7-oxo-C and 7-beta-HC pathways (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="7-oxo-C and 7-beta-HC pathways" Version="20210301" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">The Oxysterol group of compounds are oxygenated derivatives of cholesterol or its sterol precursors, e.g. 7-dehydrocholesterol (7-DHC) or desmosterol. There are three mechanisms leading to the formation of oxysterols: 1. Enzymatically (first steps of sterol metabolism, being intermediates for the formation of steroid hormones, bile acids and 1,25-dihydroxyvitamin D3); see [https://www.wikipathways.org/index.php/Pathway:WP4545 WP4545]. 2. Non-enzymatically by encountering reactive oxygen species (ROS), providing a second pool of metabolites (this pool also includes oxidized cholesterol molecules taken in from diet); described in this pathway. 3. Generation by the gut microflora and uptake through the enterohepatic circulation. Previously oxysterols where though to be inactive metabolic intermediates, however recent findings have established that these metabolites are involved in cholesterol homoeostasis, can be ligands to nuclear and G protein-coupled receptors and biomarkers of diseases (for example Niemann-Pick disease). This pathway describes Figure 4 and 5 from Griffiths et al (2020) [https://dx.doi.org/10.1016%2Fj.prostaglandins.2019.106381] and was extended with disease information.</Comment> <BiopaxRef>c02</BiopaxRef> <Graphics BoardWidth="1361.982206296812" BoardHeight="1041.2240571625853" /> <DataNode TextLabel="7-Dehydrocholesterol" GraphId="a6654" Type="Metabolite"> <Comment>aka 7-DHC</Comment> <Comment>abundant in SLOS.</Comment> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1182.2878272292446" CenterY="114.41082555416934" Width="172.353914002205" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010069" /> </DataNode> <DataNode TextLabel="3b,5a,6b-Trihydroxycholan-24-oyl-glycine" GraphId="a78bb" Type="Metabolite"> <Graphics CenterX="377.5210084033618" CenterY="725.2152451075812" Width="272.26890756302475" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST05030019" /> </DataNode> <DataNode TextLabel="3b,7b-Dihydroxychol-5-en-24-oic acid" GraphId="b860f" Type="Metabolite"> <Graphics CenterX="728.8865546218472" CenterY="954.7364792635254" Width="243.90756302521135" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04010218" /> </DataNode> <DataNode TextLabel="Irinotecan PW" GraphId="c1592" Type="Pathway"> <Graphics CenterX="135.27611940298488" CenterY="111.38452316729587" Width="117.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP229" /> </DataNode> <DataNode TextLabel="Cholesterol" GraphId="c3239" Type="Metabolite"> <Graphics CenterX="377.52100840336175" CenterY="114.41082555416934" Width="80.00000000000001" Height="19.99999999999999" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010001" /> </DataNode> <DataNode TextLabel="Sphingolipid &#xA;degradation" GraphId="c327e" Type="Pathway"> <Graphics CenterX="70.35598125689091" CenterY="370.27227432331273" Width="94.40545755237046" Height="36.5" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP4153" /> </DataNode> <DataNode TextLabel="7b-Hydroxycholesterol" GraphId="c3d2d" Type="Metabolite"> <Graphics CenterX="731.4440993788803" CenterY="254.70438538874038" Width="150.42016806722683" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010047" /> </DataNode> <DataNode TextLabel="(25R)26-Hydroxy-7-oxocholesterol" GraphId="c5605" Type="Metabolite"> <Graphics CenterX="1106.9775103910988" CenterY="326.94720353172653" Width="241.81367144432207" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04030180" /> </DataNode> <DataNode TextLabel="5alpha-specific&#xA;DDA synthase" GraphId="c699f" Type="Protein"> <Graphics CenterX="265.04448398576545" CenterY="157.042315168146" Width="114.75088967971534" Height="35.275800711743784" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Dendrogenin A" GraphId="c6aae" Type="Metabolite"> <Graphics CenterX="136.4436619718296" CenterY="195.07660895683608" Width="132.74647887323948" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST05050025" /> </DataNode> <DataNode TextLabel="Cholestane-3b,5a,6b,(25R)26-tetrol" GraphId="c6f53" Type="Metabolite"> <Graphics