Metabolic reprogramming in pancreatic cancer (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Metabolic reprogramming in pancreatic cancer" Version="20220405" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">This pathway model displays the interactions between KRAS and TP53 mutations and pancreatic cancer cells. As a consequence of these mutations, the cell undergoes reprogramming of glucose, lipid and amino acid metabolism, thereby affecting the pentose phosphate pathway (PPP), hexosamine biosynthetic pathway (HBP) and the tricarboxylic acid (TCA) cycle. The pathway curation is largely based on Figure 2 of the review article by Wang et al. in 2021 (https://doi.org/10.1038/s41392-021-00659-4). </Comment> <BiopaxRef>ebe</BiopaxRef> <Graphics BoardWidth="1408.6666666666667" BoardHeight="1310.9166666666674"/> <DataNode TextLabel="D-Ribulose 5-phosphate" GraphId="b0519" Type="Metabolite"> <Graphics CenterX="761.3333333333334" CenterY="302.66666666666595" Width="143.99999999999997" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17363"/> </DataNode> <DataNode TextLabel="cholesterol esters" GraphId="bd559" Type="Metabolite"> <Graphics CenterX="626.1666666666669" CenterY="1086.3333333333358" Width="118.33333333333326" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17002"/> </DataNode> <DataNode TextLabel="BCKA" GraphId="e2e93" Type="Metabolite"> <Comment>Branched-chain keto acid (BCKA)</Comment> <Graphics CenterX="970.1666666666679" CenterY="952.3333333333333" Width="49.666666666667254" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:191197"/> </DataNode> <DataNode TextLabel="PFKL" GraphId="b364a" Type="Protein"> <Comment>ATP-dependent 6-phosphofructokinase, liver type</Comment> <Graphics CenterX="401.83333333333337" CenterY="484.0000000000002" Width="56.999999999999545" Height="25.0" ZOrder="32770" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P17858"/> </DataNode> <DataNode TextLabel="D-Ribose 5-phosphate" GraphId="ba696" Type="Metabolite"> <Graphics CenterX="946.5" CenterY="348.33333333333326" Width="143.0" Height="25.0" ZOrder="32772" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17797"/> </DataNode> <DataNode TextLabel="MDH1" GraphId="a8ad7" Type="Protein"> <Comment>Malate dehydrogenase, cytoplasmic</Comment> <Graphics CenterX="696.0416666666666" CenterY="581.0833333333328" Width="47.91666666666641" Height="25.0" ZOrder="32774" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P40925"/> </DataNode> <DataNode TextLabel="NADPH" GraphId="b6cc7" Type="Metabolite"> <Graphics CenterX="679.8333333333342" CenterY="263.54545454545405" Width="57.0" Height="25.0" ZOrder="32776" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16474"/> </DataNode> <DataNode TextLabel="lactate" GraphId="f0413" Type="Metabolite"> <Graphics CenterX="292.1666666666663" CenterY="675.9999999999994" Width="61.00000000000081" Height="25.0" ZOrder="32778" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:24996"/> </DataNode> <DataNode TextLabel="CARM1" GraphId="b559d" Type="Protein"> <Comment>Histone-arginine methyltransferase CARM1</Comment> <Graphics CenterX="810.1666666666666" CenterY="566.3333333333334" Width="62.333333333333485" Height="25.0" ZOrder="32780" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q86X55"/> </DataNode> <DataNode TextLabel="HK2" GraphId="bb318" Type="Protein"> <Comment>Hexokinase-2</Comment> <Graphics CenterX="401.83333333333337" CenterY="252.00000000000017" Width="56.999999999999545" Height="25.0" ZOrder="32782" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P52789"/> </DataNode> <DataNode TextLabel="SOAT1" GraphId="f3ae0" Type="Protein"> <Comment>Sterol