Hedgehog signaling pathway (Drosophila melanogaster)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="ISO-8859-1"?> <Pathway xmlns="http://genmapp.org/GPML/2007" Name="Hedgehog Signaling Pathway" Data-Source="GenMAPP 2.0" Version="20061219" Author="cBio MSKCC, IOB, PandeyLab" Maintainer="GenMAPP.org" Email="cellmap-info@cellmap.org" Copyright="Freely available under Creative Commons license" Last-Modified="This pathway was converted from human by homology" Organism="Drosophila melanogaster"> <Comment Source="GenMAPP notes">NetPath:10 ; cellmap:10 - Hedgehog Signaling Pathway&#xD; This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.</Comment> <Comment Source="GenMAPP remarks">http://cancer.cellmap.org; http://www.netpath.org</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Graphics BoardWidth="22440.0" BoardHeight="21780.0" WindowWidth="19320.0" WindowHeight="10740.0" /> <DataNode TextLabel="ptc" Type="GeneProduct" BackpageHead="ptc | patched" GraphId="d30"> <Graphics Color="000000" CenterX="17550.0" CenterY="4100.0" Width="700.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="35851" /> </DataNode> <DataNode TextLabel="PTCH2" Type="GeneProduct" BackpageHead="PTCH2" GraphId="c64"> <Graphics Color="000000" CenterX="11400.0" CenterY="4100.0" Width="779.8294" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="hh" Type="GeneProduct" BackpageHead="hh | hedgehog" GraphId="eaa"> <Graphics Color="000000" CenterX="10200.0" CenterY="2050.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="42737" /> </DataNode> <DataNode TextLabel="cdc2" Type="GeneProduct" BackpageHead="cdc2 | cdc2" GraphId="d5e"> <Graphics Color="000000" CenterX="17100.0" CenterY="6900.0" Width="623.8635" Height="300.0" /> <Xref Database="Entrez Gene" ID="34411" /> </DataNode> <DataNode TextLabel="ptc" Type="GeneProduct" BackpageHead="ptc | patched" GraphId="e12"> <Graphics Color="000000" CenterX="15400.0" CenterY="4100.0" Width="800.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="35851" /> </DataNode> <DataNode TextLabel="PTCH2" Type="GeneProduct" BackpageHead="PTCH2" GraphId="c1f"> <Graphics Color="000000" CenterX="12600.0" CenterY="4100.0" Width="779.8294" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="DHH" Type="GeneProduct" BackpageHead="DHH" GraphId="f50"> <Graphics Color="000000" CenterX="12650.0" CenterY="2050.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="smo" Type="GeneProduct" BackpageHead="smo | smoothened" GraphId="e8e"> <Graphics Color="000000" CenterX="14050.0" CenterY="4100.0" Width="700.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="33196" /> </DataNode> <DataNode TextLabel="IHH" Type="GeneProduct" BackpageHead="IHH" GraphId="d3c"> <Graphics Color="000000" CenterX="16600.0" CenterY="2050.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="ptc" Type="GeneProduct" BackpageHead="ptc | patched" GraphId="dbb"> <Graphics Color="000000" CenterX="16550.0" CenterY="4100.0" Width="675.2088" Height="300.0" /> <Xref Database="Entrez Gene" ID="35851" /> </DataNode> <DataNode TextLabel="PTCH2" Type="GeneProduct" BackpageHead="PTCH2" GraphId="e50"> <Graphics Color="000000" CenterX="10200.0" CenterY="4100.0" Width="1000.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="IHH" Type="GeneProduct" BackpageHead="IHH" GraphId="d38"> <Graphics Color="000000" CenterX="11400.0" CenterY="2050.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="ci" Type="GeneProduct" BackpageHead="ci | cubitus interruptus" GraphId="f38"> <Graphics Color="000000" CenterX="12650.0" CenterY="7350.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="43767" /> </DataNode> <DataNode TextLabel="snoN" Type="GeneProduct" BackpageHead="snoN | snoN" GraphId="ca7"> <Graphics Color="000000" CenterX="14850.0" CenterY="7350.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="34085" /> </DataNode> <DataNode TextLabel="Su(fu)" Type="GeneProduct" BackpageHead="Su(fu) | Suppressor of fused" GraphId="fea"> <Graphics Color="000000" CenterX="9400.0" CenterY="6950.0" Width="700.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="41565" /> </DataNode> <DataNode TextLabel="Bin1" Type="GeneProduct" BackpageHead="Bin1 | Bicoid interacting protein 1" GraphId="cbe"> <Graphics Color="000000" CenterX="9350.0" CenterY="7350.0" Width="771.6672" Height="300.0" /> <Xref Database="Entrez Gene" ID="41965" /> </DataNode> <DataNode TextLabel="Sin3A" Type="GeneProduct" BackpageHead="Sin3A | Sin3A" GraphId="c14"> <Graphics Color="000000" CenterX="9350.0" CenterY="7750.0" Width="700.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="36382" /> </DataNode> <DataNode TextLabel="GLI1" Type="GeneProduct" BackpageHead="GLI1" GraphId="fe6"> <Graphics Color="000000" CenterX="11150.0" CenterY="7350.