CenterX="377.52100840336175" CenterY="326.94720353172653" Width="239.70588235294065" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010458" /> </DataNode> <DataNode TextLabel="3b,5a,6b-Trihydroxycholestan-(25R)26-oic acid" GraphId="c7360" Type="Metabolite"> <Graphics CenterX="377.52100840336175" CenterY="407.55563828846914" Width="295.37815126050486" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04030238" /> </DataNode> <DataNode TextLabel="CYP7A1" GraphId="c8d02" Type="GeneProduct"> <Graphics CenterX="1208.8981160564153" CenterY="181.597106658679" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="CYP7A1" /> </DataNode> <DataNode TextLabel="3b-Hydroxy-7-oxochol-5-en-24-oyl-CoA" GraphId="c8e8e" Type="Metabolite"> <Graphics CenterX="1106.9775103910988" CenterY="654.4004089507104" Width="263.8643880926137" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010461" /> </DataNode> <DataNode TextLabel="Cholestane-3b,5a,6b-triol" GraphId="ca7e7" Type="Metabolite"> <Graphics CenterX="377.5210084033618" CenterY="254.7043853887404" Width="177.73109243697456" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010052" /> </DataNode> <DataNode TextLabel="7-Oxocholesterol" GraphId="cc819" Type="Metabolite"> <Comment>aka 7-OC</Comment> <Comment>Elevated levels found in Wolman's disease</Comment> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="1106.9775103910993" CenterY="254.7043853887404" Width="134.86769570011074" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010049" /> </DataNode> <DataNode TextLabel="NPC1" GraphId="ce628" Type="GeneProduct"> <Graphics CenterX="301.24650127371694" CenterY="73.58789907200136" Width="59.20942045788167" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="NPC1" /> </DataNode> <DataNode TextLabel="3b,7b-Dihydroxychol-5-en-24-oyl-glycine" GraphId="d139b" Type="Metabolite"> <Graphics CenterX="728.8865546218508" CenterY="725.2152451075812" Width="267.0168067226887" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST05030017" /> </DataNode> <DataNode TextLabel="7b-Peroxycholesterol" GraphId="d3f87" Type="Metabolite"> <Graphics CenterX="728.8865546218472" CenterY="195.07660895683608" Width="159.8739495798317" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010459" /> </DataNode> <DataNode TextLabel="+3O2" GraphId="d4bc2" Type="Metabolite"> <Graphics CenterX="628.2437489846263" CenterY="168.50362185669127" Width="53.10474650533658" Height="24.999999999999993" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Sphingolipid &#xA;metabolism" GraphId="d58a2" Type="Pathway"> <Graphics CenterX="188.8743109151048" CenterY="444.1421750950882" Width="138.0" Height="36.5" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP4725" /> </DataNode> <DataNode TextLabel="HSD11B1" GraphId="d8acd" Type="GeneProduct"> <Graphics CenterX="893.673323166053" CenterY="291.31010570210805" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="HSD11B1" /> </DataNode> <DataNode TextLabel="3b-Hydroxy-7-oxocholest-5-en-(25R)26-oic acid" GraphId="d8dcd" Type="Metabolite"> <Graphics CenterX="1106.9775103910993" CenterY="407.55563828846914" Width="307.965821389194" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04030239" /> </DataNode> <DataNode TextLabel="3b-Hydroxy-7-oxochol-5-en-24-oic acid" GraphId="dc0d2" Type="Metabolite"> <Graphics CenterX="1106.9775103910993" CenterY="954.7364792635254" Width="279.45623673945926" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04010394" /> </DataNode> <DataNode TextLabel="3b,5a,6b-Trihydroxycholan-24-oic acid" GraphId="e15a4" Type="Metabolite"> <Graphics CenterX="377.52100840336175" CenterY="954.7364792635256" Width="257.56302521008433" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04010339" /> </DataNode> <DataNode TextLabel="3b-Hydroxy-7-oxochol-5-en-24-oyl-glycine" GraphId="e2b55" Type="Metabolite"> <Graphics CenterX="1106.9775103910988" CenterY="725.2152451075812" Width="280.4024255788322" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST05030018" /> </DataNode> <DataNode TextLabel="3b,5a-DiH-cholestan-6-one" GraphId="e78b0" Type="Metabolite"> <Comment>aka 3b,5a-Dihydroxycholestan-6-one</Comment> <Graphics CenterX="137.05753551387994" CenterY="254.7043853887404" Width="176.05633802816874" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010126" /> </DataNode> <DataNode TextLabel="3b,7b-Dihydroxycholest-5-en-(25R)26-oic