O-acyltransferase 1</Comment> <Graphics CenterX="516.1666666666665" CenterY="1120.0000000000014" Width="61.00000000000006" Height="25.0" ZOrder="32784" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P35610"/> </DataNode> <DataNode TextLabel="GPT" GraphId="d3e9f" Type="Protein"> <Comment>Alanine aminotransferase 1</Comment> <Graphics CenterX="810.6666666666669" CenterY="989.0000000000005" Width="42.0" Height="25.0" ZOrder="32786" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P24298"/> </DataNode> <DataNode TextLabel="NEAA" GraphId="dc564" Type="Metabolite"> <Comment>Full name: Non-Essential Amino Acids </Comment> <Graphics CenterX="882.8750000000001" CenterY="996.4166666666666" Width="48.25" Height="25.0" ZOrder="32788" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q9150056"/> </DataNode> <DataNode TextLabel="D-Fructose 1,6-bisphosphate" GraphId="de68a" Type="Metabolite"> <Graphics CenterX="505.1666666666667" CenterY="535.75" Width="182.58333333333337" Height="25.0" ZOrder="32790" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16905"/> </DataNode> <DataNode TextLabel="UDP-GlcNAc" GraphId="a6c73" Type="Metabolite"> <Comment>Full name: UDP-N-acetyl-D-glucosamine</Comment> <Graphics CenterX="1218.6666666666667" CenterY="438.41666666666663" Width="90.0" Height="25.0" ZOrder="32792" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16264"/> </DataNode> <DataNode TextLabel="SLC16A4" GraphId="fdfc7" Type="Protein"> <Comment>Monocarboxylate transporter 5</Comment> <Graphics CenterX="187.33333333333346" CenterY="729.9999999999978" Width="90.0" Height="25.0" ZOrder="32794" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O15374"/> </DataNode> <DataNode TextLabel="SLC43A1" GraphId="d5ecf" Type="Protein"> <Comment>Large neutral amino acids transporter small subunit 3</Comment> <Graphics CenterX="1287.999999999998" CenterY="1217.3333333333348" Width="90.0" Height="25.0" ZOrder="32796" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O75387"/> </DataNode> <DataNode TextLabel="glucose" GraphId="e4efb" Type="Metabolite"> <Graphics CenterX="505.16666666666663" CenterY="67.74999999999991" Width="90.0" Height="25.0" ZOrder="32798" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17234"/> </DataNode> <DataNode TextLabel="PGM3" GraphId="b5cad" Type="Protein"> <Comment>Phosphoacetylglucosamine mutase</Comment> <Graphics CenterX="1001.0416666666671" CenterY="486.4166666666667" Width="53.91666666666652" Height="25.0" ZOrder="32800" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O95394"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="fd6dd" Type="Protein"> <Graphics CenterX="299.83333333332723" CenterY="157.33333333333306" Width="59.66666666666691" Height="25.0" ZOrder="32802" FontWeight="Bold" FontSize="12" Valign="Middle" Color="ff3333"/> <Xref Database="Uniprot-TrEMBL" ID="P01116"/> </DataNode> <DataNode TextLabel="fatty acids" GraphId="e798f" Type="Metabolite"> <Graphics CenterX="306.66666666666646" CenterY="1010.6666666666661" Width="90.0" Height="25.0" ZOrder="32804" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:35366"/> </DataNode> <DataNode TextLabel="glucose" GraphId="ba86c" Type="Metabolite"> <Graphics CenterX="505.1666666666667" CenterY="169.75000000000028" Width="90.0" Height="25.0" ZOrder="32805" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17234"/> </DataNode> <DataNode TextLabel="HK1" GraphId="fc8a1" Type="Protein"> <Comment>Hexokinase-1</Comment> <Graphics CenterX="401.83333333333337" CenterY="222.41666666666694" Width="56.999999999999545" Height="25.0" ZOrder="32806" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P19367"/> </DataNode> <DataNode