ADHD and autism (ASD) pathways (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Cannabinoid receptor signaling" Version="20160803" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Endogenous cannabinoid receptors belong to the endocannabinoid system and are located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors. The endocannabinoid system is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory, and in mediating the psychoactive effects of cannabis. Two primary endocannabinoid receptors have been identified: CNR1 and CNR2. CNR1 is found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule), Anandamide, as well as its mimetic phytocannabinoid, THC (tetrahydrocannabinol). One other main endocannabinoid is 2-Arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD (cannabidiol). 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management. Source: https://en.wikipedia.org/wiki/Endocannabinoid_system Not all MAPK subtypes are relevant for this pathway. The relevant types have been separately added on the right side of the pathway. Source: Howlett A.C. Cannabinoid Receptor Signaling. In: Pertwee R.G. (eds) Cannabinoids. Handbook of Experimental Pharmacology, vol 168. 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Width="30.0" Height="15.0" ZOrder="33671" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57692" /> </DataNode> <DataNode TextLabel="FAD" GraphId="e6b2a" Type="Metabolite"> <Graphics CenterX="793.9541102219765" CenterY="895.7253829629302" Width="40.92099567099576" Height="18.377705627705605" ZOrder="33673" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57692" /> </DataNode> <DataNode TextLabel="B2&#xA;riboflavin" GraphId="cc73a" Type="Metabolite"> <BiopaxRef>f83</BiopaxRef> <BiopaxRef>dae</BiopaxRef> <Graphics CenterX="793.9541102219766" CenterY="1052.2437365421606" Width="89.80651193479238" Height="25.000000000000025" ZOrder="33674" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17015" /> </DataNode> <DataNode TextLabel="PLP" GraphId="f019f" Type="Metabolite"> <Graphics CenterX="2571.4335072589024" CenterY="805.843659697529" Width="29.218491436427122" Height="14.022832082131227" ZOrder="33678" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:597326" /> </DataNode> <DataNode TextLabel="PLP" GraphId="dd2b1" Type="Metabolite" GroupRef="ce20c"> <Graphics CenterX="2639.8852762237984" CenterY="585.1416723400293" Width="29.218491436427122" Height="14.022832082131227" ZOrder="33679" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:597326" /> </DataNode> <DataNode TextLabel="PLP" GraphId="f17a7" Type="Metabolite" GroupRef="d12e1"> <Graphics CenterX="2718.5566048951328" CenterY="585.5101070735964" Width="27.64811653440931" Height="14.021729692694414" ZOrder="33680" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:597326" /> </DataNode> <DataNode TextLabel="FMN" GraphId="b0de0" Type="Metabolite" GroupRef="c1d25"> <BiopaxRef>dae</BiopaxRef> <Graphics CenterX="697.9750547153343" CenterY="792.5675208428147" Width="30.0" Height="15.0" ZOrder="33681" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="cHEBI:58210" /> </DataNode> <DataNode TextLabel="cblJ&#xA;ABCD4" GraphId="de71f" Type="Protein" GroupRef="f5d18"> <Graphics CenterX="321.8233396202761" CenterY="241.8749940947888" Width="65.89969855227079" Height="31.511182219428413" ZOrder="33739" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14678" /> </DataNode> <DataNode TextLabel="Succinyl-CoA" GraphId="e518d" Type="Metabolite"> <Graphics CenterX="1708.7373994571703" CenterY="756.9669179365733" Width="90.0" Height="25.0" ZOrder="33748" FontSize="14" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15380" /> </DataNode> <DataNode