Lac-Phe pathway (Homo sapiens)

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It is linked to food intake and obesity, where it is increased after exercise and suppresses food intake.</Comment> <Graphics BoardWidth="712.1641791044772" BoardHeight="360.1096067053514"/> <DataNode TextLabel="L-phenylalanine" GraphId="a4f78" Type="Metabolite"> <Graphics CenterX="196.0" CenterY="237.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="3955e7"/> <Xref Database="ChEBI" ID="58095"/> </DataNode> <DataNode TextLabel="ABCC5" GraphId="a5f82" Type="GeneProduct"> <Graphics CenterX="507.6119402985062" CenterY="151.5067519545131" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O15440"/> </DataNode> <DataNode TextLabel="(S)-lactate" GraphId="c484a" Type="Metabolite"> <Graphics CenterX="196.0" CenterY="187.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="3955e7"/> <Xref Database="ChEBI" ID="16651"/> </DataNode> <DataNode TextLabel="Lac-Phe" GraphId="ef6b4" Type="Metabolite"> <Graphics CenterX="637.1641791044772" CenterY="186.58137882018485" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="3955e7"/> <Xref Database="ChEBI" ID="167456"/> </DataNode> <DataNode TextLabel="CNDP2" GraphId="f2148" Type="Protein"> <Graphics CenterX="286.0" CenterY="137.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q96KP4"/> </DataNode> <DataNode TextLabel="Lac-Phe" GraphId="fcf48" Type="Metabolite"> <Graphics CenterX="376.0" CenterY="187.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="3955e7"/> <Xref Database="ChEBI" ID="167456"/> </DataNode> <Interaction GraphId="c4815"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="286.0" Y="149.5" GraphRef="f2148" RelX="0.0" RelY="1.0"/> <Point X="286.0" Y="187.0" GraphRef="eefef" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c81b4"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="507.61194029850617" Y="164.0067519545131" GraphRef="a5f82" RelX="0.0" RelY="1.0"/> <Point X="506.5820895522386" Y="186.79068941009243" GraphRef="d77d3" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e173b"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="241.0" Y="237.0" GraphRef="a4f78" RelX="1.0" RelY="0.0"/> <Point X="286.0" Y="187.0" GraphRef="eefef" RelX="0.0" RelY="0.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ecef7"> <BiopaxRef>d3508</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="241.0" Y="187.0" GraphRef="c484a" RelX="1.0" RelY="0.0"/> <Point X="331.0" Y="187.0" GraphRef="fcf48" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion"/> <Anchor Position="0.5" Shape="None" GraphId="eefef"/> </Graphics> <Xref Database="Rhea" ID="RHEA:66724"/> </Interaction> <Interaction GraphId="fc181"> <BiopaxRef>d3508</BiopaxRef> <BiopaxRef>d611e</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="421.0" Y="187.0" GraphRef="fcf48" RelX="1.0" RelY="0.0"/> <Point X="592.1641791044772" Y="186.58137882018485" GraphRef="ef6b4" RelX="-1.0" RelY="0.0"/> <Anchor Position="0.5" Shape="None" GraphId="d77d3"/> </Graphics> <Xref Database="Rhea" ID="RHEA:66720"/> </Interaction> <Shape GraphId="cce14"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell"/> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/> <Graphics CenterX="307.2935203094779" CenterY="193.49597034171504" Width="400.2421018697612" Height="259.0428755641522" ZOrder="-2" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/> </Shape> <InfoBox CenterX="0.0" CenterY="0.0"/> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" 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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>obesity pathway</bp:TERM><bp:ID>PW:0000540</bp:ID><bp:Ontology>Pathway Ontology</bp:Ontology></bp:openControlledVocabulary><bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>signaling pathway</bp:TERM><bp:ID>PW:0000003</bp:ID><bp:Ontology>Pathway Ontology</bp:Ontology></bp:openControlledVocabulary><bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>classic metabolic pathway</bp:TERM><bp:ID>PW:0000002</bp:ID><bp:Ontology>Pathway Ontology</bp:Ontology></bp:openControlledVocabulary></Biopax> </Pathway>

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