GPCRs, other (Homo sapiens)

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<?xml version="1.0" encoding="ISO-8859-1"?> <Pathway xmlns="http://genmapp.org/GPML/2007" Name="GPCRs, Other" Data-Source="GenMAPP 2.0" Version="20041216" Author="Adapted from GPCRDB (Horn et al., 1998)" Maintainer="Nathan Salomonis" Email="nsalomonis@gladstone.ucsf.edu" Last-Modified="2/25/02" Organism="Homo sapiens"> <Comment Source="GenMAPP notes">This MAPP was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.</Comment> <Comment Source="GenMAPP remarks">Right-click here to see Notes.</Comment> <Comment Source="WikiPathways-category">Molecular Function</Comment> <Graphics BoardWidth="12947.6" BoardHeight="10055.9" WindowWidth="13260.0" WindowHeight="11613.0" /> <DataNode TextLabel="GPR84" Type="GeneProduct" BackpageHead="GPR84 | G protein-coupled receptor 84" GraphId="d4e"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="2350.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="53831" /> </DataNode> <DataNode TextLabel="RLN3R1" Type="GeneProduct" BackpageHead="RLN3R1 | relaxin 3 receptor 1" GraphId="d61"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="6550.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="51289" /> </DataNode> <DataNode TextLabel="TAAR3" Type="GeneProduct" BackpageHead="TAAR3 | trace amine associated receptor 3" GraphId="c66"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="6850.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="9288" /> </DataNode> <DataNode TextLabel="TAAR2" Type="GeneProduct" BackpageHead="TAAR2 | trace amine associated receptor 2" GraphId="f73"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="2650.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="9287" /> </DataNode> <DataNode TextLabel="GPR77" Type="GeneProduct" BackpageHead="GPR77 | G protein-coupled receptor 77" GraphId="b11"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="2950.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="27202" /> </DataNode> <DataNode TextLabel="GPR55" Type="GeneProduct" BackpageHead="GPR55 | G protein-coupled receptor 55" GraphId="d9c"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="3850.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="9290" /> </DataNode> <DataNode TextLabel="GPR145" Type="GeneProduct" BackpageHead="GPR145 | G protein-coupled receptor 145" GraphId="b0c"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="4150.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="84539" /> </DataNode> <DataNode TextLabel="GPR88" Type="GeneProduct" BackpageHead="GPR88 | G-protein coupled receptor 88" GraphId="c39"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="4450.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="54112" /> </DataNode> <DataNode TextLabel="GPR62" Type="GeneProduct" BackpageHead="GPR62 | G protein-coupled receptor 62" GraphId="e94"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="4750.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="118442" /> </DataNode> <DataNode TextLabel="GPR135" Type="GeneProduct" BackpageHead="GPR135 | G protein-coupled receptor 135" GraphId="b65"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="5650.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="64582" /> </DataNode> <DataNode TextLabel="GPR" Type="GeneProduct" BackpageHead="GPR | putative G protein coupled receptor" GraphId="a39"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="5950.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="11245" /> </DataNode> <DataNode TextLabel="TAAR5" Type="GeneProduct" BackpageHead="TAAR5 | trace amine associated receptor 5" GraphId="f68"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="5650.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="9038" /> </DataNode> <DataNode TextLabel="VN1R1" Type="GeneProduct" BackpageHead="VN1R1 | vomeronasal 1 receptor 1" GraphId="f96"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="7150.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="57191" /> </DataNode> <DataNode TextLabel="HRH4" Type="GeneProduct" BackpageHead="HRH4 | histamine receptor H4" GraphId="c21"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="9250.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="59340" /> </DataNode> <DataNode TextLabel="CCR5" Type="GeneProduct" BackpageHead="CCR5 | chemokine (C-C motif) receptor 5" GraphId="f93"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="4450.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="1234" /> </DataNode> <DataNode TextLabel="OR7E24" Type="GeneProduct" BackpageHead="OR7E24 | olfactory receptor family 7 subfamil..." 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GraphId="cd2"> <Graphics Color="Transparent" CenterX="5900.0" CenterY="8350.