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="HHIP" Type="GeneProduct" BackpageHead="HHIP" GraphId="de4"> <Graphics Color="000000" CenterX="18400.0" CenterY="4100.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="GAS1" Type="GeneProduct" BackpageHead="GAS1" GraphId="a0b"> <Graphics Color="000000" CenterX="9000.0" CenterY="4100.0" Width="675.2088" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="CREBBP" Type="GeneProduct" BackpageHead="CREBBP" GraphId="d57"> <Graphics Color="000000" CenterX="14150.0" CenterY="10000.0" Width="935.7953" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="mnb" Type="GeneProduct" BackpageHead="mnb | minibrain" GraphId="cc0"> <Graphics Color="000000" CenterX="14450.0" CenterY="8850.0" Width="900.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="32772" /> </DataNode> <DataNode TextLabel="GLI2" Type="GeneProduct" BackpageHead="GLI2" GraphId="a57"> <Graphics Color="000000" CenterX="11900.0" CenterY="7350.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="STK36" Type="GeneProduct" BackpageHead="STK36" GraphId="fb8"> <Graphics Color="000000" CenterX="13650.0" CenterY="5300.0" Width="731.679" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="Su(fu)" Type="GeneProduct" BackpageHead="Su(fu) | Suppressor of fused" GraphId="f6f"> <Graphics Color="000000" CenterX="7900.0" CenterY="6850.0" Width="700.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="41565" /> </DataNode> <DataNode TextLabel="cdc2" Type="GeneProduct" BackpageHead="cdc2 | cdc2" GraphId="d8e"> <Graphics Color="000000" CenterX="17400.0" CenterY="10350.0" Width="623.8635" Height="300.0" /> <Xref Database="Entrez Gene" ID="34411" /> </DataNode> <DataNode TextLabel="CycB" Type="GeneProduct" BackpageHead="CycB | Cyclin B" GraphId="ca2"> <Graphics Color="000000" CenterX="18150.0" CenterY="10350.0" Width="800.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="37618" /> </DataNode> <DataNode TextLabel="GLI1" Type="GeneProduct" BackpageHead="GLI1" GraphId="d12"> <Graphics Color="000000" CenterX="11100.0" CenterY="10400.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="GLI2" Type="GeneProduct" BackpageHead="GLI2" GraphId="dcd"> <Graphics Color="000000" CenterX="11850.0" CenterY="10400.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="ci" Type="GeneProduct" BackpageHead="ci | cubitus interruptus" GraphId="f03"> <Graphics Color="000000" CenterX="12650.0" CenterY="10400.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="43767" /> </DataNode> <DataNode TextLabel="ptc" Type="GeneProduct" BackpageHead="ptc | patched" GraphId="e6c"> <Graphics Color="000000" CenterX="15150.0" CenterY="6850.0" Width="675.2088" Height="300.0" /> <Xref Database="Entrez Gene" ID="35851" /> </DataNode> <DataNode TextLabel="Su(fu)" Type="GeneProduct" BackpageHead="Su(fu) | Suppressor of fused" GraphId="ce9"> <Graphics Color="000000" CenterX="7850.0" CenterY="10400.0" Width="700.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="41565" /> </DataNode> <DataNode TextLabel="Rab23" Type="GeneProduct" BackpageHead="Rab23 | Rab23" GraphId="fb9"> <Graphics Color="000000" CenterX="7600.0" CenterY="5950.0" Width="771.6672" Height="300.0" /> <Xref Database="Entrez Gene" ID="40701" /> </DataNode> <DataNode TextLabel="Rab23" Type="GeneProduct" BackpageHead="Rab23 | Rab23" GraphId="e80"> <Graphics Color="000000" CenterX="7550.0" CenterY="4500.0" Width="771.6672" Height="300.0" /> <Xref Database="Entrez Gene" ID="40701" /> </DataNode> <DataNode TextLabel="CycB" Type="GeneProduct" BackpageHead="CycB | Cyclin B" GraphId="e30"> <Graphics Color="000000" CenterX="18300.0" CenterY="6900.0" Width="800.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="37618" /> </DataNode> <DataNode TextLabel="smo" Type="GeneProduct" BackpageHead="smo | smoothened" GraphId="b59"> <Graphics Color="000000" CenterX="14350.0" CenterY="6850.0" Width="700.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="33196" /> </DataNode> <DataNode TextLabel="IGF2" Type="GeneProduct" BackpageHead="IGF2" GraphId="d04"> <Graphics Color="000000" CenterX="8450.0" CenterY="5900.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="DHH" Type="GeneProduct" BackpageHead="DHH" GraphId="c21"> <Graphics Color="000000" CenterX="17500.0" CenterY="2050.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="hh" Type="GeneProduct" BackpageHead="hh | hedgehog" GraphId="cfe"> <Graphics Color="000000" CenterX="15350.0" CenterY="2050.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="42737" /> </DataNode> <DataNode TextLabel="hh" Type="GeneProduct" BackpageHead="hh | hedgehog" GraphId="a69"> <Graphics Color="000000" CenterX="9000.0" CenterY="2050.