MSMP expression regulation in cancer cells and its pro-angiogenic role in ovarian tumors (Homo sapiens)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="MSMP expression regulation in cancer cells and its pro-angiogenic role in ovarian tumors" Version="20181019" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Proposed model for regulation of MSMP expression in cancer cells under hypoxic conditions and the proangiogenic role of MSMP in ovarian tumors. The recruitment of the transcriptional repressor CTCF to the MSMP enhancer region is regulated by changes in H3 acetylation of the MSMP enhancer. In hypoxic conditions, the repressor-enhancer binding is disrupted, leading to increased expression of MSMP. Secretion of MSMP triggers MAPK signaling in endothelial cells (presumably via CCR2 signaling), which promotes angiogenesis. This suggests that MSMP inhibition in combination with antiangiogenesis drugs (anti-VEGF) could be a new strategy to overcome resistance to antiangiogenesis therapy. Description adapted from Mitamura et al.</Comment> <BiopaxRef>a27</BiopaxRef> <Graphics BoardWidth="829.0" BoardHeight="494.0" /> <DataNode TextLabel="MAPK signaling" GraphId="cc697" Type="Pathway"> <Graphics CenterX="577.0" CenterY="155.0" Width="110.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP382" /> </DataNode> <DataNode TextLabel="CCR2" GraphId="cfb00" Type="GeneProduct"> <Graphics CenterX="244.0" CenterY="58.0" Width="66.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000121807" /> </DataNode> <DataNode TextLabel="Angiogenesis" GraphId="fbde6" Type="Pathway"> <Graphics CenterX="577.0" CenterY="317.0" Width="90.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> <Xref Database="WikiPathways" ID="WP1539" /> </DataNode> <DataNode TextLabel="MSMP" GraphId="d1da7" Type="GeneProduct"> <Graphics CenterX="438.0" CenterY="25.0" Width="66.0" Height="25.0" ZOrder="32769" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000215183" /> </DataNode> <DataNode TextLabel="CTCF" GraphId="fdaf6" Type="GeneProduct"> <Graphics CenterX="147.0" CenterY="148.0" Width="66.0" Height="25.0" ZOrder="32770" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000102974" /> </DataNode> <DataNode TextLabel="CCR2" GraphId="f027b" Type="GeneProduct"> <Graphics CenterX="577.0" CenterY="74.0" Width="66.0" Height="25.0" ZOrder="32771" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000121807" /> </DataNode> <DataNode TextLabel="MSMP" GraphId="f82fe" Type="GeneProduct"> <Graphics CenterX="302.0" CenterY="215.0" Width="66.0" Height="25.0" ZOrder="32773" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000215183" /> </DataNode> <DataNode TextLabel="Hypoxia" GraphId="af3c3"> <Graphics CenterX="82.5" CenterY="177.0" Width="60.0" Height="25.0" ZOrder="32774" FillColor="ffdddd" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" /> <Xref Database="Wikidata" ID="Q105688" /> </DataNode> <Interaction GraphId="id21e68210"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="471.0" Y="25.0" GraphRef="d1da7" RelX="1.0" RelY="0.0" /> <Point X="577.0" Y="61.5" GraphRef="f027b" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id22e062bf"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="577.0" Y="167.5" GraphRef="cc697" RelX="0.0" RelY="1.0" /> <Point X="577.0" Y="304.5" GraphRef="fbde6" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id6cf42c20"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="577.0" Y="86.5" GraphRef="f027b" RelX="0.0" RelY="1.0" /> <Point X="577.0" Y="142.5" GraphRef="cc697" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id91172c9a"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="112.5" Y="177.0" GraphRef="af3c3" RelX="1.0" RelY="0.0" /> <Point X="147.0" Y="177.3" GraphRef="c66f9" RelX="0.0" RelY="0.0" ArrowHead="mim-inhibition" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idadc1aca0"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="335.0" Y="215.0" GraphRef="f82fe" RelX="1.0" RelY="0.0" /> <Point X="438.0" Y="37.5" GraphRef="d1da7" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idec828738"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="147.0" Y="160.5" GraphRef="fdaf6" RelX="0.0" RelY="1.0" /> <Point X="147.0" Y="202.5" GraphRef="c331b" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" /> <Anchor Position="0.4" Shape="None" GraphId="c66f9" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idfd0d0cde"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="225.0" Y="215.0" GraphRef="ba295" RelX="1.0" RelY="0.0" /> <Point X="269.0" Y="215.0" GraphRef="f82fe" RelX="-1.0" RelY="0.0" ArrowHead="mim-transcription-translation" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="e528d"> <Graphics ConnectorType="Elbow" ZOrder="32772" LineThickness="1.0"> <Point X="405.0" Y="25.0" GraphRef="d1da7" RelX="-1.0" RelY="0.0" /> <Point X="244.0" Y="45.5" GraphRef="cfb00" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <GraphicalLine GraphId="id661ab566" GroupRef="b470e"> <Graphics ZOrder="12288" LineThickness="2.0"> <Point X="64.0" Y="225.0" /> <Point X="217.0" Y="225.0" /> </Graphics> </GraphicalLine> <Label TextLabel="Enhancer" GraphId="c331b" GroupRef="b470e"> <Graphics CenterX="147.0" CenterY="215.0" Width="68.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" /> </Label> <Shape TextLabel="Tumor cell" GraphId="ae571"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" /> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="205.0" CenterY="197.5" Width="372.0" Height="279.0" ZOrder="16384" FontSize="12" Valign="Bottom" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> </Shape> <Shape TextLabel="Nucleus" GraphId="eaca3"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Nucleus" /> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="198.5" CenterY="199.5" Width="341.0" Height="201.0" ZOrder="16384" FontSize="12" Valign="Bottom" ShapeType="Oval" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> </Shape> <Shape TextLabel="Endothelial cell" GraphId="fa129"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" /> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> <Graphics CenterX="592.0" CenterY="152.0" Width="214.0" Height="150.0" ZOrder="16384" FontSize="12" Valign="Bottom" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> </Shape> <Group GroupId="b470e" GraphId="ba295" Style="Group" /> <InfoBox CenterX="0.0" CenterY="0.0" /> <Biopax> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">endothelial cell</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CL:0000115</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">neoplastic cell</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CL:0001063</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a27"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29059175</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP).</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oncogene</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2018</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mitamura T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pradeep S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McGuire M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wu SY</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ma S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hatakeyama H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lyons YA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hisamatsu T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Noh K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Villar-Prados A</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen X</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ivan C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rodriguez-Aguayo C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hu W</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lopez-Berestein G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Coleman RL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sood AK</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ovarian cancer</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:2394</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CC chemokine mediated signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000831</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cancer pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000605</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> </Biopax> </Pathway>

• Template:AuthorInfo
• Template:CheckAvailable (protected)
• Template:Help:LiteratureReferences (protected)
• Template:PathwayPage:History
• Template:PathwayPage:Xrefs

Return to MSMP expression regulation in cancer cells and its pro-angiogenic role in ovarian tumors (Homo sapiens).