Apoptosis (Canis familiaris)

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<?xml version="1.0" encoding="ISO-8859-1"?> <Pathway xmlns="http://genmapp.org/GPML/2008a" Name="Apoptosis" Data-Source="GenMAPP 2.0" Version="20041216" Author="Alexander C. Zambon and Beth Lawlor" Maintainer="Alexander C. Zambon" Email="azambon@gladstone.ucsf.edu" Organism="Canis familiaris" Last-Modified="7/29/2009"> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today. </Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP254&amp;oldid=29955 WP254(r29955)] with a 87% conversion rate.</Comment> <Graphics BoardWidth="21917.5" BoardHeight="13466.75" WindowWidth="19304.0" WindowHeight="13230.0"/> <DataNode TextLabel="TRADD" Type="GeneProduct" BackpageHead="TRADD" GraphId="e0c" GroupRef="d59c4"> <Graphics Color="000000" CenterX="1400.0" CenterY="3320.0" Width="900.0" Height="300.0" ZOrder="32768"/> <Xref Database="Entrez Gene" ID="611262"/> </DataNode> <DataNode TextLabel="TNFSF10" Type="GeneProduct" BackpageHead="" GraphId="a9b"> <Graphics Color="000000" CenterX="2850.0" CenterY="1550.0" Width="1000.0" Height="300.0" ZOrder="32768"/> <Xref Database="" ID=""/> </DataNode> <DataNode 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