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="42737" /> </DataNode> <DataNode TextLabel="HHIP" Type="GeneProduct" BackpageHead="HHIP" GraphId="e26"> <Graphics Color="000000" CenterX="19250.0" CenterY="4100.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="HHIP" Type="GeneProduct" BackpageHead="HHIP" GraphId="a74"> <Graphics Color="000000" CenterX="20100.0" CenterY="4100.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="DHH" Type="GeneProduct" BackpageHead="DHH" GraphId="ce1"> <Graphics Color="000000" CenterX="18400.0" CenterY="2050.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="IHH" Type="GeneProduct" BackpageHead="IHH" GraphId="f48"> <Graphics Color="000000" CenterX="19300.0" CenterY="2050.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="" /> </DataNode> <DataNode TextLabel="hh" Type="GeneProduct" BackpageHead="hh | hedgehog" GraphId="a91"> <Graphics Color="000000" CenterX="20100.0" CenterY="2050.0" Width="600.0" Height="300.0" /> <Xref Database="Entrez Gene" ID="42737" /> </DataNode> <Line Style="Broken"> <Graphics Color="800040"> <Point x="900.0" y="16600.0" /> <Point x="1650.0" y="16600.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="15100.0" y="4150.0" /> <Point x="14400.0" y="4150.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="13000.0" y="4100.0" /> <Point x="13700.0" y="4100.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="14550.0" y="7350.0" /> <Point x="12950.0" y="7350.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="8450.0" y="6950.0" /> <Point x="9050.0" y="6950.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="8450.0" y="6950.0" /> <Point x="8450.0" y="7400.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="8450.0" y="7400.0" /> <Point x="9000.0" y="7400.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="9850.0" y="7350.0" /> <Point x="10850.0" y="7350.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="11100.0" y="6650.0" /> <Point x="11100.0" y="7200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="11100.0" y="6650.0" /> <Point x="9600.0" y="6650.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="12850.0" y="10000.0" /> <Point x="13700.0" y="10000.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="11200.0" y="8900.0" /> <Point x="11200.0" y="7500.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="11850.0" y="6550.0" /> <Point x="11850.0" y="7200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="11850.0" y="6550.0" /> <Point x="9600.0" y="6550.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="12600.0" y="6500.0" /> <Point x="12600.0" y="7200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="12600.0" y="6500.0" /> <Point x="9600.0" y="6500.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="11200.0" y="8900.0" /> <Point x="14000.0" y="8900.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="9400.0" y="5200.0" /> <Point x="9400.0" y="6800.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="13300.0" y="5200.0" /> <Point x="9400.0" y="5200.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="11250.0" y="5250.0" /> <Point x="11250.0" y="7200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="13300.0" y="5250.0" /> <Point x="11250.0" y="5250.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="12000.0" y="5300.0" /> <Point x="12000.0" y="7200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="13350.0" y="5300.0" /> <Point x="12000.0" y="5300.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="12800.0" y="5350.0" /> <Point x="12800.0" y="7200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="13350.0" y="5350.0" /> <Point x="12800.0" y="5350.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="14800.0" y="7800.0" /> <Point x="14800.0" y="7500.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="11900.0" y="7800.0" /> <Point x="14800.0" y="7800.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="11900.0" y="7500.0" /> <Point x="11900.0" y="7800.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="14350.0" y="3050.0" /> <Point x="14350.0" y="3950.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="14350.0" y="3050.0" /> <Point x="14850.0" y="3050.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="8250.0" y="6850.0" /> <Point x="9050.0" y="6850.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="0000ff"> <Point x="11350.0" y="8800.0" /> <Point x="11350.0" y="7500.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="0000ff"> <Point x="14000.0" y="8800.0" /> <Point x="11350.0" y="8800.0" /> </Graphics> </Line> <Line Style="Broken"> <Graphics Color="800000"> <Point x="17800.0" y="7150.0" /> <Point x="17800.0" y="10100.