acid" GraphId="e7dfd" Type="Metabolite"> <Graphics CenterX="728.886554621851" CenterY="407.55563828846914" Width="295.3781512605043" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04030235" /> </DataNode> <DataNode TextLabel="3b,5a,6b-Trihydroxycholan-24-oyl-CoA" GraphId="ed04f" Type="Metabolite"> <Graphics CenterX="377.52100840336175" CenterY="654.4004089507104" Width="257.5630252100831" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04010459" /> </DataNode> <DataNode TextLabel="3b,7b-Dihydroxychol-5-en-24-oyl-CoA" GraphId="ed8c2" Type="Metabolite"> <Graphics CenterX="728.886554621847" CenterY="654.4004089507104" Width="264.91596638655557" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04010460" /> </DataNode> <DataNode TextLabel="HSD11B2" GraphId="f0dd5" Type="GeneProduct"> <Graphics CenterX="893.673323166053" CenterY="220.4286084655309" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="HSD11B2" /> </DataNode> <DataNode TextLabel="CYP27A1" GraphId="f42e2" Type="GeneProduct"> <Graphics CenterX="553.3718022289942" CenterY="326.9472035317265" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="CYP27A1" /> </DataNode> <DataNode TextLabel="LOO*" GraphId="f62ad" Type="Metabolite"> <Comment>radical</Comment> <Graphics CenterX="462.59690686736513" CenterY="136.99084166142302" Width="53.10474650533658" Height="24.999999999999993" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="3b,24R-Dihydroxy-7-oxocholest-5-en-(25R)26-oyl-CoA" GraphId="f635c" Type="Metabolite"> <Graphics CenterX="1106.9775103910988" CenterY="550.6115136049445" Width="354.27232635060636" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04030262" /> </DataNode> <DataNode TextLabel="3b,5a,6b,24R-Tetrahydroxycholestan-(25R)26-oyl-CoA" GraphId="fa003" Type="Metabolite"> <Graphics CenterX="377.52100840336186" CenterY="550.6115136049445" Width="347.89915966386525" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04030244" /> </DataNode> <DataNode TextLabel="5a,6a-Epoxycholesterol" GraphId="fdad9" Type="Metabolite"> <Graphics CenterX="377.52100840336175" CenterY="195.07660895683608" Width="146.21848739495795" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010011" /> </DataNode> <DataNode TextLabel="7b,(25R)26-Dihydroxycholesterol" GraphId="fed6a" Type="Metabolite"> <Graphics CenterX="731.4440993788803" CenterY="326.9472035317265" Width="218.69747899159563" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04030178" /> </DataNode> <DataNode TextLabel="3b,7b,24R-Trihydroxycholest-5-en-(25R)26-oyl-CoA" GraphId="b4bc7" Type="Metabolite"> <Graphics CenterX="728.8865546218472" CenterY="549.8278145453834" Width="330.54621848739174" Height="20.0" ZOrder="32776" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST04030244" /> </DataNode> <DataNode TextLabel="BACS (SLC27A5)" GraphId="d93c2" Type="GeneProduct" GroupRef="da24f"> <Comment>Bile Acid CoA ligase (or synthetase)</Comment> <Comment>microsomal protein mostly expressed in liver [PMID:24309898, 25409824(mouse)]</Comment> <BiopaxRef>d46</BiopaxRef> <Graphics CenterX="542.24602197436" CenterY="443.1147721750569" Width="121.05633802816874" Height="27.992957746479078" ZOrder="32796" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="SLC27A5" /> </DataNode> <DataNode TextLabel="VLCS (SLC27A2)" GraphId="f16e6" Type="GeneProduct" GroupRef="da24f"> <Comment>very-long chain acyl-CoA synthetase</Comment> <Comment>expressed mostly in liver and kidney, and present in ER and peroxisome [PMID:24309898, 25409824(mouse)]</Comment> <BiopaxRef>d46</BiopaxRef> <Graphics CenterX="542.2460219743595" CenterY="469.6112510482964" Width="121.05633802816872" Height="25.000000000000043" ZOrder="32797" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="SLC27A2" /> </DataNode> <DataNode TextLabel="AMACR" GraphId="ede2e" Type="GeneProduct" GroupRef="da24f"> <Comment>alpha-methylacyl-CoA racemase</Comment> <Comment>broadly expressed [PMID:24309898, 25409824(mouse)]</Comment> <BiopaxRef>d46</BiopaxRef> <Graphics CenterX="512.4683009298396" CenterY="494.6112510482964" Width="62.00941915227634" Height="25.000000000000018" ZOrder="32798" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="AMACR" /> </DataNode> <DataNode TextLabel="ACOX2" GraphId="fce34" Type="GeneProduct" GroupRef="da24f"> <Graphics