Nucleotide Excision Repair (Homo sapiens)

<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://genmapp.org/GPML/2010a" Name="Nucleotide Excision Repair" Organism="Homo sapiens" Data-Source="Reactome - http://www.reactome.org" Version="release 35" Author="Hoeijmakers, JH" Maintainer="Gopinathrao, G">
  <Comment Source="WikiPathways-description">NER was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recovery of DNA synthesis and cell survival. Deficient NER processes have been identified from the cells of cancer-prone patients with different variants of xeroderma pigmentosum (XP), trichothiodystrophy (TTD), and CockayneÃ¢â¬â¢s syndrome.  These XP cells exhibited an ultraviolet radiation hypersensitivity leading to a hypermutability response to UV, offering a direct connection between deficient NER, increased mutations, and cancer. While the NER pathway in prokaryotes is unique, the pathway utilized in yeast and higher eukaryotes is highly conserved and includes a variety of proteins that interact to form   complexes.&lt;BR&gt; NER is involved in the repair of bulky adducts in DNA, such as UV-induced photo lesions [of both 6-4 photoproducts (6-4 pps) and cyclobutane pyrimidine dimer (CPDs)], intrastrand cross-links, large chemical adducts formed from exposure to aflatoxin, benzopyrene and other genotoxic agents.  Specific proteins have been identified that participate in base damage recognition, cleavage of the damaged strand on both sides of the lesion, excision of the oligonucleotide bearing the lesion, and accessory proteins necessary for efficient function. Polymerization and ligation restore the strand to its original state. NER consists of two related pathways called  global genomic repair (GG-NER) and transcription-coupled NER (TC-NER).  The pathways differ in the way in which DNA damage is initially recognized, but the majority of the participating molecules are shared between these two branches of NER". GG-NER is considered to be transcription-independent, removing lesions from non-transcribed regions of genome in addition to non-transcribed strands of transcribed regions. The preferential repair of UV-induced damage in transcribed strands of active genes is known as Transcription-coupled NER (TC-NER).&lt;BR&gt;Several of the proteins involved in NER are key components of the basal transcription complex TFIIH. NER proteins have also been shown to interact with the 19S regulatory subunit of the proteasome, suggesting a role in cellular regulation signal pathways. The establishment of mutant mouse models for NER genes and other DNA repair-related genes have been useful in demonstrating the associations between NER defects and cancer.&lt;BR&gt;&lt;BR&gt;</Comment>
  <BiopaxRef>lit_110555</BiopaxRef>
  <BiopaxRef>lit_110556</BiopaxRef>
  <BiopaxRef>lit_110557</BiopaxRef>
  <DataNode GraphId="n6_REACTOME_62590" TextLabel="HR23B, RAD23B &#10;homolog protein&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="521.0" CenterY="547.0" Width="114.0" Height="38.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="P54727"/>
  </DataNode>
  <DataNode GraphId="n7_REACTOME_67441" TextLabel="XPC protein&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="548.0" CenterY="586.5" Width="78.0" Height="23.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="Q01831"/>
  </DataNode>
  <DataNode GraphId="n8_REACTOME_109938" TextLabel="XPC:HR23B &#10;complex&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="411.0" CenterY="639.0" Width="88.0" Height="38.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_4017"/>
  </DataNode>
  <DataNode GraphId="n11_REACTOME_109939" TextLabel="damaged DNA &#10;substrate&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="794.5" CenterY="585.0" Width="85.0" Height="52.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_2765"/>
  </DataNode>
  <DataNode GraphId="n12_REACTOME_109940" TextLabel="XPC:HR23B:&#10;damaged DNA &#10;complex&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="832.5" CenterY="690.5" Width="95.0" Height="53.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_3245"/>
  </DataNode>
  <DataNode GraphId="n18_REACTOME_68462" TextLabel="RPA heterotrimer&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="679.5" CenterY="736.5" Width="107.0" Height="23.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_3427"/>
  </DataNode>
  <DataNode GraphId="n19_REACTOME_53491" TextLabel="DDB2, DNA &#10;damage &#10;binding protein &#10;2&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="664.0" CenterY="830.0" Width="92.0" Height="62.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="Q92466"/>
  </DataNode>
  <DataNode GraphId="n20_REACTOME_67447" TextLabel="XPG protein&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="750.0" CenterY="938.5" Width="76.0" Height="23.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="P28715"/>
  </DataNode>
  <DataNode GraphId="n21_REACTOME_67437" TextLabel="XPA protein&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="805.0" CenterY="982.5" Width="76.0" Height="23.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="P23025"/>
  </DataNode>
  <DataNode GraphId="n22_REACTOME_53489" TextLabel="DDB1, DNA damage &#10;binding protein 1&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="913.0" CenterY="862.0" Width="126.0" Height="38.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="Q16531"/>
  </DataNode>
  <DataNode GraphId="n23_REACTOME_109634" TextLabel="TFIIH&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1020.0" CenterY="827.5" Width="38.0" Height="23.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_3832"/>
  </DataNode>
  <DataNode GraphId="n24_REACTOME_109941" TextLabel="pre-incision complex &#10;in GG-NER&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1025.0" CenterY="736.0" Width="122.0" Height="38.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_5795"/>
  </DataNode>
  <DataNode GraphId="n26_REACTOME_109945" TextLabel="pre-incision &#10;complex with &#10;open DNA &#10;bubble&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1297.0" CenterY="730.5" Width="98.0" Height="75.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_5689"/>
  </DataNode>
  <DataNode GraphId="n28_REACTOME_109943" TextLabel="ERCC1:XPF &#10;complex&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1437.0" CenterY="767.0" Width="76.0" Height="38.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_3454"/>
  </DataNode>
  <DataNode GraphId="n29_REACTOME_109946" TextLabel="incision complex for &#10;GG-NER&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1586.0" CenterY="730.0" Width="118.0" Height="38.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_5159"/>
  </DataNode>
  <DataNode GraphId="n35_REACTOME_109947" TextLabel="Incision &#10;complex  with &#10;3'-incised &#10;damaged &#10;DNA&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1855.0" CenterY="720.0" Width="80.0" Height="96.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_5099"/>
  </DataNode>
  <DataNode GraphId="n41_REACTOME_109961" TextLabel="incised DNA without &#10;lesion&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="870.0" CenterY="1286.0" Width="130.0" Height="38.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3852"/>
