Metabolic pathways of fibroblasts (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Metabolic pathways of fibroblasts" Version="20230114" Organism="Homo sapiens"> <Comment></Comment> <Comment>Type your comment here</Comment> <Comment Source="WikiPathways-description">Metabolic pathways of fibroblasts: basis</Comment> <BiopaxRef>e45</BiopaxRef> <BiopaxRef>a4b</BiopaxRef> <Graphics BoardWidth="2271.014915492308" BoardHeight="1120.5833333333333" /> <DataNode TextLabel="Heparan sulfate" GraphId="a5206" Type="Metabolite" GroupRef="ae03c"> <Graphics CenterX="763.3230521233438" CenterY="292.66721916087846" Width="102.37500000000009" Height="25.749999999999996" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB00693" /> </DataNode> <DataNode TextLabel="X" GraphId="aa215" Type="GeneProduct" GroupRef="a798f"> <Graphics CenterX="2019.9209659657581" CenterY="584.1367320622652" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="Oval" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Hyaluronic acid" GraphId="ab061" Type="Metabolite"> <BiopaxRef>fef</BiopaxRef> <Graphics CenterX="614.6468458242554" CenterY="186.77192982456143" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB02061" /> </DataNode> <DataNode TextLabel="Keratan sulfate" GraphId="c7bae" Type="Metabolite" GroupRef="ae03c"> <Graphics CenterX="763.3230521233439" CenterY="346.16721916087846" Width="102.37500000000009" Height="25.749999999999996" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:60924" /> </DataNode> <DataNode TextLabel="FGFR1" GraphId="e29a3" Type="GeneProduct"> <Comment>Full name: Fibroblast growth factor receptor 1 Gene: FGFR1</Comment> <Graphics CenterX="1852.9691639818127" CenterY="673.7493558544091" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="Hexagon" /> <Xref Database="Uniprot-SwissProt" ID="P11362" /> </DataNode> <DataNode TextLabel="UDP-GlcA" GraphId="e87bf" Type="Metabolite"> <Graphics CenterX="614.6468458242555" CenterY="321.7543859649122" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17200" /> </DataNode> <DataNode TextLabel="Fatty acid" GraphId="eefb9" Type="Metabolite"> <Graphics CenterX="746.6666666666665" CenterY="1019.064110126398" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:35366" /> </DataNode> <DataNode TextLabel="UGDH" GraphId="f2375" Type="Protein"> <Graphics CenterX="540.7641330415524" CenterY="280.00000000000017" Width="51.140350877192965" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="O60701" /> </DataNode> <DataNode TextLabel="X" GraphId="f9708" Type="GeneProduct" GroupRef="a798f"> <Graphics CenterX="2019.9209659657581" CenterY="623.9239664028421" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="Hexagon" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="X" GraphId="fb3b7" Type="Metabolite" GroupRef="a798f"> <Graphics CenterX="2019.9209659657581" CenterY="439.0392143317684" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Dermatan sulfate" GraphId="fb6e3" Type="Metabolite" GroupRef="ae03c"> <Graphics CenterX="763.3230521233438" CenterY="319.41721916087846" Width="102.375" Height="27.75" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB00632" /> </DataNode> <DataNode TextLabel="X" GraphId="fcfd0" Type="GeneProduct" GroupRef="a798f"> <Graphics CenterX="2019.9209659657581" CenterY="484.03921433176964" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CD36 " GraphId="f6b73" Type="GeneProduct"> <Comment>Full name: Platelet glycoprotein 4 Gene: CD36 </Comment> <BiopaxRef>bfa</BiopaxRef> <Graphics CenterX="812.333333333333" CenterY="972.4009784075573" Width="58.66666666666719" Height="25.468623481781208" ZOrder="32770" FontSize="12" Valign="Middle" ShapeType="Oval" /> <Xref Database="Uniprot-SwissProt" ID="P16671" /> </DataNode> <DataNode TextLabel="P5CR" GraphId="feb63" Type="Protein"> <Comment>Full name: Pyrroline-5-carboxylate