CenterX="572.7301559354802" CenterY="495.3145758564804" Width="60.0841495717207" Height="25.000000000000018" ZOrder="32799" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="ACOX2" /> </DataNode> <DataNode TextLabel="DBP" GraphId="ff780" Type="GeneProduct" GroupRef="da24f"> <Comment>D-biofinctional protein; aka MFE2, HSD17B4</Comment> <Graphics CenterX="544.0910597695975" CenterY="520.3145758564805" Width="55.94945323133246" Height="24.999999999999996" ZOrder="32800" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="DBP" /> </DataNode> <DataNode TextLabel="SCPx (SCP2)" GraphId="b8436" Type="GeneProduct"> <Graphics CenterX="544.0910597695975" CenterY="621.0226727292694" Width="90.0" Height="25.0" ZOrder="32802" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="SCP2" /> </DataNode> <DataNode TextLabel="DBP" GraphId="f3434" Type="GeneProduct"> <Comment>D-biofinctional protein; aka MFE2, HSD17B4</Comment> <Graphics CenterX="544.0910597695975" CenterY="591.4183072898823" Width="55.94945323133246" Height="24.999999999999996" ZOrder="32803" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="DBP" /> </DataNode> <DataNode TextLabel="BAAT" GraphId="cc0ca" Type="GeneProduct"> <Comment>amino acid N-acyl transferase</Comment> <Graphics CenterX="544.0910597695975" CenterY="687.3761937166008" Width="55.94945323133232" Height="24.999999999999975" ZOrder="32807" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="BAAT" /> </DataNode> <DataNode TextLabel="ACOT1" GraphId="b0361" Type="Protein" GroupRef="e9943"> <Graphics CenterX="503.240798909697" CenterY="791.4943294446977" Width="90.0" Height="25.0" ZOrder="32955" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86TX2" /> </DataNode> <DataNode TextLabel="ACOT" GraphId="be891" Type="Protein" GroupRef="e9943"> <Comment>acyl-CoA thioesterase are a group of enzymes</Comment> <Graphics CenterX="544.0910597695975" CenterY="758.3411070083091" Width="90.0" Height="25.0" ZOrder="32956" FontSize="12" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="3.1.2.2" /> </DataNode> <DataNode TextLabel="ACOT2" GraphId="d36d4" Type="Protein" GroupRef="e9943"> <Comment>"originally thought to be in peroxisome [PMID:10944470)], later found to be mitochondrial [PMID:16940157]" [https://www.uniprot.org/uniprot/P49753]</Comment> <BiopaxRef>f07</BiopaxRef> <BiopaxRef>a7b</BiopaxRef> <Graphics CenterX="503.240798909697" CenterY="816.4943294446977" Width="90.0" Height="25.0" ZOrder="32957" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P49753" /> </DataNode> <DataNode TextLabel="ACOT4" GraphId="a650f" Type="Protein" GroupRef="e9943"> <Comment>"Compared to mouse peroxisomal succinyl-coenzyme A thioesterase/ACOT4, the human enzyme has a broad substrate specificity overlapping the activity of three mouse acyl-coenzyme A thioesterases, providing an explanation for the unexpectedly low number of acyl-coenzyme A thioesterase genes in the human genome [PMID:16940157]" [https://www.uniprot.org/uniprot/Q8N9L9]</Comment> <BiopaxRef>a7b</BiopaxRef> <Graphics CenterX="503.240798909697" CenterY="841.4943294446977" Width="90.0" Height="25.0" ZOrder="32958" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N9L9" /> </DataNode> <DataNode TextLabel="ACOT6" GraphId="a3420" Type="Protein" GroupRef="e9943"> <Graphics CenterX="593.2407989096972" CenterY="791.4943294446977" Width="90.0" Height="25.0" ZOrder="32959" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q3I5F7" /> </DataNode> <DataNode TextLabel="ACOT7" GraphId="b2f31" Type="Protein" GroupRef="e9943"> <Graphics CenterX="593.2407989096972" CenterY="816.4943294446977" Width="90.0" Height="25.0" ZOrder="32960" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O00154" /> </DataNode> <DataNode TextLabel="ACOT8" GraphId="ef3e5" Type="Protein" GroupRef="e9943"> <Graphics CenterX="503.240798909697" CenterY="866.4943294446977" Width="90.0" Height="25.0" ZOrder="32961" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14734" /> </DataNode> <DataNode TextLabel="ACOT9" GraphId="b4e8e" Type="Protein" GroupRef="e9943"> <Graphics CenterX="503.240798909697" CenterY="891.4943294446977" Width="90.0" Height="25.0" ZOrder="32962" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y305" /> </DataNode> <DataNode TextLabel="ACOT11" GraphId="ea41e" Type="Protein" GroupRef="e9943"> <Graphics