Cholesterol biosynthesis pathway (Homo sapiens)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://genmapp.org/GPML/2008a" Name="Cholesterol Biosynthesis" Data-Source="GenMAPP 2.0" Version="20041203" Author="Michael Lieberman and Ned Mantei" Email="genmapp@gladstone.ucsf.edu" Last-Modified="12/10/2009" Organism="Homo sapiens" Copyright="2004, Gladstone Institutes"> <Comment Source="GenMAPP notes">References: Bard, M., Bruner, D. A., Pierson, C. A., Lees, N. D., Biermann, B., Frye, L., Koegel, C., and Barbuch, R. (1996). Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase. Proc Natl Acad Sci U S A 93, 186-190. Gaylor, J. L. (2002). Membrane-bound enzymes of cholesterol synthesis from lanosterol. Biochem Biophys Res Commun 292, 1139-1146. Li, L., and Kaplan, J. (1996). Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. J Biol Chem 271, 16927-16933. Liu, X. Y., Dangel, A. W., Kelley, R. I., Zhao, W., Denny, P., Botcherby, M., Cattanach, B., Peters, J., Hunsicker, P. R., Mallon, A. M., et al. (1999). The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase. Nat Genet 22, 182-187. Ohashi, M., Mizushima, N., Kabeya, Y., and Yoshimori, T. (2003). Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J Biol Chem 278, 36819-36829. Sagami, H., Korenaga, T., and Ogura, K. (1993). Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. J Biochem (Tokyo) 114, 118-121. Yoshida, Y., Noshiro, M., Aoyama, Y., Kawamoto, T., Horiuchi, T., and Gotoh, O. (1997). Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: II. Evolutionary analysis of protein and gene structures. J Biochem (Tokyo) 122, 1122-1128. </Comment> <Comment Source="GenMAPP remarks">Right click for notes</Comment> <Comment Source="WikiPathways-category">Metabolic Process</Comment> <BiopaxRef>ec9</BiopaxRef> <BiopaxRef>d9b</BiopaxRef> <BiopaxRef>e32</BiopaxRef> <BiopaxRef>c8f</BiopaxRef> <BiopaxRef>ea9</BiopaxRef> <BiopaxRef>cdc</BiopaxRef> <BiopaxRef>e73</BiopaxRef> <Graphics BoardWidth="10862.5" BoardHeight="10972.5" /> <DataNode BackpageHead="FDPS | farnesyl diphosphate synthase (farnesyl ..." TextLabel="FDPS" Type="GeneProduct" GraphId="aa8"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FDPS | farnesyl diphosphate synthase (farnesyl ..." /> <Graphics Color="000000" CenterX="1675.0" CenterY="9500.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="2224" /> </DataNode> <DataNode BackpageHead="IDI1 | isopentenyl-diphosphate delta isomerase" TextLabel="IDI1" Type="GeneProduct" GraphId="c3b"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IDI1 | isopentenyl-diphosphate delta isomerase" /> <Graphics Color="000000" CenterX="2970.0" CenterY="6365.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="3422" /> </DataNode> <DataNode BackpageHead="HMGCS1 | 3-hydroxy-3-methylglutaryl-Coenzyme A ..." TextLabel="HMGCS1" Type="GeneProduct" GraphId="b21"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HMGCS1 | 3-hydroxy-3-methylglutaryl-Coenzyme A ..." /> <Graphics Color="000000" CenterX="4475.0" CenterY="2045.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="3157" /> </DataNode> <DataNode BackpageHead="HMGCR | 3-hydroxy-3-methylglutaryl-Coenzyme A r..." TextLabel="HMGCR" Type="GeneProduct" GraphId="d8b"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HMGCR | 3-hydroxy-3-methylglutaryl-Coenzyme A r..." /> <Graphics Color="000000" CenterX="4475.0" CenterY="3165.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="3156" /> </DataNode> <DataNode BackpageHead="MVK | mevalonate kinase (mevalonic aciduria)" TextLabel="MVK" Type="GeneProduct" GraphId="fa9"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MVK | mevalonate kinase (mevalonic aciduria)" /> <Graphics Color="000000" CenterX="4475.0" CenterY="4275.