Phosphoinositide 3-kinase (PI3K) family (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Phosphoinositide 3-kinase (PI3K) family" Version="20240522" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Classes of PI3K genes</Comment> <BiopaxRef>c11</BiopaxRef> <Graphics BoardWidth="235.0" BoardHeight="358.0" /> <DataNode TextLabel="PIK3CA" GraphId="e535e" Type="GeneProduct"> <Graphics CenterX="55.0" CenterY="97.0" Width="60.0" Height="20.0" ZOrder="33005" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000121879" /> </DataNode> <DataNode TextLabel="PIK3CB" GraphId="e017d" Type="GeneProduct"> <Graphics CenterX="55.0" CenterY="117.0" Width="60.0" Height="20.0" ZOrder="33006" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000051382" /> </DataNode> <DataNode TextLabel="PIK3CG" GraphId="b6e4d" Type="GeneProduct"> <Graphics CenterX="55.0" CenterY="137.0" Width="60.0" Height="20.0" ZOrder="33007" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000105851" /> </DataNode> <DataNode TextLabel="PIK3CD" GraphId="c1085" Type="GeneProduct"> <Graphics CenterX="55.0" CenterY="157.0" Width="60.0" Height="20.0" ZOrder="33008" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000171608" /> </DataNode> <DataNode TextLabel="PIK3R1" GraphId="a115a" Type="GeneProduct"> <Graphics CenterX="57.0" CenterY="218.0" Width="60.0" Height="20.0" ZOrder="33010" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000145675" /> </DataNode> <DataNode TextLabel="PIK3R2" GraphId="eeb64" Type="GeneProduct"> <Graphics CenterX="57.0" CenterY="238.0" Width="60.0" Height="20.0" ZOrder="33011" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000105647" /> </DataNode> <DataNode TextLabel="PIK3R3" GraphId="f7568" Type="GeneProduct"> <Graphics CenterX="57.0" CenterY="258.0" Width="60.0" Height="20.0" ZOrder="33012" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000117461" /> </DataNode> <DataNode TextLabel="PIK3R4" GraphId="e0735" Type="GeneProduct"> <Graphics CenterX="57.0" CenterY="278.0" Width="60.0" Height="20.0" ZOrder="33013" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000196455" /> </DataNode> <DataNode TextLabel="PIK3R4" GraphId="aad3e" Type="GeneProduct"> <Graphics CenterX="57.0" CenterY="298.0" Width="60.0" Height="20.0" ZOrder="33015" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000196455" /> </DataNode> <DataNode TextLabel="PIK3R6" GraphId="a4ade" Type="GeneProduct"> <Graphics CenterX="57.0" CenterY="318.0" Width="60.0" Height="20.0" ZOrder="33016" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000276231" /> </DataNode> <DataNode TextLabel="PIK3C2A" GraphId="c1029" Type="GeneProduct"> <Graphics CenterX="175.0" CenterY="97.0" Width="60.0" Height="20.0" ZOrder="33017" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000011405" /> </DataNode> <DataNode TextLabel="PIK3C2B" GraphId="aaf0c" Type="GeneProduct"> <Graphics CenterX="175.0" CenterY="117.0" Width="60.0" Height="20.0" ZOrder="33018" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000133056" /> </DataNode> <DataNode TextLabel="PIK3C2G" GraphId="fd886" Type="GeneProduct"> <Graphics CenterX="175.0" CenterY="137.0" Width="60.0" Height="20.0" ZOrder="33019" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000139144" /> </DataNode> <DataNode TextLabel="PIK3C2A" GraphId="cfcda" Type="GeneProduct"> <Graphics CenterX="174.0" CenterY="191.0" Width="60.0" Height="20.0" ZOrder="33021" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000011405" /> </DataNode> <Label TextLabel="Class 1 catalytic" GraphId="da622"> <Graphics CenterX="75.0" CenterY="75.0" Width="110.0" Height="25.0" ZOrder="33009" FillColor="ffffff" FontSize="12" Valign="Middle" Align="Left" /> </Label> <Label TextLabel="Class 1 regulatory" GraphId="a8c0c"> <Graphics CenterX="77.0" CenterY="196.0" Width="110.0" Height="25.0" ZOrder="33014" FillColor="ffffff" FontSize="12" Valign="Middle" Align="Left" /> </Label> <Label TextLabel="Class 2" GraphId="f961d"> <Graphics CenterX="171.0" CenterY="75.0" Width="60.0" Height="25.0" ZOrder="33020" FillColor="ffffff" FontSize="12" Valign="Middle" Align="Left" /> </Label> <Label TextLabel="Class 3" GraphId="d560d"> <Graphics CenterX="170.0" CenterY="169.0" Width="60.0" Height="25.0" ZOrder="33022" FillColor="ffffff" FontSize="12" Valign="Middle" Align="Left" /> </Label> <InfoBox CenterX="0.0" CenterY="0.0" /> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c11"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10209156</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Signalling through phosphoinositide 3-kinases: the lipids take centre stage.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Curr Opin Cell Biol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1999</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Leevers SJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vanhaesebroeck B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Waterfield MD</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

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