Pathways into methionine and folate cycles (Homo sapiens)

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CenterY="911.6571149641738" Width="105.0" Height="17.67496202927268" ZOrder="34290" FontSize="14" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:140785"/> </DataNode> <DataNode TextLabel="cob(I)alamin" GraphId="cca50" Type="Metabolite" GroupRef="b31bb"> <Graphics CenterX="103.34884973887577" CenterY="309.4580729710152" Width="95.58823529411771" Height="20.0" ZOrder="34296" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15982"/> </DataNode> <DataNode TextLabel="cbLA&#10;MMAA" GraphId="ba96a" Type="Protein" GroupRef="b31bb"> <Comment>Gene: MMAA</Comment> <Graphics CenterX="103.34884973887608" CenterY="334.757801985857" Width="56.62711463218302" Height="30.599458029684136" ZOrder="34298" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q8IVH4"/> </DataNode> <DataNode TextLabel="Methylmalonyl-CoA" GraphId="dedc0" Type="Metabolite"> <Graphics CenterX="105.58769888879746" CenterY="226.01718748411793" Width="115.1403916960893" Height="25.0" ZOrder="34300" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16625"/> </DataNode> <DataNode TextLabel="LMBRD1" GraphId="c3393" Type="Protein" GroupRef="beb7c"> <Comment>cblF</Comment> <BiopaxRef>d6a</BiopaxRef> <Graphics CenterX="105.54205081685534" CenterY="911.6266428459028" Width="65.67366283006095" Height="20.0" ZOrder="34304" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9NUN5"/> </DataNode> <DataNode TextLabel="MMACHC" GraphId="a6e5a" Type="Protein" GroupRef="a6fa5"> <Comment>cbLC</Comment> <BiopaxRef>d6a</BiopaxRef> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="83.91846134634655" CenterY="732.7134095342176" Width="69.04218467987891" Height="20.0" ZOrder="34306" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> </DataNode> <DataNode TextLabel="FMN" GraphId="b8d35" Type="Metabolite" GroupRef="a6fa5"> <Comment>cofactor</Comment> <Graphics CenterX="83.91846134634655" CenterY="752.7134095342175" Width="35.0" Height="20.0" ZOrder="34312" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="cHEBI:58210"/> </DataNode> <DataNode TextLabel="MMAB" GraphId="a2f71" Type="Protein" GroupRef="c5c43"> <Comment>cblB</Comment> <Graphics CenterX="259.0500759235998" CenterY="300.5740816398721" Width="50.0" Height="19.999999999999964" ZOrder="34316" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="60488"/> </DataNode> <DataNode TextLabel="PLP" GraphId="aa5b3" Type="Metabolite" GroupRef="b7a57"> <Graphics CenterX="987.7444965471235" CenterY="647.0970758887557" Width="29.218491436427122" Height="14.022832082131227" ZOrder="34324" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:597326"/> </DataNode> <DataNode TextLabel="PLP" GraphId="ff721" Type="Metabolite" GroupRef="c6c34"> <Graphics CenterX="754.0209336343112" CenterY="348.0526184937397" Width="29.218491436427122" Height="14.022832082131227" ZOrder="34326" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:597326"/> </DataNode> <DataNode TextLabel="MMADHC" GraphId="bd7d2" Type="Protein" GroupRef="c2d21"> <Comment>"cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891</Comment> <Comment>gene is called MMADHC</Comment> <BiopaxRef>d6a</BiopaxRef> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="665.4714866241854" CenterY="532.9577117302681" Width="69.31222582351963" Height="15.0" ZOrder="34332" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0"/> </DataNode> <DataNode TextLabel="MMADHC" GraphId="a95ff" Type="Protein" GroupRef="db1ac"> <Comment>"cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891</Comment> <Comment>gene is called MMADHC</Comment> <BiopaxRef>d6a</BiopaxRef> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="316.07408369876686" CenterY="535.6637652050626" Width="69.70075434611438" Height="23.25916248041142" ZOrder="34334" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0"/> </DataNode> <DataNode