TextLabel="Aspartic acid" GraphId="d5b7a" Type="Metabolite"> <Graphics CenterX="866.6666666666669" CenterY="736.3333333333319" Width="90.0" Height="25.0" ZOrder="32808" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:22660"/> </DataNode> <DataNode TextLabel="NADP+" GraphId="b6fcf" Type="Metabolite"> <Graphics CenterX="599.4999999999998" CenterY="263.54545454545405" Width="61.0" Height="25.0" ZOrder="32810" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:18009"/> </DataNode> <DataNode TextLabel="lactate" GraphId="e12d1" Type="Metabolite"> <Graphics CenterX="80.16666666666656" CenterY="675.9999999999994" Width="56.333333333333115" Height="25.0" ZOrder="32811" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:24996"/> </DataNode> <DataNode TextLabel="D-Xylulose 5-phosphate" GraphId="ecc78" Type="Metabolite"> <Graphics CenterX="946.5" CenterY="237.0" Width="150.0" Height="25.0" ZOrder="32812" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16332"/> </DataNode> <DataNode TextLabel="D-Fructose 6-phosphate" GraphId="f9497" Type="Metabolite"> <Graphics CenterX="505.16666666666663" CenterY="438.4166666666666" Width="153.0" Height="25.0" ZOrder="32814" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15946"/> </DataNode> <DataNode TextLabel="LDL" GraphId="eb41a" Type="Metabolite"> <Graphics CenterX="441.083333333334" CenterY="1268.4166666666674" Width="90.0" Height="25.0" ZOrder="32816" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:39026"/> </DataNode> <DataNode TextLabel="HMGCS2" GraphId="f9f43" Type="Protein"> <Comment>Hydroxymethylglutaryl-CoA synthase, mitochondrial</Comment> <Graphics CenterX="459.0" CenterY="887.0" Width="62.0" Height="25.0" ZOrder="32818" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P54868"/> </DataNode> <DataNode TextLabel="GFPT1" GraphId="fcae6" Type="Protein"> <Comment>Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 1</Comment> <Graphics CenterX="614.0416666666665" CenterY="486.41666666666663" Width="62.58333333333338" Height="25.0" ZOrder="32820" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q06210"/> </DataNode> <DataNode TextLabel="PKM" GraphId="efa4d" Type="Protein"> <Comment>Pyruvate kinase PKM</Comment> <Graphics CenterX="403.1666666666667" CenterY="606.6666666666638" Width="55.66666666666753" Height="25.0" ZOrder="32822" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P14618"/> </DataNode> <DataNode TextLabel="citrate" GraphId="b8c8d" Type="Metabolite"> <Graphics CenterX="517.0416666666672" CenterY="827.7499999999998" Width="68.58333333333306" Height="25.0" ZOrder="32825" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:133748"/> </DataNode> <DataNode TextLabel="SLC2A1" GraphId="af066" Type="Protein"> <Comment>Solute carrier family 2, facilitated glucose transporter member 1</Comment> <Graphics CenterX="397.8333333333334" CenterY="122.66666666666677" Width="62.33333333333292" Height="25.0" ZOrder="32826" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P11166"/> </DataNode> <DataNode TextLabel="S-acetyl-CoA" GraphId="ded52" Type="Metabolite"> <Graphics CenterX="365.74999999999875" CenterY="827.7499999999998" Width="90.0" Height="25.0" ZOrder="32827" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15351"/> </DataNode> <DataNode TextLabel="LDHA" GraphId="bd8f6" Type="Protein"> <Comment>L-lactate dehydrogenase A chain</Comment> <Graphics CenterX="390.04166666666697" CenterY="722.4166666666665" Width="65.24999999999945" Height="25.0" ZOrder="32828" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P00338"/> </DataNode> <DataNode TextLabel="Aspartic acid" GraphId="f33d4" Type="Metabolite"> <Graphics