VEGF signaling pathway (Homo sapiens)

<?xml version="1.0" encoding="ISO-8859-1"?>
<Pathway xmlns="http://genmapp.org/GPML/2008a" Name="VEGF signaling pathway" Data-Source="http://www.genome.jp/dbget-bin/show_pathway?hsa04370" Organism="Homo sapiens">
  <Attribute Key="ConversionDate" Value="20090507"/>
  <Attribute Key="KeggId" Value="path:hsa04370"/>
  <Graphics BoardWidth="30871.5" BoardHeight="18282.0" WindowWidth="0.0" WindowHeight="0.0"/>
  <DataNode TextLabel="CDC42" Type="GeneProduct" GraphId="c49ce">
    <Comment Source="KeggConverter">
Original kegg element: gene;1;hsa:998
    </Comment>
    <Graphics Color="000000" CenterX="9030.0" CenterY="10440.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="998"/>
  </DataNode>
  <DataNode TextLabel="Nitric oxide" Type="Metabolite">
    <Graphics Color="0000ff" CenterX="17490.0" CenterY="14190.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Kegg Compound" ID="C00533"/>
  </DataNode>
  <DataNode TextLabel="Calcium" Type="Metabolite">
    <Graphics Color="0000ff" CenterX="11940.0" CenterY="6900.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Kegg Compound" ID="C00076"/>
  </DataNode>
  <DataNode TextLabel="D-myo-Inositol 1,4,5-trisphosphate" Type="Metabolite">
    <Graphics Color="0000ff" CenterX="10290.0" CenterY="6900.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Kegg Compound" ID="C01245"/>
  </DataNode>
  <DataNode TextLabel="Diacylglycerol" Type="Metabolite">
    <Graphics Color="0000ff" CenterX="10260.0" CenterY="5340.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Kegg Compound" ID="C00165"/>
  </DataNode>
  <DataNode TextLabel="KDR" Type="GeneProduct" GraphId="a0745">
    <Comment Source="KeggConverter">
Original kegg element: gene;10;hsa:3791
    </Comment>
    <Graphics Color="000000" CenterX="4290.0" CenterY="9270.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="3791"/>
  </DataNode>
  <DataNode TextLabel="PLCG1" Type="GeneProduct" GroupRef="de193">
    <Comment Source="KeggConverter">
Original kegg element: gene;11;hsa:5335 hsa:5336
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="6570.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5335"/>
  </DataNode>
  <DataNode TextLabel="PLCG2" Type="GeneProduct" GroupRef="de193">
    <Comment Source="KeggConverter">
Original kegg element: gene;11;hsa:5335 hsa:5336
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="6870.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5336"/>
  </DataNode>
  <DataNode TextLabel="SPHK2" Type="GeneProduct" GroupRef="f5b56">
    <Comment Source="KeggConverter">
Original kegg element: gene;12;hsa:56848 hsa:8877
    </Comment>
    <Graphics Color="000000" CenterX="15180.0" CenterY="3480.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="56848"/>
  </DataNode>
  <DataNode TextLabel="SPHK1" Type="GeneProduct" GroupRef="f5b56">
    <Comment Source="KeggConverter">
Original kegg element: gene;12;hsa:56848 hsa:8877
    </Comment>
    <Graphics Color="000000" CenterX="15180.0" CenterY="3180.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="8877"/>
  </DataNode>
  <DataNode TextLabel="Phosphatidylinositol-3,4,5-trisphosphate" Type="Metabolite">
    <Graphics Color="0000ff" CenterX="10230.0" CenterY="13170.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Kegg Compound" ID="C05981"/>
  </DataNode>
  <DataNode TextLabel="Prostaglandin I2" Type="Metabolite">
    <Graphics Color="0000ff" CenterX="27150.0" CenterY="7530.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Kegg Compound" ID="C01312"/>
  </DataNode>
  <DataNode TextLabel="PTGS2" Type="GeneProduct" GraphId="e3246">
    <Comment Source="KeggConverter">
Original kegg element: gene;15;hsa:5743
    </Comment>
    <Graphics Color="000000" CenterX="22470.0" CenterY="6900.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5743"/>
  </DataNode>