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="12850.0" y="7500.0" /> <Point x="12850.0" y="10000.0" /> </Graphics> </Line> <Line Style="Broken"> <Graphics Color="800000"> <Point x="11100.0" y="7500.0" /> <Point x="11100.0" y="10250.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line Style="Broken"> <Graphics Color="800000"> <Point x="11850.0" y="7500.0" /> <Point x="11850.0" y="10250.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line Style="Broken"> <Graphics Color="800000"> <Point x="12650.0" y="7500.0" /> <Point x="12650.0" y="10250.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line Style="Broken"> <Graphics Color="800000"> <Point x="15350.0" y="4250.0" /> <Point x="15350.0" y="6700.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line Style="Broken"> <Graphics Color="800000"> <Point x="7900.0" y="7000.0" /> <Point x="7900.0" y="10250.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line Style="Broken"> <Graphics Color="800000"> <Point x="7600.0" y="5800.0" /> <Point x="7600.0" y="4650.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="17600.0" y="5350.0" /> <Point x="17600.0" y="6900.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="18300.0" y="5250.0" /> <Point x="18300.0" y="6750.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="17100.0" y="5450.0" /> <Point x="17100.0" y="6750.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="17400.0" y="6900.0" /> <Point x="17900.0" y="6900.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line Style="Broken"> <Graphics Color="800000"> <Point x="14750.0" y="4350.0" /> <Point x="14750.0" y="6550.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="900.0" y="8450.0" /> <Point x="1650.0" y="8450.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="000000"> <Point x="1250.0" y="5600.0" /> <Point x="1250.0" y="6450.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Line> <Graphics Color="0000ff"> <Point x="10200.0" y="2200.0" /> <Point x="10200.0" y="3050.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Line> <Graphics Color="004080"> <Point x="11400.0" y="2200.0" /> <Point x="11400.0" y="3050.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Line> <Graphics Color="8080ff"> <Point x="12600.0" y="2200.0" /> <Point x="12600.0" y="3050.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Line> <Graphics Color="8080ff"> <Point x="17500.0" y="2200.0" /> <Point x="17500.0" y="3050.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Line> <Graphics Color="004080"> <Point x="16550.0" y="2200.0" /> <Point x="16550.0" y="3050.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Line> <Graphics Color="0000ff"> <Point x="15350.0" y="2200.0" /> <Point x="15350.0" y="3050.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Line> <Graphics Color="ff8040"> <Point x="10200.0" y="3950.0" /> <Point x="10200.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="ff8040"> <Point x="11400.0" y="3950.0" /> <Point x="11400.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="ff8040"> <Point x="12600.0" y="3950.0" /> <Point x="12600.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="804040"> <Point x="15350.0" y="3950.0" /> <Point x="15350.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="804040"> <Point x="16550.0" y="3950.0" /> <Point x="16550.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="804040"> <Point x="17500.0" y="3950.0" /> <Point x="17500.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="000000"> <Point x="1250.0" y="5050.0" /> <Point x="1250.0" y="4550.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="800040"> <Point x="18400.0" y="3950.0" /> <Point x="18400.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="808080"> <Point x="9000.0" y="3950.0" /> <Point x="9000.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="808000"> <Point x="14000.0" y="3950.0" /> <Point x="14000.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="9600.0" y="6500.0" /> <Point x="9600.0" y="6800.0" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="13900.0" y="4250.0" /> <Point x="13900.0" y="5150.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="900.0" y="15000.0" /> <Point x="1650.0" y="15000.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="13550.0" y="6150.0" /> <Point x="13550.0" y="5450.0" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="13550.0" y="6150.0" /> <Point x="11350.0" y="6150.0" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="11350.0" y="6150.0" /> <Point x="11350.0" y="7200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="12100.0" y="6150.0" /> <Point x="12100.0" y="7200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="10900.0" y="7200.0" /> <Point x="10900.0" y="5950.0" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="10900.0" y="5950.0" /> <Point x="8750.0" y="5950.