CenterX="936.6666666666673" CenterY="665.9999999999981" Width="90.0" Height="25.0" ZOrder="32829" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:22660"/> </DataNode> <DataNode TextLabel="CS" GraphId="b9180" Type="Protein"> <Comment>Citrate synthase, mitochondrial</Comment> <Graphics CenterX="635.041666666667" CenterY="798.7500000000001" Width="47.916666666666515" Height="25.0" ZOrder="32830" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O75390"/> </DataNode> <DataNode TextLabel="Oxaloacetic acid" GraphId="a1ca2" Type="Metabolite"> <Graphics CenterX="792.7083333333304" CenterY="607.7499999999973" Width="114.58333333333329" Height="25.0" ZOrder="32831" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:30744"/> </DataNode> <DataNode TextLabel="citrate" GraphId="ead86" Type="Metabolite"> <Graphics CenterX="680.0416666666674" CenterY="843.4166666666661" Width="68.58333333333306" Height="25.0" ZOrder="32832" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:133748"/> </DataNode> <DataNode TextLabel="AcGlcN1P" GraphId="a4f3d" Type="Metabolite"> <Comment>Full name: N-Acetyl-D-glucosamine 1-phosphate</Comment> <Graphics CenterX="1081.0833333333333" CenterY="438.41666666666663" Width="90.0" Height="25.0" ZOrder="32834" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:7125"/> </DataNode> <DataNode TextLabel="BCAA" GraphId="b39b9" Type="Metabolite"> <Comment>Branched chain amino acids (Leu, Ile, Val)</Comment> <Graphics CenterX="1188.3749999999998" CenterY="1267.4166666666674" Width="67.2499999999992" Height="25.0" ZOrder="32835" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:22918"/> </DataNode> <DataNode TextLabel="ACLY" GraphId="ffe29" Type="Protein"> <Comment>ATP-citrate synthase</Comment> <Graphics CenterX="450.8333333333359" CenterY="784.0000000000003" Width="53.00000000000006" Height="25.0" ZOrder="32836" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P53396"/> </DataNode> <DataNode TextLabel="BCAA" GraphId="c17d1" Type="Metabolite"> <Comment>Branched chain amino acids (Leu, Ile, Val)</Comment> <Graphics CenterX="1187.0416666666663" CenterY="1146.0000000000005" Width="67.2499999999992" Height="25.0" ZOrder="32837" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:22918"/> </DataNode> <DataNode TextLabel="cholesterol" GraphId="e41e6" Type="Metabolite"> <Graphics CenterX="442.41666666666737" CenterY="1061.0833333333333" Width="90.0" Height="25.0" ZOrder="32838" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16113"/> </DataNode> <DataNode TextLabel="BCAA" GraphId="c26f9" Type="Metabolite"> <Comment>Branched chain amino acids (Leu, Ile, Val)</Comment> <Graphics CenterX="1109.375000000002" CenterY="1017.7499999999993" Width="67.2499999999992" Height="25.0" ZOrder="32839" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:22918"/> </DataNode> <DataNode TextLabel="GLS2" GraphId="a330c" Type="Protein"> <Comment>Glutaminase liver isoform, mitochondrial</Comment> <Graphics CenterX="830.5" CenterY="1068.0" Width="49.0" Height="25.0" ZOrder="32840" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9UI32"/> </DataNode> <DataNode TextLabel="GOT1" GraphId="de67e" Type="Protein"> <Comment>Aspartate aminotransferase, cytoplasmic</Comment> <Graphics CenterX="914.8333333333313" CenterY="606.6666666666679" Width="50.33333333333347" Height="25.0" ZOrder="32842" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P17174"/> </DataNode> <DataNode TextLabel="glutamine" GraphId="bb0ac" Type="Metabolite"> <Graphics CenterX="797.3333333333334" CenterY="1146.0000000000007" Width="90.0" Height="25.0" ZOrder="32843" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:28300"/> </DataNode> <DataNode