Omega-3-fatty acids in senescence (Homo sapiens)

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protein-coupled receptor 32 =RVDR1</Comment> <Graphics CenterX="230.98557185701446" CenterY="789.1209986965669" Width="90.0" Height="25.0" ZOrder="35136" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000142511" /> </DataNode> <DataNode TextLabel="7S-hydroperoxy-17S-HDHA" GraphId="f0764" Type="Metabolite"> <Graphics CenterX="851.5775443948626" CenterY="953.707416144648" Width="176.23052959501788" Height="25.0" ZOrder="35137" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:138642" /> </DataNode> <DataNode TextLabel="5S,6S,18R-TriHEPE*" GraphId="a9c4c" Type="Metabolite"> <Graphics CenterX="4807.467624531624" CenterY="1528.740994566123" Width="131.95652173913064" Height="25.0" ZOrder="35138" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="15S-HpEPE" GraphId="acdb4" Type="Metabolite"> <Graphics CenterX="4879.305019586196" CenterY="1121.1514079444237" Width="90.0" Height="25.0" ZOrder="35139" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:165266" /> </DataNode> <DataNode TextLabel="7S,8R-epoxy-17S-HDPA*" GraphId="e470c" Type="Metabolite"> <Graphics CenterX="3545.6338654753195" CenterY="1397.6178031264649" Width="158.70716510903407" Height="25.0" ZOrder="35140" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="4S,5-epoxy-17R-HDHA" GraphId="e59c4" Type="Metabolite"> <Graphics CenterX="1165.8052334603701" CenterY="674.0862629626567" Width="153.72435897435903" Height="25.0" ZOrder="35141" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:187528" /> </DataNode> <DataNode TextLabel="Hydrolase*" GraphId="dbac2"> <Graphics CenterX="1538.745411433794" CenterY="715.2778513527296" Width="90.0" Height="25.0" ZOrder="35142" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="18R-HpEPE" GraphId="bd47f" Type="Metabolite"> <Graphics CenterX="5180.975595492952" CenterY="1089.1855331666575" Width="90.0" Height="25.0" ZOrder="35143" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:138565" /> </DataNode> <DataNode TextLabel="5S,6R,18R-TriHEPE*" GraphId="eb267" Type="Metabolite"> <Graphics CenterX="4994.0596454508595" CenterY="1535.5088208358065" Width="135.06211180124288" Height="25.0" ZOrder="35144" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="5S,6S-epoxy-18S-HEPE" GraphId="adf7a" Type="Metabolite"> <Graphics CenterX="5792.192339229824" CenterY="1184.8238339252302" Width="160.4929577464796" Height="25.0" ZOrder="35145" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:138490" /> </DataNode> <DataNode TextLabel="18S-RvE2" GraphId="ff24a" Type="Metabolite"> <Graphics CenterX="6199.012537858129" CenterY="1383.088110963603" Width="90.0" Height="25.0" ZOrder="35147" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:137034" /> </DataNode> <DataNode TextLabel="17R-HDHA" GraphId="f6ded" Type="Metabolite"> <Graphics CenterX="1166.5180414939757" CenterY="776.2296856408825" Width="90.0" Height="25.0" ZOrder="35148" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:91137" /> </DataNode> <DataNode TextLabel="17S-HpDHA" GraphId="b7e70" Type="Metabolite"> <Graphics CenterX="1528.8510372853207" CenterY="953.707416144648" Width="90.0" Height="25.0" ZOrder="35149" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:136113" /> </DataNode> <DataNode TextLabel="12-oxo-RvE1" GraphId="f2c6c" Type="Metabolite"> <Graphics CenterX="5181.120650731576" CenterY="1760.5129460566568" Width="90.0" Height="25.0" ZOrder="35150" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:165264" /> </DataNode> <DataNode TextLabel="18S-RvE1" GraphId="a626c" Type="Metabolite"> <Graphics CenterX="5792.458158954377" CenterY="1308.1883199065387" Width="90.0" Height="25.0" ZOrder="35151" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:137038" /> </DataNode> <DataNode TextLabel="13,14-epoxy-DPA*" GraphId="c4f61" Type="Metabolite"> <Graphics CenterX="3805.110015375564" CenterY="1299.685791946003" Width="114.61325966850981" Height="25.0" ZOrder="35152" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Mar1(n-3 DPA)" GraphId="b0ffa" Type="Metabolite"> <Graphics CenterX="3804.636476572644" CenterY="1484.4937317327394" Width="90.0" Height="25.0" ZOrder="35153" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:140256" /> </DataNode> <DataNode TextLabel="4S,5-epoxy-17S-HDHA" GraphId="e980d" Type="Metabolite"> <Graphics CenterX="830.6975819785332" CenterY="1189.9100210213837" Width="148.16865698526948" Height="25.0" ZOrder="35154" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:138647" /> </DataNode> <DataNode TextLabel="Non-enzymatic hydrolysis" GraphId="d5691"> <Graphics CenterX="5462.885102349821" CenterY="1454.108239007197" Width="165.64965197215835" Height="25.0" ZOrder="35155" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="RvD2(n-3 DPA)*" GraphId="a21f0" Type="Metabolite"> <Graphics CenterX="3457.5033798631093" CenterY="1514.40110653605" Width="107.30529595015722" Height="25.0" ZOrder="35156" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="AT-RvD4" GraphId="cd7a9" Type="Metabolite"> <Graphics