  </DataNode>
  <DataNode GraphId="n42_REACTOME_109960" TextLabel="excised DNA &#10;fragment with &#10;lesion&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="899.0" CenterY="1163.5" Width="92.0" Height="53.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_2556"/>
  </DataNode>
  <DataNode GraphId="n44_REACTOME_68440" TextLabel="PCNA homotrimer&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="446.0" CenterY="1433.5" Width="128.0" Height="23.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_2542"/>
  </DataNode>
  <DataNode GraphId="n45_REACTOME_68483" TextLabel="DNA polymerase &#10;epsilon&#10;" Type="Complex">
    <BiopaxRef>lit_68474</BiopaxRef>
    <Graphics Color="000000" CenterX="547.0" CenterY="1508.0" Width="100.0" Height="50.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_4621"/>
  </DataNode>
  <DataNode GraphId="n46_REACTOME_110300" TextLabel="dNTP&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="415.5" CenterY="1136.5" Width="43.0" Height="23.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_2960"/>
  </DataNode>
  <DataNode GraphId="n47_REACTOME_68436" TextLabel="RFC Heteropentamer&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="872.5" CenterY="1585.0" Width="149.0" Height="28.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_4881"/>
  </DataNode>
  <DataNode GraphId="n48_REACTOME_109964" TextLabel="newly synthesized &#10;DNA fragment&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="891.5" CenterY="1381.5" Width="133.0" Height="53.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3448"/>
  </DataNode>
  <DataNode GraphId="n60_REACTOME_68450" TextLabel="DNA Polymerase &#10;delta tetramer&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="382.0" CenterY="1205.0" Width="128.0" Height="38.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_5801"/>
  </DataNode>
  <DataNode GraphId="n66_REACTOME_53787" TextLabel="DNA ligase I&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="1003.0" CenterY="1258.5" Width="92.0" Height="23.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="P18858"/>
  </DataNode>
  <DataNode GraphId="n67_REACTOME_109966" TextLabel="Repaired double-&#10;stranded DNA&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="1123.0" CenterY="1370.0" Width="128.0" Height="38.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_4318"/>
  </DataNode>
  <DataNode GraphId="n73_REACTOME_110291" TextLabel="damaged DNA &#10;substrate:nascent &#10;mRNA hybrid&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="1337.5" CenterY="1246.5" Width="107.0" Height="53.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3022"/>
  </DataNode>
  <DataNode GraphId="n74_REACTOME_109909" TextLabel="RNA Polymerase II &#10;holoenzyme &#10;complex &#10;(hyperphosphorylat&#10;ed)&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1209.5" CenterY="1187.5" Width="113.0" Height="91.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_4889"/>
  </DataNode>
  <DataNode GraphId="n75_REACTOME_110292" TextLabel="Active Pol II  &#10;transcription complex &#10;with damaged DNA &#10;hybrid&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1474.5" CenterY="1184.0" Width="127.0" Height="68.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_3609"/>
  </DataNode>
  <DataNode GraphId="n81_REACTOME_110293" TextLabel="Stalled Pol II &#10;complex with &#10;damaged DNA &#10;hybrid&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1665.0" CenterY="1184.0" Width="110.0" Height="68.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_3072"/>
  </DataNode>
  <DataNode GraphId="n83_REACTOME_67411" TextLabel="XPA-binding &#10;protein 2&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="1448.5" CenterY="1062.0" Width="97.0" Height="38.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="Q9HCS7"/>
  </DataNode>
  <DataNode GraphId="n84_REACTOME_54429" TextLabel="CSB protein&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="1536.0" CenterY="1102.5" Width="88.0" Height="23.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="Q03468"/>
  </DataNode>
  <DataNode GraphId="n85_REACTOME_52835" TextLabel="CSA protein&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="1574.0" CenterY="951.5" Width="88.0" Height="23.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="Q13216"/>
  </DataNode>
  <DataNode GraphId="n86_REACTOME_65748" TextLabel="TFIIS protein&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="1634.5" CenterY="1003.5" Width="97.0" Height="23.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="P23193"/>
  </DataNode>
  <DataNode GraphId="n87_REACTOME_110276" TextLabel="Transcription-&#10;coupled (TC) repair &#10;complex&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1812.5" CenterY="1038.5" Width="115.0" Height="53.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_3969"/>
  </DataNode>
  <DataNode GraphId="n89_REACTOME_110294" TextLabel="Stalled Pol II in TC-&#10;NER&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1813.5" CenterY="1364.0" Width="119.0" Height="38.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_4443"/>
  </DataNode>
  <DataNode GraphId="n91_REACTOME_110298" TextLabel="damaged DNA &#10;substrate:nascent &#10;mRNA hybrid with &#10;3' incision&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="2042.5" CenterY="1283.5" Width="115.0" Height="83.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_2845"/>
  </DataNode>
  <DataNode GraphId="n97_REACTOME_110303" TextLabel="damaged DNA &#10;substrate:nascent &#10;mRNA hybrid with &#10;dual incisions&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="1791.0" CenterY="838.5" Width="122.0" Height="75.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_5428"/>
  </DataNode>
  <DataNode GraphId="n119_REACTOME_110300" TextLabel="dNTP&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="1788.5" CenterY="1722.5" Width="43.0" Height="23.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_2960"/>
  </DataNode>
  <DataNode GraphId="n121_REACTOME_110300" TextLabel="dNTP&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="814.5" CenterY="1333.5" Width="43.0" Height="23.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_2960"/>
  </DataNode>
  <DataNode GraphId="n122_REACTOME_68450" TextLabel="DNA Polymerase &#10;delta tetramer&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="1436.0" CenterY="1600.0" Width="128.0" Height="38.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_5801"/>
  </DataNode>
  <DataNode GraphId="n136_REACTOME_110295" TextLabel="repaired DNA &#10;template:nascent &#10;mRNA hybrid&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="1093.5" CenterY="551.0" Width="115.0" Height="68.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_5433"/>
  </DataNode>
  <DataNode GraphId="n146_REACTOME_110296" TextLabel="Active Pol II complex &#10;with repaired DNA &#10;template:mRNA &#10;hybrid&#10;" Type="Complex">
    <Graphics Color="000000" CenterX="2420.5" CenterY="552.5" Width="119.0" Height="83.0" Valign="Middle" FillColor="ccffff" ShapeType="RoundedRectangle" LineThickness="2"/>