TextLabel="S-acetyl-CoA" GraphId="c1040" Type="Metabolite"> <Graphics CenterX="719.3750000000005" CenterY="779.0833333333336" Width="90.0" Height="25.0" ZOrder="32844" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15351"/> </DataNode> <DataNode TextLabel="glutamate" GraphId="e3b0e" Type="Metabolite"> <Graphics CenterX="1050.5" CenterY="931.7499999999999" Width="67.66666666666606" Height="25.0" ZOrder="32845" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:14321"/> </DataNode> <DataNode TextLabel="PDHA1" GraphId="d0000" Type="Protein" GroupRef="b6da5"> <Comment>Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial</Comment> <Graphics CenterX="671.125" CenterY="707.75" Width="43.75" Height="25.0" ZOrder="32846" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P08559"/> </DataNode> <DataNode TextLabel="Oxoglutaric acid" GraphId="c667c" Type="Metabolite"> <Graphics CenterX="1136.4999999999984" CenterY="980.7499999999993" Width="101.66666666666652" Height="25.0" ZOrder="32847" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:30915"/> </DataNode> <DataNode TextLabel="BCKDHA" GraphId="c1429" Type="Protein"> <Comment>2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial</Comment> <Graphics CenterX="935.9999999999993" CenterY="897.9999999999998" Width="57.333333333333485" Height="25.0" ZOrder="32848" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P12694"/> </DataNode> <DataNode TextLabel="GLUD1" GraphId="e7ca5" Type="Protein"> <Comment>Glutamate dehydrogenase 1, mitochondrial</Comment> <Graphics CenterX="1171.1666666666572" CenterY="926.0833333333337" Width="63.916666666666515" Height="25.0" ZOrder="32849" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P00367"/> </DataNode> <DataNode TextLabel="DLD" GraphId="d3b5c" Type="Protein" GroupRef="b6da5"> <Comment>Dihydrolipoyl dehydrogenase, mitochondrial</Comment> <Graphics CenterX="732.125" CenterY="679.4166666666674" Width="27.75" Height="25.0" ZOrder="32850" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P09622"/> </DataNode> <DataNode TextLabel="Oxoglutaric acid" GraphId="e9e0e" Type="Metabolite"> <Graphics CenterX="905.1666666666689" CenterY="1025.7500000000005" Width="101.66666666666652" Height="25.0" ZOrder="32851" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:30915"/> </DataNode> <DataNode TextLabel="D-glucosamine 6-phosphate" GraphId="b2ff5" Type="Metabolite"> <Graphics CenterX="753.3750000000025" CenterY="438.4166666666666" Width="178.58333333333405" Height="25.0" ZOrder="32852" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:58725"/> </DataNode> <DataNode TextLabel="ME1" GraphId="b2ceb" Type="Protein"> <Comment>NADP-dependent malic enzyme</Comment> <Graphics CenterX="557.7083333333321" CenterY="614.083333333334" Width="54.58333333333347" Height="25.0" ZOrder="32854" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P48163"/> </DataNode> <DataNode TextLabel="pyruvate" GraphId="e4ecb" Type="Metabolite"> <Graphics CenterX="505.1666666666666" CenterY="675.9999999999994" Width="68.9999999999999" Height="25.0" ZOrder="32856" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15361"/> </DataNode> <DataNode TextLabel="Oxaloacetic acid" GraphId="f22e9" Type="Metabolite"> <Graphics CenterX="866.6666666666667" CenterY="843.4166666666662" Width="114.58333333333329" Height="25.0" ZOrder="32858" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:30744"/> </DataNode> <DataNode TextLabel="succinyl-CoA" GraphId="a4ff4" Type="Metabolite"> <Graphics CenterX="844.4166666666648" CenterY="929.4166666666661" Width="90.0" Height="25.0" ZOrder="32860" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15380"/> </DataNode> <DataNode