Omega-6-fatty acids in senescence (Homo sapiens)

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<Graphics CenterX="1119.1045794688916" CenterY="1625.4641186926656" Width="154.5764122045071" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000104325" /> </DataNode> <DataNode TextLabel="EPHX2" GraphId="bf782" Type="GeneProduct"> <Graphics CenterX="2131.54689403167" CenterY="930.5724725943966" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000120915" /> </DataNode> <DataNode TextLabel="5(S),6(R)-DiHETE" GraphId="bf8d2" Type="Metabolite"> <Graphics CenterX="1589.7853828306265" CenterY="1018.5614849187936" Width="114.60556844547581" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="PubChem-compound" ID="5283160" /> </DataNode> <DataNode TextLabel="DH-PGF1α*" GraphId="bf932" Type="Metabolite"> <Graphics CenterX="3512.753861319923" CenterY="1145.1897623569826" Width="76.39925805210392" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="15-keto-13,14-dihydro-PGE1" GraphId="c04f1" Type="Metabolite"> <BiopaxRef>ae8</BiopaxRef> <Graphics CenterX="3484.267650386272" CenterY="133.74981884123036" Width="156.14267526496872" Height="28.5" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:134499" /> </DataNode> <DataNode TextLabel="PGDS" GraphId="c0518" Type="GeneProduct"> <Comment>=Prostaglandin D synthase</Comment> <Graphics CenterX="2471.3165238924657" CenterY="300.4396711895687" Width="75.47245470937237" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000107317" /> </DataNode> <DataNode TextLabel="Non-enzymatic" GraphId="c0988"> <Graphics CenterX="3398.1998391342463" CenterY="654.6417812225808" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="16-COOH-tetranor-LTB3*" GraphId="c0ae9" Type="Metabolite"> <Graphics CenterX="2107.2069630056567" CenterY="1087.1499056146818" Width="161.36828644501273" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="9-hydroxyprostaglandin dehydrogenase*" GraphId="c0d06" Type="GeneProduct"> <Graphics CenterX="3521.993529693103" CenterY="2669.961629858772" Width="238.30932531008733" Height="27.24208855916241" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="DH-PGF2α" GraphId="c1546" Type="Metabolite"> <BiopaxRef>d16</BiopaxRef> <Graphics CenterX="3741.7786205687876" CenterY="926.5612526124523" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:183014" /> </DataNode> <DataNode TextLabel="15-ketoprostaglandin reductase" GraphId="c1582" Type="GeneProduct"> <Graphics CenterX="1447.4398797595206" CenterY="1209.4188376753525" Width="195.30060120240466" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000140043" /> </DataNode> <DataNode TextLabel="EXE4" GraphId="c1977" Type="Metabolite"> <Graphics CenterX="1911.0190072446446" CenterY="1859.7909999203864" Width="90.00000000000017" Height="25.00000000000005" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:63986" /> </DataNode> <DataNode TextLabel="9α, 11β-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid*" GraphId="c1db4" Type="Metabolite"> <BiopaxRef>cfe</BiopaxRef> <Graphics CenterX="4556.070295576713" CenterY="1971.4116962614398" Width="400.1837260677444" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="PTGER1" GraphId="c21c7" Type="Complex" GroupRef="d96e0"> <Comment>=prostaglandin E receptor 1 =EP1</Comment> <BiopaxRef>f45</BiopaxRef> <BiopaxRef>f01</BiopaxRef> <Graphics CenterX="1950.3266105910402" CenterY="3304.615520577744" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000160951" /> </DataNode> <DataNode TextLabel="9,15-dideoxy-Δ9,12,14-PGD2*" GraphId="c23ba" Type="Metabolite"> <Graphics CenterX="3313.6257530242106" CenterY="1811.254782654208" Width="179.8464619492661" Height="25.85113484646206" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="TRXB3" GraphId="c241d" Type="Metabolite"> <Graphics CenterX="2027.1337234910982" CenterY="900.9401164204459" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:35032" /> </DataNode> <DataNode TextLabel="13,14-dihydro-15-keto-PGD2 " GraphId="c25b7" Type="Metabolite"> <Comment>DK-PGD2</Comment> <BiopaxRef>e39</BiopaxRef> <Graphics CenterX="4221.652163924858" CenterY="1727.8091848455622" Width="190.91700133868835" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:72603" /> </DataNode> <DataNode TextLabel="15-hydroxy PG dehydrogenase*&#xA;prostaglandin Δreductase*&#xA;β-oxidase*" GraphId="c3ebb" Type="GeneProduct"> <Comment>Lumped reaction</Comment> <Graphics CenterX="3657.5724656560024" CenterY="2980.3004396808533" Width="184.1162029459898" Height="51.41805523852898" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="12(S)-HpETE" GraphId="c4103" Type="Metabolite"> <Graphics CenterX="2508.2016753332664" CenterY="870.4732456340794" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15626" /> </DataNode> <DataNode TextLabel="15-epi-LXB4" GraphId="c475d" Type="Metabolite"> <Graphics CenterX="2045.8375777972085" CenterY="1439.0918586642033" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMFA03040007" /> </DataNode> <DataNode TextLabel="ABCC4" GraphId="c4cb8" Type="GeneProduct"> <Graphics CenterX="6394.906002399573" CenterY="1459.1852917853685" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000125257" /> </DataNode> <DataNode TextLabel="PGH2" GraphId="c550c" Type="Metabolite"> <Comment>PGH2 is the abbreviation of PGG2</Comment> <Graphics CenterX="2934.8905030140468" CenterY="2236.9068998423527" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="15554" /> </DataNode> <DataNode TextLabel="PG-9KR" GraphId="c5d64" Type="GeneProduct"> <Comment>PG-9KR= Prostaglandin-9-ketoreductase</Comment> <Graphics CenterX="2807.0573776737724" CenterY="2661.0610146106396" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000159228" /> </DataNode> <DataNode TextLabel="DPEP" GraphId="c5f76" Type="GeneProduct"> <Graphics CenterX="1833.4328477032066" CenterY="1810.8319721904725" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="1.3.4.13" /> </DataNode> <DataNode TextLabel="PGI1*" GraphId="c6099" Type="Metabolite"> <Graphics CenterX="2525.8461995347475" CenterY="184.79553679347188" Width="47.16666666666981" Height="32.50000000000012" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Beta-oxidation" GraphId="c6b36"> <Graphics CenterX="2346.488662263494" CenterY="2074.1422257934955" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="20-COOH-LTB4" GraphId="c7393" Type="Metabolite"> <Graphics CenterX="1677.4900039623924" CenterY="1087.0862000648399" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:27562" /> </DataNode> <DataNode TextLabel="13,14-dihydro-PGF2α" GraphId="c7642" Type="Metabolite"> <Graphics CenterX="2076.913124664893" CenterY="2836.2495821086454" Width="125.11869436201769" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="88346" /> </DataNode> <DataNode TextLabel="AKR1C3" GraphId="c7880" Type="GeneProduct" GroupRef="ea786"> <Comment>=aldo-keto reductase family 1 member C3</Comment> <Graphics CenterX="2635.7085440525407" CenterY="2319.761077403293" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000196139" /> </DataNode> <DataNode TextLabel="5(S)-HETE" GraphId="c7aa8" Type="Metabolite"> <Graphics CenterX="1339.6950976132362" CenterY="982.2462271339155" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:28209" /> </DataNode> <DataNode TextLabel="DH-PGD2" GraphId="c7c70" Type="Metabolite"> <Graphics CenterX="3511.097236097235" CenterY="819.5346320346309" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMFA03010156" /> </DataNode> <DataNode