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="4598" /> </DataNode> <DataNode BackpageHead="MVD | mevalonate (diphospho) decarboxylase" TextLabel="MVD" Type="GeneProduct" GraphId="c55"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MVD | mevalonate (diphospho) decarboxylase" /> <Graphics Color="000000" CenterX="4475.0" CenterY="6365.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="4597" /> </DataNode> <DataNode BackpageHead="FDPS | farnesyl diphosphate synthase (farnesyl ..." TextLabel="FDPS" Type="GeneProduct" GraphId="ee8"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FDPS | farnesyl diphosphate synthase (farnesyl ..." /> <Graphics Color="000000" CenterX="4145.0" CenterY="7775.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="2224" /> </DataNode> <DataNode BackpageHead="FDFT1 | farnesyl-diphosphate farnesyltransferas..." TextLabel="FDFT1" Type="GeneProduct" GraphId="f32"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FDFT1 | farnesyl-diphosphate farnesyltransferas..." /> <Graphics Color="000000" CenterX="6185.0" CenterY="9825.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="2222" /> </DataNode> <DataNode BackpageHead="DHCR7 | 7-dehydrocholesterol reductase" TextLabel="DHCR7" Type="GeneProduct" GraphId="db2"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DHCR7 | 7-dehydrocholesterol reductase" /> <Graphics Color="000000" CenterX="9255.0" CenterY="3100.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="1717" /> </DataNode> <DataNode BackpageHead="SC5DL | sterol-C5-desaturase (ERG3 delta-5-desa..." TextLabel="SC5DL" Type="GeneProduct" GraphId="f2b"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SC5DL | sterol-C5-desaturase (ERG3 delta-5-desa..." /> <Graphics Color="000000" CenterX="9255.0" CenterY="4250.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="6309" /> </DataNode> <DataNode BackpageHead="LSS | lanosterol synthase (23-oxidosqualene-la..." TextLabel="LSS" Type="GeneProduct" GraphId="f92"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LSS | lanosterol synthase (23-oxidosqualene-la..." /> <Graphics Color="000000" CenterX="9255.0" CenterY="7185.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="4047" /> </DataNode> <DataNode BackpageHead="SQLE | squalene epoxidase" TextLabel="SQLE" Type="GeneProduct" GraphId="b6d"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SQLE | squalene epoxidase" /> <Graphics Color="000000" CenterX="9255.0" CenterY="8485.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="6713" /> </DataNode> <DataNode BackpageHead="PMVK | phosphomevalonate kinase" TextLabel="PMVK" Type="GeneProduct" GraphId="e5c"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PMVK | phosphomevalonate kinase" /> <Graphics Color="000000" CenterX="4475.0" CenterY="5325.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="10654" /> </DataNode> <DataNode BackpageHead="NSDHL | NAD(P) dependent steroid dehydrogenase-..." TextLabel="NSDHL" Type="GeneProduct" GraphId="a12" GroupRef="c1291"> <Comment Source="GenMAPP remarks">NAD(P) dependent steroid dehydrogenase-like</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="NSDHL | NAD(P) dependent steroid dehydrogenase-..." /> <Graphics Color="000000" CenterX="9255.0" CenterY="5205.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="50814" /> </DataNode> <DataNode BackpageHead="CYP51A1 | cytochrome P450 family 51 subfamily..." TextLabel="CYP51A1" Type="GeneProduct" GraphId="d4d" GroupRef="c1291"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CYP51A1 | cytochrome P450 family 51 subfamily..." /> <Graphics Color="000000" CenterX="9255.0" CenterY="5805.