ACE inhibitor pathway (Canis familiaris)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://genmapp.org/GPML/2008a" Name="ACE Inhibitor Pathway" Data-Source="GenMAPP 2.0" Version="20041216" Author="Caroline F. Thorn" Email="genmapp@gladstone.ucsf.edu" Last-Modified="12/9/2009" Organism="Canis familiaris"> <Comment Source="GenMAPP notes">https://www.pharmgkb.org/search/pathway/ace-inhibitor.jsp Model non-tissue specific cell displaying genes which may be involved in the ACE inhibitor pathway.</Comment> <Comment Source="GenMAPP remarks">Adapted from PharmGKB (right click for info)</Comment> <Comment Source="WikiPathways-category">Physiological Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP554&amp;amp;oldid=30178 WP554(r30178)] with a 88% conversion rate.</Comment> <Comment Source="WikiPathways-description">The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&amp;objCls=Pathway)</Comment> <BiopaxRef>b93</BiopaxRef> <Graphics BoardWidth="11247.5" BoardHeight="7705.5" /> <DataNode BackpageHead="AGT" TextLabel="AGT" Type="GeneProduct" GraphId="a57"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="AGT" /> <Graphics Color="000000" CenterX="2245.0" CenterY="1305.0" Width="900.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="403783" /> </DataNode> <DataNode BackpageHead="REN" TextLabel="REN" Type="GeneProduct" GraphId="ea3"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="REN" /> <Graphics Color="000000" CenterX="1990.0" CenterY="1980.0" Width="900.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="403838" /> </DataNode> <DataNode BackpageHead="ACE" TextLabel="ACE" Type="GeneProduct" GraphId="ab9"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACE" /> <Graphics Color="000000" CenterX="1665.0" CenterY="3505.0" 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</DataNode> <DataNode BackpageHead="ACE Inhibitor" TextLabel="ACE Inhibitor" Type="Metabolite" GraphId="de7"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACE Inhibitor" /> <Graphics Color="cc0000" CenterX="4285.0" CenterY="2320.0" Width="1400.0" Height="300.0" ZOrder="32768" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Angiotensin II" Type="Metabolite" GraphId="ff099"> <Graphics Color="0000ff" CenterX="1620.0" CenterY="4365.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="HMDB" ID="HMDB01035" /> </DataNode> <DataNode TextLabel="Angiotensin I" Type="Metabolite" GraphId="b0bb0"> <Graphics Color="0000ff" CenterX="1665.0" CenterY="2895.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="PubChem" ID="3081372" /> </DataNode> <DataNode TextLabel="Bradykinin" Type="Metabolite" GraphId="f0af8"> <Graphics Color="0000ff" CenterX="7170.0" CenterY="2640.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="HMDB" ID="HMDB04246" /> </DataNode> <DataNode TextLabel="Aldosterone" Type="Metabolite" GraphId="e48f5"> <Graphics Color="0000ff" CenterX="2310.0" CenterY="6855.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="Kegg Compound" ID="C01780" /> </DataNode> <Line Style="Solid" GraphId="e43ba"> <Graphics ZOrder="12288" Color="008000"> <Point x="7000.0" y="1520.0" GraphRef="ac4" relX="0.0" relY="1.0" /> <Point x="7170.0" y="2490.0" GraphRef="f0af8" relX="0.0" relY="-1.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line Style="Solid" GraphId="eebe1"> <Graphics ZOrder="12288" Color="008000"> <Point x="2245.0" y="1455.0" GraphRef="a57" relX="0.0" relY="1.0" /> <Point x="1665.0" y="2745.0" GraphRef="b0bb0" relX="0.0" relY="-1.0" ArrowHead="Arrow" /> <Anchor position="0.4" Shape="None" GraphId="b3037" /> </Graphics> </Line> <Line Style="Solid" GraphId="fb225"> <Graphics ZOrder="12288" Color="008000"> <Point x="1620.0" y="4515.0" GraphRef="ff099" relX="0.0" relY="1.0" /> <Point x="1730.0" 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BL</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hooper NM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Korstanje R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Osterhaus AD</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Timens W</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Turner AJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Navis G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">van Goor H</bp:AUTHORS> </bp:PublicationXRef> </Biopax> </Pathway>

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