    <Xref Database="Reactome" ID="REACT_2462"/>
  </DataNode>
  <DataNode GraphId="n169_REACTOME_110300" TextLabel="dNTP&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="692.5" CenterY="1799.5" Width="43.0" Height="23.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_2960"/>
  </DataNode>
  <DataNode GraphId="n170_REACTOME_109964" TextLabel="newly synthesized &#10;DNA fragment&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="225.5" CenterY="1012.5" Width="133.0" Height="53.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3448"/>
  </DataNode>
  <DataNode GraphId="n176_REACTOME_109964" TextLabel="newly synthesized &#10;DNA fragment&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="957.5" CenterY="1467.5" Width="133.0" Height="53.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3448"/>
  </DataNode>
  <DataNode GraphId="n178_REACTOME_109964" TextLabel="newly synthesized &#10;DNA fragment&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="1270.5" CenterY="1490.5" Width="133.0" Height="53.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3448"/>
  </DataNode>
  <DataNode GraphId="n180_REACTOME_109964" TextLabel="newly synthesized &#10;DNA fragment&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="332.5" CenterY="1382.5" Width="133.0" Height="53.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3448"/>
  </DataNode>
  <DataNode GraphId="n182_REACTOME_109964" TextLabel="newly synthesized &#10;DNA fragment&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="1572.5" CenterY="666.5" Width="133.0" Height="53.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3448"/>
  </DataNode>
  <DataNode GraphId="n183_REACTOME_109961" TextLabel="incised DNA without &#10;lesion&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="312.0" CenterY="1276.0" Width="130.0" Height="38.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3852"/>
  </DataNode>
  <DataNode GraphId="n185_REACTOME_109961" TextLabel="incised DNA without &#10;lesion&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="771.0" CenterY="1228.0" Width="130.0" Height="38.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3852"/>
  </DataNode>
  <DataNode GraphId="n191_REACTOME_109961" TextLabel="incised DNA &#10;without lesion&#10;" Type="Unknown">
    <Graphics Color="000000" CenterX="1020.0" CenterY="922.5" Width="80.0" Height="61.0" Valign="Middle" FillColor="ccffcc"/>
    <Xref Database="Reactome" ID="REACT_3852"/>
  </DataNode>
  <DataNode GraphId="n193_REACTOME_54427" TextLabel="ERCC1, DNA excision &#10;repair protein&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="1566.0" CenterY="778.5" Width="144.0" Height="27.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="P07992"/>
  </DataNode>
  <DataNode GraphId="n194_REACTOME_67445" TextLabel="XPF &#10;protein&#10;" Type="Protein">
    <Graphics Color="000000" CenterX="1692.5" CenterY="752.5" Width="65.0" Height="25.0" Valign="Middle" FillColor="ccffcc" ShapeType="RoundedRectangle"/>
    <Xref Database="UniProt" ID="Q92889"/>
  </DataNode>
  <Line GraphId="e_5_REACTOME_109948">
    <Comment Source="Reactome summation">XPC is mutated in individuals with xeroderma pigmentosum from genetic Complementation Group C (XP-C). It forms a tight heterodimeric complex with human Rad 23B homolog, HR23B and is thought to bind to the damaged site with lesion first triggering subsequent reactions&lt;BR&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="457.0" Y="586.0" GraphId="e_5_0"/>
      <Point X="411.0" Y="586.0" GraphId="e_5_1"/>
      <Point X="411.0" Y="617.0" GraphId="e_5_2" GraphRef="n8_REACTOME_109938" RelX="0.0" RelY="-1.1578947368421053" ArrowHead="Arrow"/>
      <Anchor Position="0.0" GraphId="e_5_a_i"/>
      <Anchor Position="0.5974025974025974" GraphId="e_5_a_p"/>
    </Graphics>
  </Line>
  <Line GraphId="e_5_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="489.0" Y="569.0" GraphId="e_5_i0_0" GraphRef="n6_REACTOME_62590" RelX="-0.5614035087719298" RelY="1.1578947368421053"/>
      <Point X="457.0" Y="586.0" GraphId="e_5_i0_1" GraphRef="e_5_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_5_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="506.0" Y="586.0" GraphId="e_5_i1_0" GraphRef="n7_REACTOME_67441" RelX="-1.0769230769230769" RelY="0.0"/>
      <Point X="457.0" Y="586.0" GraphId="e_5_i1_1" GraphRef="e_5_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_10_REACTOME_109949">
    <Comment Source="Reactome summation">Disruption of normal Watson-Crick base pairing and altered chemistry in the damaged strand involving bases may act as signals of damage that are recognized by XPC:HR23B complex.&lt;BR&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="793.0" Y="639.0" GraphId="e_10_0"/>
      <Point X="827.0" Y="639.0" GraphId="e_10_1"/>
      <Point X="829.0" Y="661.0" GraphId="e_10_2" GraphRef="n12_REACTOME_109940" RelX="-0.06315789473684211" RelY="-1.0943396226415094" ArrowHead="Arrow"/>
      <Anchor Position="0.0" GraphId="e_10_a_i"/>
      <Anchor Position="0.6061608545378238" GraphId="e_10_a_p"/>
    </Graphics>
  </Line>
  <Line GraphId="e_10_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="458.0" Y="639.0" GraphId="e_10_i0_0" GraphRef="n8_REACTOME_109938" RelX="1.0681818181818181" RelY="0.0"/>
      <Point X="793.0" Y="639.0" GraphId="e_10_i0_1" GraphRef="e_10_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_10_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="793.0" Y="614.0" GraphId="e_10_i1_0" GraphRef="n11_REACTOME_109939" RelX="-0.023529411764705882" RelY="1.1153846153846154"/>
      <Point X="793.0" Y="639.0" GraphId="e_10_i1_1" GraphRef="e_10_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_17_REACTOME_73936">
    <Comment Source="Reactome summation">Transcription factor II H (TFIIH) and XPG are added to the damaged site on the DNA to form a pre-incision complex along with lesioned DNA template.&lt;BR&gt;</Comment>
    <BiopaxRef>lit_110564</BiopaxRef>
    <BiopaxRef>lit_110738</BiopaxRef>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="831.0" Y="735.0" GraphId="e_17_0"/>
      <Point X="909.0" Y="735.0" GraphId="e_17_1"/>
      <Point X="961.0" Y="735.0" GraphId="e_17_2" GraphRef="n24_REACTOME_109941" RelX="-1.0491803278688525" RelY="-0.05263157894736842" ArrowHead="Arrow"/>
      <Anchor Position="0.0" GraphId="e_17_a_i"/>
      <Anchor Position="0.6" GraphId="e_17_a_p"/>
    </Graphics>
  </Line>
  <Line GraphId="e_17_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="736.0" Y="735.0" GraphId="e_17_i0_0" GraphRef="n18_REACTOME_68462" RelX="1.0654205607476634" RelY="-0.08695652173913043"/>
      <Point X="831.0" Y="735.0" GraphId="e_17_i0_1" GraphRef="e_17_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_17_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="831.0" Y="720.0" GraphId="e_17_i1_0" GraphRef="n12_REACTOME_109940" RelX="-0.021052631578947368" RelY="1.1320754716981132"/>
      <Point X="831.0" Y="735.0" GraphId="e_17_i1_1" GraphRef="e_17_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_17_i2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="713.0" Y="803.0" GraphId="e_17_i2_0" GraphRef="n19_REACTOME_53491" RelX="1.065217391304348" RelY="-0.8709677419354839"/>