TextLabel="cob(II)alamin" GraphId="d4228" Type="Metabolite" GroupRef="c2d21"> <Comment>Should be cob(II)alamin according to literature</Comment> <Graphics CenterX="666.131278231716" CenterY="434.16585863905357" Width="89.53305977917793" Height="20.0" ZOrder="34631" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16304"/> </DataNode> <DataNode TextLabel="MMACHC" GraphId="e6863" Type="Protein" GroupRef="c2d21"> <Comment>Gene is called MMAC</Comment> <BiopaxRef>d6a</BiopaxRef> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="665.4714866241854" CenterY="502.9577117302674" Width="69.31222582351963" Height="15.0" ZOrder="34632" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> </DataNode> <DataNode TextLabel="FAD" GraphId="bb772" Type="Metabolite" GroupRef="c2d21"> <Comment>cofactor</Comment> <Graphics CenterX="665.4714866241851" CenterY="517.9577117302676" Width="35.00000000000003" Height="15.0" ZOrder="34633" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:57692"/> </DataNode> <DataNode TextLabel="FAD" GraphId="bf713" Type="Metabolite" GroupRef="c2d21"> <Graphics CenterX="569.8373168422615" CenterY="478.1375845007685" Width="35.00000000000003" Height="15.000000000000037" ZOrder="34635" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:57692"/> </DataNode> <DataNode TextLabel="MMACHC" GraphId="e61f3" Type="Protein" GroupRef="ecc0c"> <Comment>cbLC</Comment> <BiopaxRef>d6a</BiopaxRef> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="311.80311559434693" CenterY="731.4142111786485" Width="63.516797093539886" Height="20.0" ZOrder="34754" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> </DataNode> <DataNode TextLabel="FAD" GraphId="f0fb2" Type="Metabolite" GroupRef="ecc0c"> <Comment>cofactor</Comment> <Graphics CenterX="311.803115594346" CenterY="751.4142111786489" Width="35.00000000000005" Height="20.00000000000002" ZOrder="34755" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:57692"/> </DataNode> <DataNode TextLabel="cob(II)alamin" GraphId="c188d" Type="Metabolite" GroupRef="db1ac"> <Comment>Should be cob(II)alamin according to literature</Comment> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="315.49356322721496" CenterY="473.6768475415709" Width="98.25573259214246" Height="22.018062544108645" ZOrder="34757" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16304"/> </DataNode> <DataNode TextLabel="cob(II)alamin" GraphId="d4524" Type="Metabolite"> <Comment>Should be cob(II)alamin according to literature</Comment> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="196.2538723920876" CenterY="747.8342048187786" Width="98.25573259214246" Height="21.973419686965737" ZOrder="34760" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16304"/> </DataNode> <DataNode TextLabel="MMACHC" GraphId="f455f" Type="Protein" GroupRef="db1ac"> <Comment>cbLC</Comment> <BiopaxRef>d6a</BiopaxRef> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="315.49356322721854" CenterY="494.68587881362527" Width="63.516797093539886" Height="20.0" ZOrder="34762" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> </DataNode> <DataNode TextLabel="FAD" GraphId="b9e31" Type="Metabolite" GroupRef="db1ac"> <Comment>cofactor</Comment> <Graphics CenterX="316.2053069994586" CenterY="515.1692405822934" Width="35.00000000000005" Height="20.00000000000002" ZOrder="34763" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:57692"/> </DataNode> <DataNode TextLabel="MMADHC" GraphId="a0f6b" Type="Protein" GroupRef="caa18"> <Comment>"cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891</Comment> <Comment>gene is called MMADHC</Comment> <BiopaxRef>d6a</BiopaxRef> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="84.97322890824009" CenterY="530.5123726208994" Width="69.70075434611438" Height="22.224824324441542" ZOrder="34765" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0"/> </DataNode> <DataNode TextLabel="cob(II)alamin" GraphId="a2cd9" Type="Metabolite" GroupRef="caa18"> <Comment>Should be cob(II)alamin