CenterX="1241.5071565372941" CenterY="576.259339885733" Width="90.0" Height="25.0" ZOrder="35157" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:138616" /> </DataNode> <DataNode TextLabel="10,11-dihydro-RvE1" GraphId="de88e" Type="Metabolite"> <Graphics CenterX="5181.287491776046" CenterY="1948.1139775537163" Width="110.10416666666758" Height="25.0" ZOrder="35158" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:165277" /> </DataNode> <DataNode TextLabel="14-HpDPA" GraphId="e9feb" Type="Metabolite"> <Graphics CenterX="3804.9605290102872" CenterY="1167.0083447625825" Width="90.0" Height="25.0" ZOrder="35159" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:136353" /> </DataNode> <DataNode TextLabel="4S-hydroperoxy-17S-HDHA" GraphId="cd16f" Type="Metabolite"> <Graphics CenterX="1144.969311509027" CenterY="1189.8089954429406" Width="163.13006230529604" Height="25.0" ZOrder="35160" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:138641" /> </DataNode> <DataNode TextLabel="PGH3" GraphId="dd762" Type="Metabolite"> <Graphics CenterX="4492.35853877557" CenterY="1420.031226629444" Width="65.82951538025516" Height="25.0" ZOrder="35176" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:134407" /> </DataNode> <DataNode TextLabel="ELOVL5" GraphId="a4e47" Type="GeneProduct"> <Comment>fatty acid elongase 5</Comment> <Graphics CenterX="4684.838751277517" CenterY="491.905832691416" Width="90.0" Height="25.0" ZOrder="35177" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000012660" /> </DataNode> <DataNode TextLabel="TXAS" GraphId="b88c3" Type="GeneProduct"> <Graphics CenterX="4398.153953097611" CenterY="1367.947399311401" Width="54.34163456919069" Height="25.0" ZOrder="35178" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000059377" /> </DataNode> <DataNode TextLabel="PGDS" GraphId="adb0f" Type="GeneProduct"> <Graphics CenterX="4577.697907461503" CenterY="1390.9121793038048" Width="64.77333374361692" Height="25.0" ZOrder="35179" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000107317" /> </DataNode> <DataNode TextLabel="PGI3" GraphId="c19ea" Type="Metabolite"> <Graphics CenterX="4556.574799006028" CenterY="1324.7209203247653" Width="57.917229404751545" Height="25.0" ZOrder="35180" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Eicosatetraenoic acid (20:4,w3)" GraphId="c0c9e" Type="Metabolite"> <Graphics CenterX="4492.309331148457" CenterY="567.4454687126845" Width="216.69025509231201" Height="25.0" ZOrder="35181" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:166893" /> </DataNode> <DataNode TextLabel="PGF3α" GraphId="dcb4e" Type="Metabolite"> <Graphics CenterX="4321.127207300908" CenterY="1530.5968293215597" Width="61.548242608329836" Height="25.0" ZOrder="35182" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:36075" /> </DataNode> <DataNode TextLabel="PGD3" GraphId="b6762" Type="Metabolite"> <Graphics CenterX="4667.528380496472" CenterY="1419.989552522215" 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</DataNode> <DataNode TextLabel="Phospholipase A2" GraphId="c0e36" Type="GeneProduct"> <Graphics CenterX="4587.0432253087365" CenterY="151.57622180212593" Width="117.91354938252698" Height="25.0" ZOrder="35187" FontSize="12" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="PGIS" GraphId="e237b" Type="GeneProduct"> <Graphics CenterX="4586.356996382809" CenterY="1354.6518170680902" Width="61.33762081227711" Height="25.0" ZOrder="35188" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000124212" /> </DataNode> <DataNode TextLabel="TxA3" GraphId="eb80e" Type="Metabolite"> <Graphics CenterX="4300.768850294557" CenterY="1419.2609306930453" Width="62.41180165501864" Height="25.0" ZOrder="35189" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:165349" /> </DataNode> <DataNode TextLabel="α-Linolenic acid (18:3,w3)" GraphId="fa2ae" Type="Metabolite"> <Comment>IUPAC Name: 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<Comment>7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid</Comment> <Graphics CenterX="2123.1092776268392" CenterY="1485.3398604813676" Width="76.06025386609376" Height="22.619129655323825" ZOrder="35215" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:138249" /> </DataNode> <DataNode TextLabel="Maresin 2" GraphId="a224e" Type="Metabolite"> <Comment>(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid</Comment> <Graphics CenterX="2017.3111613695305" CenterY="1425.4855778650706" Width="67.45496867095821" Height="23.757139893006112" ZOrder="35216" FontSize="12" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:138248" /> </DataNode> <DataNode TextLabel="MCTR1" GraphId="daee2" Type="Metabolite"> <Comment>(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid</Comment> <Graphics CenterX="2272.7551781058464" CenterY="1413.2008391136526" Width="73.22438804512907" Height="26.519245662612505" 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