      <Point X="831.0" Y="735.0" GraphId="e_17_i2_1" GraphRef="e_17_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_17_i3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="754.0" Y="924.0" GraphId="e_17_i3_0" GraphRef="n20_REACTOME_67447" RelX="0.10526315789473684" RelY="-1.2173913043478262"/>
      <Point X="831.0" Y="735.0" GraphId="e_17_i3_1" GraphRef="e_17_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_17_i4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="806.0" Y="968.0" GraphId="e_17_i4_0" GraphRef="n21_REACTOME_67437" RelX="0.02631578947368421" RelY="-1.2173913043478262"/>
      <Point X="831.0" Y="735.0" GraphId="e_17_i4_1" GraphRef="e_17_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_17_i5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="900.0" Y="840.0" GraphId="e_17_i5_0" GraphRef="n22_REACTOME_53489" RelX="-0.20634920634920634" RelY="-1.1578947368421053"/>
      <Point X="831.0" Y="735.0" GraphId="e_17_i5_1" GraphRef="e_17_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_17_i6">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="998.0" Y="817.0" GraphId="e_17_i6_0" GraphRef="n23_REACTOME_109634" RelX="-1.1578947368421053" RelY="-0.8695652173913043"/>
      <Point X="831.0" Y="735.0" GraphId="e_17_i6_1" GraphRef="e_17_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_25_REACTOME_73934">
    <Comment Source="Reactome summation">Two DNA helicases XPG and XPD, which are part of TFIIH, unwind DNA duplex around this lesion to form an open bubble structure that exposes the damaged site.&lt;BR&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1089.0" Y="727.0" GraphId="e_25_0" GraphRef="n24_REACTOME_109941" RelX="1.0491803278688525" RelY="-0.47368421052631576"/>
      <Point X="1187.0" Y="731.0" GraphId="e_25_1"/>
      <Point X="1245.0" Y="730.0" GraphId="e_25_2" GraphRef="n26_REACTOME_109945" RelX="-1.0612244897959184" RelY="0.0" ArrowHead="Arrow"/>
      <Anchor Position="0.628364797482537" GraphId="e_25_a_p"/>
    </Graphics>
  </Line>
  <Line GraphId="e_25_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="1089.0" Y="734.0" GraphId="e_25_c__0_0" GraphRef="n24_REACTOME_109941" RelX="1.0491803278688525" RelY="-0.10526315789473684"/>
      <Point X="1187.0" Y="731.0" GraphId="e_25_c__0_1" GraphRef="e_25_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_27_REACTOME_109953">
    <Comment Source="Reactome summation">ERCC1-XPF complex with 5Ã¢â¬â¢ endonuclease activity binds to this pre-incision complex around the bubble structure to form an active incision complex.&lt;BR&gt;</Comment>
    <BiopaxRef>lit_110739</BiopaxRef>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1438.0" Y="730.0" GraphId="e_27_0"/>
      <Point X="1490.0" Y="730.0" GraphId="e_27_1"/>
      <Point X="1524.0" Y="730.0" GraphId="e_27_2" GraphRef="n29_REACTOME_109946" RelX="-1.0508474576271187" RelY="0.0" ArrowHead="Arrow"/>
      <Anchor Position="0.0" GraphId="e_27_a_i"/>
      <Anchor Position="0.6046511627906976" GraphId="e_27_a_p"/>
    </Graphics>
  </Line>
  <Line GraphId="e_27_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1437.0" Y="745.0" GraphId="e_27_i0_0" GraphRef="n28_REACTOME_109943" RelX="0.0" RelY="-1.1578947368421053"/>
      <Point X="1438.0" Y="730.0" GraphId="e_27_i0_1" GraphRef="e_27_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_27_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1349.0" Y="730.0" GraphId="e_27_i1_0" GraphRef="n26_REACTOME_109945" RelX="1.0612244897959184" RelY="0.0"/>
      <Point X="1438.0" Y="730.0" GraphId="e_27_i1_1" GraphRef="e_27_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_34_REACTOME_73938">
    <Comment Source="Reactome summation">The cleavage of the damaged strand of DNA 3' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound.  The incision is carried out by XPG.&lt;BR&gt;</Comment>
    <BiopaxRef>lit_110739</BiopaxRef>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1648.0" Y="718.0" GraphId="e_34_0" GraphRef="n29_REACTOME_109946" RelX="1.0508474576271187" RelY="-0.631578947368421"/>
      <Point X="1725.0" Y="720.0" GraphId="e_34_1"/>
      <Point X="1812.0" Y="720.0" GraphId="e_34_2" GraphRef="n35_REACTOME_109947" RelX="-1.075" RelY="0.0" ArrowHead="Arrow"/>
      <Anchor Position="0.4695961853635673" GraphId="e_34_a_p"/>
    </Graphics>
  </Line>
  <Line GraphId="e_34_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="1648.0" Y="725.0" GraphId="e_34_c__0_0" GraphRef="n29_REACTOME_109946" RelX="1.0508474576271187" RelY="-0.2631578947368421"/>
      <Point X="1725.0" Y="720.0" GraphId="e_34_c__0_1" GraphRef="e_34_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_REACTOME_73939">
    <Comment Source="Reactome summation">The cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision is carried out by ERCC1-XPF complex.&lt;BR&gt;</Comment>
    <BiopaxRef>lit_110739</BiopaxRef>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1812.0" Y="734.0" GraphId="e_40_0" GraphRef="n35_REACTOME_109947" RelX="-1.075" RelY="0.2916666666666667"/>
      <Point X="1559.0" Y="830.0" GraphId="e_40_1"/>
      <Point X="923.0" Y="1102.0" GraphId="e_40_2"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_3"/>
      <Anchor Position="0.8663239507312855" GraphId="e_40_a_p"/>
      <Anchor Position="1.0" GraphId="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="424.0" Y="661.0" GraphId="e_40_o0_0" ArrowHead="Arrow" GraphRef="n8_REACTOME_109938" RelX="0.29545454545454547" RelY="1.1578947368421053"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_o0_1" GraphRef="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="664.0" Y="751.0" GraphId="e_40_o1_0" ArrowHead="Arrow"/>
      <Point X="580.0" Y="812.0" GraphId="e_40_o1_1" GraphRef="n18_REACTOME_68462" RelX="-1.8504672897196262" RelY="6.608695652173913"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_o1_2" GraphRef="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_o2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1403.0" Y="789.0" GraphId="e_40_o2_0" ArrowHead="Arrow" GraphRef="n28_REACTOME_109943" RelX="-0.8947368421052632" RelY="1.1578947368421053"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_o2_1" GraphRef="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_o3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="675.0" Y="864.0" GraphId="e_40_o3_0" ArrowHead="Arrow" GraphRef="n19_REACTOME_53491" RelX="0.2391304347826087" RelY="1.096774193548387"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_o3_1" GraphRef="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_o4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="803.0" Y="997.0" GraphId="e_40_o4_0" ArrowHead="Arrow" GraphRef="n21_REACTOME_67437" RelX="-0.05263157894736842" RelY="1.3043478260869565"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_o4_1" GraphRef="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_o5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="751.0" Y="953.0" GraphId="e_40_o5_0" ArrowHead="Arrow" GraphRef="n20_REACTOME_67447" RelX="0.02631578947368421" RelY="1.3043478260869565"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_o5_1" GraphRef="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_o6">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="850.0" Y="1154.0" GraphId="e_40_o6_0" ArrowHead="Arrow" GraphRef="n42_REACTOME_109960" RelX="-1.065217391304348" RelY="-0.33962264150943394"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_o6_1" GraphRef="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_o7">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="903.0" Y="884.0" GraphId="e_40_o7_0" ArrowHead="Arrow" GraphRef="n22_REACTOME_53489" RelX="-0.15873015873015872" RelY="1.1578947368421053"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_o7_1" GraphRef="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_o8">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1011.0" Y="842.0" GraphId="e_40_o8_0" ArrowHead="Arrow" GraphRef="n23_REACTOME_109634" RelX="-0.47368421052631576" RelY="1.3043478260869565"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_o8_1" GraphRef="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_o9">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="986.0" Y="956.0" GraphId="e_40_o9_0" ArrowHead="Arrow" GraphRef="n191_REACTOME_109961" RelX="-0.85" RelY="1.1147540983606556"/>
      <Point X="780.0" Y="1142.0" GraphId="e_40_o9_1" GraphRef="e_40_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_40_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="1812.0" Y="739.0" GraphId="e_40_c__0_0" GraphRef="n35_REACTOME_109947" RelX="-1.075" RelY="0.3958333333333333"/>
      <Point X="1589.0" Y="851.0" GraphId="e_40_c__0_1"/>
      <Point X="923.0" Y="1102.0" GraphId="e_40_c__0_2" GraphRef="e_40_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_REACTOME_109968">
    <Comment Source="Reactome summation">At the beginning of this reaction, 1 molecule of 'dNTP', 1 molecule of 'incised DNA without lesion', 1 molecule of 'RPA heterotrimer', 1 molecule of 'PCNA homotrimer', 1 molecule of 'RFC Heteropentamer', and 1 molecule of 'DNA polymerase epsilon' are present. At the end of this reaction, 1 molecule of 'incised DNA without lesion', 1 molecule of 'RPA heterotrimer', 1 molecule of 'PCNA homotrimer', 1 molecule of 'RFC Heteropentamer', 1 molecule of 'newly synthesized DNA fragment ', and 1 molecule of 'DNA polymerase epsilon' are present.&lt;br&gt;&lt;br&gt; This reaction takes place in the 'nucleus' and  is mediated by the 'DNA-directed DNA polymerase activity' of 'DNA polymerase epsilon'.&lt;br&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="766.0" Y="1423.0" GraphId="e_43_0"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_1"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_2"/>
      <Anchor Position="0.0" GraphId="e_43_a_i"/>
      <Anchor Position="NaN" GraphId="e_43_a_p"/>
      <Anchor Position="1.0" GraphId="e_43_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="641.0" Y="751.0" GraphId="e_43_i0_0" GraphRef="n18_REACTOME_68462" RelX="-0.7102803738317757" RelY="1.3043478260869565"/>
      <Point X="426.0" Y="813.0" GraphId="e_43_i0_1"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_i0_2" GraphRef="e_43_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="469.0" Y="1419.0" GraphId="e_43_i1_0" GraphRef="n44_REACTOME_68440" RelX="0.359375" RelY="-1.2173913043478262"/>
      <Point X="734.0" Y="1291.0" GraphId="e_43_i1_1"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_i1_2" GraphRef="e_43_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_i2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="600.0" Y="1483.0" GraphId="e_43_i2_0" GraphRef="n45_REACTOME_68483" RelX="1.06" RelY="-1.0"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_i2_1" GraphRef="e_43_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_i3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="847.0" Y="1568.0" GraphId="e_43_i3_0" GraphRef="n47_REACTOME_68436" RelX="-0.33557046979865773" RelY="-1.2142857142857142"/>
      <Point X="707.0" Y="1492.0" GraphId="e_43_i3_1"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_i3_2" GraphRef="e_43_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_i4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="807.0" Y="1348.0" GraphId="e_43_i4_0" GraphRef="n121_REACTOME_110300" RelX="-0.32558139534883723" RelY="1.3043478260869565"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_i4_1" GraphRef="e_43_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_i5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="763.0" Y="1250.0" GraphId="e_43_i5_0" GraphRef="n185_REACTOME_109961" RelX="-0.12307692307692308" RelY="1.1578947368421053"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_i5_1" GraphRef="e_43_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="650.0" Y="751.0" GraphId="e_43_o0_0" ArrowHead="Arrow"/>
      <Point X="461.0" Y="823.0" GraphId="e_43_o0_1" GraphRef="n18_REACTOME_68462" RelX="-4.074766355140187" RelY="7.565217391304348"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_o0_2" GraphRef="e_43_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="513.0" Y="1432.0" GraphId="e_43_o1_0" ArrowHead="Arrow"/>
      <Point X="639.0" Y="1432.0" GraphId="e_43_o1_1" GraphRef="n44_REACTOME_68440" RelX="3.015625" RelY="-0.08695652173913043"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_o1_2" GraphRef="e_43_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_o2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="600.0" Y="1488.0" GraphId="e_43_o2_0" ArrowHead="Arrow" GraphRef="n45_REACTOME_68483" RelX="1.06" RelY="-0.8"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_o2_1" GraphRef="e_43_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_o3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="862.0" Y="1568.0" GraphId="e_43_o3_0" ArrowHead="Arrow" GraphRef="n47_REACTOME_68436" RelX="-0.1342281879194631" RelY="-1.2142857142857142"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_o3_1" GraphRef="e_43_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_o4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="888.0" Y="1476.0" GraphId="e_43_o4_0" ArrowHead="Arrow"/>
      <Point X="854.0" Y="1481.0" GraphId="e_43_o4_1" GraphRef="n176_REACTOME_109964" RelX="-1.5488721804511278" RelY="0.5283018867924528"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_o4_2" GraphRef="e_43_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_o5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="770.0" Y="1250.0" GraphId="e_43_o5_0" ArrowHead="Arrow" GraphRef="n185_REACTOME_109961" RelX="-0.015384615384615385" RelY="1.1578947368421053"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_o5_1" GraphRef="e_43_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_43_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="600.0" Y="1495.0" GraphId="e_43_c__0_0" GraphRef="n45_REACTOME_68483" RelX="1.06" RelY="-0.52"/>
      <Point X="766.0" Y="1423.0" GraphId="e_43_c__0_1" GraphRef="e_43_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_REACTOME_109969">