TextLabel="CYP4F8" GraphId="c7ccf" Type="GeneProduct"> <Graphics CenterX="2799.6743565701463" CenterY="2619.1294496484106" Width="81.03885398536124" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000186526" /> </DataNode> <DataNode TextLabel="Isomerase" GraphId="c85ae" Type="GeneProduct"> <Graphics CenterX="3460.0" CenterY="194.8384715181743" Width="78.0" Height="19.5" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="DH-PGE2" GraphId="c9490" Type="Metabolite"> <Graphics CenterX="3620.4004329004374" CenterY="1050.0541125541122" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:185711" /> </DataNode> <DataNode TextLabel="Isomerization" GraphId="ca7ea"> <Graphics CenterX="5556.519692707926" CenterY="966.846257843606" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="LGE2" GraphId="cb547" Type="Metabolite"> <Comment>Levuglandin E2</Comment> <Graphics CenterX="2717.615654724154" CenterY="2174.8347320991315" Width="68.44902319902273" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:34821" /> </DataNode> <DataNode TextLabel="H-PGDS&#xA;" GraphId="cbb93" Type="GeneProduct" GroupRef="db253"> <Graphics CenterX="3119.68872197377" CenterY="2026.5401426936903" Width="103.65789473684214" Height="25.6573143531043" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000163106" /> </DataNode> <DataNode TextLabel="LTF4" GraphId="cbcd0" Type="Metabolite"> <Graphics CenterX="1429.0" CenterY="1363.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:27491" /> </DataNode> <DataNode TextLabel="PRAK" GraphId="cc638" Type="Protein"> <Graphics CenterX="3576.708333333333" CenterY="456.41666666666663" Width="39.250000000001265" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Non-enzymatic conversion" GraphId="cd009"> <Graphics CenterX="1380.052204176334" CenterY="864.2691415313225" Width="156.3689095127609" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="6-trans-LTB4" GraphId="cd3dd" Type="Metabolite"> <Graphics CenterX="1567.120416471195" CenterY="861.1775299263018" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:63981" /> </DataNode> <DataNode TextLabel="Carbonyl reductase*" GraphId="cdcee" Type="GeneProduct"> <Graphics CenterX="2199.165183104286" CenterY="2775.5003831835043" Width="123.63501483679504" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Reductase" GraphId="cf177"> <Graphics CenterX="1800.6012024048086" CenterY="1199.3987975951907" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="y-linolenic acid (18:3,w6)" GraphId="cf6a6" Type="Metabolite"> <Comment>GLA(18:3 w6)</Comment> <Graphics CenterX="2098.573205351464" CenterY="345.5751656555704" Width="154.85358929707218" Height="26.26050420168074" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="28661" /> </DataNode> <DataNode TextLabel="PGDS" GraphId="cfb51" Type="GeneProduct"> <Graphics CenterX="3440.646225151314" CenterY="877.7199127577281" Width="67.81368821292817" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000107317" /> </DataNode> <DataNode TextLabel="Ca2+" GraphId="d1383" Type="Metabolite"> <Graphics CenterX="2162.6524523997555" CenterY="1824.7455470737925" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="PGE synthase" GraphId="d1950" Type="GeneProduct"> <Graphics CenterX="3021.1267605633793" CenterY="2442.2535211267605" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000148344" /> </DataNode> <DataNode TextLabel="PGI2" GraphId="d22ea" Type="Metabolite"> <Comment>Synonym for PGI2 is "Prostacyclin"</Comment> <Graphics CenterX="3347.459241764029" CenterY="2552.59024523669" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15552" /> </DataNode> <DataNode TextLabel="LGD2" GraphId="d2db1" Type="Metabolite"> <Comment>Levuglandin D2</Comment> <Graphics CenterX="2777.164524431637" CenterY="2340.4135967595666" Width="57.49128055823457" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:34820" /> </DataNode> <DataNode TextLabel="9α,11α-PGF2α" GraphId="d3b73" Type="Metabolite"> <Graphics CenterX="2655.6870806437205" CenterY="2720.6561260223284" Width="116.56896648224556" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15553" /> </DataNode> <DataNode TextLabel="9α,11β-PGF2α" GraphId="d41a6" Type="Metabolite"> <Graphics CenterX="4009.3638328821335" CenterY="1970.849343964435" Width="128.26181635751038" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="15553" /> </DataNode> <DataNode TextLabel="TXAS" GraphId="d4b2b" Type="GeneProduct"> <Comment>=Thromboxane synthase</Comment> <Graphics CenterX="2733.0939851525372" CenterY="164.49683314137786" Width="63.604651162790816" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000059377" /> </DataNode> <DataNode TextLabel="Prostaglandin [e]" GraphId="d4ee4" Type="Metabolite"> <Graphics CenterX="6495.543763211889" CenterY="1343.67893915409" Width="112.06337058012309" Height="23.406168682076995" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Beta-oxidation" GraphId="d56b8" Type="Pathway"> <Graphics CenterX="3058.202206547298" CenterY="1463.5475755931534" Width="90.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP5241" /> </DataNode> <DataNode TextLabel="13,14-dihydro-15-keto-PGE2" GraphId="d62ab" Type="Metabolite"> <Comment>PGEM= Metabolites downstream of PGE2</Comment> <Graphics CenterX="2934.669408987724" CenterY="3556.8155843033264" Width="178.02429634689787" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15550" /> </DataNode> <DataNode TextLabel="EXA4" GraphId="d6364" Type="Metabolite"> <Graphics CenterX="2226.182751511655" CenterY="1682.2068306663484" Width="90.00000000000017" Height="25.00000000000005" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:63983" /> </DataNode> <DataNode TextLabel="CYP4F8" GraphId="d699e" Type="GeneProduct"> <Comment>=cytochrome P450 family 4 subfamily F member 8</Comment> <Graphics CenterX="3155.7863150510025" CenterY="2185.1278775205756" Width="90.0" Height="32.227586027066536" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000186526" /> </DataNode> <DataNode TextLabel="LTC4S" GraphId="d7647" Type="GeneProduct" GroupRef="f74a0"> <Graphics CenterX="2091.811900908053" CenterY="1588.0693631743743" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000213316" /> </DataNode> <DataNode TextLabel="Eicosadienoic acid (20:2,w6)" GraphId="d7c5f" Type="Metabolite"> <Graphics CenterX="2407.408542276482" CenterY="343.02616122362383" Width="171.32610251401064" Height="24.234140629065735" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:73731" /> </DataNode> <DataNode TextLabel="Irradiation-induced senescence" GraphId="d7c6e"> <BiopaxRef>c9d</BiopaxRef> <Graphics CenterX="1396.9872821342458" CenterY="619.7934156229576" Width="205.5027435859408" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="cc00cc" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="PGG1" GraphId="d805a" Type="Metabolite"> <Graphics CenterX="2457.2748639290426" CenterY="486.5166861524414" Width="66.78878377487308" Height="29.833333333333485" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="133739" /> </DataNode> <DataNode TextLabel="GSH" GraphId="d92c1" Type="Protein"> <Comment>Cofactor</Comment> <Graphics CenterX="2069.0" CenterY="1756.5" Width="68.0" Height="27.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="KEGG Genes" ID="C00051" /> </DataNode> <DataNode TextLabel="PGC1" GraphId="d9c45" Type="Metabolite"> <Graphics CenterX="3406.2466427867907" CenterY="240.5752665572536" Width="47.5" Height="27.