according to literature</Comment> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="84.9732289082394" CenterY="472.409971813572" Width="98.25573259214246" Height="22.018062544108645" ZOrder="34766" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16304"/> </DataNode> <DataNode TextLabel="MMACHC" GraphId="fa899" Type="Protein" GroupRef="caa18"> <Comment>cbLC</Comment> <BiopaxRef>d6a</BiopaxRef> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="84.97322890824002" CenterY="493.4190030856263" Width="63.516797093539886" Height="20.0" ZOrder="34767" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> </DataNode> <DataNode TextLabel="FMN" GraphId="b13f1" Type="Metabolite" GroupRef="caa18"> <BiopaxRef>dae</BiopaxRef> <Graphics CenterX="83.54974136375577" CenterY="511.4023648542934" Width="35.00000000000003" Height="15.000000000000037" ZOrder="34769" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="cHEBI:58210"/> </DataNode> <DataNode TextLabel="MMAA" GraphId="dcf83" Type="Protein" GroupRef="c5c43"> <Comment>cbLA</Comment> <Graphics CenterX="259.0500759235998" CenterY="280.5740816398723" Width="50.0" Height="19.999999999999964" ZOrder="34776" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q8IVH4"/> </DataNode> <DataNode TextLabel="TCN2" GraphId="cb0f8" Type="Protein"> <Comment>aka Transcobalamin 2</Comment> <Graphics CenterX="228.57988576398535" CenterY="1193.5131113981683" Width="55.0" Height="20.0" ZOrder="34812" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P20062"/> </DataNode> <DataNode TextLabel="TCN1" GraphId="a4900" Type="Protein"> <Comment>aka haptocorrin or transcobalamin 1</Comment> <Comment>Produced in saliva and stomach</Comment> <BiopaxRef>af9</BiopaxRef> <Graphics CenterX="392.69606007388137" CenterY="1449.4094701668962" Width="55.0" Height="20.0" ZOrder="34813" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P20061"/> </DataNode> <DataNode TextLabel="CUBN" GraphId="c6826" Type="Protein" GroupRef="bc4c5"> <Comment>aka cubilin</Comment> <Graphics CenterX="386.42166673029817" CenterY="1307.1857665068308" Width="55.0" Height="20.0" ZOrder="34814" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O60494"/> </DataNode> <DataNode TextLabel="Cbl" GraphId="b475f" Type="Metabolite" GroupRef="b8033"> <Graphics CenterX="305.68443985319203" CenterY="1482.3172964054756" Width="55.0" Height="20.0" ZOrder="34815" FontSize="14" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:23334"/> </DataNode> <DataNode TextLabel="cobalamins&#10;" GraphId="ecb8c" Type="Metabolite" GroupRef="f0895"> <Graphics CenterX="304.4845966082104" CenterY="1574.593972598219" Width="81.31597946455234" Height="20.0" ZOrder="34816" FontSize="14" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:23334"/> </DataNode> <DataNode TextLabel="TCN1" GraphId="ee828" Type="Protein" GroupRef="b8033"> <Comment>aka haptocorrin or transcobalamin 1</Comment> <Graphics CenterX="305.68443985319203" CenterY="1502.3172964054756" Width="55.0" Height="20.0" ZOrder="34817" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P20061"/> </DataNode> <DataNode TextLabel="Cbl" GraphId="e8b1a" Type="Metabolite"> <BiopaxRef>af9</BiopaxRef> <Graphics CenterX="305.68443985319203" CenterY="1420.207000790871" Width="55.0" Height="20.0" ZOrder="34818" FontSize="14" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:23334"/> </DataNode> <DataNode TextLabel="Cbl" GraphId="fc51a" Type="Metabolite" GroupRef="fba28"> <Graphics CenterX="305.68443985319203" CenterY="1338.8840327933358" Width="55.0" Height="20.0" ZOrder="34820" FontSize="14" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:23334"/> </DataNode> <DataNode TextLabel="CBLIF" GraphId="d6766" Type="Protein"> <Comment>aka (gastric) intrinsic factor, transcobalamin III</Comment> <Comment>Located in gastric parietal cells</Comment> <Graphics CenterX="382.0284089822242" CenterY="1401.8952812158736" Width="55.0" Height="20.0" ZOrder="34821" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P27352"/> </DataNode> <DataNode