    <Comment Source="Reactome summation">At the beginning of this reaction, 1 molecule of 'dNTP', 1 molecule of 'incised DNA without lesion', 1 molecule of 'RPA heterotrimer', 1 molecule of 'PCNA homotrimer', 1 molecule of 'RFC Heteropentamer', and 1 molecule of 'DNA Polymerase delta tetramer' are present. At the end of this reaction, 1 molecule of 'incised DNA without lesion', 1 molecule of 'RPA heterotrimer', 1 molecule of 'PCNA homotrimer', 1 molecule of 'RFC Heteropentamer', 1 molecule of 'newly synthesized DNA fragment ', and 1 molecule of 'DNA Polymerase delta tetramer' are present.&lt;br&gt;&lt;br&gt; This reaction takes place in the 'nucleus' and  is mediated by the 'delta DNA polymerase activity' of 'DNA Polymerase delta tetramer'.&lt;br&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="571.0" Y="1301.0" GraphId="e_59_0"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_1"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_2"/>
      <Anchor Position="0.0" GraphId="e_59_a_i"/>
      <Anchor Position="NaN" GraphId="e_59_a_p"/>
      <Anchor Position="1.0" GraphId="e_59_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="623.0" Y="739.0" GraphId="e_59_i0_0" GraphRef="n18_REACTOME_68462" RelX="-1.0467289719626167" RelY="0.2608695652173913"/>
      <Point X="345.0" Y="759.0" GraphId="e_59_i0_1"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_i0_2" GraphRef="e_59_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="449.0" Y="1419.0" GraphId="e_59_i1_0" GraphRef="n44_REACTOME_68440" RelX="0.046875" RelY="-1.2173913043478262"/>
      <Point X="460.0" Y="1390.0" GraphId="e_59_i1_1"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_i1_2" GraphRef="e_59_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_i2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="398.0" Y="1227.0" GraphId="e_59_i2_0" GraphRef="n60_REACTOME_68450" RelX="0.25" RelY="1.1578947368421053"/>
      <Point X="434.0" Y="1266.0" GraphId="e_59_i2_1"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_i2_2" GraphRef="e_59_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_i3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="425.0" Y="1151.0" GraphId="e_59_i3_0" GraphRef="n46_REACTOME_110300" RelX="0.46511627906976744" RelY="1.3043478260869565"/>
      <Point X="503.0" Y="1237.0" GraphId="e_59_i3_1"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_i3_2" GraphRef="e_59_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_i4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="850.0" Y="1568.0" GraphId="e_59_i4_0" GraphRef="n47_REACTOME_68436" RelX="-0.2953020134228188" RelY="-1.2142857142857142"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_i4_1" GraphRef="e_59_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_i5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="347.0" Y="1298.0" GraphId="e_59_i5_0" GraphRef="n183_REACTOME_109961" RelX="0.5384615384615384" RelY="1.1578947368421053"/>
      <Point X="776.0" Y="1527.0" GraphId="e_59_i5_1"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_i5_2" GraphRef="e_59_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="623.0" Y="743.0" GraphId="e_59_o0_0" ArrowHead="Arrow"/>
      <Point X="385.0" Y="777.0" GraphId="e_59_o0_1" GraphRef="n18_REACTOME_68462" RelX="-5.4953271028037385" RelY="3.5652173913043477"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_o0_2" GraphRef="e_59_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="419.0" Y="1227.0" GraphId="e_59_o1_0" ArrowHead="Arrow" GraphRef="n60_REACTOME_68450" RelX="0.578125" RelY="1.1578947368421053"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_o1_1" GraphRef="e_59_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_o2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="456.0" Y="1419.0" GraphId="e_59_o2_0" ArrowHead="Arrow" GraphRef="n44_REACTOME_68440" RelX="0.15625" RelY="-1.2173913043478262"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_o2_1" GraphRef="e_59_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_o3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="857.0" Y="1568.0" GraphId="e_59_o3_0" ArrowHead="Arrow" GraphRef="n47_REACTOME_68436" RelX="-0.20134228187919462" RelY="-1.2142857142857142"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_o3_1" GraphRef="e_59_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_o4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="402.0" Y="1359.0" GraphId="e_59_o4_0" ArrowHead="Arrow" GraphRef="n180_REACTOME_109964" RelX="1.0526315789473684" RelY="-0.8679245283018868"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_o4_1" GraphRef="e_59_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_o5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="380.0" Y="1282.0" GraphId="e_59_o5_0" ArrowHead="Arrow" GraphRef="n183_REACTOME_109961" RelX="1.0461538461538462" RelY="0.3157894736842105"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_o5_1" GraphRef="e_59_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_59_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="419.0" Y="1227.0" GraphId="e_59_c__0_0" GraphRef="n60_REACTOME_68450" RelX="0.578125" RelY="1.1578947368421053"/>
      <Point X="571.0" Y="1301.0" GraphId="e_59_c__0_1" GraphRef="e_59_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_65_REACTOME_74968">
    <Comment Source="Reactome summation">DNA Ligase 1 ligates the newly synthesized fragment to the gap in the template DNA. &lt;BR&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="951.0" Y="1326.0" GraphId="e_65_0"/>
      <Point X="1001.0" Y="1325.0" GraphId="e_65_1"/>
      <Point X="1069.0" Y="1326.0" GraphId="e_65_2"/>
      <Anchor Position="0.0" GraphId="e_65_a_i"/>
      <Anchor Position="0.42375123950825944" GraphId="e_65_a_p"/>
      <Anchor Position="1.0" GraphId="e_65_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_65_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="908.0" Y="1308.0" GraphId="e_65_i0_0" GraphRef="n41_REACTOME_109961" RelX="0.5846153846153846" RelY="1.1578947368421053"/>
      <Point X="951.0" Y="1326.0" GraphId="e_65_i0_1" GraphRef="e_65_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_65_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="994.0" Y="1273.0" GraphId="e_65_i1_0" GraphRef="n66_REACTOME_53787" RelX="-0.1956521739130435" RelY="1.3043478260869565"/>
      <Point X="951.0" Y="1326.0" GraphId="e_65_i1_1" GraphRef="e_65_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_65_i2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="919.0" Y="1352.0" GraphId="e_65_i2_0" GraphRef="n48_REACTOME_109964" RelX="0.42105263157894735" RelY="-1.0943396226415094"/>
      <Point X="951.0" Y="1326.0" GraphId="e_65_i2_1" GraphRef="e_65_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_65_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1014.0" Y="1273.0" GraphId="e_65_o0_0" ArrowHead="Arrow" GraphRef="n66_REACTOME_53787" RelX="0.2391304347826087" RelY="1.3043478260869565"/>
      <Point X="1069.0" Y="1326.0" GraphId="e_65_o0_1" GraphRef="e_65_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_65_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1099.0" Y="1348.0" GraphId="e_65_o1_0" ArrowHead="Arrow" GraphRef="n67_REACTOME_109966" RelX="-0.375" RelY="-1.1578947368421053"/>