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15546" /> </DataNode> <DataNode TextLabel="Tetranor-PGDM" GraphId="da865" Type="Metabolite"> <Graphics CenterX="4221.509266440799" CenterY="1610.3275632357243" Width="113.54961832061073" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMFA03010221" /> </DataNode> <DataNode TextLabel="NAT2" GraphId="db8e3" Type="GeneProduct"> <Graphics CenterX="1066.0000000000023" CenterY="1410.0000000000007" Width="54.66666666666836" Height="30.66666666666643" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000156006" /> </DataNode> <DataNode TextLabel="Unknown" GraphId="dc059"> <Graphics CenterX="3579.1330970779504" CenterY="1088.3411868019932" Width="60.90969581749047" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="ALOX15B" GraphId="dc45a" Type="GeneProduct" GroupRef="db9b5"> <Graphics CenterX="2733.657266980375" CenterY="1631.0492443248725" Width="90.00000000000017" Height="24.99999999999993" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000179593" /> </DataNode> <DataNode TextLabel="Dehydration" 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ID="ENSG00000108839" /> </DataNode> <DataNode TextLabel="HPGD " GraphId="e2657" Type="GeneProduct"> <Comment>15-PGDH=15-hydroxy-prostaglandin dehydrogenase</Comment> <Graphics CenterX="2503.5721649387265" CenterY="2767.4206299950215" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000164120" /> </DataNode> <DataNode TextLabel="Linoleic acid (18:2,w6)" GraphId="e3325" Type="Metabolite"> <Comment>LA (18:2 w6)</Comment> <Graphics CenterX="1606.4408352668213" CenterY="344.91006553413513" Width="151.1183294663574" Height="25.820131068270257" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="17351" /> </DataNode> <DataNode TextLabel="cAMP" GraphId="e36fe" Type="Metabolite"> <Graphics CenterX="4664.257021970306" CenterY="350.416716962429" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="ChEBI" ID="CHEBI:17489" /> </DataNode> <DataNode TextLabel="15-keto-PGD2" GraphId="e38c7" Type="Metabolite"> <BiopaxRef>e42</BiopaxRef> <Graphics CenterX="4221.5376645622455" CenterY="1844.0629218801967" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15557" /> </DataNode> <DataNode TextLabel="Dehydrase" GraphId="e3fdb" Type="GeneProduct"> <Graphics CenterX="3213.33668840582" CenterY="193.24162003082074" Width="74.0" Height="19.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Omega-oxidation" GraphId="e4217" Type="Pathway"> <Graphics CenterX="4365.878937064919" CenterY="1637.9542395693136" Width="108.43351342997106" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP206" /> </DataNode> <DataNode TextLabel="RAS" GraphId="e4cc5" Type="Metabolite"> <Graphics CenterX="3526.59781524037" CenterY="384.5487505230168" Width="52.49999999999964" Height="31.166666666666682" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="DH-PGH2*" GraphId="e50c7" Type="Metabolite"> <Graphics CenterX="3580.6395343576837" CenterY="927.2044022057029" Width="71.60309187321252" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="HXB3" GraphId="e618d" Type="Metabolite"> <Graphics CenterX="2216.9657422512237" CenterY="818.9233278955954" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:34784" /> </DataNode> <DataNode TextLabel="Arachidonic Acid (20:4,w6)" GraphId="e6402" Type="Metabolite"> <Graphics CenterX="2837.0590229235972" CenterY="927.5540628108117" Width="150.62111801242213" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="15843" /> </DataNode> <DataNode TextLabel="Spontaneous hydrolysis" GraphId="e65f0"> <Graphics CenterX="3533.707858637525" CenterY="2588.119042083238" Width="138.35038363171356" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="delta10-reductase" GraphId="e689a"> <Graphics CenterX="1619.4842498295832" CenterY="1209.3522082528225" Width="107.12424849699376" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="2,3 dinor-6-keto-PGF1α" GraphId="e779a" Type="Metabolite"> <BiopaxRef>df6</BiopaxRef> <Graphics CenterX="3842.987157869724" CenterY="2949.8498366607914" Width="141.62618083670503" Height="28.263795423956715" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="73944" /> </DataNode> <DataNode TextLabel="L-PGDS&#xA;" GraphId="e7a44" Type="GeneProduct" GroupRef="db253"> <Graphics CenterX="3119.68872197377" 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Type="GeneProduct" GroupRef="f74a0"> <Graphics CenterX="2091.8119009080538" CenterY="1613.0693631743743" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000084207" /> </DataNode> <DataNode TextLabel="Excretion via urine" GraphId="f5117" Type="Pathway"> <Graphics CenterX="4056.841466990956" CenterY="2846.506342113553" Width="128.6083608360835" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="cc00cc" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="TxA" GraphId="f63c3" Type="Metabolite"> <Graphics CenterX="2707.5873154128526" CenterY="2005.8030782964142" Width="54.24411840136072" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15627" /> </DataNode> <DataNode TextLabel="DH-TxA2*" GraphId="f6f42" Type="Metabolite"> <Graphics CenterX="3616.8442023093235" CenterY="817.5157207133957" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="PGG2" GraphId="f7608" Type="Metabolite"> <Comment>Prostaglandin G2 is abbreviated as PGG2</Comment> <Graphics CenterX="2841.2129770913784" CenterY="1839.12286528781" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="27647" /> </DataNode> <DataNode TextLabel="4,13-diketo-7,9-dihydroxy-2,3-dinor prostanoic acid*" GraphId="f80ba" Type="Metabolite"> <Comment>Lumped reaction</Comment> <Graphics CenterX="3407.7038292482684" CenterY="3025.7039760829402" Width="284.5693135935399" Height="29.093497851191024" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Senescence phenotype" GraphId="f8698" Type="Pathway"> <Graphics CenterX="2174.001560331898" CenterY="3309.074822365573" Width="145.59434664255403" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="cc00cc" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Δ6-trans-12-epi-LTB4" GraphId="f8b6f" Type="Metabolite"> <Graphics CenterX="1602.503473063175" CenterY="904.3041297124909" Width="144.4773889281949" Height="26.56649616368228" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:63982" /> </DataNode> <DataNode TextLabel="Beta-oxidation" GraphId="f985a" Type="Pathway"> <Graphics CenterX="3162.790697674415" CenterY="3749.199243413745" Width="90.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP5241" /> </DataNode> <DataNode TextLabel="β-oxidation" GraphId="fa1e6" Type="Complex"> <Graphics CenterX="1854.7946855808082" CenterY="2655.3675520801066" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="15-deoxy-Δ12,14-PGJ2" GraphId="fdaa8" Type="Metabolite"> <Comment>=15d-PGJ2</Comment> <Graphics CenterX="3372.9835772567044" CenterY="1454.154492201951" Width="148.2482598607886" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="34159" /> </DataNode> <DataNode TextLabel="Albumin-mediated degradation" GraphId="fdba4" Type="Complex"> <Graphics CenterX="3123.3618625887093" CenterY="3703.316172956412" Width="174.28348909657356" Height="21.21590792151203" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="GGT1" GraphId="ff1c8" Type="GeneProduct"> <Graphics CenterX="1795.1676859921592" CenterY="1719.4418989737424" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000100031" /> </DataNode> <DataNode TextLabel="Gi" GraphId="ff5a7" Type="Complex"> <Graphics CenterX="4503.417369588959" CenterY="365.8983356572133" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Hydrolase" GraphId="ff909"> <Graphics