TextLabel="RPIA" GraphId="e9d01" Type="Protein"> <Comment>Ribose-5-phosphate isomerase</Comment> <Graphics CenterX="895.5000000000025" CenterY="309.66666666666674" Width="45.0" Height="25.0" ZOrder="32862" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P49247"/> </DataNode> <DataNode TextLabel="malates" GraphId="aebe1" Type="Metabolite"> <Graphics CenterX="640.7083333333316" CenterY="623.7499999999992" Width="63.91666666666879" Height="25.0" ZOrder="32864" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:25115"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="dafb2" Type="Protein"> <Graphics CenterX="286.83333333332723" CenterY="483.33333333333326" Width="59.66666666666691" Height="25.0" ZOrder="32865" FontWeight="Bold" FontSize="12" Valign="Middle" Color="ff3333"/> <Xref Database="Uniprot-TrEMBL" ID="P01116"/> </DataNode> <DataNode TextLabel="glutamate" GraphId="ccc3c" Type="Metabolite"> <Graphics CenterX="740.0000000000011" CenterY="1025.7500000000005" Width="90.0" Height="25.0" ZOrder="32866" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:14321"/> </DataNode> <DataNode TextLabel="GNPNAT1" GraphId="bb8bb" Type="Protein"> <Comment>Glucosamine 6-phosphate N-acetyltransferase</Comment> <Graphics CenterX="860.8333333333335" CenterY="486.4166666666667" Width="75.66666666666617" Height="25.0" ZOrder="32868" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q96EK6"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="c5f12" Type="Protein"> <Graphics CenterX="286.83333333332723" CenterY="233.33333333333294" Width="59.66666666666691" Height="25.0" ZOrder="32868" FontWeight="Bold" FontSize="12" Valign="Middle" Color="ff3333"/> <Xref Database="Uniprot-TrEMBL" ID="P01116"/> </DataNode> <DataNode TextLabel="SLC16A1" GraphId="c8153" Type="Protein"> <Comment>Monocarboxylate transporter 1</Comment> <Graphics CenterX="189.33333333333346" CenterY="611.9999999999989" Width="90.0" Height="25.0" ZOrder="32870" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P53985"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="eb28a" Type="Protein"> <Graphics CenterX="791.8333333333272" CenterY="645.9999999999986" Width="59.66666666666691" Height="25.0" ZOrder="32871" FontWeight="Bold" FontSize="12" Valign="Middle" Color="ff3333"/> <Xref Database="Uniprot-TrEMBL" ID="P01116"/> </DataNode> <DataNode TextLabel="GOT2" GraphId="e17c9" Type="Protein"> <Comment>Aspartate aminotransferase, mitochondrial</Comment> <Graphics CenterX="936.0416666666656" CenterY="780.4166666666655" Width="53.25" Height="25.0" ZOrder="32872" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P00505"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="d0cfa" Type="Protein"> <Graphics CenterX="1019.4999999999911" CenterY="606.6666666666679" Width="59.66666666666691" Height="25.0" ZOrder="32874" FontWeight="Bold" FontSize="12" Valign="Middle" Color="ff3333"/> <Xref Database="Uniprot-TrEMBL" ID="P01116"/> </DataNode> <DataNode TextLabel="HMGCR" GraphId="ff5f2" Type="Protein"> <Comment>3-hydroxy-3-methylglutaryl-coenzyme A reductase</Comment> <Graphics CenterX="499.3750000000017" CenterY="991.7499999999984" Width="67.91666666666674" Height="25.0" ZOrder="32874" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P04035"/> </DataNode> <DataNode TextLabel="FASN" GraphId="d2508" Type="Protein"> <Comment>Fatty acid synthase</Comment> <Graphics CenterX="256.83333333333337" CenterY="904.0000000000007" Width="54.33333333333326" Height="25.0" ZOrder="32876" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P49327"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="edeee" Type="Protein"> <Graphics