  <DataNode TextLabel="PLA2G4B" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="5580.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="100137049"/>
  </DataNode>
  <DataNode TextLabel="PLA2G2D" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="3480.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="26279"/>
  </DataNode>
  <DataNode TextLabel="PLA2G2E" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="6780.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="30814"/>
  </DataNode>
  <DataNode TextLabel="PLA2G3" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="4080.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="50487"/>
  </DataNode>
  <DataNode TextLabel="PLA2G1B" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="4380.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5319"/>
  </DataNode>
  <DataNode TextLabel="PLA2G2A" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="3180.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5320"/>
  </DataNode>
  <DataNode TextLabel="PLA2G4A" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="5280.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5321"/>
  </DataNode>
  <DataNode TextLabel="PLA2G5" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="7080.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5322"/>
  </DataNode>
  <DataNode TextLabel="PLA2G2F" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="5880.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="64600"/>
  </DataNode>
  <DataNode TextLabel="PLA2G12A" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="3780.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="81579"/>
  </DataNode>
  <DataNode TextLabel="PLA2G6" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="6480.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="8398"/>
  </DataNode>
  <DataNode TextLabel="PLA2G10" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="4680.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="8399"/>
  </DataNode>
  <DataNode TextLabel="PLA2G12B" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="4980.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="84647"/>
  </DataNode>
  <DataNode TextLabel="JMJD7-PLA2G4B" Type="GeneProduct" GroupRef="aca44">
    <Comment Source="KeggConverter">
Original kegg element: gene;16;hsa:100137049 hsa:26279 hsa:30814 hsa:50487 hsa:5319 hsa:5320 hsa:5321 hsa:5322 hsa:64600 hsa:81579 hsa:8398 hsa:8399 hsa:84647 hsa:8681
    </Comment>
    <Graphics Color="000000" CenterX="24510.0" CenterY="6180.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="8681"/>
  </DataNode>
  <DataNode TextLabel="HSPB1" Type="GeneProduct" GraphId="b2c17">
    <Comment Source="KeggConverter">
Original kegg element: gene;17;hsa:3315
    </Comment>
    <Graphics Color="000000" CenterX="18840.0" CenterY="10950.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="3315"/>
  </DataNode>
  <DataNode TextLabel="MAPKAPK3" Type="GeneProduct" GroupRef="fb87b">
    <Comment Source="KeggConverter">
Original kegg element: gene;18;hsa:7867 hsa:9261
    </Comment>
    <Graphics Color="000000" CenterX="15570.0" CenterY="10650.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="7867"/>
  </DataNode>
  <DataNode TextLabel="MAPKAPK2" Type="GeneProduct" GroupRef="fb87b">
    <Comment Source="KeggConverter">
Original kegg element: gene;18;hsa:7867 hsa:9261
    </Comment>
    <Graphics Color="000000" CenterX="15570.0" CenterY="10950.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="9261"/>
  </DataNode>
  <DataNode TextLabel="CHP" Type="GeneProduct" GroupRef="f6c73">
    <Comment Source="KeggConverter">
Original kegg element: gene;19;hsa:11261 hsa:5530 hsa:5532 hsa:5533 hsa:5534 hsa:5535 hsa:63928
    </Comment>
    <Graphics Color="000000" CenterX="15600.0" CenterY="7500.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="11261"/>
  </DataNode>
  <DataNode TextLabel="PPP3CA" Type="GeneProduct" GroupRef="f6c73">
