17p13.3 (YWHAE) copy number variation (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="17p13.3 (YWHAE) copy number variation" Version="20230503" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">The 17p13.3 deletion or duplication ranging from chr17:1250000 to chr17:1300000, affects YWHAE gene. The YWHAE gene plays a role in a lot of different processes and is closely related to many diseases. </Comment> <Graphics BoardWidth="4935.4935295286" BoardHeight="1066.7978906249955" /> <DataNode TextLabel="Tyrosine" GraphId="a59fc" Type="Metabolite"> <Graphics CenterX="238.6067728744041" CenterY="338.51743683041724" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="18186" /> </DataNode> <DataNode TextLabel="Dopamine" GraphId="aac03" Type="Metabolite"> <Graphics CenterX="399.0338709677416" CenterY="452.67970011685105" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="18243" /> </DataNode> <DataNode TextLabel="Noradrenaline" GraphId="b6292" Type="Metabolite"> <Graphics CenterX="399.0338709677416" CenterY="534.890322580646" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="33569" /> </DataNode> <DataNode TextLabel="Cytoplasmic &#xA;dynein complex" GraphId="b9013" Type="Complex"> <Graphics CenterX="938.1444114012015" CenterY="291.1576164723971" Width="108.65881742534285" Height="29.574957023982403" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="BioCyc" ID="GO:0005868" /> </DataNode> <DataNode TextLabel="Apoptosis" GraphId="b917c" Type="Pathway"> <Graphics CenterX="725.8918889110462" CenterY="165.53444369696638" Width="90.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP254" /> </DataNode> <DataNode TextLabel="DBH" GraphId="bdfaa" Type="Protein"> <Graphics CenterX="300.6331220547893" CenterY="488.56895930692076" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P09172" /> </DataNode> <DataNode TextLabel="NDEL1" GraphId="c6934" Type="Protein"> <Comment>By binding to phosphorylated NUDEL, YWHAE prevents dephosphorylation of phosphorylated NUDEL by PP2A</Comment> <Comment>Type your comment here</Comment> <Comment>Type your comment here</Comment> <Graphics CenterX="1215.6589223325527" CenterY="145.9476384708292" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9GZM8" /> </DataNode> <DataNode TextLabel="YWHAE&#xA;" GraphId="ce3ca" Type="Protein" GroupRef="a6c47"> <Graphics CenterX="82.27772741045754" CenterY="161.937663215631" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62258" /> </DataNode> <DataNode TextLabel="YWHAB" GraphId="d2406" Type="Protein" GroupRef="a6c47"> <Graphics CenterX="82.27772741045754" CenterY="185.60432988229763" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P31946" /> </DataNode> <DataNode TextLabel="CDK5" 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