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="1595" /> </DataNode> <DataNode BackpageHead="SC4MOL | sterol-C4-methyl oxidase-like" TextLabel="SC4MOL" Type="GeneProduct" GraphId="b31" GroupRef="c1291"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SC4MOL | sterol-C4-methyl oxidase-like" /> <Graphics Color="000000" CenterX="9255.0" CenterY="5505.0" Width="1000.0" Height="300.0" ZOrder="32768" /> <Xref Database="Entrez Gene" ID="6307" /> </DataNode> <DataNode TextLabel="Acetyl-CoA" Type="Metabolite" GraphId="fb3"> <Graphics Color="0000ff" CenterX="5550.0" CenterY="1485.0" Width="1115.0" Height="240.0" ZOrder="32768" /> <Xref Database="CAS" ID="72-89-9" /> </DataNode> <DataNode TextLabel="Squalene" Type="Metabolite" GraphId="f02"> <Graphics Color="0000ff" CenterX="8100.0" CenterY="9135.0" Width="995.0" Height="240.0" ZOrder="32768" /> <Xref Database="CAS" ID="111-02-4" /> </DataNode> <DataNode TextLabel="Lathosterol" Type="Metabolite" GraphId="b63"> <Graphics Color="0000ff" CenterX="8100.0" CenterY="4700.0" Width="1145.0" Height="240.0" ZOrder="32768" /> <Xref Database="CAS" ID="80-99-9" /> </DataNode> <DataNode TextLabel="Cholesterol" Type="Metabolite" GraphId="e9f"> <Graphics Color="0000ff" CenterX="8100.0" CenterY="2500.0" Width="1160.0" Height="240.0" ZOrder="32768" /> <Xref Database="CAS" ID="57-88-5" /> </DataNode> <DataNode TextLabel="HMG-CoA" Type="Metabolite" GraphId="e89f4"> <Graphics Color="0000ff" CenterX="5550.0" CenterY="2692.5" Width="1260.5" Height="285.0" ZOrder="32768" /> <Xref Database="CAS" ID="" /> </DataNode> <DataNode TextLabel="Mevalonic acid" Type="Metabolite" GraphId="a6a21"> <Graphics Color="0000ff" CenterX="5550.0" CenterY="3825.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="CAS" ID="150-97-0" /> </DataNode> <DataNode TextLabel="Mevalonic acid-5P" Type="Metabolite" GraphId="ef0dc"> <Graphics Color="0000ff" CenterX="5550.0" CenterY="4905.0" Width="1470.0" Height="300.0" ZOrder="32768" /> <Xref Database="CAS" ID="73566-35-5" /> </DataNode> <DataNode TextLabel="Mevalonic acid 5-pyrophosphate" Type="Metabolite" GraphId="c3220"> <Graphics Color="0000ff" CenterX="5550.0" CenterY="5880.0" Width="2535.0" Height="300.0" ZOrder="32768" /> <Xref Database="CAS" ID="1492-08-6" /> </DataNode> <DataNode TextLabel="farnesyl pyrophosphate" Type="Metabolite" GraphId="a7690"> <Graphics Color="0000ff" CenterX="5550.0" CenterY="8670.0" Width="1860.0" Height="300.0" ZOrder="32768" /> <Xref Database="CAS" ID="13058-04-3" /> </DataNode> <DataNode TextLabel="Geranyl-PP" Type="Metabolite" GraphId="e993b"> <Graphics Color="0000ff" CenterX="3135.0" CenterY="8670.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="CAS" ID="6699-20-3" /> </DataNode> <DataNode TextLabel="Dimethylallylpyrophosphate" Type="Metabolite" GraphId="fce72"> <Graphics Color="0000ff" CenterX="1215.0" CenterY="6990.0" Width="2130.0" Height="300.0" ZOrder="32768" /> <Xref Database="CAS" ID="358-72-5" /> </DataNode> <DataNode TextLabel="7-Dehydrocholesterol" Type="Metabolite" GraphId="d931a"> <Graphics Color="0000ff" CenterX="8100.0" CenterY="3629.75" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="CAS" ID="434-16-2" /> </DataNode> <DataNode TextLabel="Lanosterin" Type="Metabolite" GraphId="b6fae"> <Graphics Color="0000ff" CenterX="8100.0" CenterY="6555.0" Width="1200.0" Height="300.0" ZOrder="32768" /> <Xref Database="CAS" ID="79-63-0" /> </DataNode> <DataNode TextLabel="(S)-2,3-Epoxysqualene" Type="Metabolite" GraphId="a6667"> <Graphics