reductase 1, mitochondrial Gene: PYCR1</Comment> <Graphics CenterX="1243.5872641509425" CenterY="423.83333333333377" Width="60.07075471698134" Height="25.0" ZOrder="32774" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P32322" /> </DataNode> <DataNode TextLabel="Glycine" GraphId="bacc2" Type="Metabolite"> <Graphics CenterX="799.0421940928273" CenterY="544.9718706047821" Width="90.0" Height="25.0" ZOrder="32776" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="15428" /> </DataNode> <DataNode TextLabel="GLUT1" GraphId="a1b56" Type="Protein"> <Comment>Full name: Solute carrier family 2, facilitated glucose transporter member 1 Gene: SLC2A1</Comment> <BiopaxRef>c42</BiopaxRef> <Graphics CenterX="150.8750000000001" CenterY="185.5" Width="53.79952830188686" Height="25.0" ZOrder="32778" FontSize="12" Valign="Middle" ShapeType="Oval" /> <Xref Database="Uniprot-SwissProt" ID="P11166" /> </DataNode> <DataNode TextLabel="Proline" GraphId="b09a3" Type="Metabolite"> <Graphics CenterX="1191.3104427181072" CenterY="462.5399825455419" Width="90.0" Height="25.0" ZOrder="32780" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17203" /> </DataNode> <DataNode TextLabel="GLS" GraphId="c5cf2" Type="Protein"> <Comment>Full name: Glutaminase kidney isoform, mitochondrial Gene: GLS</Comment> <Graphics CenterX="963.8750000000008" CenterY="298.1199782844732" Width="51.25" Height="25.0" ZOrder="32782" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="O94925" /> </DataNode> <DataNode TextLabel="P5C" GraphId="cadef" Type="Metabolite"> <Graphics CenterX="1191.3104427181072" CenterY="396.26150153288387" Width="40.28755210288" Height="25.0" ZOrder="32784" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15893" /> </DataNode> <DataNode TextLabel="Nucleotide Biosynthesis" GraphId="c26c0" Type="Pathway"> <Graphics CenterX="610.4630518471645" CenterY="436.6524884691605" Width="167.82257802660274" Height="25.0" ZOrder="32788" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="4bb6e8" /> <Xref Database="WikiPathways" ID="WP404" /> </DataNode> <DataNode TextLabel="GLDH" GraphId="fe52c" Type="Protein"> <Comment>Full name: Glutamate dehydrogenase 1 Gene: GLUD1</Comment> <BiopaxRef>b3c</BiopaxRef> <Graphics CenterX="1033.5000000000002" CenterY="757.0000000000006" Width="51.66666666666764" Height="25.0" ZOrder="32790" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P00367" /> </DataNode> <DataNode TextLabel="G6PI" GraphId="eba99" Type="GeneProduct"> <Comment>Full name: Glucose-6-phosphate isomerase Gene: GPI</Comment> <BiopaxRef>e5b</BiopaxRef> <Graphics CenterX="152.25438432835838" CenterY="366.41666666666663" Width="40.24999999999977" Height="25.0" ZOrder="32792" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P06744" /> </DataNode> <DataNode TextLabel="SHMT" GraphId="ef94f" Type="Protein"> <Comment>Full name: Serine hydroxymethyltransferase, cytosolic Gene: SHMT1</Comment> <BiopaxRef>d15</BiopaxRef> <Graphics CenterX="651.2823588053377" CenterY="587.75" Width="66.76861572265625" Height="25.0" ZOrder="32794" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="O62585" /> </DataNode> <DataNode TextLabel="P3H4" GraphId="fb40c" Type="GeneProduct" GroupRef="aecb2"> <Comment>Full name: Endoplasmic reticulum protein SC65 Gene: P3H4</Comment> <Graphics CenterX="1659.582995951412" CenterY="253.45479082321262" Width="90.0" Height="25.0" ZOrder="32796" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="Q92791" /> </DataNode> <DataNode TextLabel="LPAR1" GraphId="cc6a5" Type="GeneProduct"> <Graphics CenterX="1406.1068526064046" CenterY="972.8273665343385" Width="90.0" Height="25.0" ZOrder="32798" FontSize="12" Valign="Middle" ShapeType="Hexagon" /> <Xref Database="Ensembl" ID="ENSG00000198121" /> </DataNode> <DataNode TextLabel="LOX" GraphId="b442f" Type="GeneProduct" GroupRef="ebe3d"> <Comment>Full