EPO receptor signaling (Pan troglodytes)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://genmapp.org/GPML/2008a" Name="EPO Receptor Signaling" Version="20081110" Author="Thomas Kelder" Last-Modified="12/9/2009" Organism="Pan troglodytes"> <Comment Source="WikiPathways-description">The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP581&amp;oldid=22574 WP581(r22574)] with a 88% conversion rate.</Comment> <Graphics BoardWidth="17820.0" BoardHeight="13200.0" WindowWidth="18000.0" WindowHeight="12000.0"/> <DataNode TextLabel="EPOR" Type="GeneProduct" GraphId="eda83" GroupRef="df8a7" BackpageHead="EPOR"> <Graphics Color="000000" CenterX="6795.0" CenterY="2895.0" Width="1200.0" Height="870.0" ZOrder="-26"/> <Xref Database="Entrez Gene" ID="455728"/> </DataNode> <DataNode TextLabel="JAK2" Type="GeneProduct" BackpageHead="JAK2" GraphId="cff3e" GroupRef="df8a7"> <Graphics Color="000000" CenterX="5640.0" CenterY="3645.0" Width="1200.0" Height="300.0" ZOrder="-22"/> <Xref Database="Entrez Gene" ID="464979"/> 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Height="240.5" ZOrder="-28" Rotation="0.0"/> </Shape> <Shape Type="Rectangle" Style="Solid" GraphId="cead5" GroupRef="b7148"> <Graphics FillColor="ffff99" Color="ff6600" CenterX="8474.75" CenterY="2879.75" Width="14400.5" Height="240.5" ZOrder="-28" Rotation="0.0"/> </Shape> <Group GroupId="d0755" GraphId="cbd49" Style="Complex"> <Comment>Not sure if complex consists of both A and B isoforms [thomas-081110]</Comment> </Group> <Group GroupId="b4157" GraphId="da768" Style="Complex"/> <Group GroupId="a6e19" GraphId="a7cb0" Style="Complex"/> <Group GroupId="d6c58" GraphId="f473a" Style="Group"/> <Group GroupId="d829a" GraphId="bc2b8" Style="Group"/> <Group GroupId="ce0f4" GraphId="ee500" Style="Complex"/> <Group GroupId="e49e1" GraphId="e3bcf" Style="Complex"/> <Group GroupId="b128c" GraphId="f97e7" Style="Complex"/> <Group GroupId="e2ef6" GraphId="cfbf2" Style="Complex"/> <Group GroupId="df8a7" GraphId="e7fae" Style="Group"/> <Group GroupId="c9c1c" GraphId="bb6fc" Style="Complex"/> <Group 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