Color="0000ff" CenterX="8100.0" CenterY="7890.0" Width="1845.0" Height="300.0" ZOrder="32768" /> <Xref Database="CAS" ID="9029-62-3" /> </DataNode> <DataNode TextLabel="isopentenyl pyrophosphate" Type="Metabolite" GraphId="db29a"> <Graphics Color="0000ff" CenterX="5550.0" CenterY="7005.0" Width="2010.0" Height="300.0" ZOrder="32768" /> <Xref Database="CAS" ID="358-71-4" /> </DataNode> <Line Style="Solid" GraphId="ce5bf"> <Graphics ZOrder="12288" Color="000000"> <Point x="5550.0" y="767.5" GraphRef="eba" relX="0.0" relY="1.0" /> <Point x="5550.0" y="1365.0" GraphRef="fb3" relX="0.0" relY="-1.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line Style="Solid" GraphId="b48ab"> <Graphics ZOrder="12288" Color="000000"> <Point x="5550.0" y="2835.0" GraphRef="e89f4" relX="0.0" relY="1.0" /> <Point x="5550.0" y="3675.0" GraphRef="a6a21" relX="0.0" relY="-1.0" ArrowHead="Arrow" /> <Anchor position="0.4" Shape="None" GraphId="f9df0" /> </Graphics> </Line> <Line Style="Solid" GraphId="e5499"> <Graphics ZOrder="12288" Color="000000"> <Point x="5550.0" y="3975.0" GraphRef="a6a21" relX="0.0" relY="1.0" /> <Point x="5550.0" y="4755.0" GraphRef="ef0dc" relX="0.0" relY="-1.0" ArrowHead="Arrow" /> <Anchor position="0.4" Shape="None" GraphId="bba75" /> </Graphics> </Line> <Line Style="Solid" GraphId="afc8c"> <Graphics ZOrder="12288" Color="000000"> <Point x="5550.0" y="5055.0" GraphRef="ef0dc" relX="0.0" relY="1.0" /> <Point x="5550.0" y="5730.0" GraphRef="c3220" relX="0.0" relY="-1.0" ArrowHead="Arrow" /> <Anchor position="0.4" Shape="None" GraphId="fbcdb" /> </Graphics> </Line> <Line Style="Solid" GraphId="df029"> <Graphics ZOrder="12288" Color="000000"> <Point x="5550.0" y="6030.0" GraphRef="c3220" relX="0.0" relY="1.0" /> <Point x="5550.0" y="6855.0" GraphRef="db29a" relX="0.0" relY="-1.0" ArrowHead="Arrow" /> <Anchor position="0.4" Shape="None" GraphId="cd7d3" /> </Graphics> </Line> <Line Style="Solid" GraphId="fba14"> <Graphics ZOrder="12288" Color="000000"> <Point x="5550.0" y="7155.0" GraphRef="db29a" relX="0.0" relY="1.0" /> <Point x="5550.0" y="8520.0" GraphRef="a7690" relX="0.0" relY="-1.0" ArrowHead="Arrow" /> <Anchor position="0.45054945054945056" Shape="None" GraphId="c86c0" /> </Graphics> </Line> <Line Style="Solid" GraphId="a76ac"> <Graphics ConnectorType="Elbow" ZOrder="12288" Color="000000"> <Point x="1215.0" y="7140.0" GraphRef="fce72" relX="0.0" relY="1.0" /> <Point x="2535.0" y="8670.0" GraphRef="e993b" relX="-1.0" relY="0.0" ArrowHead="Arrow" /> <Anchor position="0.6952832268018515" Shape="None" GraphId="c4ce3" /> </Graphics> </Line> <Line Style="Solid" GraphId="c42f1"> <Graphics ZOrder="12288" Color="000000"> <Point x="3735.0" y="8670.0" GraphRef="e993b" relX="1.0" relY="0.0" /> <Point x="4620.0" y="8670.0" GraphRef="a7690" relX="-1.0" relY="0.0" ArrowHead="Arrow" /> <Anchor position="0.4576271186440678" Shape="None" GraphId="d6cf4" /> </Graphics> </Line> <Line Style="Solid" GraphId="e5d42"> <Graphics ZOrder="12288" Color="000000"> <Point x="2280.0" y="6990.0" GraphRef="fce72" relX="1.0" relY="0.0" ArrowHead="Arrow" /> <Point x="4545.0" y="7005.0" GraphRef="db29a" relX="-1.0" relY="0.0" ArrowHead="Arrow" /> <Anchor position="0.3046662573458469" Shape="None" GraphId="a45b2" /> </Graphics> </Line> <Line Style="Solid" GraphId="d8699"> <Graphics ConnectorType="Elbow" ZOrder="12288" Color="000000"> <Point x="5550.0" y="8820.0" GraphRef="a7690" relX="0.0" relY="1.0" /> <Point x="7602.5" y="9135.0" GraphRef="f02" relX="-1.0" relY="0.0" ArrowHead="Arrow" /> <Anchor position="0.4" Shape="None" GraphId="dc8c8" /> </Graphics> </Line> <Line