CenterX="503.240798909697" CenterY="916.4943294446977" Width="90.0" Height="25.0" ZOrder="32963" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WXI4" /> </DataNode> <DataNode TextLabel="ACOT12" GraphId="ac1e6" Type="Protein" GroupRef="e9943"> <Graphics CenterX="593.2407989096971" CenterY="866.4943294446977" Width="90.0" Height="25.0" ZOrder="32964" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WYK0" /> </DataNode> <DataNode TextLabel="ACOT13" GraphId="ef31c" Type="Protein" GroupRef="e9943"> <Graphics CenterX="593.2407989096971" CenterY="891.4943294446977" Width="90.0" Height="25.0" ZOrder="32965" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPJ3" /> </DataNode> <DataNode TextLabel="ACOT7L" GraphId="b0e4a" Type="Protein" GroupRef="e9943"> <Comment>"Could be the product of a pseudogene. The peptide used to produce antibodies against ACOT7L matches at 85% with ACOT7 and the antibodies may not be specific to ACOT7L." [https://www.uniprot.org/uniprot/Q6ZUV0]</Comment> <Graphics CenterX="593.2407989096972" CenterY="841.4943294446977" Width="90.0" Height="25.0" ZOrder="32966" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6ZUV0" /> </DataNode> <DataNode TextLabel="ACOT15" GraphId="ced7f" Type="Protein" GroupRef="e9943"> <Graphics CenterX="593.2407989096972" CenterY="916.4943294446977" Width="90.0" Height="25.0" ZOrder="32967" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N1Q8" /> </DataNode> <DataNode TextLabel="ChEH" GraphId="c8de2" Type="Protein"> <Comment>AKA cholesterol epoxide hydrolase (ChEH); EC: 3.3.2.11</Comment> <Comment>"ChEH is a dimer of 7-dehydrocholesterol reductase (DHCR7) and 3β-hydroxysteroid-Δ8-Δ7-isomerase (D8D7I)"</Comment> <BiopaxRef>ae1</BiopaxRef> <Graphics CenterX="451.9301709612553" CenterY="225.16943556021127" Width="90.0" Height="25.0" ZOrder="32971" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P34913" /> </DataNode> <DataNode TextLabel="CYP27A1" GraphId="b8193" Type="GeneProduct"> <Graphics CenterX="1208.8981160564156" CenterY="291.31010570210805" Width="90.0" Height="25.0" ZOrder="32972" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="CYP27A1" /> </DataNode> <DataNode TextLabel="BACS (SLC27A5)" GraphId="cd48d" Type="GeneProduct" GroupRef="e8a55"> <Comment>Bile Acid CoA ligase (or synthetase)</Comment> <Comment>microsomal protein mostly expressed in liver [PMID:24309898, 25409824(mouse)]</Comment> <BiopaxRef>d46</BiopaxRef> <Graphics CenterX="1233.6672437466254" CenterY="442.40258081984257" Width="121.05633802816874" Height="27.992957746479078" ZOrder="32975" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="SLC27A5" /> </DataNode> <DataNode TextLabel="VLCS (SLC27A2)" GraphId="d3a48" Type="GeneProduct" GroupRef="e8a55"> <Comment>very-long chain acyl-CoA synthetase</Comment> <Comment>expressed mostly in liver and kidney, and present in ER and peroxisome [PMID:24309898, 25409824(mouse)]</Comment> <BiopaxRef>d46</BiopaxRef> <Graphics CenterX="1233.6672437466248" CenterY="468.8990596930821" Width="121.05633802816872" Height="25.000000000000043" ZOrder="32976" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="SLC27A2" /> </DataNode> <DataNode TextLabel="AMACR" GraphId="ff065" Type="GeneProduct" GroupRef="e8a55"> <Comment>alpha-methylacyl-CoA racemase</Comment> <Comment>broadly expressed [PMID:24309898, 25409824(mouse)]</Comment> <BiopaxRef>d46</BiopaxRef> <Graphics CenterX="1203.889522702105" CenterY="493.8990596930821" Width="62.00941915227634" Height="25.000000000000018" ZOrder="32977" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="AMACR" /> </DataNode> <DataNode TextLabel="ACOX2" GraphId="e6239" Type="GeneProduct" GroupRef="e8a55"> <Graphics CenterX="1264.151377707746" CenterY="494.6023845012661" Width="60.0841495717207" Height="25.000000000000018" ZOrder="32978" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="ACOX2" /> </DataNode> <DataNode TextLabel="DBP" GraphId="ce14d" Type="GeneProduct" GroupRef="e8a55"> <Comment>D-biofinctional protein; aka MFE2, HSD17B4</Comment> <Graphics CenterX="1235.5122815418629" CenterY="519.6023845012661" Width="55.94945323133246" Height="24.999999999999996" ZOrder="32979" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="DBP" /> </DataNode> <DataNode TextLabel="SCPx (SCP2)" GraphId="f9fcc" Type="GeneProduct"> <Graphics CenterX="1230.8719103121741" CenterY="617.1375648304859" Width="90.0" Height="25.0" ZOrder="32980" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="SCP2" /> </DataNode> <DataNode TextLabel="DBP" GraphId="bb16c" Type="GeneProduct"> <Comment>D-biofinctional protein; aka MFE2, HSD17B4</Comment> <Graphics CenterX="1230.8719103121741" CenterY="592.1375648304859" Width="55.94945323133246" Height="24.999999999999996" ZOrder="32981" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="DBP" /> </DataNode> <DataNode TextLabel="BAAT" GraphId="d16c6" Type="GeneProduct"> <Comment>amino acid N-acyl transferase</Comment> <Graphics CenterX="1243.6329311938441" CenterY="687.3761937166007" Width="55.94945323133232" Height="24.999999999999975" ZOrder="32983" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="BAAT" /> </DataNode> <DataNode TextLabel="ACOT1" GraphId="e0b6f" Type="Protein" GroupRef="cbb9c"> <Graphics CenterX="1196.9822062968117" CenterY="792.213586985301" Width="90.0" Height="25.0" ZOrder="32985" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86TX2" /> </DataNode> <DataNode TextLabel="ACOT" GraphId="e51c1" Type="Protein" GroupRef="cbb9c"> <Comment>acyl-CoA thioesterase are a group of enzymes</Comment> <Graphics CenterX="1237.832467156712" CenterY="759.0603645489125" Width="90.0" Height="25.0" ZOrder="32986" FontSize="12" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="3.1.2.2" /> </DataNode> <DataNode TextLabel="ACOT2" GraphId="f8041" Type="Protein" GroupRef="cbb9c"> <Comment>"originally thought to be in peroxisome [PMID:10944470)], later found to be mitochondrial [PMID:16940157]" [https://www.uniprot.org/uniprot/P49753]</Comment> <BiopaxRef>f07</BiopaxRef> <BiopaxRef>a7b</BiopaxRef> <Graphics CenterX="1196.9822062968117" CenterY="817.213586985301" Width="90.0" Height="25.0" ZOrder="32987" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P49753" /> </DataNode> <DataNode TextLabel="ACOT4" GraphId="ef2be" Type="Protein" GroupRef="cbb9c"> <Comment>"Compared to mouse peroxisomal succinyl-coenzyme A thioesterase/ACOT4, the human enzyme has a broad substrate specificity overlapping the activity of three mouse acyl-coenzyme A thioesterases, providing an explanation for the unexpectedly low number of acyl-coenzyme A thioesterase genes in the human genome [PMID:16940157]" [https://www.uniprot.org/uniprot/Q8N9L9]</Comment> <BiopaxRef>a7b</BiopaxRef> <Graphics CenterX="1196.9822062968117" CenterY="842.213586985301" Width="90.0" Height="25.0" ZOrder="32988" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N9L9" /> </DataNode> <DataNode TextLabel="ACOT6" GraphId="e4d80" Type="Protein" GroupRef="cbb9c"> <Graphics CenterX="1286.982206296812" CenterY="792.213586985301" Width="90.0" Height="25.0" ZOrder="32989" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q3I5F7" /> </DataNode> <DataNode TextLabel="ACOT7" GraphId="f2d97" Type="Protein" GroupRef="cbb9c"> <Graphics CenterX="1286.982206296812" CenterY="817.213586985301" Width="90.0" Height="25.0" ZOrder="32990" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O00154" /> </DataNode> <DataNode TextLabel="ACOT8" GraphId="ff78a" Type="Protein" GroupRef="cbb9c"> <Graphics CenterX="1196.9822062968117" CenterY="867.213586985301" Width="90.0" Height="25.0" ZOrder="32991" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14734" /> </DataNode> <DataNode TextLabel="ACOT9" GraphId="b4b9f" Type="Protein" GroupRef="cbb9c"> <Graphics CenterX="1196.9822062968117" CenterY="892.213586985301" Width="90.0" Height="25.0" ZOrder="32992" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y305" /> </DataNode> <DataNode TextLabel="ACOT11" GraphId="e2bec" Type="Protein" GroupRef="cbb9c"> <Graphics CenterX="1196.9822062968117" CenterY="917.213586985301" Width="90.0" Height="25.0" ZOrder="32993" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WXI4" /> </DataNode> <DataNode TextLabel="ACOT12" GraphId="bfaec" Type="Protein" GroupRef="cbb9c"> <Graphics CenterX="1286.9822062968117" CenterY="867.213586985301" Width="90.0" Height="25.0" ZOrder="32994" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WYK0" /> </DataNode> <DataNode TextLabel="ACOT13" GraphId="d31d9" Type="Protein" GroupRef="cbb9c"> <Graphics