name: Lysyl oxidase homolog 2 Gene: LOXL2</Comment> <BiopaxRef>d52</BiopaxRef> <Graphics CenterX="1659.582995951412" CenterY="109.8542510121462" Width="90.0" Height="25.0" ZOrder="32800" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="Q9Y4K0" /> </DataNode> <DataNode TextLabel="BMP1" GraphId="c3662" Type="GeneProduct" GroupRef="d27a5"> <Comment>Full name: Bone morphogenetic protein 1 Gene: BMP1</Comment> <BiopaxRef>a00</BiopaxRef> <Graphics CenterX="1477.6666666666624" CenterY="609.2257085020245" Width="90.0" Height="24.881916329284195" ZOrder="32802" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P13497" /> </DataNode> <DataNode TextLabel="Collagen" GraphId="e6a14" Type="GeneProduct"> <Graphics CenterX="1561.0590418353509" CenterY="45.961395628211264" Width="90.0" Height="25.0" ZOrder="32804" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:3815" /> </DataNode> <DataNode TextLabel="FGFR4" GraphId="f11a1" Type="GeneProduct"> <Comment>Full name: Fibroblast growth factor receptor 4 Gene: FGFR4</Comment> <Graphics CenterX="1852.969163981813" CenterY="751.5826891877449" Width="90.0" Height="25.0" ZOrder="32806" FontSize="12" Valign="Middle" ShapeType="Hexagon" /> <Xref Database="Uniprot-SwissProt" ID="P22455" /> </DataNode> <DataNode TextLabel="UGP2" GraphId="def13" Type="Protein"> <Comment>Full name: UTP--glucose-1-phosphate uridylyltransferase Gene: UGP2</Comment> <BiopaxRef>eb2</BiopaxRef> <Graphics CenterX="399.2914870162988" CenterY="280.00000000000017" Width="46.4556262522337" Height="25.0" ZOrder="32808" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="Q16851" /> </DataNode> <DataNode TextLabel="Serine" GraphId="e5a76" Type="Metabolite"> <Graphics CenterX="515.8649789029532" CenterY="544.9718706047821" Width="90.0" Height="25.0" ZOrder="32810" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17822" /> </DataNode> <DataNode TextLabel="ADAMTS2" GraphId="c118b" Type="GeneProduct" GroupRef="d27a5"> <Comment>Full name: A disintegrin and metalloproteinase with thrombospondin motifs 2 Gene: ADAMTS2</Comment> <BiopaxRef>a00</BiopaxRef> <Graphics CenterX="1477.6666666666624" CenterY="634.2847503373824" Width="90.0" Height="25.0" ZOrder="32814" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="O95450" /> </DataNode> <DataNode TextLabel="PHGDH" GraphId="b112e" Type="Protein" GroupRef="cbf7b"> <Comment>Full name: D-3-phosphoglycerate dehydrogenase Gene: PHGDH</Comment> <Graphics CenterX="399.00186157226545" CenterY="578.1875843454795" Width="91.0" Height="25.0" ZOrder="32816" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="O43175" /> </DataNode> <DataNode TextLabel="RhoA" GraphId="e9117" Type="Protein"> <Comment>Full name: Transforming protein RhoA/Ras homolog family member A Gene: RHOA</Comment> <Graphics CenterX="1270.4957799581587" CenterY="907.0000000000003" Width="90.0" Height="25.0" ZOrder="32818" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P61586" /> </DataNode> <DataNode TextLabel="P5CS" GraphId="e7cae" Type="Protein"> <Comment>Full name: Delta-1-pyrroline-5-carboxylate synthase Gene: ALDH18A1</Comment> <Graphics CenterX="1125.952284739719" CenterY="304.6199782844731" Width="50.09543052055869" Height="25.0" ZOrder="32820" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P54886" /> </DataNode> <DataNode TextLabel="PSP" GraphId="efcbb" Type="Protein" GroupRef="cbf7b"> <Comment>Full name: Phosphoserine phosphatase Gene: PSPH</Comment> <Graphics CenterX="399.00186157226545" CenterY="628.1875843454795" Width="90.0" Height="25.0" ZOrder="32822" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P78330" /> </DataNode> <DataNode TextLabel="PLC" GraphId="d0eeb" Type="Protein"> <Comment>Full name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Gene: PLCG1</Comment> <Graphics