    <Comment Source="KeggConverter">
Original kegg element: gene;19;hsa:11261 hsa:5530 hsa:5532 hsa:5533 hsa:5534 hsa:5535 hsa:63928
    </Comment>
    <Graphics Color="000000" CenterX="15600.0" CenterY="6300.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5530"/>
  </DataNode>
  <DataNode TextLabel="PPP3CB" Type="GeneProduct" GroupRef="f6c73">
    <Comment Source="KeggConverter">
Original kegg element: gene;19;hsa:11261 hsa:5530 hsa:5532 hsa:5533 hsa:5534 hsa:5535 hsa:63928
    </Comment>
    <Graphics Color="000000" CenterX="15600.0" CenterY="6900.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5532"/>
  </DataNode>
  <DataNode TextLabel="PPP3CC" Type="GeneProduct" GroupRef="f6c73">
    <Comment Source="KeggConverter">
Original kegg element: gene;19;hsa:11261 hsa:5530 hsa:5532 hsa:5533 hsa:5534 hsa:5535 hsa:63928
    </Comment>
    <Graphics Color="000000" CenterX="15600.0" CenterY="6000.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5533"/>
  </DataNode>
  <DataNode TextLabel="PPP3R1" Type="GeneProduct" GroupRef="f6c73">
    <Comment Source="KeggConverter">
Original kegg element: gene;19;hsa:11261 hsa:5530 hsa:5532 hsa:5533 hsa:5534 hsa:5535 hsa:63928
    </Comment>
    <Graphics Color="000000" CenterX="15600.0" CenterY="7800.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5534"/>
  </DataNode>
  <DataNode TextLabel="PPP3R2" Type="GeneProduct" GroupRef="f6c73">
    <Comment Source="KeggConverter">
Original kegg element: gene;19;hsa:11261 hsa:5530 hsa:5532 hsa:5533 hsa:5534 hsa:5535 hsa:63928
    </Comment>
    <Graphics Color="000000" CenterX="15600.0" CenterY="7200.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5535"/>
  </DataNode>
  <DataNode TextLabel="CHP2" Type="GeneProduct" GroupRef="f6c73">
    <Comment Source="KeggConverter">
Original kegg element: gene;19;hsa:11261 hsa:5530 hsa:5532 hsa:5533 hsa:5534 hsa:5535 hsa:63928
    </Comment>
    <Graphics Color="000000" CenterX="15600.0" CenterY="6600.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="63928"/>
  </DataNode>
  <DataNode TextLabel="AKT3" Type="GeneProduct" GroupRef="d9e10">
    <Comment Source="KeggConverter">
Original kegg element: gene;20;hsa:10000 hsa:207 hsa:208
    </Comment>
    <Graphics Color="000000" CenterX="11190.0" CenterY="15210.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="10000"/>
  </DataNode>
  <DataNode TextLabel="AKT1" Type="GeneProduct" GroupRef="d9e10">
    <Comment Source="KeggConverter">
Original kegg element: gene;20;hsa:10000 hsa:207 hsa:208
    </Comment>
    <Graphics Color="000000" CenterX="11190.0" CenterY="14610.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="207"/>
  </DataNode>
  <DataNode TextLabel="AKT2" Type="GeneProduct" GroupRef="d9e10">
    <Comment Source="KeggConverter">
Original kegg element: gene;20;hsa:10000 hsa:207 hsa:208
    </Comment>
    <Graphics Color="000000" CenterX="11190.0" CenterY="14910.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="208"/>
  </DataNode>
  <DataNode TextLabel="PIK3R5" Type="GeneProduct" GroupRef="d6b69">
    <Comment Source="KeggConverter">
Original kegg element: gene;21;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="11340.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="23533"/>
  </DataNode>
  <DataNode TextLabel="PIK3CA" Type="GeneProduct" GroupRef="d6b69">
    <Comment Source="KeggConverter">
Original kegg element: gene;21;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="12840.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5290"/>
  </DataNode>
  <DataNode TextLabel="PIK3CB" Type="GeneProduct" GroupRef="d6b69">
    <Comment Source="KeggConverter">
Original kegg element: gene;21;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="12240.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5291"/>
  </DataNode>
  <DataNode TextLabel="PIK3CD" Type="GeneProduct" GroupRef="d6b69">