TextLabel="CBLIF" GraphId="cc254" Type="Protein" GroupRef="fba28"> <Comment>aka intrinsic factor</Comment> <Graphics CenterX="305.68443985319203" CenterY="1358.8840327933358" Width="55.0" Height="20.0" ZOrder="34822" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P27352"/> </DataNode> <DataNode TextLabel="Cbl" GraphId="c8629" Type="Metabolite" GroupRef="ea5ad"> <Graphics CenterX="305.68443985319203" CenterY="1231.4213390546824" Width="55.0" Height="20.0" ZOrder="34825" FontSize="14" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:23334"/> </DataNode> <DataNode TextLabel="CBLIF" GraphId="e71d9" Type="Protein" GroupRef="ea5ad"> <Comment>aka intrinsic factor</Comment> <Graphics CenterX="305.68443985319203" CenterY="1251.4213390546827" Width="55.0" Height="20.0" ZOrder="34826" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P27352"/> </DataNode> <DataNode TextLabel="AMN" GraphId="da282" Type="Protein" GroupRef="bc4c5"> <Comment>aka amnionless</Comment> <Graphics CenterX="386.42166673029817" CenterY="1327.1857665068308" Width="55.0" Height="20.0" ZOrder="34827" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9BXJ7"/> </DataNode> <DataNode TextLabel="Cbl" GraphId="c6a20" Type="Metabolite" GroupRef="c6d0b"> <Graphics CenterX="189.22399541493468" CenterY="1070.2361789804527" Width="55.0" Height="20.0" ZOrder="34842" FontSize="14" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:23334"/> </DataNode> <DataNode TextLabel="TCN2" GraphId="c1b85" Type="Protein" GroupRef="c6d0b"> <Comment>aka Transcobalamin 2</Comment> <BiopaxRef>af9</BiopaxRef> <Graphics CenterX="189.22399541493468" CenterY="1090.2361789804527" Width="55.0" Height="20.0" ZOrder="34843" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P20062"/> </DataNode> <DataNode TextLabel="CBLIF" GraphId="a6060" Type="Protein"> <Comment>aka (gastric) intrinsic factor, transcobalamin III</Comment> <Comment>Located in gastric parietal cells</Comment> <Graphics CenterX="200.27413754129384" CenterY="1309.9469754039096" Width="55.0" Height="20.0" ZOrder="34845" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P27352"/> </DataNode> <DataNode TextLabel="TCN1" GraphId="ed76f" Type="Protein"> <Comment>aka haptocorrin or transcobalamin 1</Comment> <Comment>Produced in saliva and stomach</Comment> <BiopaxRef>af9</BiopaxRef> <Graphics CenterX="376.86372659435955" CenterY="1541.6530730258025" Width="55.0" Height="20.0" ZOrder="34847" FontSize="14" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P20061"/> </DataNode> <DataNode TextLabel="B2" GraphId="d0faa" Type="Metabolite"> <BiopaxRef>f83</BiopaxRef> <BiopaxRef>dae</BiopaxRef> <BiopaxRef>e60</BiopaxRef> <Graphics CenterX="533.6392864583058" CenterY="1330.7449763304496" Width="35.0" Height="20.0" ZOrder="34848" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17015"/> </DataNode> <DataNode TextLabel="B2" GraphId="b6e2b" Type="Metabolite"> <BiopaxRef>f83</BiopaxRef> <BiopaxRef>dae</BiopaxRef> <BiopaxRef>e60</BiopaxRef> <Graphics CenterX="531.5384461221713" CenterY="1218.593459117012" Width="35.0" Height="20.0" ZOrder="34849" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17015"/> </DataNode> <DataNode TextLabel="Cbl" GraphId="ba08e" Type="Metabolite"> <BiopaxRef>af9</BiopaxRef> <Graphics CenterX="305.68443985319203" CenterY="1175.7485160370827" Width="55.0" Height="20.0" ZOrder="34850" FontSize="14" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:23334"/> </DataNode> <DataNode TextLabel="Cbl" GraphId="f212a" Type="Metabolite"> <BiopaxRef>af9</BiopaxRef> <Graphics CenterX="305.68443985319203" CenterY="1087.2605378498572" Width="55.0" Height="20.0" ZOrder="34851" FontSize="14" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:23334"/> </DataNode> <DataNode TextLabel="MMACHC" GraphId="eb1cf" Type="Protein" GroupRef="beb7c"> <Comment>cbLC</Comment> <BiopaxRef>d6a</BiopaxRef> <BiopaxRef>b51</BiopaxRef> <Graphics