CenterX="2133.3485564512916" CenterY="1324.5165005361164" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="PTGES2&#xA;" GraphId="f32d9" Type="GeneProduct" GroupRef="ab164"> <Comment>=microsomal prostaglandin E synthase 2 (PTGES2)</Comment> <Graphics CenterX="3122.007893898675" CenterY="2527.31050868295" Width="89.99999999999997" Height="25.000000000000036" ZOrder="32785" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000148334" /> </DataNode> <DataNode TextLabel="PTGES3&#xA;" GraphId="dea29" Type="GeneProduct" GroupRef="ab164"> <Comment>=prostaglandin E synthase 3 (cPGES)</Comment> <Graphics CenterX="3122.0078938986753" CenterY="2551.255656362275" Width="89.99999999999997" Height="24.999999999999947" ZOrder="32786" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000110958" /> </DataNode> <DataNode TextLabel="AKR1B1" GraphId="ab604" Type="GeneProduct" GroupRef="ea786"> <Comment>=aldo-keto reductase family 1 member B </Comment> <Graphics CenterX="2635.708544052541" CenterY="2344.761077403293" Width="90.00000000000001" Height="25.000000000000036" ZOrder="32787" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000085662" /> </DataNode> <DataNode TextLabel="PTGDR2 " GraphId="ae923" Type="Complex" GroupRef="a64d7"> <Comment>=prostaglandin D2 receptor 2 =DP2</Comment> <BiopaxRef>cfe</BiopaxRef> <Graphics CenterX="4325.864175400387" CenterY="364.9635532157947" Width="90.0" Height="25.0" ZOrder="32792" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000183134" /> </DataNode> <DataNode TextLabel="19-OH-PGE2" GraphId="fcec0" Type="Metabolite"> <Graphics CenterX="2826.3095301247527" CenterY="2552.8865288476286" Width="90.0" Height="25.0" ZOrder="32795" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:165313" /> </DataNode> <DataNode TextLabel="15-keto-PGE2" GraphId="be715" Type="Metabolite"> <Graphics CenterX="2934.6120913226046" CenterY="3322.982736119056" Width="90.0" Height="25.0" ZOrder="32796" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="15547" /> </DataNode> <DataNode TextLabel="PTGER2" GraphId="a2dd9" Type="Complex" GroupRef="d96e0"> <Comment>=prostaglandin E receptor 2 =EP2</Comment> <BiopaxRef>f45</BiopaxRef> <BiopaxRef>f01</BiopaxRef> <Graphics CenterX="1950.3266105910402" CenterY="3329.6155205777422" Width="90.0" Height="25.0" ZOrder="32806" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000125384" /> </DataNode> <DataNode TextLabel="PTGER3&#xA;" GraphId="c8410" Type="Complex" GroupRef="d96e0"> <Comment>=prostaglandin E receptor 3 =EP3</Comment> <BiopaxRef>f45</BiopaxRef> <BiopaxRef>f01</BiopaxRef> <Graphics CenterX="1950.3266105910402" CenterY="3354.6155205777422" Width="90.0" Height="25.0" ZOrder="32807" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000050628" /> </DataNode> <DataNode TextLabel="PTGER4&#xA;" GraphId="aa4d5" Type="Complex" GroupRef="d96e0"> <Comment>=prostaglandin E receptor 4 =EP4</Comment> <BiopaxRef>f45</BiopaxRef> <BiopaxRef>f01</BiopaxRef> <Graphics CenterX="1950.3266105910411" CenterY="3379.615520577743" Width="90.0" Height="25.0" ZOrder="32808" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000171522" /> </DataNode> <DataNode TextLabel="PGC2" GraphId="b24b4" Type="Metabolite"> <Comment>PGC2=Prostaglandin C2</Comment> <Graphics CenterX="2860.2432155626816" CenterY="2943.046225138237" Width="90.0" Height="25.0" ZOrder="32816" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="27555" /> </DataNode> <DataNode TextLabel="PGB2" GraphId="f5856" Type="Metabolite"> <Comment>PGB2=Prostaglandin B2</Comment> <Graphics CenterX="2860.8988349860597" CenterY="3040.3079250547576" Width="90.0" Height="25.0" ZOrder="32817" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="28099" /> </DataNode> <DataNode TextLabel="PTGFR " GraphId="dc2b5" Type="Complex"> <Comment>Prostaglandin F receptor : FP Activation of FP by PGF2α results in the IP3 and DAG formation as well as in the mobilization of Ca2+. </Comment> <Graphics CenterX="2607.1070730373235" CenterY="2392.223505436493" Width="90.0" Height="25.0" ZOrder="32818" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000122420" /> </DataNode> <DataNode TextLabel="TxB" GraphId="a0046" Type="Metabolite"> <Graphics CenterX="2460.684206431749" CenterY="2006.6491673578323" Width="57.431888415104844" Height="25.0" ZOrder="32821" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:28728" /> </DataNode> <DataNode TextLabel="TBXA2R" GraphId="b5357" Type="Complex"> <Comment>=thromboxane A2 receptor</Comment> <Graphics CenterX="2600.865101411543" CenterY="1816.8475683245558" Width="90.0" Height="25.0" ZOrder="32822" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000006638" /> </DataNode> <DataNode TextLabel="Gs" GraphId="e310b" Type="Complex"> <Comment>PGI2 binding to the associated IP receptor (coupled to Gs) leads to an activation of the AC and thus to an increase of intracellular cAMP. Its elevation downregulates store-mediated calcium entry, calcium mobilization and secretion, as well as platelet adhesion to subendothelial collagen via integrin α2β1. The cAMP increase further results in an activation of protein kinase-A (PKA) and in principle, in an inhibition of platelet activation. Analogous to cAMP, PKA activity has been associated with a reduced Ca2+ release from intra-platelet stores </Comment> <Graphics CenterX="3664.097492506633" CenterY="2465.792998989649" Width="90.0" Height="25.0" ZOrder="32825" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="PTGIR" GraphId="fee34" Type="Complex"> <Comment>prostaglandin I2 receptor</Comment> <Graphics CenterX="3513.4476730120496" CenterY="2466.847851310324" Width="90.0" Height="25.0" ZOrder="32826" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000160013" /> </DataNode> <DataNode TextLabel="cAMP" GraphId="e1300" Type="Metabolite"> <Comment>PGI2 binding to the associated IP receptor (coupled to Gs) leads to an activation of the AC and thus to an increase of intracellular cAMP. Its elevation downregulates store-mediated calcium entry, calcium mobilization and secretion, as well as platelet adhesion to subendothelial collagen via integrin α2β1. The cAMP increase further results in an activation of protein kinase-A (PKA) and in principle, in an inhibition of platelet activation. Analogous to cAMP, PKA activity has been associated with a reduced Ca2+ release from intra-platelet stores</Comment> <Graphics CenterX="3834.1144197692206" CenterY="2465.7929989896493" Width="90.0" Height="25.0" ZOrder="32827" FontSize="12" Valign="Middle" /> <Xref Database="ChEBI" ID="CHEBI:17489" /> </DataNode> <DataNode TextLabel="Membrane phospholipids" GraphId="e4861" Type="Metabolite"> <Graphics CenterX="2837.50014252934" CenterY="561.3341563294924" Width="154.0" Height="25.0" ZOrder="33065" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16247" /> </DataNode> <DataNode TextLabel="Cytosolic phospholipase A2" GraphId="f6dba" Type="Protein"> <Graphics CenterX="1668.7090540425813" CenterY="711.3658758809221" Width="188.71257485029935" Height="25.0" ZOrder="33076" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="Cytosolic phospholipase A2" GraphId="a6239" Type="Protein"> <Graphics CenterX="2611.7257900398836" CenterY="709.959406120022" Width="161.20744965749418" Height="25.0" ZOrder="33077" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="p38 MAPK" GraphId="b4551" Type="GeneProduct"> <Graphics CenterX="1834.210385353141" CenterY="602.269753221965" Width="90.0" Height="25.0" ZOrder="33079" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000185386" /> </DataNode> <DataNode