    <Comment Source="KeggConverter">
Original kegg element: gene;21;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="13440.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5293"/>
  </DataNode>
  <DataNode TextLabel="PIK3CG" Type="GeneProduct" GroupRef="d6b69">
    <Comment Source="KeggConverter">
Original kegg element: gene;21;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="11940.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5294"/>
  </DataNode>
  <DataNode TextLabel="PIK3R1" Type="GeneProduct" GroupRef="d6b69">
    <Comment Source="KeggConverter">
Original kegg element: gene;21;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="12540.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5295"/>
  </DataNode>
  <DataNode TextLabel="PIK3R2" Type="GeneProduct" GroupRef="d6b69">
    <Comment Source="KeggConverter">
Original kegg element: gene;21;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="11640.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5296"/>
  </DataNode>
  <DataNode TextLabel="PIK3R3" Type="GeneProduct" GroupRef="d6b69">
    <Comment Source="KeggConverter">
Original kegg element: gene;21;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="13140.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="8503"/>
  </DataNode>
  <DataNode TextLabel="NFAT5" Type="GeneProduct" GroupRef="da8ff">
    <Comment Source="KeggConverter">
Original kegg element: gene;22;hsa:10725 hsa:4772 hsa:4773 hsa:4775 hsa:4776
    </Comment>
    <Graphics Color="000000" CenterX="18090.0" CenterY="7500.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="10725"/>
  </DataNode>
  <DataNode TextLabel="NFATC1" Type="GeneProduct" GroupRef="da8ff">
    <Comment Source="KeggConverter">
Original kegg element: gene;22;hsa:10725 hsa:4772 hsa:4773 hsa:4775 hsa:4776
    </Comment>
    <Graphics Color="000000" CenterX="18090.0" CenterY="6900.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="4772"/>
  </DataNode>
  <DataNode TextLabel="NFATC2" Type="GeneProduct" GroupRef="da8ff">
    <Comment Source="KeggConverter">
Original kegg element: gene;22;hsa:10725 hsa:4772 hsa:4773 hsa:4775 hsa:4776
    </Comment>
    <Graphics Color="000000" CenterX="18090.0" CenterY="7200.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="4773"/>
  </DataNode>
  <DataNode TextLabel="NFATC3" Type="GeneProduct" GroupRef="da8ff">
    <Comment Source="KeggConverter">
Original kegg element: gene;22;hsa:10725 hsa:4772 hsa:4773 hsa:4775 hsa:4776
    </Comment>
    <Graphics Color="000000" CenterX="18090.0" CenterY="6300.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="4775"/>
  </DataNode>
  <DataNode TextLabel="NFATC4" Type="GeneProduct" GroupRef="da8ff">
    <Comment Source="KeggConverter">
Original kegg element: gene;22;hsa:10725 hsa:4772 hsa:4773 hsa:4775 hsa:4776
    </Comment>
    <Graphics Color="000000" CenterX="18090.0" CenterY="6600.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="4776"/>
  </DataNode>
  <DataNode TextLabel="PRKCA" Type="GeneProduct" GroupRef="a3a1f">
    <Comment Source="KeggConverter">
Original kegg element: gene;23;hsa:5578 hsa:5579 hsa:5582
    </Comment>
    <Graphics Color="000000" CenterX="13680.0" CenterY="4350.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5578"/>
  </DataNode>
  <DataNode TextLabel="PRKCB" Type="GeneProduct" GroupRef="a3a1f">
    <Comment Source="KeggConverter">
Original kegg element: gene;23;hsa:5578 hsa:5579 hsa:5582
    </Comment>
    <Graphics Color="000000" CenterX="13680.0" CenterY="4950.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5579"/>
  </DataNode>
  <DataNode TextLabel="PRKCG" Type="GeneProduct" GroupRef="a3a1f">
    <Comment Source="KeggConverter">
Original kegg element: gene;23;hsa:5578 hsa:5579 hsa:5582
    </Comment>
    <Graphics Color="000000" CenterX="13680.0" CenterY="4650.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5582"/>