CenterX="718.833333333329" CenterY="486.41666666666663" Width="59.66666666666691" Height="25.0" ZOrder="32877" FontWeight="Bold" FontSize="12" Valign="Middle" Color="ff3333"/> <Xref Database="Uniprot-TrEMBL" ID="P01116"/> </DataNode> <DataNode TextLabel="GLUD1" GraphId="b1bb0" Type="Protein"> <Comment>Glutamate dehydrogenase 1, mitochondrial</Comment> <Graphics CenterX="628.0416666666657" CenterY="975.7500000000005" Width="63.916666666666515" Height="25.0" ZOrder="32878" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P00367"/> </DataNode> <DataNode TextLabel="UAP1" GraphId="d4400" Type="Protein"> <Comment>UDP-N-acetylhexosamine pyrophosphorylase</Comment> <Graphics CenterX="1146.833333333332" CenterY="486.4166666666667" Width="50.33333333333397" Height="25.0" ZOrder="32880" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q16222"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="f7edf" Type="Protein"> <Graphics CenterX="1002.833333333328" CenterY="291.3333333333333" Width="59.66666666666691" Height="25.0" ZOrder="32880" FontWeight="Bold" FontSize="12" Valign="Middle" Color="ff3333"/> <Xref Database="Uniprot-TrEMBL" ID="P01116"/> </DataNode> <DataNode TextLabel="DLAT" GraphId="b7d89" Type="Protein" GroupRef="b6da5"> <Comment>Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial</Comment> <Graphics CenterX="652.5" CenterY="679.4166666666674" Width="37.0" Height="25.0" ZOrder="32882" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P10515"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="e045f" Type="Protein"> <Graphics CenterX="293.4999999999858" CenterY="738.0000000000002" Width="59.66666666666691" Height="25.0" ZOrder="32883" 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FontSize="12" Valign="Middle" Color="ff3333"/> <Xref Database="Uniprot-TrEMBL" ID="P01116"/> </DataNode> <DataNode TextLabel="LDLR" GraphId="f4ea6" Type="Protein"> <Comment>Low-density lipoprotein receptor</Comment> <Graphics CenterX="533.0833333333321" CenterY="1216.0833333333323" Width="90.0" Height="25.0" ZOrder="32888" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P01130"/> </DataNode> <DataNode TextLabel="RPE" GraphId="f675d" Type="Protein"> <Comment>Ribulose-phosphate 3-epimerase</Comment> <Graphics CenterX="895.5000000000025" CenterY="271.6666666666667" Width="45.0" Height="25.0" ZOrder="32890" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q96AT9"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="f46a3" Type="Protein"> <Graphics CenterX="610.8333333333263" CenterY="1042.333333333334" Width="59.66666666666691" Height="25.0" ZOrder="32891" FontWeight="Bold" FontSize="12" Valign="Middle" Color="ff3333"/> <Xref Database="Uniprot-TrEMBL" ID="P01116"/> </DataNode> <DataNode TextLabel="GPI" GraphId="f51d3" Type="Protein"> <Comment>Glucose-6-phosphate isomerase</Comment> <Graphics CenterX="401.83333333333337" CenterY="369.33333333333303" Width="56.999999999999545" Height="25.0" ZOrder="32892" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P06744"/> </DataNode> <DataNode TextLabel="Oxoglutaric acid" GraphId="b2d76" Type="Metabolite"> <Graphics CenterX="680.0416666666674" CenterY="929.4166666666661" Width="107.41666666666657" Height="25.0" ZOrder="32894" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:30915"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="a12dd" Type="Protein"> <Graphics CenterX="916.166666666658" CenterY="552.6666666666678" Width="59.66666666666691" Height="25.0" ZOrder="32896" FontWeight="Bold" FontSize="12" Valign="Middle" Color="ff3333"/> <Xref Database="Uniprot-TrEMBL" ID="P01116"/> </DataNode> <DataNode TextLabel="HMG-CoA" GraphId="f0732" 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