Style="Solid" GraphId="f8234"> <Graphics ZOrder="12288" Color="000000"> <Point x="8100.0" y="9015.0" GraphRef="f02" relX="0.0" relY="-1.0" /> <Point x="8100.0" y="8040.0" GraphRef="a6667" relX="0.0" relY="1.0" ArrowHead="Arrow" /> <Anchor position="0.5538461538461539" Shape="None" GraphId="c8fcf" /> </Graphics> </Line> <Line Style="Solid" GraphId="e49fd"> <Graphics ZOrder="12288" Color="000000"> <Point x="8100.0" y="7740.0" GraphRef="a6667" relX="0.0" relY="-1.0" /> <Point x="8100.0" y="6705.0" GraphRef="b6fae" relX="0.0" relY="1.0" ArrowHead="Arrow" /> <Anchor position="0.5362318840579711" Shape="None" GraphId="b1970" /> </Graphics> </Line> <Line Style="Broken" GraphId="eee2c"> <Graphics ZOrder="12288" Color="000000"> <Point x="8100.0" y="6405.0" GraphRef="b6fae" relX="0.0" relY="-1.0" /> <Point x="8100.0" y="4820.0" GraphRef="b63" relX="0.0" relY="1.0" ArrowHead="Arrow" /> <Anchor position="0.5594855305466238" Shape="None" GraphId="a90f7" /> </Graphics> </Line> <Line Style="Solid" GraphId="ebba8"> <Graphics ZOrder="12288" Color="000000"> <Point x="8100.0" y="4580.0" GraphRef="b63" relX="0.0" relY="-1.0" /> <Point x="8100.0" y="3779.75" GraphRef="d931a" relX="0.0" relY="1.0" ArrowHead="Arrow" /> <Anchor position="0.4" Shape="None" GraphId="dc6bd" /> </Graphics> </Line> <Line Style="Solid" GraphId="be91e"> <Graphics ZOrder="12288" Color="000000"> <Point x="8100.0" y="3479.75" GraphRef="d931a" relX="0.0" relY="-1.0" /> <Point x="8100.0" y="2620.0" GraphRef="e9f" relX="0.0" relY="1.0" ArrowHead="Arrow" /> <Anchor position="0.45332945623727827" Shape="None" GraphId="a0eb0" /> </Graphics> </Line> <Line Style="Solid" GraphId="a94b2"> <Graphics ZOrder="12288" Color="000000"> <Point x="5550.0" y="1605.0" GraphRef="fb3" relX="0.0" relY="1.0" /> <Point x="5550.0" y="2550.0" GraphRef="e89f4" relX="0.0" relY="-1.0" ArrowHead="Arrow" /> <Anchor position="0.4603174603174603" Shape="None" GraphId="d94e5" /> </Graphics> </Line> <Line Style="Solid" GraphId="ab9eb"> <Graphics ZOrder="12288" Color="000000"> <Point x="4975.0" y="2045.0" GraphRef="b21" relX="1.0" relY="0.0" /> <Point x="5550.0" y="2040.0" GraphRef="d94e5" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="e2c7f"> <Graphics ZOrder="12288" Color="000000"> <Point x="4975.0" y="3165.0" GraphRef="d8b" relX="1.0" relY="0.0" /> <Point x="5550.0" y="3171.0" GraphRef="f9df0" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="cc8f4"> <Graphics ZOrder="12288" Color="000000"> <Point x="4975.0" y="4275.0" GraphRef="fa9" relX="1.0" relY="0.0" /> <Point x="5550.0" y="4287.0" GraphRef="bba75" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="a7f0d"> <Graphics ZOrder="12288" Color="000000"> <Point x="4975.0" y="5325.0" GraphRef="e5c" relX="1.0" relY="0.0" /> <Point x="5550.0" y="5325.0" GraphRef="fbcdb" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="ff1a4"> <Graphics ZOrder="12288" Color="000000"> <Point x="4975.0" y="6365.0" GraphRef="c55" relX="1.0" relY="0.0" /> <Point x="5550.0" y="6360.0" GraphRef="cd7d3" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="f899f"> <Graphics ZOrder="12288" Color="000000"> <Point x="2970.0" y="6515.0" GraphRef="c3b" relX="0.0" relY="1.0" /> <Point x="2970.0690728883433" y="6994.569993860187" GraphRef="a45b2" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="b2b6e"> <Graphics ZOrder="12288" Color="000000"> <Point x="1675.0" y="9350.0" GraphRef="aa8" relX="0.0" relY="-1.0" /> <Point x="1666.5571963852767" y="8670.0" GraphRef="c4ce3" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="ae096"> <Graphics ZOrder="12288" Color="000000"> <Point