  </DataNode>
  <DataNode TextLabel="PTK2" Type="GeneProduct" GraphId="e9826">
    <Comment Source="KeggConverter">
Original kegg element: gene;24;hsa:5747
    </Comment>
    <Graphics Color="000000" CenterX="15540.0" CenterY="8940.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5747"/>
  </DataNode>
  <DataNode TextLabel="MAPK14" Type="GeneProduct" GroupRef="d7d9a">
    <Comment Source="KeggConverter">
Original kegg element: gene;25;hsa:1432 hsa:5600 hsa:5603 hsa:6300
    </Comment>
    <Graphics Color="000000" CenterX="11940.0" CenterY="10650.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="1432"/>
  </DataNode>
  <DataNode TextLabel="MAPK11" Type="GeneProduct" GroupRef="d7d9a">
    <Comment Source="KeggConverter">
Original kegg element: gene;25;hsa:1432 hsa:5600 hsa:5603 hsa:6300
    </Comment>
    <Graphics Color="000000" CenterX="11940.0" CenterY="10950.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5600"/>
  </DataNode>
  <DataNode TextLabel="MAPK13" Type="GeneProduct" GroupRef="d7d9a">
    <Comment Source="KeggConverter">
Original kegg element: gene;25;hsa:1432 hsa:5600 hsa:5603 hsa:6300
    </Comment>
    <Graphics Color="000000" CenterX="11940.0" CenterY="11250.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5603"/>
  </DataNode>
  <DataNode TextLabel="MAPK12" Type="GeneProduct" GroupRef="d7d9a">
    <Comment Source="KeggConverter">
Original kegg element: gene;25;hsa:1432 hsa:5600 hsa:5603 hsa:6300
    </Comment>
    <Graphics Color="000000" CenterX="11940.0" CenterY="10350.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="6300"/>
  </DataNode>
  <DataNode TextLabel="PXN" Type="GeneProduct" GraphId="a85dc">
    <Comment Source="KeggConverter">
Original kegg element: gene;26;hsa:5829
    </Comment>
    <Graphics Color="000000" CenterX="15540.0" CenterY="9600.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5829"/>
  </DataNode>
  <DataNode TextLabel="SH2D2A" Type="GeneProduct" GraphId="cf74d">
    <Comment Source="KeggConverter">
Original kegg element: gene;27;hsa:9047
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="5460.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="9047"/>
  </DataNode>
  <DataNode TextLabel="SRC" Type="GeneProduct" GraphId="cab9c">
    <Comment Source="KeggConverter">
Original kegg element: gene;28;hsa:6714
    </Comment>
    <Graphics Color="000000" CenterX="5970.0" CenterY="11550.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="6714"/>
  </DataNode>
  <DataNode TextLabel="SHC2" Type="GeneProduct" GraphId="cb01f">
    <Comment Source="KeggConverter">
Original kegg element: gene;29;hsa:25759
    </Comment>
    <Graphics Color="000000" CenterX="8100.0" CenterY="7890.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="25759"/>
  </DataNode>
  <DataNode TextLabel="VEGFA" Type="GeneProduct" GraphId="c6f0a">
    <Comment Source="KeggConverter">
Original kegg element: gene;30;hsa:7422
    </Comment>
    <Graphics Color="000000" CenterX="2160.0" CenterY="9270.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="7422"/>
  </DataNode>
  <DataNode TextLabel="MAPK1" Type="GeneProduct" GroupRef="feb7e">
    <Comment Source="KeggConverter">
Original kegg element: gene;33;hsa:5594 hsa:5595
    </Comment>
    <Graphics Color="000000" CenterX="23370.0" CenterY="3720.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5594"/>
  </DataNode>
  <DataNode TextLabel="MAPK3" Type="GeneProduct" GroupRef="feb7e">
    <Comment Source="KeggConverter">
Original kegg element: gene;33;hsa:5594 hsa:5595
    </Comment>
    <Graphics Color="000000" CenterX="23370.0" CenterY="4020.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5595"/>
  </DataNode>
  <DataNode TextLabel="MAP2K1" Type="GeneProduct" GroupRef="f9072">
    <Comment Source="KeggConverter">
Original kegg element: gene;34;hsa:5604 hsa:5605
    </Comment>