TextLabel="MMUT" GraphId="e4dca" Type="Protein" GroupRef="db94d"> <Comment>aka methylmalonyl-CoA mutase or MCM</Comment> <Graphics CenterX="1653.6155309698127" CenterY="801.1688252795319" Width="61.129367024370765" Height="20.0" ZOrder="33749" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P22033" /> </DataNode> <DataNode TextLabel="Cbl" GraphId="caa3e" Type="Metabolite"> <Graphics CenterX="191.59359532415402" CenterY="98.33777357047848" Width="35.0" Height="20.0" ZOrder="33754" FontSize="14" Valign="Middle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q3329800" /> </DataNode> <DataNode TextLabel="CD320" GraphId="e3fb9" Type="Protein"> <Comment>Aka CD320 receptor</Comment> <Graphics CenterX="254.4333921102839" CenterY="156.87534973838623" Width="50.37492194057184" Height="20.0" ZOrder="33756" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPF0" /> </DataNode> <DataNode TextLabel="R-cob(III)alamin" GraphId="d1295" Type="Metabolite"> <Graphics CenterX="189.562451112915" CenterY="235.683118598529" Width="105.0" Height="17.67496202927268" ZOrder="33757" FontSize="14" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:140785" /> </DataNode> <DataNode TextLabel="cob(II)alamin" GraphId="b3eb4" Type="Metabolite"> <Comment>Should be cob(II)alamin according to literature</Comment> <Graphics CenterX="186.5616311614441" CenterY="411.92905899185735" Width="98.25573259214246" Height="34.4607010086383" ZOrder="33760" FontSize="14" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16304" /> </DataNode> <DataNode TextLabel="cob(I)alamin" GraphId="cca50" Type="Metabolite"> <Graphics CenterX="1535.735294117647" CenterY="984.4846445286373" Width="95.58823529411771" Height="20.0" ZOrder="33769" FontSize="14" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="cob(I)alamin" /> </DataNode> <DataNode TextLabel="cbLA&#xA;MMAA" GraphId="ba96a" Type="Protein"> <Comment>Gene: MMAA</Comment> <Graphics CenterX="1279.0613027698582" CenterY="1092.1427759435817" Width="56.62711463218302" Height="30.599458029684136" ZOrder="33771" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IVH4" /> </DataNode> <DataNode TextLabel="Methylmalonyl-CoA" GraphId="dedc0" Type="Metabolite"> <Graphics CenterX="1567.5880569937806" CenterY="758.2456903150899" Width="142.23898562013682" Height="25.0" ZOrder="33772" FontSize="14" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16625" /> </DataNode> <DataNode TextLabel="MMADHC" GraphId="dd102" Type="Protein"> <Comment>"cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891</Comment> <Comment>gene is called MMADHC</Comment> <Graphics CenterX="209.52739166494268" CenterY="621.1621083518534" Width="76.94069736144795" Height="25.749631184168862" ZOrder="33774" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0" /> </DataNode> <DataNode TextLabel="cblF&#xA;LMBRD1" GraphId="c3393" Type="Protein" GroupRef="f5d18"> <Graphics CenterX="319.9052132701419" CenterY="274.8320737214723" Width="65.67366283006095" Height="30.932867482428545" ZOrder="33779" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NUN5" /> </DataNode> <DataNode TextLabel="cbLC&#xA;MMACHC" GraphId="a6e5a" Type="Protein" GroupRef="f927c"> <Comment>Gene is called MMAC</Comment> <Graphics CenterX="79.89897035598533" CenterY="367.4434068639179" Width="69.04218467987891" Height="37.21349975178755" ZOrder="33782" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1" /> </DataNode> <DataNode TextLabel="cbLC&#xA;MMACHC" GraphId="fd182" Type="Protein" GroupRef="f4fe1"> <Comment>Gene is called MMAC</Comment> <Graphics CenterX="296.86229110840225" CenterY="356.4190679248279" Width="63.516797093539886" Height="30.296660388588542" ZOrder="33783" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1" /> </DataNode> <DataNode