TextLabel="Non-enzymatic dehydration" GraphId="b8e17"> <Graphics CenterX="2589.4475546004314" CenterY="1957.8397180377087" Width="158.6219645583651" Height="25.0" ZOrder="33082" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="11-hydroxy-9,15-dioxo-prost-5-en-1,20-dioic acid*" GraphId="be1fa" Type="Metabolite"> <BiopaxRef>e39</BiopaxRef> <Graphics CenterX="2882.417701478269" CenterY="3890.7805125719315" Width="277.0872274143297" Height="25.0" ZOrder="33084" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="7α-hydroxy-5,11-diketo-tetranorprosta-1,16-dioc acid*" GraphId="f70cc" Type="Metabolite"> <BiopaxRef>b90</BiopaxRef> <Graphics CenterX="3094.1267173975143" CenterY="3849.3338763599177" Width="284.93208904076437" Height="25.0" ZOrder="33085" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Dinor-4,13-diketo-7,9-dihydroxy-prostanoic acid*" GraphId="d2962" Type="Metabolite"> <Graphics CenterX="4270.142267310872" CenterY="2808.7445807160866" Width="280.88047815098224" Height="25.0" ZOrder="33090" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Dinor-4,13-diketo-7,9-dihydroxy-prostan-1,18-dioic acid*" GraphId="c9dfe" Type="Metabolite"> <Graphics CenterX="4270.142267310872" CenterY="2904.197040557511" Width="305.8744293833839" Height="25.0" ZOrder="33091" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Unknown" GraphId="ae2c1"> <Graphics CenterX="4344.824580072009" CenterY="2856.9760579816825" Width="54.945054945054224" Height="23.48901098901159" ZOrder="33092" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="2,3-dinor 6-keto pentanor*" GraphId="cf9a7" Type="Metabolite"> <Comment></Comment> <Graphics CenterX="3749.186899219587" CenterY="2870.1119745069045" Width="151.74155776750518" Height="29.093497851191024" ZOrder="33093" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="19-OH-6-keto-PGF1α" GraphId="f4d59" Type="Metabolite"> <Comment></Comment> <Graphics CenterX="3431.7237170491117" CenterY="2876.0656599302943" Width="137.40818087504078" Height="25.30746426550464" ZOrder="33094" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="172589" /> </DataNode> <DataNode TextLabel="6,15-Diketo-13,14-dihydro-PGF1α" GraphId="f3a3f" Type="Metabolite"> <Graphics CenterX="3843.6518143917106" CenterY="2552.0742638349" Width="198.20474777447936" Height="25.0" ZOrder="33097" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:72595" /> </DataNode> <DataNode TextLabel="6,15-Diketo-13,14-dihydro-2,3-dinor PGF1α*" GraphId="e5145" Type="Metabolite"> <Comment>6,15-Diketo-13,14-dihydro-2,3-dinor PGF1a = 15 kd dinor</Comment> <Graphics CenterX="4215.896306020913" CenterY="2552.7620458592446" Width="247.55192878338275" Height="25.0" ZOrder="33098" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Unknown" GraphId="e4762"> <Graphics CenterX="3726.9084649826946" CenterY="2629.3463253132845" Width="54.945054945054224" Height="23.947932752767112" ZOrder="33101" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="2,3-dinor-11β-PGF2α" GraphId="c3690" Type="Metabolite"> <BiopaxRef>cfe</BiopaxRef> <Graphics CenterX="4222.8624809960775" CenterY="1971.5496030585296" Width="127.94211664362733" Height="25.0" ZOrder="33103" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:165323" /> </DataNode> <DataNode TextLabel="Unknown" GraphId="e29ec"> <Graphics CenterX="4105.975880151205" CenterY="2028.5674850332712" Width="54.945054945054224" Height="23.947932752767112" ZOrder="33104" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="2,3-Dinor-TxB2" GraphId="a4088" Type="Metabolite"> <Graphics CenterX="2215.3146919257015" CenterY="2051.6541875159814" Width="99.75899166753935" Height="25.0" ZOrder="33222" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:89991" /> </DataNode> <DataNode TextLabel="11-hydroxythromboxane B2 dehydrogenase" GraphId="d8c4c" Type="GeneProduct"> <Comment>11-hydroxythromboxane B2 dehydrogenase is the same as cytosolic aldehyde dehydrogenase</Comment> <Comment>Type your comment here</Comment> <Graphics CenterX="2392.0000000000005" CenterY="1930.458015267177" Width="258.6666666666679" Height="25.0" ZOrder="33223" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000165092" /> </DataNode> <DataNode TextLabel="Unknown" GraphId="f057a"> <Graphics CenterX="3988.2444949857313" CenterY="2676.1173254113296" Width="58.59559296079071" Height="22.979530604107666" ZOrder="33224" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Unknown" GraphId="abe33"> <Graphics CenterX="3128.797876367001" CenterY="95.30513865194214" Width="54.945054945054224" Height="23.947932752767112" ZOrder="33225" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Unknown" GraphId="da77d"> <Graphics CenterX="3348.8747207067404" CenterY="87.1308525506366" Width="54.945054945054224" Height="23.947932752767112" ZOrder="33226" FontSize="12" Valign="Middle" /> <Xref Database="KEGG Reaction" ID="R13041" /> </DataNode> <DataNode TextLabel="Unknown" GraphId="c884e"> <Graphics CenterX="3599.624715336288" CenterY="90.36013712101109" Width="54.945054945054224" Height="23.947932752767112" ZOrder="33227" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="PTGS1" GraphId="cf335" Type="GeneProduct" GroupRef="a1bc0"> <Comment>Prostaglandin-endoperoxide synthase 1 =cyclooxygenase (COX)</Comment> <Graphics CenterX="3103.750156548871" CenterY="472.8309347459266" Width="101.06969049367426" Height="24.999999999999968" ZOrder="33232" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000095303" /> </DataNode> <DataNode TextLabel="PTGS2" GraphId="e345f" Type="GeneProduct" GroupRef="a1bc0"> <Comment>prostaglandin-endoperoxide synthase 2 =cyclooxygenase (COX)</Comment> <Graphics CenterX="3103.750156548931" CenterY="447.83093474592624" Width="101.06969049367444" Height="24.99999999999999" ZOrder="33233" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000073756" /> </DataNode> <DataNode TextLabel="15-deoxy-Δ12,14-PGD2" GraphId="ff297" Type="Metabolite"> <Comment>=15d-PGJ2</Comment> <Graphics CenterX="3372.3547950112943" CenterY="1702.9767361214406" Width="148.2482598607886" Height="25.0" ZOrder="33282" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:63999" /> </DataNode> <DataNode TextLabel="ELOVL2" GraphId="ca5e4" Type="GeneProduct" GroupRef="ca389"> <Comment>fatty acid elongase 2</Comment> <Graphics CenterX="2974.9326199337343" CenterY="1000.2729039262883" Width="61.533578942890436" Height="25.0" ZOrder="33288" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000197977" /> </DataNode> <DataNode TextLabel="ELOVL5" GraphId="cd3e9" Type="GeneProduct"> <Comment>fatty acid elongase 5</Comment> <Graphics CenterX="1973.8100601121616" CenterY="440.26360179363536" Width="90.0" Height="25.0" ZOrder="33306" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000012660" /> </DataNode> <DataNode TextLabel="FADS2" GraphId="ca86b" Type="GeneProduct"> <Comment>gene=FADS2 Δ6-Desaturase</Comment> <Graphics CenterX="2168.766664309175" CenterY="291.3329979445962" Width="90.0" Height="25.0" ZOrder="33307" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000134824" /> </DataNode> <DataNode TextLabel="FADS1" GraphId="a1ecc" Type="GeneProduct"> <Comment>Δ5-Desaturase</Comment> <Graphics CenterX="2622.631312608466" CenterY="741.0226781675522" Width="66.25873324256446" Height="25.0" ZOrder="33308" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000149485" /> </DataNode> <DataNode TextLabel="ELOVL5" GraphId="cefc6" Type="GeneProduct" GroupRef="ca389"> <Comment>fatty