    <Graphics Color="000000" CenterX="21090.0" CenterY="4020.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5604"/>
  </DataNode>
  <DataNode TextLabel="MAP2K2" Type="GeneProduct" GroupRef="f9072">
    <Comment Source="KeggConverter">
Original kegg element: gene;34;hsa:5604 hsa:5605
    </Comment>
    <Graphics Color="000000" CenterX="21090.0" CenterY="3720.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5605"/>
  </DataNode>
  <DataNode TextLabel="RAF1" Type="GeneProduct" GraphId="e64f8">
    <Comment Source="KeggConverter">
Original kegg element: gene;35;hsa:5894
    </Comment>
    <Graphics Color="000000" CenterX="19590.0" CenterY="3240.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5894"/>
  </DataNode>
  <DataNode TextLabel="HRAS" Type="GeneProduct" GroupRef="c8e49">
    <Comment Source="KeggConverter">
Original kegg element: gene;36;hsa:3265 hsa:3845 hsa:4893
    </Comment>
    <Graphics Color="000000" CenterX="17280.0" CenterY="3210.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="3265"/>
  </DataNode>
  <DataNode TextLabel="KRAS" Type="GeneProduct" GroupRef="c8e49">
    <Comment Source="KeggConverter">
Original kegg element: gene;36;hsa:3265 hsa:3845 hsa:4893
    </Comment>
    <Graphics Color="000000" CenterX="17280.0" CenterY="2610.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="3845"/>
  </DataNode>
  <DataNode TextLabel="NRAS" Type="GeneProduct" GroupRef="c8e49">
    <Comment Source="KeggConverter">
Original kegg element: gene;36;hsa:3265 hsa:3845 hsa:4893
    </Comment>
    <Graphics Color="000000" CenterX="17280.0" CenterY="2910.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="4893"/>
  </DataNode>
  <DataNode TextLabel="NOS3" Type="GeneProduct" GraphId="eeae0">
    <Comment Source="KeggConverter">
Original kegg element: gene;37;hsa:4846
    </Comment>
    <Graphics Color="000000" CenterX="14730.0" CenterY="14130.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="4846"/>
  </DataNode>
  <DataNode TextLabel="CASP9" Type="GeneProduct" GraphId="d3627">
    <Comment Source="KeggConverter">
Original kegg element: gene;38;hsa:842
    </Comment>
    <Graphics Color="000000" CenterX="14730.0" CenterY="15300.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="842"/>
  </DataNode>
  <DataNode TextLabel="BAD" Type="GeneProduct" GraphId="f7c12">
    <Comment Source="KeggConverter">
Original kegg element: gene;39;hsa:572
    </Comment>
    <Graphics Color="000000" CenterX="14730.0" CenterY="16470.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="572"/>
  </DataNode>
  <DataNode TextLabel="RAC1" Type="GeneProduct" GroupRef="d86c8">
    <Comment Source="KeggConverter">
Original kegg element: gene;40;hsa:5879 hsa:5880 hsa:5881
    </Comment>
    <Graphics Color="000000" CenterX="16620.0" CenterY="12270.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5879"/>
  </DataNode>
  <DataNode TextLabel="RAC2" Type="GeneProduct" GroupRef="d86c8">
    <Comment Source="KeggConverter">
Original kegg element: gene;40;hsa:5879 hsa:5880 hsa:5881
    </Comment>
    <Graphics Color="000000" CenterX="16620.0" CenterY="12870.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5880"/>
  </DataNode>
  <DataNode TextLabel="RAC3" Type="GeneProduct" GroupRef="d86c8">
    <Comment Source="KeggConverter">
Original kegg element: gene;40;hsa:5879 hsa:5880 hsa:5881
    </Comment>
    <Graphics Color="000000" CenterX="16620.0" CenterY="12570.0" Width="1200.0" Height="300.0" ZOrder="32768"/>
    <Xref Database="Entrez Gene" ID="5881"/>
  </DataNode>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;11;19
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="8820.0" y="6720.0" GraphRef="b0197" relX="1.0" relY="0.0"/>
      <Point x="14880.0" y="6900.0" GraphRef="a7eed" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;11;23
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="8820.0" y="6720.0" GraphRef="b0197" relX="1.0" relY="0.0"/>