CenterX="1569.0000000000002" CenterY="907.0000000000003" Width="90.0" Height="25.0" ZOrder="32824" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P19174" /> </DataNode> <DataNode TextLabel="P3H3" GraphId="c18d5" Type="GeneProduct" GroupRef="aecb2"> <Comment>Full name: Prolyl 3-hydroxylase 3 Gene: P3H3</Comment> <Graphics CenterX="1659.582995951412" CenterY="303.45479082321253" Width="90.0" Height="25.0" ZOrder="32826" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="Q8IVL6" /> </DataNode> <DataNode TextLabel="Hsp47" GraphId="fff43" Type="GeneProduct"> <Comment>Full name: Serpin H1 Gene: SERPINH1</Comment> <BiopaxRef>f5a</BiopaxRef> <Graphics CenterX="1659.582995951412" CenterY="443.66666666666663" Width="90.0" Height="25.0" ZOrder="32828" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P50454" /> </DataNode> <DataNode TextLabel="PSA" GraphId="a0bf7" Type="Protein" GroupRef="cbf7b"> <Comment>Full name: Phosphoserine aminotransferase Gene: PSAT1</Comment> <Graphics CenterX="399.00186157226545" CenterY="603.1875843454795" Width="90.0" Height="25.0" ZOrder="32830" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="Q9Y617" /> </DataNode> <DataNode TextLabel="LDH" GraphId="f44eb" Type="GeneProduct"> <Comment>Full name: L-lactate dehydrogenase A chain Gene: LDHA</Comment> <BiopaxRef>dc9</BiopaxRef> <Graphics CenterX="148.92105099502498" CenterY="754.7842358802166" Width="43.36082808366063" Height="25.0" ZOrder="32832" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P00338" /> </DataNode> <DataNode TextLabel="Glutamate" GraphId="adf5f" Type="Metabolite"> <Graphics CenterX="1041.903875139346" CenterY="337.92816819954993" Width="80.19224972131042" Height="25.0" ZOrder="32834" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29985" /> </DataNode> <DataNode TextLabel="HK" GraphId="dbd12" Type="Protein"> <Comment>Full name: Hexokinase-4 Gene: GCK </Comment> <BiopaxRef>cf9</BiopaxRef> <Graphics CenterX="150.58771766169173" CenterY="277.23218215548104" Width="26.583333333333428" Height="25.0" ZOrder="32836" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="P35557" /> </DataNode> <DataNode TextLabel="G6P" GraphId="b89f0" Type="Metabolite"> <Graphics CenterX="203.87316709033902" CenterY="322.6874999999999" Width="38.166666666665776" Height="29.166666666666686" ZOrder="32838" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB01401" /> </DataNode> <DataNode TextLabel="Pentose Phosphate Pathway" GraphId="ef155" Type="Pathway"> <Graphics CenterX="374.2072760971411" CenterY="436.6524884691605" Width="182.0" Height="25.0" ZOrder="32840" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="4bb6e8" /> <Xref Database="WikiPathways" ID="WP134" /> </DataNode> <DataNode TextLabel="Fatty acid β-oxidation" GraphId="f55a7" Type="Pathway"> <Graphics CenterX="746.6666666666665" CenterY="827.3840900700742" Width="159.28571428571422" Height="25.0" ZOrder="32842" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="4bb6e8" /> <Xref Database="WikiPathways" ID="WP143" /> </DataNode> <DataNode TextLabel="TCA cycle" GraphId="baab1" Type="Pathway"> <Graphics CenterX="883.3312839320608" CenterY="701.0853823419276" Width="90.0" Height="25.0" ZOrder="32844" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="4bb6e8" /> <Xref Database="WikiPathways" ID="WP78" /> </DataNode> <DataNode TextLabel="GLS" GraphId="f10c3" Type="Protein"> <Comment>Full name: Glutaminase kidney isoform, mitochondrial Gene: GLS</Comment> <BiopaxRef>e0b</BiopaxRef> <Graphics CenterX="1037.5000000000014" CenterY="654.7227377320944" Width="42.26519213583697" Height="25.0" ZOrder="32846" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-SwissProt" ID="O94925" /> </DataNode> <DataNode TextLabel="Acetyl-CoA" GraphId="eda76" Type="Metabolite"> <Graphics CenterX="746.6666666666665" CenterY="702.0853823419276" Width="90.0" Height="25.0" ZOrder="32848" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB01206" /> </DataNode> <DataNode