acid elongase 5</Comment> <Graphics CenterX="2974.9326199337343" CenterY="975.2696250227534" Width="61.53357894289044" Height="25.0" ZOrder="33309" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000012660" /> </DataNode> <DataNode TextLabel="Excretion via urine" GraphId="c05bd"> <Graphics CenterX="5548.788141717176" CenterY="555.4096880358529" Width="118.34161184476352" Height="25.0" ZOrder="33314" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="cc00cc" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Excretion via urine" GraphId="a31f4"> <Graphics CenterX="3208.3000411482003" CenterY="2721.1699387042786" Width="124.75293140045656" Height="25.0" ZOrder="33315" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="cc00cc" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Excretion via urine" GraphId="d215a" Type="Pathway"> <Graphics CenterX="3999.5201507121988" CenterY="2618.1077325681404" Width="117.46504627123615" Height="25.0" ZOrder="33316" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="cc00cc" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Excretion via urine" GraphId="b8c33" Type="Pathway"> <Graphics CenterX="3872.674110734116" CenterY="227.58122144650304" Width="114.06178741540273" Height="25.0" ZOrder="33317" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="cc00cc" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Δ13-reductase" GraphId="fb716" Type="GeneProduct"> <Comment>=15-oxo-prostaglandin Δ13-reductase</Comment> <Graphics CenterX="4298.857840367393" CenterY="1796.7185144710427" Width="90.0" Height="25.0" ZOrder="33319" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000140043" /> </DataNode> <DataNode TextLabel="Unknown" GraphId="a5af5"> <Graphics CenterX="2140.8591651193296" CenterY="2666.3429377835114" Width="54.945054945054224" Height="23.48901098901159" ZOrder="33322" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Δ13-reductase" GraphId="c23db" Type="GeneProduct"> <Comment>=15-oxoprostaglandin-Δ13-reductase</Comment> <Graphics CenterX="3057.129686087949" CenterY="3419.5289928323996" Width="90.0" Height="25.0" ZOrder="33324" FontSize="12" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="1.3.1.48" /> </DataNode> <DataNode TextLabel="Excretion via urine" GraphId="cae35" Type="Pathway"> <Graphics CenterX="3397.20106062794" CenterY="3850.0838557043053" Width="117.46504627123615" Height="25.0" ZOrder="33327" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="cc00cc" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="6,15-diketo PGF1α" GraphId="d01f8" Type="Metabolite"> <Comment></Comment> <Graphics CenterX="3813.330747443387" CenterY="2507.768923190151" Width="126.33922061443974" Height="24.42294338577805" ZOrder="33329" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Unknown" GraphId="a539d"> <Graphics CenterX="2871.496880194256" 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CenterX="1100.6158164230887" CenterY="1345.0125644497932" Width="72.76690035579777" Height="29.51749999999925" ZOrder="33362" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000167261" /> </DataNode> <DataNode TextLabel="LTC4S" GraphId="c0965" Type="GeneProduct"> <Graphics CenterX="1100.6158164230887" CenterY="1190.4726533094274" Width="72.76690035579777" Height="25.49693706209714" ZOrder="33363" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000213316" /> </DataNode> <DataNode TextLabel="GGT5" GraphId="daab2" Type="GeneProduct" GroupRef="af49b"> <Comment>=gamma-glutamyltransferase 5</Comment> <Graphics CenterX="1100.6158164230887" CenterY="1268.1439611537305" Width="72.76690035579777" Height="29.51749999999925" ZOrder="33364" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000099998" /> </DataNode> <DataNode TextLabel="LTA4H" GraphId="cc5f9" Type="GeneProduct"> <Graphics CenterX="1255.4213797140608" 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Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB11135" /> </DataNode> <DataNode TextLabel="LTD4" GraphId="ea48d" Type="Metabolite"> <Graphics CenterX="1188.0431506985692" CenterY="1292.0388248446557" Width="90.0" Height="25.0" ZOrder="33398" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:28666" /> </DataNode> <DataNode TextLabel="LTA4" GraphId="ca06b" Type="Metabolite"> <Graphics CenterX="1188.0431121551903" CenterY="1080.366241018224" Width="90.0" Height="25.0" ZOrder="33401" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15651" /> </DataNode> <DataNode TextLabel="LTE4" GraphId="ee483" Type="Metabolite"> <Graphics CenterX="1188.0431506985692" CenterY="1362.3721581779891" Width="90.0" Height="25.0" ZOrder="33402" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15650" /> </DataNode> <DataNode TextLabel="LTC4" GraphId="c1e7b" Type="Metabolite"> <Graphics CenterX="1188.0431506985692" CenterY="1223.3721581779891" Width="90.0" Height="25.0" ZOrder="33403" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16978" /> </DataNode> <DataNode TextLabel="SASP" GraphId="c8b08" Type="Pathway"> <Graphics CenterX="1339.9770371493316" CenterY="1167.1113020530165" Width="90.0" Height="25.0" ZOrder="33413" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="cc00cc" /> <Xref Database="WikiPathways" ID="WP3391" /> </DataNode> <DataNode TextLabel="FLAP" GraphId="c13e5" Type="GeneProduct" GroupRef="cdcca"> <Comment>gene = ALOX5AP FLAP= 5-lipoxygenase activating protein</Comment> <Graphics CenterX="969.664455476963" CenterY="1009.1943877854981" Width="89.99999999999997" Height="25.0" ZOrder="33414" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000132965" /> </DataNode> <DataNode TextLabel="HPGD " GraphId="d74cd" Type="GeneProduct"> <Comment>15-PGDH=15-hydroxy-prostaglandin dehydrogenase</Comment> <Graphics CenterX="3103.0031603570624" CenterY="2964.987154855291" Width="90.0" Height="25.0" ZOrder="33415" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000164120" /> </DataNode> <DataNode TextLabel="HPGD " GraphId="e165d" Type="GeneProduct"> <Comment>15-PGDH=15-hydroxy-prostaglandin dehydrogenase</Comment> <Graphics CenterX="3475.4119020844078" CenterY="2514.2549773763867" Width="90.0" Height="25.0" ZOrder="33416" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000164120" /> </DataNode> <DataNode TextLabel="HPGD " GraphId="caf34" Type="GeneProduct"> <Comment>15-PGDH=15-hydroxy-prostaglandin dehydrogenase</Comment> <Graphics CenterX="4108.415019383232" CenterY="1804.6670715370976" Width="90.0" Height="25.0" ZOrder="33417" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000164120" /> </DataNode> <DataNode TextLabel="Prostaglandin [c]" GraphId="d4659" Type="Metabolite"> <Graphics 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Height="23.406168682076995" ZOrder="33421" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Prostaglandin [c]" GraphId="da566" Type="Metabolite"> <Graphics CenterX="6296.363980892911" CenterY="1557.2189924454415" Width="112.06337058012309" Height="23.406168682076995" ZOrder="33422" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="DH-PGI2" GraphId="a66f3" Type="Metabolite"> <Graphics CenterX="3513.9569805194797" CenterY="1051.8244949494936" Width="90.0" Height="25.0" ZOrder="33423" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:165328" /> </DataNode> <DataNode TextLabel="Non-enzymatic" GraphId="bcccd"> <Graphics CenterX="3374.405811623244" CenterY="611.4248479644243" Width="94.87575150300614" Height="33.146296055119365" ZOrder="33424" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CysLT1R" 