      <Point x="12960.0" y="4650.0" GraphRef="c9a8c" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;11;16
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="8820.0" y="6720.0" GraphRef="b0197" relX="1.0" relY="0.0"/>
      <Point x="23790.0" y="5130.0" GraphRef="e8667" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;11;37
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="8100.0" y="7140.0" GraphRef="b0197" relX="0.0" relY="1.0"/>
      <Point x="14130.0" y="14130.0" GraphRef="eeae0" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;21;40
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="8820.0" y="12390.0" GraphRef="c43cf" relX="1.0" relY="0.0"/>
      <Point x="15900.0" y="12570.0" GraphRef="e6489" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;21;20
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="8820.0" y="12390.0" GraphRef="c43cf" relX="1.0" relY="0.0"/>
      <Point x="10470.0" y="14910.0" GraphRef="aa366" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;30;10
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="2760.0" y="9270.0" GraphRef="c6f0a" relX="1.0" relY="0.0"/>
      <Point x="3690.0" y="9270.0" GraphRef="a0745" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;10;27
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="4290.0" y="9120.0" GraphRef="a0745" relX="0.0" relY="-1.0"/>
      <Point x="7500.0" y="5460.0" GraphRef="cf74d" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;10;11
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="4290.0" y="9120.0" GraphRef="a0745" relX="0.0" relY="-1.0"/>
      <Point x="7380.0" y="6720.0" GraphRef="b0197" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;10;29
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="4290.0" y="9120.0" GraphRef="a0745" relX="0.0" relY="-1.0"/>
      <Point x="7500.0" y="7890.0" GraphRef="cb01f" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;10;24
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="4890.0" y="9270.0" GraphRef="a0745" relX="1.0" relY="0.0"/>
      <Point x="14940.0" y="8940.0" GraphRef="e9826" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;10;26
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="4890.0" y="9270.0" GraphRef="a0745" relX="1.0" relY="0.0"/>
      <Point x="14940.0" y="9600.0" GraphRef="a85dc" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;10;1
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="4890.0" y="9270.0" GraphRef="a0745" relX="1.0" relY="0.0"/>
      <Point x="8430.0" y="10440.0" GraphRef="c49ce" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;10;21
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="4290.0" y="9420.0" GraphRef="a0745" relX="0.0" relY="1.0"/>
      <Point x="8100.0" y="11070.0" GraphRef="c43cf" relX="0.0" relY="-1.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;10;28
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="4290.0" y="9420.0" GraphRef="a0745" relX="0.0" relY="1.0"/>
      <Point x="5370.0" y="11550.0" GraphRef="cab9c" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;28;21
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="5970.0" y="11700.0" GraphRef="cab9c" relX="0.0" relY="1.0"/>
      <Point x="7380.0" y="12390.0" GraphRef="c43cf" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;23;35
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="14400.0" y="4650.0" GraphRef="c9a8c" relX="1.0" relY="0.0"/>
      <Point x="18990.0" y="3240.0" GraphRef="e64f8" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;36;35
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="18000.0" y="2910.0" GraphRef="bcd20" relX="1.0" relY="0.0"/>
      <Point x="18990.0" y="3240.0" GraphRef="e64f8" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;33;16
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="23370.0" y="4290.0" GraphRef="e014e" relX="0.0" relY="1.0"/>