TextLabel="FAD" GraphId="c8696" Type="Metabolite" GroupRef="f4fe1"> <Comment>cofactor</Comment> <Graphics CenterX="299.42207437981426" CenterY="328.54346500326085" Width="35.0" Height="20.0" ZOrder="33784" FontSize="14" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16238" /> </DataNode> <DataNode TextLabel="FMN" GraphId="b8d35" Type="Metabolite" GroupRef="f927c"> <Comment>cofactor</Comment> <Graphics CenterX="80.60515074331855" CenterY="337.01847516984253" Width="35.0" Height="20.0" ZOrder="33785" FontSize="14" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17621" /> </DataNode> <DataNode TextLabel="MMAB&#xA;cblB" GraphId="a2f71" Type="Protein"> <Comment>gene: MMAB</Comment> <Graphics CenterX="1600.4697797730473" CenterY="1066.0198692979022" Width="63.79351170257033" Height="35.40860346647495" ZOrder="33787" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="60488" /> </DataNode> <DataNode TextLabel="PLP" GraphId="c1c38" Type="Metabolite" GroupRef="d0530"> <Graphics CenterX="573.4408707422477" CenterY="271.3730609688208" Width="29.218491436427122" Height="14.022832082131227" ZOrder="33789" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:597326" /> </DataNode> <DataNode TextLabel="PLP" GraphId="ade29" Type="Metabolite" GroupRef="c3678"> <Graphics CenterX="1344.3451797587738" CenterY="707.1968747938033" Width="29.218491436427122" Height="14.022832082131227" ZOrder="33790" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:597326" /> </DataNode> <DataNode TextLabel="PLP" GraphId="e12d0" Type="Metabolite" GroupRef="caf4b"> <Graphics CenterX="1376.4307518258315" CenterY="641.2596759784869" Width="29.218491436427122" Height="14.022832082131227" ZOrder="33791" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:597326" /> </DataNode> <DataNode TextLabel="PLP" GraphId="aa5b3" Type="Metabolite" GroupRef="b7a57"> <Graphics CenterX="1186.8875526401248" CenterY="571.24926308348" Width="29.218491436427122" Height="14.022832082131227" ZOrder="33792" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:597326" /> </DataNode> <DataNode TextLabel="PLP" GraphId="ff721" Type="Metabolite" GroupRef="c6c34"> <Graphics CenterX="814.9198898469651" CenterY="370.12422712408113" Width="29.218491436427122" Height="14.022832082131227" ZOrder="33793" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:597326" /> </DataNode> <DataNode TextLabel="PLP" GraphId="a3bcd" Type="Metabolite" GroupRef="c734a"> <Graphics CenterX="2877.552242408156" CenterY="691.0662377700208" Width="29.218491436427122" Height="14.022832082131227" ZOrder="33794" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:597326" /> </DataNode> <DataNode TextLabel="R-cob(III)alamin" GraphId="eb494" Type="Metabolite"> <Graphics CenterX="188.7296819863069" CenterY="284.27485861207015" Width="105.0" Height="17.67496202927268" ZOrder="33795" FontSize="14" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:140785" /> </DataNode> <DataNode TextLabel="CblD-1&#xA;MMADHC" GraphId="bd7d2" Type="Protein"> <Comment>"cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891</Comment> <Comment>gene is called MMADHC</Comment> <Graphics CenterX="280.59063134372985" CenterY="492.77533070326325" Width="85.68621278354031" Height="34.48495514779718" ZOrder="33796" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0" /> </DataNode> <DataNode TextLabel="CblD-2&#xA;MMADHC" GraphId="a95ff" Type="Protein"> <Comment>"cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891</Comment> <Comment>gene is called MMADHC</Comment> <Graphics CenterX="155.88445485783055" CenterY="509.10926899727576" Width="85.68621278354033" Height="34.48495514779715" ZOrder="33797" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0" /> </DataNode> <DataNode