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Shape="None" GraphId="e8eeb" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e4869"> <BiopaxRef>e89</BiopaxRef> <BiopaxRef>ffb</BiopaxRef> <BiopaxRef>d9c</BiopaxRef> <BiopaxRef>d41</BiopaxRef> <Graphics ZOrder="33672" LineStyle="Broken" LineThickness="1.0"> <Point X="5188.54674379357" Y="341.6269249850287" GraphRef="c18e3" RelX="0.0" RelY="1.0" /> <Point X="5074.242235429137" Y="373.09481471989585" GraphRef="dc4c3" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="dd4e9" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f7462"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>b5e</BiopaxRef> <BiopaxRef>d4d</BiopaxRef> <BiopaxRef>d24</BiopaxRef> <Graphics ZOrder="33673" LineThickness="1.0"> <Point X="5239.984072709269" Y="182.64784429893044" GraphRef="cbe6d" RelX="0.0" RelY="1.0" /> <Point X="5239.346822236046" Y="222.36928897287342" GraphRef="ddc5a" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="ebd76" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e4741"> <Comment></Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>b5e</BiopaxRef> <BiopaxRef>d4d</BiopaxRef> <BiopaxRef>d24</BiopaxRef> <Graphics ZOrder="33674" LineStyle="Broken" LineThickness="1.0"> <Point X="5239.346822236046" Y="247.36928897287342" GraphRef="ddc5a" RelX="0.0" RelY="1.0" /> <Point X="5188.54674379357" Y="316.6269249850287" GraphRef="c18e3" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f21fe"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>f1b</BiopaxRef> <BiopaxRef>adc</BiopaxRef> <BiopaxRef>c02</BiopaxRef> <Graphics ZOrder="33675" LineStyle="Broken" LineThickness="1.0"> <Point X="5056.450695460884" Y="234.65941673054013" GraphRef="da12b" RelX="-1.0" RelY="0.0" /> <Point X="4980.26096500497" Y="234.65941673054013" GraphRef="ac510" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ba7eb"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>a9d</BiopaxRef> <Graphics ZOrder="33676" LineStyle="Broken" LineThickness="1.0"> <Point X="5284.346822236046" Y="234.86928897287342" GraphRef="ddc5a" RelX="1.0" RelY="0.0" /> <Point X="5381.159434058049" Y="273.8999253278646" GraphRef="c49b0" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="a9887"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>adc</BiopaxRef> <BiopaxRef>c02</BiopaxRef> <Graphics ZOrder="33677" LineStyle="Broken" LineThickness="1.0"> <Point X="5194.346822236046" Y="234.86928897287342" GraphRef="ddc5a" RelX="-1.0" RelY="0.0" /> <Point X="5146.450695460884" Y="234.65941673054013" GraphRef="da12b" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="acdee"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>b5e</BiopaxRef> <Graphics ZOrder="33678" LineStyle="Broken" LineThickness="1.0"> <Point X="5299.455520726699" Y="343.6546642109918" GraphRef="b9a77" RelX="0.0" RelY="1.0" /> <Point X="5301.76787168024" Y="390.7494543758818" GraphRef="dfef8" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="d9ad5"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>b5e</BiopaxRef> <Graphics ZOrder="33679" LineStyle="Broken" LineThickness="1.0"> <Point X="5239.346822236046" Y="247.36928897287342" GraphRef="ddc5a" RelX="0.0" RelY="1.0" /> <Point X="5410.732280038324" Y="313.4437376098133" GraphRef="b2678" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="c9e3f"> <BiopaxRef>e89</BiopaxRef> <BiopaxRef>ffb</BiopaxRef> <Graphics ZOrder="33680" LineStyle="Broken" LineThickness="1.0"> <Point X="5074.242235429137" Y="398.09481471989585" GraphRef="dc4c3" RelX="0.0" RelY="1.0" /> <Point X="5074.480864947516" Y="445.9328220386187" GraphRef="a9a51" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="b2f5d"> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>fa7</BiopaxRef> <BiopaxRef>c85</BiopaxRef> <Graphics ZOrder="33681" LineThickness="1.0"> <Point X="5188.54674379357" Y="341.6269249850287" GraphRef="c18e3" RelX="0.0" RelY="1.0" /> <Point X="5187.498010778301" Y="419.17053217256233" GraphRef="a886e" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="ea58d" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="a695e"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <Graphics ZOrder="33697" LineStyle="Broken" LineThickness="1.0"> <Point X="5301.76787168024" Y="415.7494543758818" GraphRef="dfef8" RelX="0.0" RelY="1.0" /> <Point X="5301.583059518406" Y="515.6814173582486" GraphRef="d62ad" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="a1817"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <Graphics ZOrder="33700" LineStyle="Broken" LineThickness="1.0"> <Point X="5857.123998313853" Y="381.3132720614019" GraphRef="d3ae6" RelX="0.0" RelY="1.0" /> <Point X="5858.569160190382" Y="438.07237177636165" GraphRef="e32b2" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="d9672"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>a9d</BiopaxRef> <Graphics ZOrder="33701" LineStyle="Broken" LineThickness="1.0"> <Point X="5902.235140885501" Y="272.1522054549963" GraphRef="d2cc4" RelX="1.0" RelY="0.0" /> <Point X="5978.360873134202" Y="315.7141862946164" GraphRef="c7ade" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f39c2"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>adc</BiopaxRef> <Graphics ZOrder="33702" LineStyle="Broken" LineThickness="1.0"> <Point X="5677.865580750856" Y="272.3825085561585" GraphRef="faadb" RelX="-1.0" RelY="0.0" /> <Point X="5620.762477136125" Y="272.3825085561596" GraphRef="a7c67" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e1ca4"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>f0d</BiopaxRef> <Graphics ZOrder="33703" LineStyle="Broken" LineThickness="1.0"> <Point X="5811.665213544683" Y="148.74747492287224" GraphRef="be8b0" RelX="-1.0" RelY="0.0" /> <Point X="5767.653799481941" Y="148.69623726156289" GraphRef="b125b" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e0efb"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <Graphics ZOrder="33704" LineStyle="Broken" LineThickness="1.0"> <Point X="5963.205982362724" Y="381.754916612158" GraphRef="df9d7" RelX="0.0" RelY="1.0" /> <Point X="5963.487727389531" Y="434.1571210447624" GraphRef="fc311" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f7b81"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>d4d</BiopaxRef> <BiopaxRef>d24</BiopaxRef> <Graphics ZOrder="33705" LineStyle="Broken" LineThickness="1.0"> <Point X="5857.235140885501" Y="284.6522054549963" GraphRef="d2cc4" RelX="0.0" RelY="1.0" /> <Point X="5750.446355857288" Y="358.7639830225055" GraphRef="d725d" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="d2629"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <Graphics ZOrder="33706" LineStyle="Broken" LineThickness="1.0"> <Point X="5857.235140885501" Y="284.6522054549963" GraphRef="d2cc4" RelX="0.0" RelY="1.0" /> <Point X="5963.205982362724" Y="356.754916612158" GraphRef="df9d7" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="a8742"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <Graphics ZOrder="33707" LineStyle="Broken" LineThickness="1.0"> <Point X="5857.235140885501" Y="284.6522054549963" GraphRef="d2cc4" RelX="0.0" RelY="1.0" /> <Point X="5857.123998313853" Y="356.3132720614019" GraphRef="d3ae6" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="a941a"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>a9d</BiopaxRef> <Graphics ZOrder="33708" LineStyle="Broken" LineThickness="1.0"> <Point X="5902.235140885501" Y="272.1522054549963" GraphRef="d2cc4" RelX="1.0" RelY="0.0" /> <Point