      <Point x="24510.0" y="2910.0" GraphRef="e8667" relX="0.0" relY="-1.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;1;25
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="9630.0" y="10440.0" GraphRef="c49ce" relX="1.0" relY="0.0"/>
      <Point x="11220.0" y="10800.0" GraphRef="eaf9b" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;12;36
    </Comment>
    <Comment Source="KeggConverter">
indirect; ..&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="15900.0" y="3330.0" GraphRef="a2464" relX="1.0" relY="0.0"/>
      <Point x="16560.0" y="2910.0" GraphRef="bcd20" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;23;12
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="13680.0" y="4080.0" GraphRef="c9a8c" relX="0.0" relY="-1.0"/>
      <Point x="14460.0" y="3330.0" GraphRef="a2464" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;35;34
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="19590.0" y="3390.0" GraphRef="e64f8" relX="0.0" relY="1.0"/>
      <Point x="20370.0" y="3870.0" GraphRef="c5be9" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;34;33
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="21810.0" y="3870.0" GraphRef="c5be9" relX="1.0" relY="0.0"/>
      <Point x="22650.0" y="3870.0" GraphRef="e014e" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;25;18
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="12660.0" y="10800.0" GraphRef="eaf9b" relX="1.0" relY="0.0"/>
      <Point x="14850.0" y="10800.0" GraphRef="eb496" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;18;17
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="16290.0" y="10800.0" GraphRef="eb496" relX="1.0" relY="0.0"/>
      <Point x="18240.0" y="10950.0" GraphRef="b2c17" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Broken">
    <Comment Source="KeggConverter">
PPrel;20;37
    </Comment>
    <Comment Source="KeggConverter">
activation; --&gt;
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="11910.0" y="14910.0" GraphRef="aa366" relX="1.0" relY="0.0"/>
      <Point x="14130.0" y="14130.0" GraphRef="eeae0" relX="-1.0" relY="0.0" ArrowHead="Arrow"/>
    </Graphics>
  </Line>
  <Line Style="Solid">
    <Comment Source="KeggConverter">
PPrel;20;38
    </Comment>
    <Comment Source="KeggConverter">
inhibition; --|
    </Comment>
    <Graphics ZOrder="12288" Color="000000">
      <Point x="11910.0" y="14910.0" GraphRef="aa366" relX="1.0" relY="0.0"/>
      <Point x="14130.0" y="15300.0" GraphRef="d3627" relX="-1.0" relY="0.0" ArrowHead="TBar"/>
    </Graphics>
  </Line>
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PPrel;20;39
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    <Comment Source="KeggConverter">
inhibition; --|
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    <Comment Source="KeggConverter">
PPrel;19;22
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    <Comment Source="KeggConverter">
activation; --&gt;
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    <Comment Source="KeggConverter">
PPrel;22;15
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    <Comment Source="KeggConverter">
expression; --&gt;
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PPrel;11;27
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binding/association; ---
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http://www.genome.jp/kegg/pathway/hsa/hsa04020.html
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http://www.genome.jp/kegg/pathway/hsa/hsa04210.html
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http://www.genome.jp/kegg/pathway/hsa/hsa04510.html
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http://www.genome.jp/kegg/pathway/hsa/hsa04010.html
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http://www.genome.jp/kegg/pathway/hsa/hsa00590.html
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