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="ff0000"> <Point x="11700.0" y="6300.0" /> <Point x="11700.0" y="7200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="ff0000"> <Point x="11700.0" y="6300.0" /> <Point x="9550.0" y="6300.0" /> </Graphics> </Line> <Line> <Graphics Color="ff0000"> <Point x="11000.0" y="6300.0" /> <Point x="11000.0" y="7200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="ff0000"> <Point x="9550.0" y="6800.0" /> <Point x="9550.0" y="6300.0" /> </Graphics> </Line> <Line> <Graphics Color="ff0000"> <Point x="16550.0" y="4750.0" /> <Point x="16550.0" y="8700.0" /> </Graphics> </Line> <Line> <Graphics Color="000000"> <Point x="16550.0" y="4250.0" /> <Point x="16550.0" y="4550.0" /> </Graphics> </Line> <Line> <Graphics Color="ff0000"> <Point x="16550.0" y="8700.0" /> <Point x="17650.0" y="8700.0" /> </Graphics> </Line> <Line> <Graphics Color="ff0000"> <Point x="17650.0" y="8700.0" /> <Point x="17650.0" y="10100.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="ff0000"> <Point x="9800.0" y="7450.0" /> <Point x="10850.0" y="7450.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="ff0000"> <Point x="900.0" y="15400.0" /> <Point x="1650.0" y="15400.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="15500.0" y="5450.0" /> <Point x="15500.0" y="4250.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="15500.0" y="5450.0" /> <Point x="17100.0" y="5450.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="15600.0" y="5350.0" /> <Point x="15600.0" y="4250.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="15600.0" y="5350.0" /> <Point x="17600.0" y="5350.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="15700.0" y="5250.0" /> <Point x="15700.0" y="4250.0" /> </Graphics> </Line> <Line> <Graphics Color="008000"> <Point x="15700.0" y="5250.0" /> <Point x="18300.0" y="5250.0" /> </Graphics> </Line> <Line> <Graphics Color="000000"> <Point x="900.0" y="8800.0" /> <Point x="1450.0" y="8800.0" /> </Graphics> </Line> <Line> <Graphics Color="000000"> <Point x="10200.0" y="4250.0" /> <Point x="10200.0" y="4550.0" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="7850.0" y="5350.0" /> <Point x="7850.0" y="5800.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="10200.0" y="4800.0" /> <Point x="10200.0" y="5350.0" /> </Graphics> </Line> <Line> <Graphics Color="8000ff"> <Point x="7850.0" y="5350.0" /> <Point x="10200.0" y="5350.0" /> </Graphics> </Line> <Line> <Graphics Color="0000ff"> <Point x="1400.0" y="9350.0" /> <Point x="1450.0" y="9450.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="bfbf00"> <Point x="900.0" y="9800.0" /> <Point x="1650.0" y="9800.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="00eaea"> <Point x="900.0" y="10200.0" /> <Point x="1650.0" y="10200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="8080ff"> <Point x="900.0" y="10600.0" /> <Point x="1650.0" y="10600.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="00ff00"> <Point x="900.0" y="11000.0" /> <Point x="1650.0" y="11000.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="0000ff"> <Point x="900.0" y="12200.0" /> <Point x="1650.0" y="12200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="ff00ff"> <Point x="900.0" y="12600.0" /> <Point x="1650.0" y="12600.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="0080c0"> <Point x="900.0" y="13000.0" /> <Point x="1650.0" y="13000.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="a400a4"> <Point x="900.0" y="11400.0" /> <Point x="1650.0" y="11400.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="ff80c0"> <Point x="900.0" y="11800.0" /> <Point x="1650.0" y="11800.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="808000"> <Point x="900.0" y="13400.0" /> <Point x="1650.0" y="13400.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="afafaf"> <Point x="900.0" y="13800.0" /> <Point x="1650.0" y="13800.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="ff8000"> <Point x="900.0" y="14200.0" /> <Point x="1650.0" y="14200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="eaea00"> <Point x="900.0" y="14600.0" /> <Point x="1650.0" y="14600.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line Style="Broken"> <Graphics Color="0080ff"> <Point x="900.0" y="16200.0" /> <Point x="1650.0" y="16200.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line Style="Broken"> <Graphics Color="00ffff"> <Point x="900.0" y="15800.0" /> <Point x="1650.0" y="15800.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line> <Graphics Color="0000ff"> <Point x="9000.0" y="2200.0" /> <Point x="9000.0" y="3050.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Line> <Graphics Color="800040"> <Point x="19250.0" y="3950.0" /> <Point x="19250.