.3777555110207" Y="493.9038076152335" GraphRef="fa1b8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="afded"> <Graphics ZOrder="32816" LineThickness="1.0" Color="0033ff"> <Point X="456.09049549768343" Y="436.54375997635447"/> <Point X="457.0623140284388" Y="411.22663223933534" ArrowHead="mim-binding"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="c412b"> <Graphics ZOrder="32817" LineThickness="1.0" Color="0033ff"> <Point X="948.0" Y="522.0"/> <Point X="948.0" Y="499.0" ArrowHead="mim-binding"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="c0387"> <Graphics ZOrder="32818" LineThickness="1.0" Color="0033ff"> <Point X="336.0" Y="812.0"/> <Point X="336.0" Y="789.0" ArrowHead="mim-binding"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="dfc7a"> <Graphics ZOrder="32819" LineThickness="1.0" Color="0033ff"> <Point X="477.0" Y="770.0"/> <Point X="477.0" Y="747.0" ArrowHead="mim-binding"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="a238b"> <Graphics ZOrder="32820" LineThickness="1.0" Color="0033ff"> <Point X="486.0" Y="675.0"/> <Point X="486.0" Y="652.0" ArrowHead="mim-binding"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="d963a"> <Graphics ZOrder="32821" LineThickness="1.0" Color="0033ff"> <Point X="885.0" Y="501.0"/> <Point X="885.0" Y="522.0" ArrowHead="mim-binding"/> </Graphics> </GraphicalLine> <GraphicalLine GraphId="d95a9"> <Graphics ZOrder="32822" LineThickness="1.0" Color="0033ff"> <Point X="881.0" Y="449.0"/> <Point X="881.0" Y="470.0" ArrowHead="mim-binding"/> </Graphics> </GraphicalLine> <Label TextLabel="translocation" GraphId="a69f3"> <Graphics CenterX="990.3679330806842" CenterY="460.97717937801576" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="AMP/ATP ratio" GraphId="b1552"> <Graphics CenterX="509.844018181339" CenterY="423.51260296213474" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Mitochondrial Membrane Potential" GraphId="d57e1"> <Graphics CenterX="439.2916266914044" CenterY="803.0450510012787" Width="209.51835730452171" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Glycolytic enzymes" GraphId="e238c"> <Graphics CenterX="677.11024220091" CenterY="614.0932742950948" Width="128.07362596564948" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Complex formation" GraphId="ef9a1"> <Graphics CenterX="877.4642812945361" CenterY="237.8186155095065" Width="118.3002582049849" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/> </Label> <Shape GraphId="b6f51"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Nucleus"/> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/> <Graphics CenterX="1046.3431863727458" CenterY="677.6057114228456" Width="397.2955911823653" Height="262.0230460921846" ZOrder="16384" FontSize="12" Valign="Middle" ShapeType="Oval" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/> </Shape> <Shape GraphId="bdb15"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Mitochondria"/> <Graphics CenterX="445.2666701778793" CenterY="720.1908817635268" Width="369.2374749498989" Height="198.8967935871737" ZOrder="16384" FontSize="12" Valign="Middle" ShapeType="Mitochondria" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/> </Shape> <Shape GraphId="e95a4"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Organelle"/> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/> <Graphics CenterX="649.2985971943895" CenterY="515.0300601202401" Width="1232.4649298597183" Height="653.3066132264529" ZOrder="16384" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/> </Shape> <Group GroupId="f840f" GraphId="a7de9" Style="Complex"/> <Group GroupId="e348d" GraphId="c5732"/> <Group GroupId="d42ee" GraphId="cdb28" Style="Group"/> <Group GroupId="e788b" GraphId="e3cd1" Style="Complex"/> <Group GroupId="f35d6" GraphId="e69fe" Style="Group"/> <Group GroupId="e4ff8" GraphId="fa1b8" Style="Group"/> <InfoBox CenterX="0.0" CenterY="0.0"/> <Biopax> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mTOR signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000180</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">phosphatidylinositol 3-kinase-Akt signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000232</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">vitamin D signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001013</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca5"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25660022</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Rep</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ferreira GB</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vanherwegen AS</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Eelen G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gutiérrez AC</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Lommel L</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Marchal K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Verlinden L</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Verstuyf A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nogueira T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Georgiadou M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schuit F</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Eizirik DL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gysemans C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carmeliet P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Overbergh L</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mathieu C</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

• Template:AuthorInfo
• Template:CheckAvailable (protected)
• Template:Help:LiteratureReferences (protected)
• Template:PathwayPage:History
• Template:PathwayPage:Xrefs

Return to PI3K/AKT/mTOR - vitamin D3 signaling (Homo sapiens).