CenterX="1286.9822062968117" CenterY="892.213586985301" Width="90.0" Height="25.0" ZOrder="32995" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPJ3" /> </DataNode> <DataNode TextLabel="ACOT7L" GraphId="ffc11" Type="Protein" GroupRef="cbb9c"> <Comment>"Could be the product of a pseudogene. The peptide used to produce antibodies against ACOT7L matches at 85% with ACOT7 and the antibodies may not be specific to ACOT7L." [https://www.uniprot.org/uniprot/Q6ZUV0]</Comment> <Graphics CenterX="1286.982206296812" CenterY="842.213586985301" Width="90.0" Height="25.0" ZOrder="32996" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6ZUV0" /> </DataNode> <DataNode TextLabel="ACOT15" GraphId="ce523" Type="Protein" GroupRef="cbb9c"> <Graphics CenterX="1286.982206296812" CenterY="917.213586985301" Width="90.0" Height="25.0" ZOrder="32997" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N1Q8" /> </DataNode> <DataNode TextLabel="HSD11B2" GraphId="e110d" Type="GeneProduct"> <Graphics CenterX="893.6733231660529" CenterY="371.11226105064486" Width="90.0" Height="25.0" ZOrder="33011" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="HSD11B2" /> </DataNode> <DataNode TextLabel="HSD11B1" GraphId="ef9e7" Type="GeneProduct"> <Graphics CenterX="893.673323166053" CenterY="471.5979141902569" Width="90.0" Height="25.0" ZOrder="33013" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="HSD11B1" /> </DataNode> <DataNode TextLabel="HSD11B2" GraphId="ef5ba" Type="GeneProduct"> <Graphics CenterX="896.4902245745037" CenterY="917.040778440312" Width="90.0" Height="25.0" ZOrder="33014" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="HSD11B2" /> </DataNode> <DataNode TextLabel="HSD11B1" GraphId="a399e" Type="GeneProduct"> <Graphics CenterX="903.5324780956305" CenterY="998.7240571625854" Width="90.0" Height="25.0" ZOrder="33015" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="HSD11B1" /> </DataNode> <DataNode TextLabel="HSD11B2" GraphId="a3f32" Type="GeneProduct"> <Graphics CenterX="262.948547465587" CenterY="296.61075472386375" Width="90.0" Height="25.0" ZOrder="33019" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="HSD11B2" /> </DataNode> <DataNode TextLabel="LOOH" GraphId="bc5e8" Type="Metabolite"> <Comment></Comment> <Graphics CenterX="628.2437489846263" CenterY="136.99084166142302" Width="53.10474650533658" Height="25.0" ZOrder="33020" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="LO*" GraphId="e375f" Type="Metabolite"> <Comment>radical (deoxidised)</Comment> <Graphics CenterX="462.59690686736513" CenterY="170.02872268025538" Width="53.10474650533658" Height="24.999999999999993" ZOrder="33024" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="LOO*" GraphId="c66f0" Type="Metabolite"> <Comment>radical</Comment> <Graphics CenterX="798.8229196605404" CenterY="82.31422474599994" Width="53.10474650533658" Height="24.999999999999993" ZOrder="33026" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="LOH" GraphId="dd89e" Type="Metabolite"> <Comment></Comment> <Graphics CenterX="947.4121924814285" CenterY="130.64400441906338" Width="53.10474650533658" Height="25.0" ZOrder="33027" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="+1O2" GraphId="b52a9" Type="Metabolite"> <Graphics CenterX="947.4121924814285" CenterY="166.42117693842545" Width="53.10474650533658" Height="24.999999999999993" ZOrder="33028" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="DHCR7" GraphId="de27d" Type="Protein"> <Comment>"ChEH is a dimer of 7-dehydrocholesterol reductase (DHCR7) and 3β-hydroxysteroid-Δ8-Δ7-isomerase (D8D7I)"</Comment> <Comment>the 3beta-hydroxysteroid delta7 reductase (DHCR7), which is the regulatory subunit. [https://en.wikipedia.org/wiki/Cholesterol-5,6-oxide_hydrolase]</Comment> <BiopaxRef>afa</BiopaxRef> <Graphics CenterX="566.242518927804" CenterY="208.32617627675356" Width="90.0" Height="25.0" ZOrder="33033" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UBM7" /> </DataNode> <DataNode TextLabel="D8D7I" GraphId="b0a29" Type="Protein"> <Comment>"ChEH is a dimer of 7-dehydrocholesterol reductase (DHCR7) and 3β-hydroxysteroid-Δ8-Δ7-isomerase (D8D7I)"</Comment> <Comment>also known as the emopamyl binding protein (EBP), which is the catalytic subunit [https://en.wikipedia.org/wiki/Cholesterol-5,6-oxide_hydrolase]</Comment> <BiopaxRef>afa</BiopaxRef> <Graphics