Estrogen signaling (Canis familiaris)

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<?xml version="1.0" encoding="ISO-8859-1"?> <Pathway xmlns="http://genmapp.org/GPML/2008a" Name="estrogen signalling" Version="20090518" Author="Laura van Zon" Organism="Canis familiaris" Last-Modified="7/29/2009"> <Comment Source="WikiPathways-description">Estrogen receptor refers to a group of receptors which are activated by the hormone 17&amp;#x3b2;-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP712&amp;oldid=29739 WP712(r29739)] with a 91% conversion rate.</Comment> <Graphics BoardWidth="20757.0" BoardHeight="20735.0" WindowWidth="18000.0" WindowHeight="12000.0"/> <DataNode TextLabel="ESR1" Type="GeneProduct" GraphId="d23be" GroupRef="ac3eb" BackpageHead="ESR1"> <Graphics Color="000000" CenterX="14324.75" CenterY="3014.75" Width="1590.5" Height="390.5" ZOrder="32768"/> <Xref Database="Entrez Gene" ID="403640"/> </DataNode> <DataNode TextLabel="ESR1" Type="GeneProduct" GraphId="ab408" GroupRef="b6d8f" BackpageHead="ESR1"> <Graphics Color="000000" CenterX="14549.75" CenterY="4844.75" Width="1590.5" Height="390.5" ZOrder="32768"/> <Xref Database="Entrez Gene" ID="403640"/> 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