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="3356" /> </DataNode> <DataNode TextLabel="IL8RB" Type="GeneProduct" BackpageHead="IL8RB | interleukin 8 receptor beta" GraphId="a06"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="2350.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="3579" /> </DataNode> <DataNode TextLabel="IL8RA" Type="GeneProduct" BackpageHead="IL8RA | interleukin 8 receptor alpha" GraphId="a58"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="2650.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="3577" /> </DataNode> <DataNode TextLabel="Q9UDD7" Type="GeneProduct" BackpageHead="fragment" GraphId="c81"> <Graphics Color="Transparent" CenterX="11950.0" CenterY="2350.0" Width="1000.0" Height="300.0" /> <Xref Database="SwissProt" ID="Q9UDD7" /> </DataNode> <DataNode TextLabel="Q9UDD8" Type="GeneProduct" BackpageHead="fragment" GraphId="f0d"> <Graphics Color="Transparent" CenterX="11950.0" CenterY="2650.0" Width="1000.0" Height="300.0" /> <Xref Database="SwissProt" ID="Q9UDD8" /> </DataNode> <DataNode TextLabel="Q9UEB1" Type="GeneProduct" BackpageHead="fragment" GraphId="f36"> <Graphics Color="Transparent" CenterX="11950.0" CenterY="2950.0" Width="1000.0" Height="300.0" /> <Xref Database="SwissProt" ID="Q9UEB1" /> </DataNode> <DataNode TextLabel="OR10A2" Type="GeneProduct" BackpageHead="OR10A2 | olfactory receptor family 10 subfami..." 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GraphId="a8b"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="6550.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="53829" /> </DataNode> <DataNode TextLabel="GPR132" Type="GeneProduct" BackpageHead="GPR132 | G protein-coupled receptor 132" GraphId="bc8"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="6850.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="29933" /> </DataNode> <DataNode TextLabel="GPR73L1" Type="GeneProduct" BackpageHead="GPR73L1 | G protein-coupled receptor 73-like 1" GraphId="d87"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="7450.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="128674" /> </DataNode> <DataNode TextLabel="GPR133" Type="GeneProduct" BackpageHead="GPR133 | G protein-coupled receptor 133" GraphId="ec7"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="7150.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="283383" /> </DataNode> <DataNode TextLabel="GPR18" Type="GeneProduct" BackpageHead="GPR18 | G protein-coupled receptor 18" GraphId="a14"> <Graphics Color="Transparent" CenterX="1550.0" CenterY="7750.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="2841" /> </DataNode> <DataNode TextLabel="OR10A1" Type="GeneProduct" BackpageHead="OR10A1 fragment" GraphId="e55"> <Graphics Color="Transparent" CenterX="5900.0" CenterY="2950.0" Width="1000.0" Height="300.0" /> <Xref Database="SwissProt" ID="O95223" /> </DataNode> <DataNode TextLabel="CCR2" Type="GeneProduct" BackpageHead="CCR2 | chemokine (C-C motif) receptor 2" GraphId="ea6"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="4150.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="1231" /> </DataNode> <DataNode TextLabel="ADRA1D" Type="GeneProduct" BackpageHead="ADRA1D | adrenergic alpha-1D- receptor" GraphId="cb0"> <Graphics Color="Transparent" CenterX="5900.0" CenterY="5350.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="146" /> </DataNode> <DataNode TextLabel="ADORA3" Type="GeneProduct" BackpageHead="ADORA3 | adenosine A3 receptor" GraphId="f9c"> <Graphics Color="Transparent" CenterX="5900.0" CenterY="5050.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="140" /> </DataNode> <DataNode TextLabel="ADRB2" Type="GeneProduct" BackpageHead="ADRB2 | adrenergic beta-2- receptor surface" GraphId="e89"> <Graphics Color="Transparent" CenterX="5900.0" CenterY="5950.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="154" /> </DataNode> <DataNode TextLabel="OR7E18P" Type="GeneProduct" BackpageHead="OR7E18P | olfactory receptor family 7 subfami..." 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GraphId="d8a"> <Graphics Color="Transparent" CenterX="5900.0" CenterY="4750.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="9620" /> </DataNode> <DataNode TextLabel="O60411" Type="GeneProduct" BackpageHead="fragment" GraphId="eb6"> <Graphics Color="Transparent" CenterX="11950.0" CenterY="4150.0" Width="1000.0" Height="300.0" /> <Xref Database="SwissProt" ID="O60411" /> </DataNode> <DataNode TextLabel="OR51A1P" Type="GeneProduct" BackpageHead="OR51A1P | olfactory receptor family 51 subfam..." 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GraphId="ca0"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="7750.