CenterX="230.93035590299496" CenterY="890.8483082644201" Width="63.516797093539886" Height="20.900786068562553" ZOrder="34902" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> </DataNode> <DataNode TextLabel="GNMT" GraphId="f8942" Type="Protein"> <Graphics CenterX="368.3889556466417" CenterY="407.893044228967" Width="55.0" Height="20.0" ZOrder="34907" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q14749"/> </DataNode> <DataNode TextLabel="glycine" GraphId="f1b36" Type="Metabolite"> <BiopaxRef>de7</BiopaxRef> <Graphics CenterX="393.3482261690768" CenterY="564.9822760706978" Width="50.0" Height="20.0" ZOrder="34908" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:57305"/> </DataNode> <DataNode TextLabel="serine" GraphId="cee1e" Type="Metabolite"> <BiopaxRef>de7</BiopaxRef> <Graphics CenterX="1247.0888377657832" CenterY="608.2069507381929" Width="41.536610182716814" Height="20.981056506806908" ZOrder="35049" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q82980657"/> </DataNode> <DataNode TextLabel="glycine" GraphId="e5f8a" Type="Metabolite"> <BiopaxRef>de7</BiopaxRef> <Graphics CenterX="1197.630228294002" CenterY="695.395669035679" Width="50.0" Height="20.0" ZOrder="35050" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:57305"/> </DataNode> <DataNode TextLabel="vitamin B6" GraphId="e9df0" Type="Metabolite"> <Comment/> <Graphics CenterX="936.1643877436653" CenterY="1425.6566694044973" Width="79.73684210526318" Height="25.0" ZOrder="35131" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:27306"/> </DataNode> <DataNode TextLabel="NGLY1" GraphId="a18fc" Type="Protein" GroupRef="bf3c4"> <Comment>PNG hydrolase, PNGH</Comment> <Graphics CenterX="1101.8544468796422" CenterY="1259.0965456656431" Width="45.0" Height="20.0" ZOrder="35132" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q96IV0"/> </DataNode> <DataNode TextLabel="SLC?" GraphId="f2d05" Type="Protein"> <Graphics CenterX="1089.6047150804313" CenterY="1161.2837928299352" Width="33.62828713574925" Height="19.607320540158597" ZOrder="35133" FontSize="12" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="ALPI" GraphId="a43de" Type="Protein" GroupRef="c9c15"> <Comment>Intestinal-type alkaline phosphatase</Comment> <Graphics CenterX="1041.6410373484587" CenterY="1194.4587145793748" Width="44.724789915965374" Height="20.10294117647109" ZOrder="35134" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P09923"/> </DataNode> <DataNode TextLabel="Zn2+" GraphId="fc699" Type="Metabolite" GroupRef="bf3c4"> <Graphics CenterX="1101.8544468796422" CenterY="1279.0965456656431" Width="35.0" Height="20.0" ZOrder="35135" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:29105"/> </DataNode> <DataNode TextLabel="PNPO" GraphId="fb1fc" Type="Protein"> <Graphics CenterX="1021.5668241465099" CenterY="965.3510804974869" Width="50.0" Height="20.0" ZOrder="35137" FontSize="12" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9NVS9"/> </DataNode> <DataNode TextLabel="PLP" GraphId="c4f31" Type="Metabolite"> <Comment>pyridoxal 5'-phosphate</Comment> <BiopaxRef>f9c</BiopaxRef> <Graphics CenterX="1149.4872002809097" CenterY="1342.0587300471034" Width="35.0" Height="20.0" ZOrder="35150" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:597326"/> </DataNode> <DataNode TextLabel="PMP" GraphId="bf324" Type="Metabolite"> <Comment>pyridoxamine 5'-phosphate</Comment> <BiopaxRef>f9c</BiopaxRef> <Graphics CenterX="907.7364071318351" CenterY="1342.0587300471034" Width="35.0" Height="20.0" ZOrder="35151" FontSize="12" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:18335"/> </DataNode> <DataNode TextLabel="PNP" GraphId="cb138" Type="Metabolite"> <Comment>pyridoxine 5′-phosphate</Comment> <BiopaxRef>f9c</BiopaxRef> <Graphics 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TextLabel="SLC?" 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Return to Pathways into methionine and folate cycles (Homo sapiens).