X="5985.73695703147" Y="272.2143570278389" GraphRef="e7ef5" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f59b5"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>adc</BiopaxRef> <Graphics ZOrder="33709" LineStyle="Broken" LineThickness="1.0"> <Point X="5812.235140885501" Y="272.1522054549963" GraphRef="d2cc4" RelX="-1.0" RelY="0.0" /> <Point X="5767.865580750856" Y="272.3825085561585" GraphRef="faadb" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e4e90"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>d4d</BiopaxRef> <BiopaxRef>d24</BiopaxRef> <Graphics ZOrder="33710" LineStyle="Broken" LineThickness="1.0"> <Point X="5856.665213544683" Y="161.24747492287224" GraphRef="be8b0" RelX="0.0" RelY="1.0" /> <Point X="5857.235140885501" Y="259.6522054549963" GraphRef="d2cc4" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="b665f" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="a6861"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <Graphics ZOrder="33719" LineStyle="Broken" LineThickness="1.0"> <Point X="5858.569160190382" Y="463.07237177636165" GraphRef="e32b2" RelX="0.0" RelY="1.0" /> <Point X="5857.406369492708" Y="517.7180570873313" GraphRef="f79d0" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="bd4d6"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>a9d</BiopaxRef> <Graphics ZOrder="33725" LineStyle="Broken" LineThickness="1.0"> <Point X="4906.184387463445" Y="862.2348102431803" GraphRef="f6a29" RelX="1.0" RelY="0.0" /> <Point X="5126.547905325203" Y="909.8536063431186" GraphRef="a4041" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ef8be"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>f0d</BiopaxRef> <Graphics ZOrder="33726" LineStyle="Broken" LineThickness="1.0"> <Point X="4906.821637936651" Y="633.7769089511063" GraphRef="a0dbe" RelX="1.0" RelY="0.0" /> <Point X="5034.4429437190265" Y="632.7826069691315" GraphRef="ddd91" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e509f"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>d4d</BiopaxRef> <BiopaxRef>d24</BiopaxRef> <Graphics ZOrder="33727" LineStyle="Broken" LineThickness="1.0"> <Point X="4861.184387463445" Y="874.7348102431803" GraphRef="f6a29" RelX="0.0" RelY="1.0" /> <Point X="5138.038247463704" Y="969.2017835189205" GraphRef="ba05d" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="aee89"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <Graphics ZOrder="33728" LineStyle="Broken" LineThickness="1.0"> <Point X="4861.184387463445" Y="874.7348102431803" GraphRef="f6a29" RelX="0.0" RelY="1.0" /> <Point X="4859.013370167627" Y="948.4764570478501" GraphRef="fdbb4" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="eaefc" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f18fb"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <Graphics ZOrder="33729" LineStyle="Broken" LineThickness="1.0"> <Point X="4971.146827602416" Y="973.2400998835842" GraphRef="ced88" RelX="0.0" RelY="1.0" /> <Point X="4970.379667440909" Y="1023.7491924999431" GraphRef="e92f8" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ebf8e"> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>d4d</BiopaxRef> <BiopaxRef>d24</BiopaxRef> <Graphics ZOrder="33730" LineStyle="Broken" LineThickness="1.0"> <Point X="4861.821637936651" Y="646.2769089511063" GraphRef="a0dbe" RelX="0.0" RelY="1.0" /> <Point X="4861.184387463445" Y="849.7348102431803" GraphRef="f6a29" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> <Anchor Position="0.4" Shape="None" GraphId="c0894" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e26c2"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>a9d</BiopaxRef> <Graphics ZOrder="33731" LineStyle="Broken" LineThickness="1.0"> <Point X="4906.184387463445" Y="862.2348102431803" GraphRef="f6a29" RelX="1.0" RelY="0.0" /> <Point X="5131.422979507656" Y="864.274754930176" GraphRef="a2136" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="c5561"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>adc</BiopaxRef> <Graphics ZOrder="33732" LineStyle="Broken" LineThickness="1.0"> <Point X="4816.184387463445" Y="862.2348102431803" GraphRef="f6a29" RelX="-1.0" RelY="0.0" /> <Point X="5129.50464591614" Y="739.3611167321955" GraphRef="c8f80" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="b4617"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>adc</BiopaxRef> <Graphics ZOrder="33733" LineStyle="Broken" LineThickness="1.0"> <Point X="5219.50464591614" Y="739.3611167321955" GraphRef="c8f80" RelX="1.0" RelY="0.0" /> <Point X="5318.687297796309" Y="739.5931069641857" GraphRef="d516d" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f1958"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <Graphics ZOrder="33734" LineStyle="Broken" LineThickness="1.0"> <Point X="4861.184387463445" Y="874.7348102431803" GraphRef="f6a29" RelX="0.0" RelY="1.0" /> <Point X="4971.146827602416" Y="948.2400998835842" GraphRef="ced88" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f3d96"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <Graphics ZOrder="33735" LineStyle="Broken" LineThickness="1.0"> <Point X="4859.013370167627" Y="973.4764570478501" GraphRef="fdbb4" RelX="0.0" RelY="1.0" /> <Point X="4859.013370167628" Y="1023.4068148055148" GraphRef="aca62" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f2865"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <Graphics ZOrder="33746" LineStyle="Broken" LineThickness="1.0"> <Point X="4859.013370167628" Y="1048.729224203982" GraphRef="aca62" RelX="0.0" RelY="1.0" /> <Point X="4859.409000703794" Y="1103.9332788576125" GraphRef="e8b78" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="d78fd"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <Graphics ZOrder="33751" LineStyle="Broken" LineThickness="1.0"> <Point X="6156.158914217203" Y="799.5851536788958" GraphRef="b8c76" RelX="1.0" RelY="0.0" /> <Point X="6272.606399527697" Y="761.4154605289017" GraphRef="d92e2" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ab623"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>a9d</BiopaxRef> <Graphics ZOrder="33752" LineStyle="Broken" LineThickness="1.0"> <Point X="6068.628050019673" Y="800.2423936133486" /> <Point X="5693.119306157732" Y="833.0833872224467" GraphRef="f9f11" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="f6f89"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>adc</BiopaxRef> <Graphics ZOrder="33753" LineStyle="Broken" LineThickness="1.0"> <Point X="6264.149951626482" Y="873.4886624508265" GraphRef="c037a" RelX="0.0" RelY="1.0" /> <Point X="6264.40911805684" Y="950.2513126834053" GraphRef="ceb43" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="fb180"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>a9d</BiopaxRef> <Graphics ZOrder="33754" LineStyle="Broken" LineThickness="1.0"> <Point X="6066.158914217203" Y="799.5851536788958" GraphRef="b8c76" RelX="-1.0" RelY="0.0" /> <Point X="5700.195920297294" Y="781.9071234659606" GraphRef="c4a6a" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e17a6"> <Comment>Hypothetical reaction</Comment> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>b7c</BiopaxRef> <BiopaxRef>d4d</BiopaxRef> <BiopaxRef>d24</BiopaxRef> <Graphics ZOrder="33755" LineStyle="Broken" LineThickness="1.0"> <Point X="6111.501423925136" Y="666.3076400789766" GraphRef="eba63" RelX="0.0" RelY="1.0" /> <Point X="6111.158914217203" Y="787.0851536788958" GraphRef="b8c76" RelX="0.0" RelY="-1.0" 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