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="800040"> <Point x="20100.0" y="3950.0" /> <Point x="20100.0" y="3150.0" ArrowHead="ReceptorRound" /> </Graphics> </Line> <Line> <Graphics Color="8080ff"> <Point x="18400.0" y="2200.0" /> <Point x="18400.0" y="3050.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Line> <Graphics Color="004080"> <Point x="19250.0" y="2200.0" /> <Point x="19250.0" y="3050.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Line> <Graphics Color="0000ff"> <Point x="20100.0" y="2200.0" /> <Point x="20100.0" y="3050.0" ArrowHead="LigandRound" /> </Graphics> </Line> <Label TextLabel="Translocation" GraphId="def"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2550.0" CenterY="16600.0" Width="1370.0" Height="240.0" /> </Label> <Label TextLabel="Plasma membrane" GraphId="ebd"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="3250.0" CenterY="19450.0" Width="1880.0" Height="240.0" /> </Label> <Label TextLabel="Cytoplasm" GraphId="e05"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2850.0" CenterY="17000.0" Width="1070.0" Height="240.0" /> </Label> <Label TextLabel="Endosome" GraphId="d4a"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2850.0" CenterY="17700.0" Width="1070.0" Height="240.0" /> </Label> <Label TextLabel="Nucleus" GraphId="e61"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2750.0" CenterY="19100.0" Width="830.0" Height="240.0" /> </Label> <Label TextLabel="CY-&gt;NU" GraphId="b72"> <Graphics FontWeight="Bold" FontSize="120" Color="ff00ff" CenterX="18200.0" CenterY="9000.0" Width="635.0" Height="180.0" /> </Label> <Label TextLabel="CY-&gt;NU" GraphId="baf"> <Graphics FontWeight="Bold" FontSize="120" Color="ff00ff" CenterX="12300.0" CenterY="9150.0" Width="635.0" Height="180.0" /> </Label> <Label TextLabel="CY-&gt;NU" GraphId="e88"> <Graphics FontWeight="Bold" FontSize="120" Color="ff00ff" CenterX="10750.0" CenterY="9150.0" Width="635.0" Height="180.0" /> </Label> <Label TextLabel="CY-&gt;NU" GraphId="e4c"> <Graphics FontWeight="Bold" FontSize="120" Color="ff00ff" CenterX="11500.0" CenterY="9150.0" Width="635.0" Height="180.0" /> </Label> <Label TextLabel="PM-&gt;EN" GraphId="c50"> <Graphics FontWeight="Bold" FontSize="120" Color="ff00ff" CenterX="15700.0" CenterY="5800.0" Width="665.0" Height="180.0" /> </Label> <Label TextLabel="CY-&gt;NU" GraphId="ba9"> <Graphics FontWeight="Bold" FontSize="120" Color="ff00ff" CenterX="8300.0" CenterY="9100.0" Width="635.0" Height="180.0" /> </Label> <Label TextLabel="CY-&gt;PM" GraphId="ea4"> <Graphics FontWeight="Bold" FontSize="120" Color="ff00ff" CenterX="7950.0" CenterY="5150.0" Width="665.0" Height="180.0" /> </Label> <Label TextLabel="PM-&gt;EN" GraphId="da4"> <Graphics FontWeight="Bold" FontSize="120" Color="ff00ff" CenterX="14350.0" CenterY="5800.0" Width="665.0" Height="180.0" /> </Label> <Label TextLabel="Molecular Association" GraphId="e58"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2950.0" CenterY="8450.0" Width="2165.0" Height="240.0" /> </Label> <Label TextLabel="Ligand" GraphId="efa"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2200.0" CenterY="5550.0" Width="740.0" Height="240.0" /> </Label> <Label TextLabel="Receptor" GraphId="dc3"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2300.0" CenterY="5150.0" Width="935.0" Height="240.0" /> </Label> <Label TextLabel="Molecule in the pathway" GraphId="ad3"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="3750.0" CenterY="6750.0" Width="2420.0" Height="240.0" /> </Label> <Label TextLabel="Gene Symbol" GraphId="ab9"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="1600.0" CenterY="6700.0" Width="1370.0" Height="240.0" /> </Label> <Label TextLabel="Activation" GraphId="b1f"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2400.0" CenterY="15000.0" Width="1025.0" Height="240.0" /> </Label> <Label TextLabel="D" GraphId="dd8"> <Graphics FontName="Symbol" FontWeight="Bold" FontSize="150" Color="000000" CenterX="16550.0" CenterY="4650.0" Width="215.0" Height="240.0" /> </Label> <Label TextLabel="Inhibition" GraphId="cb9"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2350.0" CenterY="15400.0" Width="980.0" Height="240.0" /> </Label> <Label TextLabel="Accession Number: NetPath_10; cellmap:10" GraphId="c0a"> <Graphics FontWeight="Bold" FontSize="180" Color="000000" CenterX="3250.0" CenterY="3900.0" Width="5120.0" Height="285.0" /> </Label> <Label TextLabel="Proteins in a complex interaction" GraphId="ea5"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="4150.0" CenterY="7350.0" Width="3245.0" Height="240.0" /> </Label> <Label TextLabel="Enzyme