TextLabel="CblD&#xA;MMADHC" GraphId="e788d" Type="Protein"> <Comment>"cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891</Comment> <Comment>gene is called MMADHC</Comment> <Graphics CenterX="72.92056512329162" CenterY="465.5521002132445" Width="85.68621278354031" Height="34.48495514779715" ZOrder="33798" FontSize="14" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0" /> </DataNode> <DataNode TextLabel="CYP3A4" GraphId="b087f" Type="GeneProduct" GroupRef="cb050"> <Graphics CenterX="5012.762667410151" CenterY="759.7253119524617" Width="80.0" Height="20.0" ZOrder="33839" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000160868" /> </DataNode> <DataNode TextLabel="CYP2C19" GraphId="dece5" Type="GeneProduct" GroupRef="cb050"> <BiopaxRef>bff</BiopaxRef> <Graphics CenterX="5012.762667410151" CenterY="740.7253119524614" Width="80.0" Height="20.0" ZOrder="33840" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000165841" /> </DataNode> <DataNode TextLabel="ADCY1" GraphId="d696d" Type="GeneProduct"> <Graphics CenterX="5071.085001411636" CenterY="889.5472650467841" Width="94.0" Height="20.0" ZOrder="33869" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="CHEBI:58165" /> </DataNode> <DataNode TextLabel="CNR1&#xA;CB1" GraphId="bd90f" Type="GeneProduct"> <Graphics CenterX="5008.421358336014" CenterY="1049.6288256403957" Width="80.0" Height="33.35967854382576" ZOrder="33878" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21554" /> </DataNode> <DataNode TextLabel="CYP2C9" GraphId="eeb27" Type="GeneProduct"> <Graphics CenterX="4867.759838355713" CenterY="993.6733153761885" Width="50.89257422027819" Height="20.0" ZOrder="33879" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000138109" /> </DataNode> <DataNode TextLabel="11-OH-THC" GraphId="d7877" Type="Metabolite"> <Graphics CenterX="4801.9513835030675" CenterY="1141.3090122134647" Width="80.0" Height="16.836810824559052" ZOrder="33880" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0060906" /> </DataNode> <DataNode TextLabel="MAPK " GraphId="a0380" Type="GeneProduct"> <Graphics CenterX="5077.671477622202" CenterY="957.4610525214831" Width="80.0" Height="20.0" ZOrder="33881" FontSize="10" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="2.7.11.24" /> </DataNode> <DataNode TextLabel="Phosphatidylethanolamine" GraphId="a28fe" Type="Metabolite"> <Graphics CenterX="5379.183833801957" CenterY="841.2830655177024" Width="128.0" Height="20.0" ZOrder="33882" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0060501" /> </DataNode> <DataNode TextLabel="DAGLB" GraphId="d7154" Type="GeneProduct" GroupRef="ece7a"> <Graphics CenterX="5385.23787679788" CenterY="708.5689305757843" Width="45.0" Height="20.0" ZOrder="33883" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000164535" /> </DataNode> <DataNode TextLabel="cAMP " GraphId="ae4b4" Type="Metabolite"> <Graphics CenterX="5181.501041511886" CenterY="821.8361121645792" Width="80.0" Height="20.0" ZOrder="33884" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:58165" /> </DataNode> <DataNode TextLabel="AHR" GraphId="ff1c3" Type="GeneProduct" GroupRef="fb84d"> <Graphics CenterX="5706.0319885025765" CenterY="1234.919182875929" Width="80.0" Height="20.0" ZOrder="33885" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000106546" /> </DataNode> <DataNode TextLabel="NAPEPLD" GraphId="d06d9" Type="Protein" GroupRef="ce9ef"> <BiopaxRef>f43</BiopaxRef> <Graphics CenterX="5493.761366033372" CenterY="933.479427494173" Width="55.0" Height="20.0" ZOrder="33886" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="NAPEPLD" /> </DataNode> <DataNode