Somitogenesis in the context of spondylocostal dysostosis (Homo sapiens)

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The effect of Lfng on Notch1 signaling is contradictory; it can potentiate Notch1 signaling in cultured mammalian cells, and inhibit signaling in the embryo. Mesp2 protein activates the transcription of Lfng, Ripply2 and Epha4. Ripply2 inhibits the transcription of Mesp2 and Epha4 is implicated in somite border formation in zebrafish but is not required for this in mouse. 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Return to Somitogenesis in the context of spondylocostal dysostosis (Homo sapiens).