complex" GraphId="a19"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="3400.0" CenterY="7950.0" Width="1715.0" Height="240.0" /> </Label> <Label TextLabel="(Protein-protein interaction)" GraphId="a76"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="5400.0" CenterY="8450.0" Width="2705.0" Height="240.0" /> </Label> <Label TextLabel="D" GraphId="bca"> <Graphics FontName="Symbol" FontWeight="Bold" FontSize="150" Color="000000" CenterX="1600.0" CenterY="8800.0" Width="215.0" Height="240.0" /> </Label> <Label TextLabel="Reaction through unknown mechanisms/molecules" GraphId="fb2"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="4300.0" CenterY="8800.0" Width="4925.0" Height="240.0" /> </Label> <Label TextLabel="PM" GraphId="f40"> <Graphics FontWeight="Bold" FontSize="150" Color="ff00ff" CenterX="2050.0" CenterY="19450.0" Width="380.0" Height="240.0" /> </Label> <Label TextLabel="CY" GraphId="bd2"> <Graphics FontWeight="Bold" FontSize="150" Color="ff00ff" CenterX="2050.0" CenterY="17000.0" Width="335.0" Height="240.0" /> </Label> <Label TextLabel="EN" GraphId="ffe"> <Graphics FontWeight="Bold" FontSize="150" Color="ff00ff" CenterX="2050.0" CenterY="17700.0" Width="335.0" Height="240.0" /> </Label> <Label TextLabel="NU" GraphId="e0c"> <Graphics FontWeight="Bold" FontSize="150" Color="ff00ff" CenterX="2050.0" CenterY="19100.0" Width="350.0" Height="240.0" /> </Label> <Label TextLabel="D" GraphId="aa1"> <Graphics FontName="Symbol" FontWeight="Bold" FontSize="150" Color="000000" CenterX="10200.0" CenterY="4650.0" Width="215.0" Height="240.0" /> </Label> <Label TextLabel="Autophosphorylation" GraphId="cb1"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2900.0" CenterY="9350.0" Width="2045.0" Height="240.0" /> </Label> <Label TextLabel="Acetylation" GraphId="fe5"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2450.0" CenterY="9800.0" Width="1145.0" Height="240.0" /> </Label> <Label TextLabel="Deacetylation" GraphId="d9d"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2550.0" CenterY="10200.0" Width="1385.0" Height="240.0" /> </Label> <Label TextLabel="Glycosylation" GraphId="af6"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2550.0" CenterY="10600.0" Width="1355.0" Height="240.0" /> </Label> <Label TextLabel="Methylation" GraphId="fbf"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2450.0" CenterY="11000.0" Width="1190.0" Height="240.0" /> </Label> <Label TextLabel="Demethylation" GraphId="e2a"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2600.0" CenterY="11400.0" Width="1460.0" Height="240.0" /> </Label> <Label TextLabel="Phosphorylation" GraphId="a7b"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2650.0" CenterY="12200.0" Width="1625.0" Height="240.0" /> </Label> <Label TextLabel="Dephosphorylation" GraphId="bcf"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2800.0" CenterY="12600.0" Width="1865.0" Height="240.0" /> </Label> <Label TextLabel="Proteolytic cleavage" GraphId="c6a"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2900.0" CenterY="13000.0" Width="2030.0" Height="240.0" /> </Label> <Label TextLabel="Sumoylation" GraphId="e9a"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2500.0" CenterY="13400.0" Width="1280.0" Height="240.0" /> </Label> <Label TextLabel="Desumoylation" GraphId="a50"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2600.0" CenterY="13800.0" Width="1490.0" Height="240.0" /> </Label> <Label TextLabel="Ubiquitination" GraphId="ced"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2550.0" CenterY="14200.0" Width="1415.0" Height="240.0" /> </Label> <Label TextLabel="Deubiquitination" GraphId="af3"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2700.0" CenterY="14600.0" Width="1655.0" Height="240.0" /> </Label> <Label TextLabel="Recruitment" GraphId="fd6"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2500.0" CenterY="15800.0" Width="1235.0" Height="240.0" /> </Label> <Label TextLabel="Control" GraphId="c4e"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2250.0" CenterY="16200.0" Width="770.0" Height="240.0" /> </Label> <Label TextLabel="Extracellular" GraphId="de0"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2950.0" CenterY="17350.0" Width="1295.0" Height="240.0" /> </Label> <Label TextLabel="EC" GraphId="c78"> <Graphics FontWeight="Bold" FontSize="150" Color="ff00ff" CenterX="2050.0" CenterY="17350.0" Width="335.0" Height="240.0" /> </Label> <Label TextLabel="Endoplasmic reticulum" GraphId="e32"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="3450.0" CenterY="18050.0" Width="2255.0" Height="240.0" /> </Label> <Label TextLabel="ER" GraphId="ff1"> <Graphics