CenterX="565.9951664863519" CenterY="254.98056547257926" Width="90.0" Height="25.0" ZOrder="33034" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15125" /> </DataNode> <DataNode TextLabel="Cholesterol" GraphId="b46c5" Type="Metabolite"> <Graphics CenterX="613.7352759467904" CenterY="43.80235305859786" Width="80.00000000000001" Height="19.99999999999999" ZOrder="33048" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010001" /> </DataNode> <DataNode TextLabel="NPC2" GraphId="ea650" Type="GeneProduct"> <Graphics CenterX="511.62677581020625" CenterY="80.18132603509434" Width="61.82107524525907" Height="25.0" ZOrder="33049" FontSize="12" Valign="Middle" /> <Xref Database="HGNC" ID="NPC2" /> </DataNode> <DataNode TextLabel="Cholesterol" GraphId="b81cd" Type="Metabolite"> <Graphics CenterX="377.52100840336175" CenterY="43.80235305859785" Width="80.00000000000001" Height="19.99999999999999" ZOrder="33051" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMST01010001" /> </DataNode> <Interaction> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="265.04448398576545" Y="174.68021552401788" GraphRef="c699f" RelX="0.0" RelY="1.0" /> <Point X="263.7738193869094" Y="195.07660895683608" GraphRef="c50f5" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id1846c121"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="893.673323166053" Y="459.0979141902569" GraphRef="ef9e7" RelX="0.0" RelY="-1.0" /> <Point X="894.576692073831" Y="412.55563828846914" GraphRef="c3421" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id23b20445"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="893.673323166053" Y="232.9286084655309" GraphRef="f0dd5" RelX="0.0" RelY="1.0" /> <Point X="893.8303296742602" Y="249.7043853887404" GraphRef="b518a" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id2f9ee186"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="893.673323166053" Y="278.81010570210805" GraphRef="d8acd" RelX="0.0" RelY="-1.0" /> <Point X="893.8303296742602" Y="259.7043853887404" GraphRef="ed8b7" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id3300e533"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1163.8981160564156" Y="291.31010570210805" GraphRef="b8193" RelX="-1.0" RelY="0.0" /> <Point X="1106.977510391099" Y="292.0788011380561" GraphRef="f4187" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id39810ae6"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1164.884813125967" Y="480.25424322393457" GraphRef="a20cb" RelX="-1.0" RelY="0.0" /> <Point X="1106.977510391099" Y="480.99652430739167" GraphRef="e0adc" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id46e14cf1"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="903.5324780956305" Y="986.2240571625854" GraphRef="a399e" RelX="0.0" RelY="-1.0" /> <Point X="903.728813559322" Y="959.7364792635254" GraphRef="d31d8" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id50bbf497"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="489.1492801200334" Y="136.99084166142302" GraphRef="f62ad" RelX="1.0" RelY="0.0" /> <Point X="568.3335402518226" Y="119.41082555416932" GraphRef="f08a9" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id5a73f99c"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1215.658204578178" Y="687.3761937166007" GraphRef="d16c6" RelX="-1.0" RelY="0.0" /> <Point X="1106.9775103910988" Y="687.6761705205918" GraphRef="c11e5" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id5fcc132e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1143.982206296812" Y="838.1369757671068" GraphRef="e40c6" RelX="-1.0" RelY="0.0" /> <Point X="1106.977510391099" Y="837.4487781635015" GraphRef="fdf23" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id6ca3ee13"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1202.897183696508" Y="592.1375648304859" GraphRef="bb16c" RelX="-1.0" RelY="0.0" /> <Point X="1106.9775103910988" Y="594.1270717432509" GraphRef="d6a37" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id7f465a65"> <Comment>Mechanism of transport to ER and plasma membrane has yet to be established [PMID: 24664998]</Comment> <BiopaxRef>c07</BiopaxRef> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="377.52100840336175" Y="53.802353058597845" GraphRef="b81cd" RelX="0.0" RelY="1.0" /> 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