x="6185.0" y="9675.0" GraphRef="f32" relX="0.0" relY="-1.0" /> <Point x="6182.0" y="9135.0" GraphRef="dc8c8" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="f1ef6"> <Graphics ZOrder="12288" Color="000000"> <Point x="8755.0" y="8485.0" GraphRef="b6d" relX="-1.0" relY="0.0" /> <Point x="8100.0" y="8475.0" GraphRef="c8fcf" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="e87c7"> <Graphics ZOrder="12288" Color="000000"> <Point x="8755.0" y="7185.0" GraphRef="f92" relX="-1.0" relY="0.0" /> <Point x="8100.0" y="7185.0" GraphRef="b1970" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="f4392"> <Graphics ZOrder="12288" Color="000000"> <Point x="8635.0" y="5505.0" GraphRef="c2be5" relX="-1.0" relY="0.0" /> <Point x="8100.0" y="5518.215434083601" GraphRef="a90f7" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="e0761"> <Graphics ZOrder="12288" Color="000000"> <Point x="8755.0" y="4250.0" GraphRef="f2b" relX="-1.0" relY="0.0" /> <Point x="8100.0" y="4259.9" GraphRef="dc6bd" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="d4b95"> <Graphics ZOrder="12288" Color="000000"> <Point x="8755.0" y="3100.0" GraphRef="db2" relX="-1.0" relY="0.0" /> <Point x="8100.0" y="3090.0" GraphRef="a0eb0" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="e0ce7"> <Graphics ZOrder="12288" Color="000000"> <Point x="4645.0" y="7775.0" GraphRef="ee8" relX="1.0" relY="0.0" /> <Point x="5550.0" y="7770.0" GraphRef="c86c0" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Line Style="Solid" GraphId="caee4"> <Graphics ZOrder="12288" Color="000000"> <Point x="4145.0" y="7925.0" GraphRef="ee8" relX="0.0" relY="1.0" /> <Point x="4140.0" y="8670.0" GraphRef="d6cf4" relX="0.0" relY="0.0" ArrowHead="mim-stimulation" /> </Graphics> </Line> <Label TextLabel="Fatty Acid Degradation" GraphId="eba"> <Graphics FontWeight="Bold" FontSize="180" Color="0000ff" CenterX="5550.0" CenterY="625.0" Width="2690.0" Height="285.0" ZOrder="28672" /> </Label> <Group GroupId="c1291" GraphId="c2be5" /> <InfoBox CenterX="125.0" CenterY="75.0" /> <Legend CenterX="9875.0" CenterY="775.0" /> <Biopax> <bp:PublicationXRef xmlns:bp="http://www.biopax.org/release/biopax-level2.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ec9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8552601</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Proc Natl Acad Sci U S A</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1996</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bard M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bruner DA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pierson CA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lees ND</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biermann B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Frye L</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Koegel C</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Barbuch R</bp:AUTHORS> </bp:PublicationXRef> <bp:PublicationXRef xmlns:bp="http://www.biopax.org/release/biopax-level2.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d9b"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11969204</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Membrane-bound enzymes of cholesterol synthesis from lanosterol.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochem Biophys Res Commun</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gaylor JL</bp:AUTHORS> </bp:PublicationXRef> <bp:PublicationXRef xmlns:bp="http://www.biopax.org/release/biopax-level2.