LDL- influence on CD14 and TLR4 (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="LDL- influence on CD14 and TLR4" Version="20220728" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Electronegative LDL (LDL(-)) is a plasma LDL subfraction inducing induces cytokine release in monocytes by activating TLR4. The subsequent phosphorylation of p38 MAPK phosphorylation (which is higher compared to native LDL) through TLR4 and PI3k/Akt pathways activates NF-kB, AP-1 and CREB. These last three have a direct effect on four cytokines (IL1beta, IL6, IL10 and MCP1), with bold black letters for the highest level of cytokine induction, gray letters for the lowest level and regular letter for the intermediate induction.</Comment> <BiopaxRef>d81</BiopaxRef> <Graphics BoardWidth="1000.0" BoardHeight="754.8095238095243" /> <DataNode TextLabel="P38 MAPK (14)" GraphId="d20c2" Type="Protein" GroupRef="e5874"> <Graphics CenterX="548.3809523809525" CenterY="417.4761904761897" Width="116.0" Height="25.0" ZOrder="-10" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16539" /> </DataNode> <DataNode TextLabel="P38 MAPK (12)" GraphId="a69e2" Type="Protein" GroupRef="e5874"> <Graphics CenterX="432.38095238095246" CenterY="417.4761904761897" Width="116.0" Height="25.0" ZOrder="-8" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P53778" /> </DataNode> <DataNode TextLabel="P38 MAPK (13)" GraphId="e1f58" Type="Protein" GroupRef="e5874"> <Graphics CenterX="548.3809523809525" CenterY="392.47619047619" Width="116.0" Height="25.0" ZOrder="-4" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15264" /> </DataNode> <DataNode TextLabel="P38 MAPK (11)" GraphId="cecd5" Type="Protein" GroupRef="e5874"> <Graphics CenterX="432.38095238095246" CenterY="392.47619047619" Width="116.0" Height="25.0" ZOrder="-2" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15759" /> </DataNode> <DataNode TextLabel="LDL-" GraphId="a5f02" Type="Metabolite"> <Comment>High content in Cer, Sph, NEFA</Comment> <Graphics CenterX="379.0" CenterY="97.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:192800" /> </DataNode> <DataNode TextLabel="NFKB1" GraphId="a630f" Type="Protein" GroupRef="ee1e0"> <Graphics CenterX="760.9523809523804" CenterY="416.19047619047586" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P19838" /> </DataNode> <DataNode TextLabel="CD14" GraphId="af4c6" Type="Protein"> <Graphics CenterX="276.0" CenterY="161.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P08571" /> </DataNode> <DataNode TextLabel="AKT" GraphId="bc602" Type="Protein" GroupRef="bb5dc"> <Comment>aka Protein kinase B (PKB); Unknown if AKT1, AKT2, or AKT3 are meant in publication</Comment> <Graphics CenterX="534.0" CenterY="231.61904761904762" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="2.7.11" /> </DataNode> <DataNode TextLabel="CREB1" GraphId="c34b4" Type="Protein" GroupRef="ee7b8"> <Graphics CenterX="185.38095238095224" CenterY="472.3809523809517" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P16220" /> </DataNode> <DataNode TextLabel="IL10" GraphId="da7db" Type="GeneProduct" GroupRef="f4e1a"> <Graphics CenterX="276.0" CenterY="590.8095238095243" Width="90.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="16" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000136634" /> </DataNode> <DataNode TextLabel="TLR4" GraphId="e7cf8" Type="Protein"> <Graphics CenterX="488.0" CenterY="161.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O00206" /> </DataNode> <DataNode TextLabel="P38 MAPK (11)" GraphId="f0e2d" Type="Protein" GroupRef="cbce4"> <Graphics CenterX="432.0" CenterY="303.0952380952376" Width="116.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15759" /> </DataNode> <DataNode TextLabel="PI3K" GraphId="fab7c" Type="Protein" GroupRef="bb5dc"> <Comment>Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes; paper doesn't mention which enzyme specifically is involved</Comment> <Graphics CenterX="444.0" CenterY="231.61904761904762" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="InterPro" ID="IPR000403" /> </DataNode> <DataNode TextLabel="AP-1" GraphId="fb0c8" Type="Protein"> <Comment>The structure of AP-1 is a heterodimer composed of proteins belonging to the c-Fos, c-Jun, ATF and JDP families; not specified in paper which one is meant.</Comment> <Graphics CenterX="491.0" CenterY="529.8095238095243" Width="90.0" Height="25.0" ZOrder="32769" FontSize="12" Valign="Middle" /> <Xref Database="InterPro" ID="IPR000837" /> </DataNode> <DataNode TextLabel="P38 MAPK (12)" GraphId="a25b1" Type="Protein" GroupRef="cbce4"> <Graphics CenterX="432.0" CenterY="328.0952380952376" Width="116.0" Height="25.0" ZOrder="32777" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P53778" /> </DataNode> <DataNode TextLabel="P38 MAPK (13)" GraphId="d961c" Type="Protein" GroupRef="cbce4"> <Graphics 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