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="2692" /> </DataNode> <DataNode TextLabel="GRCA" Type="GeneProduct" BackpageHead="GRCA | gene rich cluster A gene" GraphId="baf"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="8050.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="27239" /> </DataNode> <DataNode TextLabel="GPR83" Type="GeneProduct" BackpageHead="GPR83 | G protein-coupled receptor 83" GraphId="adf"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="8350.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="10888" /> </DataNode> <DataNode TextLabel="GRM1" Type="GeneProduct" BackpageHead="GRM1 | glutamate receptor metabotropic 1" GraphId="c22"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="8650.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="2911" /> </DataNode> <DataNode TextLabel="DRD3" Type="GeneProduct" BackpageHead="DRD3 | dopamine receptor D3" GraphId="a82"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="4750.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="1814" /> </DataNode> <DataNode TextLabel="DRD4" Type="GeneProduct" BackpageHead="DRD4 | dopamine receptor D4" GraphId="cb8"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="5050.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="1815" /> </DataNode> <DataNode TextLabel="EMR2" Type="GeneProduct" BackpageHead="EMR2 | egf-like module containing mucin-like ..." GraphId="ff7"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="5650.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="30817" /> </DataNode> <DataNode TextLabel="EBI2" Type="GeneProduct" BackpageHead="EBI2 | Epstein-Barr virus induced gene 2 (lymph..." GraphId="dcc"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="5950.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="1880" /> </DataNode> <DataNode TextLabel="EDNRA" Type="GeneProduct" BackpageHead="EDNRA | endothelin receptor type A" GraphId="a04"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="6550.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="1909" /> </DataNode> <DataNode TextLabel="EMR3" Type="GeneProduct" BackpageHead="EMR3 | egf-like module containing mucin-like ..." GraphId="f5f"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="5350.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="84658" /> </DataNode> <DataNode TextLabel="FY" Type="GeneProduct" BackpageHead="FY | Duffy blood group" GraphId="e5f"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="7450.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="2532" /> </DataNode> <DataNode TextLabel="ALG6" Type="GeneProduct" BackpageHead="ALG6 | asparagine-linked glycosylation 6 homolo..." GraphId="a6a"> <Graphics Color="Transparent" CenterX="7800.0" CenterY="2350.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="29929" /> </DataNode> <DataNode TextLabel="P2RY11" Type="GeneProduct" BackpageHead="P2RY11 | purinergic receptor P2Y G-protein cou..." GraphId="d0a"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="5350.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="5032" /> </DataNode> <DataNode TextLabel="MASS1" Type="GeneProduct" BackpageHead="MASS1 | monogenic audiogenic seizure susceptib..." GraphId="c45"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="4450.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="84059" /> </DataNode> <DataNode TextLabel="LPHN3" Type="GeneProduct" BackpageHead="LPHN3 | latrophilin 3" GraphId="acf"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="3550.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="23284" /> </DataNode> <DataNode TextLabel="LPHN2" Type="GeneProduct" BackpageHead="LPHN2 | latrophilin 2" GraphId="ef2"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="3850.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="23266" /> </DataNode> <DataNode TextLabel="PTGFR" Type="GeneProduct" BackpageHead="PTGFR | prostaglandin F receptor (FP)" GraphId="edc"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="5050.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="5737" /> </DataNode> <DataNode TextLabel="SSTR2" Type="GeneProduct" BackpageHead="SSTR2 | somatostatin receptor 2" GraphId="fbf"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="6250.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="6752" /> </DataNode> <DataNode TextLabel="SMO" Type="GeneProduct" BackpageHead="SMO | smoothened homolog (Drosophila)" GraphId="e02"> <Graphics Color="Transparent" CenterX="9750.0" CenterY="5950.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="6608" /> </DataNode> <InfoBox CenterX="76.5" CenterY="640.0" /> <Legend CenterX="16620.0" CenterY="1778.0" /> </Pathway>

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