TextLabel="Pyruvate" GraphId="f7d09" Type="Metabolite"> <Graphics CenterX="202.20650042367237" CenterY="699.0853823419277" Width="86.75000000000001" Height="24.99999999999998" ZOrder="32850" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB00243" /> </DataNode> <DataNode TextLabel="Glutamine" GraphId="d9b8c" Type="Metabolite"> <Graphics CenterX="892.6079216921919" CenterY="337.92816819954993" Width="90.00000000000001" Height="25.000000000000018" ZOrder="32852" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18050" /> </DataNode> <DataNode TextLabel="αKG" GraphId="d7ba8" Type="Metabolite"> <Graphics CenterX="924.274588358859" CenterY="752.6241378385457" Width="46.30541871921196" Height="25.0" ZOrder="32854" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB00208" /> </DataNode> <DataNode TextLabel="Glucose" GraphId="ba5c9" Type="Metabolite"> <Graphics CenterX="203.87316709033902" CenterY="244.9447525848538" Width="61.83516624299432" Height="25.0" ZOrder="32856" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB00122" /> </DataNode> <DataNode TextLabel="3PG" GraphId="e6840" Type="Metabolite"> <Graphics CenterX="203.87316709033902" CenterY="543.9718706047821" Width="38.25" Height="20.75" ZOrder="32858" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB00807" /> </DataNode> <DataNode TextLabel="F6P" GraphId="ef6c5" Type="Metabolite"> <Graphics CenterX="203.87316709033902" CenterY="408.25536103891466" Width="38.16666666666577" Height="25.00000000000001" ZOrder="32860" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15946" /> </DataNode> <DataNode TextLabel="Lactic acid" GraphId="f1584" Type="Metabolite"> <Graphics CenterX="202.20650042367237" CenterY="806.7240291547382" Width="86.75" Height="21.75" ZOrder="32862" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB00190" /> </DataNode> <DataNode TextLabel="Glutamine" GraphId="f7955" Type="Metabolite"> <Graphics CenterX="892.6079216921919" CenterY="150.77381128273228" Width="90.00000000000001" Height="25.000000000000018" ZOrder="32870" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18050" /> </DataNode> <DataNode TextLabel="SLC1A5" GraphId="ab1b7" Type="GeneProduct"> <Comment>Full name: Neutral amino acid transporter B(0) Gene: SLC1A5</Comment> <BiopaxRef>e0b</BiopaxRef> <Graphics CenterX="959.0416666666678" CenterY="598.2712440693404" Width="61.21374602239983" Height="23.31686488523195" ZOrder="32872" FontSize="12" Valign="Middle" ShapeType="Oval" /> <Xref Database="Uniprot-SwissProt" ID="Q15758" /> </DataNode> <DataNode TextLabel="L-glutamate" GraphId="d76ed" Type="Metabolite"> <Graphics CenterX="1027.4789283226937" CenterY="712.4187156752771" Width="94.23748571385204" Height="28.911248933214324" ZOrder="32874" FontSize="12" 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ID="WP3365" /> </DataNode> <DataNode TextLabel="MCT1" GraphId="c9da3" Type="Protein"> <Comment>Full name: Monocarboxylate transporter 1 Gene: SLC16A1</Comment> <BiopaxRef>edf</BiopaxRef> <Graphics CenterX="146.92105099502507" CenterY="978.3852901484478" Width="53.79952830188686" Height="25.0" ZOrder="32892" FontSize="12" Valign="Middle" ShapeType="Oval" /> <Xref Database="Uniprot-SwissProt" ID="P53985" /> </DataNode> <DataNode TextLabel="Lactic acid" GraphId="ad8cf" Type="Metabolite"> <Graphics CenterX="202.20650042367237" CenterY="1019.064110126398" Width="86.75" Height="21.75" ZOrder="32894" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB00190" /> </DataNode> <DataNode TextLabel="G1P" GraphId="b4158" Type="Metabolite"> <Graphics CenterX="349.00617454822606" CenterY="322.0734649122807" Width="44.66594855591896" Height="25.00000000000001" ZOrder="32896" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29042" /> </DataNode> 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