FontWeight="Bold" FontSize="150" Color="ff00ff" CenterX="2050.0" CenterY="18050.0" Width="335.0" Height="240.0" /> </Label> <Label TextLabel="Golgi apparatus" GraphId="ce5"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="3100.0" CenterY="18400.0" Width="1595.0" Height="240.0" /> </Label> <Label TextLabel="GO" GraphId="f2b"> <Graphics FontWeight="Bold" FontSize="150" Color="ff00ff" CenterX="2050.0" CenterY="18400.0" Width="380.0" Height="240.0" /> </Label> <Label TextLabel="Mitochondrion" GraphId="c2b"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="3050.0" CenterY="18750.0" Width="1445.0" Height="240.0" /> </Label> <Label TextLabel="MT" GraphId="bb8"> <Graphics FontWeight="Bold" FontSize="150" Color="ff00ff" CenterX="2050.0" CenterY="18750.0" Width="365.0" Height="240.0" /> </Label> <Label TextLabel="Palmitoylation" GraphId="df0"> <Graphics FontWeight="Bold" FontSize="150" Color="000000" CenterX="2600.0" CenterY="11800.0" Width="1460.0" Height="240.0" /> </Label> <Label TextLabel="HOMOLOGY MAPP" GraphId="c9a"> <Graphics FontWeight="Bold" FontSize="180" Color="008000" CenterX="850.0" CenterY="300.0" Width="1340.0" Height="285.0" /> </Label> <Shape Type="Rectangle" GraphId="fbe"> <Graphics FillColor="Transparent" Color="000000" CenterX="3800.0" CenterY="11950.0" Width="6200.0" Height="15700.0" Rotation="0.0" /> </Shape> <Shape Type="Brace" GraphId="d01"> <Graphics FillColor="Transparent" Color="0000ff" CenterX="9850.0" CenterY="7350.0" Width="1100.0" Height="130.0" Rotation="1.5707963267948966" /> </Shape> <Shape Type="Brace" GraphId="bd7"> <Graphics FillColor="Transparent" Color="0000ff" CenterX="14850.0" CenterY="3050.0" Width="2000.0" Height="130.0" Rotation="4.71238898038469" /> </Shape> <Shape Type="Brace" GraphId="a89"> <Graphics FillColor="Transparent" Color="0000ff" CenterX="17800.0" CenterY="10050.0" Width="1500.0" Height="130.0" Rotation="0.0" /> </Shape> <Shape Type="Brace" GraphId="c3f"> <Graphics FillColor="Transparent" Color="0000ff" CenterX="17800.0" CenterY="7200.0" Width="1900.0" Height="130.0" Rotation="3.141592653589793" /> </Shape> <Shape Type="Brace" GraphId="e83"> <Graphics FillColor="Transparent" Color="0000ff" CenterX="14750.0" CenterY="4400.0" Width="1100.0" Height="130.0" Rotation="3.141592653589793" /> </Shape> <Shape Type="Brace" GraphId="b23"> <Graphics FillColor="Transparent" Color="0000ff" CenterX="14750.0" CenterY="6550.0" Width="900.0" Height="130.0" Rotation="0.0" /> </Shape> <Shape Type="Rectangle" GraphId="df9"> <Graphics FillColor="Transparent" Color="000000" CenterX="1600.0" CenterY="6700.0" Width="1400.0" Height="400.0" Rotation="0.0" /> </Shape> <Shape Type="Rectangle" GraphId="ffc"> <Graphics FillColor="Transparent" Color="000000" CenterX="1250.0" CenterY="5500.0" Width="500.0" Height="200.0" Rotation="0.0" /> </Shape> <Shape Type="Rectangle" GraphId="f83"> <Graphics FillColor="Transparent" Color="000000" CenterX="1250.0" CenterY="5150.0" Width="500.0" Height="200.0" Rotation="0.0" /> </Shape> <Shape Type="Rectangle" GraphId="ee4"> <Graphics FillColor="Transparent" Color="000000" CenterX="1200.0" CenterY="7300.0" Width="500.0" Height="200.0" Rotation="0.0" /> </Shape> <Shape Type="Rectangle" GraphId="ad5"> <Graphics FillColor="Transparent" Color="000000" CenterX="1800.0" CenterY="7300.0" Width="500.0" Height="200.0" Rotation="0.0" /> </Shape> <Shape Type="Brace" GraphId="b37"> <Graphics FillColor="Transparent" Color="0000ff" CenterX="1500.0" CenterY="7050.0" Width="800.0" Height="130.0" Rotation="0.0" /> </Shape> <Shape Type="Brace" GraphId="ffb"> <Graphics FillColor="Transparent" Color="0000ff" CenterX="1500.0" CenterY="7550.0" Width="800.0" Height="130.0" Rotation="3.141592653589793" /> </Shape> <Shape Type="Rectangle" GraphId="b8e"> <Graphics FillColor="Transparent" Color="000000" CenterX="1200.0" CenterY="7950.0" Width="500.0" Height="200.0" Rotation="0.0" /> </Shape> <Shape Type="Rectangle" GraphId="f0a"> <Graphics FillColor="Transparent" Color="000000" CenterX="1800.0" CenterY="7950.0" Width="500.0" Height="200.0" Rotation="0.0" /> </Shape> <Shape Type="Brace" GraphId="b6e"> <Graphics FillColor="Transparent" Color="ff00ff" CenterX="1500.0" CenterY="7700.0" Width="800.0" Height="130.0" Rotation="0.0" /> </Shape> <Shape Type="Brace" GraphId="d6e"> <Graphics FillColor="Transparent" Color="ff00ff" CenterX="1500.0" CenterY="8200.0" Width="800.0" Height="130.0" Rotation="3.141592653589793" /> </Shape> <Shape Type="Arc" GraphId="ab5"> <Graphics FillColor="Transparent" Color="0000ff" CenterX="1250.0" CenterY="9400.0" Width="300.0" Height="608.2762" Rotation="3.141593" /> </Shape> <InfoBox CenterX="125.0" CenterY="1175.0" /> <Legend CenterX="0.0" CenterY="0.0" /> </Pathway>

Return to Hedgehog signaling pathway (Drosophila melanogaster).