TextLabel="ADCY7" GraphId="f15b1" Type="GeneProduct"> <BiopaxRef>b2b</BiopaxRef> <Graphics CenterX="5097.302786054882" CenterY="1284.7226775743347" Width="80.0" Height="20.0" ZOrder="33887" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="ADCY7" /> </DataNode> <DataNode TextLabel="NAPE" GraphId="e0ed3" Type="Metabolite"> <Graphics CenterX="5375.657995298028" CenterY="891.9105035151151" Width="80.0" Height="20.0" ZOrder="33888" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:61232" /> </DataNode> <DataNode TextLabel="DAGLA" GraphId="fb17f" Type="GeneProduct" GroupRef="ece7a"> <BiopaxRef>f43</BiopaxRef> <Graphics CenterX="5385.23787679788" CenterY="688.5689305757845" Width="45.0" Height="20.0" ZOrder="33889" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000134780" /> </DataNode> <DataNode TextLabel="Arachidonic acid" GraphId="a9fac" Type="Metabolite"> <Graphics CenterX="5295.730095549708" CenterY="668.1488109424974" Width="80.0" Height="20.0" ZOrder="33890" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0001043" /> </DataNode> <DataNode TextLabel="THC" GraphId="f1b65" Type="Metabolite" GroupRef="e3590"> <Graphics CenterX="4910.510271387896" CenterY="1141.3090122134647" Width="37.369207772796344" Height="20.0" ZOrder="33891" FontSize="10" Valign="Middle" Color="ff6600" /> <Xref Database="HMDB" ID="HMDB0041865" /> </DataNode> <DataNode TextLabel="1''-hydroxycannabidiol" GraphId="d0550" Type="Metabolite" GroupRef="a4372"> <BiopaxRef>bff</BiopaxRef> <Graphics CenterX="4928.820817607268" CenterY="548.6773601717921" Width="118.0" Height="20.0" ZOrder="33892" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:133056" /> </DataNode> <DataNode TextLabel="2-arachidonoylglycerol" GraphId="bb0af" Type="Metabolite" GroupRef="b3eff"> <Graphics CenterX="5191.065726998662" CenterY="1134.488660355869" Width="122.0" Height="20.0" ZOrder="33893" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0004666" /> </DataNode> <DataNode TextLabel="protein tyrosine kinases" GraphId="d7e60" Type="Pathway" GroupRef="fb84d"> <Graphics CenterX="5706.031988502588" CenterY="1296.782043747599" Width="149.4547325102879" Height="20.0" ZOrder="33894" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="FAAH" GraphId="a65cb" Type="GeneProduct" GroupRef="c966f"> <BiopaxRef>f43</BiopaxRef> <Graphics CenterX="5459.750510758254" CenterY="1021.0104912766086" Width="55.0" Height="20.0" ZOrder="33895" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000117480" /> </DataNode> <DataNode TextLabel="Glutamate" GraphId="f9a92" Type="Metabolite"> <Graphics CenterX="4716.9835807610925" CenterY="1055.207293916517" Width="80.0" Height="20.0" ZOrder="33896" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0000148" /> </DataNode> <DataNode TextLabel="ADORA2A" GraphId="b3398" Type="GeneProduct"> <BiopaxRef>e7f</BiopaxRef> <Graphics CenterX="4941.830348982469" CenterY="1202.9218946527878" Width="80.0" Height="20.0" ZOrder="33897" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P29274" /> </DataNode> <DataNode TextLabel="CNR2&#xA;CB2" GraphId="b0400" Type="GeneProduct"> <Graphics CenterX="5074.420918167195" CenterY="1200.9011728948403" Width="80.0" Height="33.46773849912818" ZOrder="33898" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P34972" /> </DataNode> <DataNode TextLabel="Ca2+" GraphId="df3fd" Type="Metabolite" GroupRef="ece7a"> <Graphics CenterX="5385.647119256675" CenterY="728.728124576875" Width="45.0" Height="20.0" ZOrder="33899" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="ATP" GraphId="d5e01" Type="Metabolite"> <Graphics CenterX="5063.453422464268" CenterY="821.8003978788647" 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