Type II interferon signaling (IFNG) (Bos taurus)

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<?xml version="1.0" encoding="ISO-8859-1"?> <Pathway xmlns="http://genmapp.org/GPML/2008a" Name="Type II interferon signaling (IFNG)" Version="20090121" Author="Thomas Kelder" Last-Modified="7/29/2009" Organism="Bos taurus"> <Comment Source="WikiPathways-description">Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP619&amp;amp;amp;oldid=28124 WP619(r28124)] with a 84% conversion rate.</Comment> <BiopaxRef>f74</BiopaxRef> <Graphics BoardWidth="29700.0" BoardHeight="15493.5" WindowWidth="18000.0" WindowHeight="12000.0" /> <DataNode TextLabel="IFNG" Type="GeneProduct" BackpageHead="IFNG" GraphId="ad082" GroupRef="e2df7"> <Graphics Color="000000" CenterX="2040.0" CenterY="3105.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="281237" /> </DataNode> <DataNode TextLabel="IFNG" Type="GeneProduct" BackpageHead="IFNG" GraphId="b506a" GroupRef="e2df7"> <Graphics Color="000000" CenterX="2040.0" CenterY="3405.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="281237" /> </DataNode> <DataNode TextLabel="IFNG" Type="GeneProduct" BackpageHead="IFNG" GraphId="b739b"> <Graphics Color="000000" CenterX="2040.0" CenterY="5130.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="281237" /> </DataNode> <DataNode TextLabel="IFNGR1" Type="GeneProduct" BackpageHead="IFNGR1" GraphId="e6eda" GroupRef="bf74f"> <Graphics Color="000000" CenterX="5190.0" CenterY="2805.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="508619" /> </DataNode> <DataNode TextLabel="IFNGR2" Type="GeneProduct" BackpageHead="IFNGR2" GraphId="c97af" GroupRef="bf74f"> <Graphics Color="000000" CenterX="5190.0" CenterY="3105.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="514889" /> </DataNode> <DataNode TextLabel="JAK1" Type="GeneProduct" GraphId="d6a35" GroupRef="bf74f"> <Graphics Color="000000" CenterX="5190.0" CenterY="3405.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="JAK2" Type="GeneProduct" BackpageHead="JAK2" GraphId="fa442" GroupRef="bf74f"> <Graphics Color="000000" CenterX="5190.0" CenterY="3705.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="525246" /> </DataNode> <DataNode TextLabel="JAK2" Type="GeneProduct" BackpageHead="JAK2" GraphId="dd317" GroupRef="a1dfa"> <Graphics Color="000000" CenterX="5160.0" CenterY="5820.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="525246" /> </DataNode> <DataNode TextLabel="IFNGR2" Type="GeneProduct" BackpageHead="IFNGR2" GraphId="f8b8c" GroupRef="a1dfa"> <Graphics Color="000000" CenterX="5160.0" CenterY="5220.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="514889" /> </DataNode> <DataNode TextLabel="IFNGR1" Type="GeneProduct" BackpageHead="IFNGR1" GraphId="e9f60" GroupRef="a1dfa"> <Graphics Color="000000" CenterX="5160.0" CenterY="4920.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref 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