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e32"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8663358</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1996</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li L</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kaplan J</bp:AUTHORS> </bp:PublicationXRef> <bp:PublicationXRef xmlns:bp="http://www.biopax.org/release/biopax-level2.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c8f"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10369263</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Genet</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1999</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu XY</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dangel AW</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kelley RI</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhao W</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Denny P</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Botcherby M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cattanach B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peters J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hunsicker PR</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mallon AM</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Strivens MA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bate R</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Miller W</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rhodes M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brown SD</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Herman GE</bp:AUTHORS> </bp:PublicationXRef> <bp:PublicationXRef xmlns:bp="http://www.biopax.org/release/biopax-level2.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ea9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">12837764</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2003</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ohashi M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mizushima N</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kabeya Y</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yoshimori T</bp:AUTHORS> </bp:PublicationXRef> <bp:PublicationXRef xmlns:bp="http://www.biopax.org/release/biopax-level2.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cdc"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8407863</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biochem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1993</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sagami H</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Korenaga T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ogura K</bp:AUTHORS> </bp:PublicationXRef> <bp:PublicationXRef xmlns:bp="http://www.biopax.org/release/biopax-level2.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e73"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">9498553</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biochem</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1997</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Noshiro M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Aoyama Y</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kawamoto T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gotoh O</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Horiuchi T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yoshida Y</bp:AUTHORS> </bp:PublicationXRef> </Biopax> </Pathway>

• Template:AuthorInfo
• Template:CheckAvailable (protected)
• Template:Help:LiteratureReferences (protected)
• Template:PathwayPage:History
• Template:PathwayPage:Xrefs

Return to Cholesterol biosynthesis pathway (Homo sapiens).