      <Point X="1069.0" Y="1326.0" GraphId="e_65_o1_1" GraphRef="e_65_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_65_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="1002.0" Y="1273.0" GraphId="e_65_c__0_0" GraphRef="n66_REACTOME_53787" RelX="-0.021739130434782608" RelY="1.3043478260869565"/>
      <Point X="1001.0" Y="1325.0" GraphId="e_65_c__0_1" GraphRef="e_65_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_72_REACTOME_110301">
    <Comment Source="Reactome summation">An active Pol II complex consisting mainly of the Pol II holoenzyme transcribes the damaged DNA template. &lt;BR&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1337.0" Y="1185.0" GraphId="e_72_0"/>
      <Point X="1374.0" Y="1186.0" GraphId="e_72_1"/>
      <Point X="1408.0" Y="1185.0" GraphId="e_72_2" GraphRef="n75_REACTOME_110292" RelX="-1.0393700787401574" RelY="0.029411764705882353" ArrowHead="Arrow"/>
      <Anchor Position="0.0" GraphId="e_72_a_i"/>
      <Anchor Position="0.5211099799989845" GraphId="e_72_a_p"/>
    </Graphics>
  </Line>
  <Line GraphId="e_72_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1337.0" Y="1217.0" GraphId="e_72_i0_0" GraphRef="n73_REACTOME_110291" RelX="0.0" RelY="-1.0943396226415094"/>
      <Point X="1337.0" Y="1185.0" GraphId="e_72_i0_1" GraphRef="e_72_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_72_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1269.0" Y="1186.0" GraphId="e_72_i1_0" GraphRef="n74_REACTOME_109909" RelX="1.0619469026548674" RelY="-0.02197802197802198"/>
      <Point X="1337.0" Y="1185.0" GraphId="e_72_i1_1" GraphRef="e_72_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_80_REACTOME_109972">
    <Comment Source="Reactome summation">At the site of damage, the Pol II complex is arrested resulting in reduced levels of transcription.  Several models have been proposed to explain the mechanism of this transcriptional downregulation. These include a. hyperphosphorylation of Pol II  resulting in aborted entry to new pre-initiation complexes b. sequestration of TATA-binding proteins (TBP)  c. enhanced use of TFIIH complexes for repair purposes precluding their use in transcription.&lt;BR&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1541.0" Y="1183.0" GraphId="e_80_0" GraphRef="n75_REACTOME_110292" RelX="1.0551181102362204" RelY="-0.029411764705882353"/>
      <Point X="1571.0" Y="1183.0" GraphId="e_80_1"/>
      <Point X="1607.0" Y="1183.0" GraphId="e_80_2" GraphRef="n81_REACTOME_110293" RelX="-1.0545454545454545" RelY="-0.029411764705882353" ArrowHead="Arrow"/>
      <Anchor Position="0.45454545454545453" GraphId="e_80_a_p"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_REACTOME_109973">
    <Comment Source="Reactome summation">A proper assembly of repair complex may require displacement of Pol II from the damage site exposing a significant length of the corresponding template DNA with the lesions. Speculations on the mode of this displacement of Pol II are available from experimental evidences: a. CSB mediated dissociation of Pol II  b. degradation of Pol II  c. CSB mediated remodeling of damaged DNA-RNA PII interface etc.&lt;BR&gt;The TC-repair complex now consists of damaged DNA template: nascent mRNA hybrid. The damage site needs to be exposed to subsequent endonuclease activities.&lt;BR&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1552.0" Y="1036.0" GraphId="e_82_0"/>
      <Point X="1606.0" Y="1035.0" GraphId="e_82_1"/>
      <Point X="1665.0" Y="1035.0" GraphId="e_82_2"/>
      <Anchor Position="0.0" GraphId="e_82_a_i"/>
      <Anchor Position="0.4779188820358568" GraphId="e_82_a_p"/>
      <Anchor Position="1.0" GraphId="e_82_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1500.0" Y="1049.0" GraphId="e_82_i0_0" GraphRef="n83_REACTOME_67411" RelX="1.0721649484536082" RelY="-0.6842105263157895"/>
      <Point X="1552.0" Y="1036.0" GraphId="e_82_i0_1" GraphRef="e_82_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1538.0" Y="1088.0" GraphId="e_82_i1_0" GraphRef="n84_REACTOME_54429" RelX="0.045454545454545456" RelY="-1.2173913043478262"/>
      <Point X="1552.0" Y="1036.0" GraphId="e_82_i1_1" GraphRef="e_82_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_i2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1445.0" Y="789.0" GraphId="e_82_i2_0" GraphRef="n28_REACTOME_109943" RelX="0.21052631578947367" RelY="1.1578947368421053"/>
      <Point X="1552.0" Y="1036.0" GraphId="e_82_i2_1" GraphRef="e_82_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_i3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1571.0" Y="966.0" GraphId="e_82_i3_0" GraphRef="n85_REACTOME_52835" RelX="-0.06818181818181818" RelY="1.3043478260869565"/>
      <Point X="1552.0" Y="1036.0" GraphId="e_82_i3_1" GraphRef="e_82_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_i4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="791.0" Y="942.0" GraphId="e_82_i4_0" GraphRef="n20_REACTOME_67447" RelX="1.0789473684210527" RelY="0.34782608695652173"/>
      <Point X="1552.0" Y="1036.0" GraphId="e_82_i4_1" GraphRef="e_82_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_i5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1639.0" Y="1147.0" GraphId="e_82_i5_0" GraphRef="n81_REACTOME_110293" RelX="-0.4727272727272727" RelY="-1.088235294117647"/>
      <Point X="1552.0" Y="1036.0" GraphId="e_82_i5_1" GraphRef="e_82_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_i6">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1605.0" Y="1018.0" GraphId="e_82_i6_0" GraphRef="n86_REACTOME_65748" RelX="-0.5979381443298969" RelY="1.3043478260869565"/>
      <Point X="1552.0" Y="1036.0" GraphId="e_82_i6_1" GraphRef="e_82_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_i7">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1042.0" Y="834.0" GraphId="e_82_i7_0" GraphRef="n23_REACTOME_109634" RelX="1.1578947368421053" RelY="0.6086956521739131"/>
      <Point X="1552.0" Y="1036.0" GraphId="e_82_i7_1" GraphRef="e_82_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1752.0" Y="1036.0" GraphId="e_82_o0_0" ArrowHead="Arrow" GraphRef="n87_REACTOME_110276" RelX="-1.0434782608695652" RelY="-0.07547169811320754"/>
      <Point X="1665.0" Y="1035.0" GraphId="e_82_o0_1" GraphRef="e_82_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_82_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1665.0" Y="1147.0" GraphId="e_82_o1_0" ArrowHead="Arrow" GraphRef="n81_REACTOME_110293" RelX="0.0" RelY="-1.088235294117647"/>
      <Point X="1665.0" Y="1035.0" GraphId="e_82_o1_1" GraphRef="e_82_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_88_REACTOME_109974">
    <Comment Source="Reactome summation">At the beginning of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', and 1 molecule of 'Stalled Pol II complex with damaged DNA hybrid' are present. At the end of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', 1 molecule of 'Stalled Pol II in TC-NER', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid' are present.&lt;br&gt;&lt;br&gt; This reaction takes place in the 'nucleus'.&lt;br&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1773.0" Y="1183.0" GraphId="e_88_0"/>
