Inhibition of GNAQ-regulated signaling in uveal melanoma (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Inhibition of GNAQ-regulated signaling in uveal melanoma" Version="20240626" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">This pathway describes parallel and converging signaling pathways driven by Gαq (GNAQ) in Uveal Melanoma, and the inhibitory effects of Darovasertib and FAKi (FAK inhibitor). Key points from [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694608/ Arang et al]: Darovasertib is a dual inhibitor of PKC and PRK/PKN; downstream of mutant Gαq darovasertib blocks ERK and diminishes FAK activity; Darovasertib and FAKi act synergistically in preclinical uveal melanoma models. 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