      <Point X="1786.0" Y="1219.0" GraphId="e_88_1"/>
      <Point X="1812.0" Y="1245.0" GraphId="e_88_2"/>
      <Anchor Position="0.0" GraphId="e_88_a_i"/>
      <Anchor Position="0.5100324364306792" GraphId="e_88_a_p"/>
      <Anchor Position="1.0" GraphId="e_88_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_88_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1804.0" Y="1068.0" GraphId="e_88_i0_0" GraphRef="n87_REACTOME_110276" RelX="-0.1391304347826087" RelY="1.1320754716981132"/>
      <Point X="1773.0" Y="1183.0" GraphId="e_88_i0_1" GraphRef="e_88_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_88_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1723.0" Y="1183.0" GraphId="e_88_i1_0" GraphRef="n81_REACTOME_110293" RelX="1.0545454545454545" RelY="-0.029411764705882353"/>
      <Point X="1773.0" Y="1183.0" GraphId="e_88_i1_1" GraphRef="e_88_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_88_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1812.0" Y="1068.0" GraphId="e_88_o0_0" ArrowHead="Arrow" GraphRef="n87_REACTOME_110276" RelX="0.0" RelY="1.1320754716981132"/>
      <Point X="1812.0" Y="1245.0" GraphId="e_88_o0_1" GraphRef="e_88_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_88_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1394.0" Y="1245.0" GraphId="e_88_o1_0" ArrowHead="Arrow" GraphRef="n73_REACTOME_110291" RelX="1.0654205607476634" RelY="-0.03773584905660377"/>
      <Point X="1812.0" Y="1245.0" GraphId="e_88_o1_1" GraphRef="e_88_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_88_o2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1812.0" Y="1342.0" GraphId="e_88_o2_0" ArrowHead="Arrow" GraphRef="n89_REACTOME_110294" RelX="-0.01680672268907563" RelY="-1.1578947368421053"/>
      <Point X="1812.0" Y="1245.0" GraphId="e_88_o2_1" GraphRef="e_88_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_90_REACTOME_109975">
    <Comment Source="Reactome summation">At the beginning of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid' are present. At the end of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with 3' incision' are present.&lt;br&gt;&lt;br&gt; This reaction takes place in the 'nucleus' and  is mediated by the 'endodeoxyribonuclease activity' of 'Transcription-coupled (TC) repair complex'.&lt;br&gt;</Comment>
    <BiopaxRef>lit_113805</BiopaxRef>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1698.0" Y="1287.0" GraphId="e_90_0"/>
      <Point X="1882.0" Y="1287.0" GraphId="e_90_1"/>
      <Point X="1949.0" Y="1287.0" GraphId="e_90_2"/>
      <Anchor Position="0.0" GraphId="e_90_a_i"/>
      <Anchor Position="0.7330677290836654" GraphId="e_90_a_p"/>
      <Anchor Position="1.0" GraphId="e_90_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_90_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1394.0" Y="1252.0" GraphId="e_90_i0_0" GraphRef="n73_REACTOME_110291" RelX="1.0654205607476634" RelY="0.22641509433962265"/>
      <Point X="1698.0" Y="1287.0" GraphId="e_90_i0_1" GraphRef="e_90_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_90_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1799.0" Y="1068.0" GraphId="e_90_i1_0" GraphRef="n87_REACTOME_110276" RelX="-0.22608695652173913" RelY="1.1320754716981132"/>
      <Point X="1698.0" Y="1287.0" GraphId="e_90_i1_1" GraphRef="e_90_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_90_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1982.0" Y="1285.0" GraphId="e_90_o0_0" ArrowHead="Arrow" GraphRef="n91_REACTOME_110298" RelX="-1.0434782608695652" RelY="0.04819277108433735"/>
      <Point X="1949.0" Y="1287.0" GraphId="e_90_o0_1" GraphRef="e_90_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_90_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1826.0" Y="1068.0" GraphId="e_90_o1_0" ArrowHead="Arrow" GraphRef="n87_REACTOME_110276" RelX="0.24347826086956523" RelY="1.1320754716981132"/>
      <Point X="1949.0" Y="1287.0" GraphId="e_90_o1_1" GraphRef="e_90_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_90_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="1819.0" Y="1068.0" GraphId="e_90_c__0_0" GraphRef="n87_REACTOME_110276" RelX="0.12173913043478261" RelY="1.1320754716981132"/>
      <Point X="1882.0" Y="1287.0" GraphId="e_90_c__0_1" GraphRef="e_90_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_96_REACTOME_109976">
    <Comment Source="Reactome summation">At the beginning of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with 3' incision' are present. At the end of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', 1 molecule of 'excised DNA fragment with lesion', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with dual incisions' are present.&lt;br&gt;&lt;br&gt; This reaction takes place in the 'nucleus' and  is mediated by the 'endodeoxyribonuclease activity' of 'Transcription-coupled (TC) repair complex'.&lt;br&gt;</Comment>
    <BiopaxRef>lit_113805</BiopaxRef>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1989.0" Y="1041.0" GraphId="e_96_0"/>
      <Point X="1972.0" Y="921.0" GraphId="e_96_1"/>
      <Point X="1836.0" Y="921.0" GraphId="e_96_2"/>
      <Anchor Position="0.0" GraphId="e_96_a_i"/>
      <Anchor Position="0.47122488402019663" GraphId="e_96_a_p"/>
      <Anchor Position="1.0" GraphId="e_96_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_96_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="2032.0" Y="1239.0" GraphId="e_96_i0_0" GraphRef="n91_REACTOME_110298" RelX="-0.17391304347826086" RelY="-1.0602409638554218"/>
      <Point X="1989.0" Y="1041.0" GraphId="e_96_i0_1" GraphRef="e_96_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_96_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1873.0" Y="1038.0" GraphId="e_96_i1_0" GraphRef="n87_REACTOME_110276" RelX="1.0608695652173914" RelY="0.0"/>
      <Point X="1989.0" Y="1041.0" GraphId="e_96_i1_1" GraphRef="e_96_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_96_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1811.0" Y="879.0" GraphId="e_96_o0_0" ArrowHead="Arrow" GraphRef="n97_REACTOME_110303" RelX="0.32786885245901637" RelY="1.0933333333333333"/>
      <Point X="1836.0" Y="921.0" GraphId="e_96_o0_1" GraphRef="e_96_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_96_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1817.0" Y="1009.0" GraphId="e_96_o1_0" ArrowHead="Arrow" GraphRef="n87_REACTOME_110276" RelX="0.08695652173913043" RelY="-1.0943396226415094"/>
      <Point X="1836.0" Y="921.0" GraphId="e_96_o1_1" GraphRef="e_96_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_96_o2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="948.0" Y="1145.0" GraphId="e_96_o2_0" ArrowHead="Arrow"/>
      <Point X="1551.0" Y="921.0" GraphId="e_96_o2_1" GraphRef="n42_REACTOME_109960" RelX="14.173913043478262" RelY="-9.132075471698114"/>
      <Point X="1836.0" Y="921.0" GraphId="e_96_o2_2" GraphRef="e_96_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_96_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="1848.0" Y="1009.0" GraphId="e_96_c__0_0" GraphRef="n87_REACTOME_110276" RelX="0.6260869565217392" RelY="-1.0943396226415094"/>
      <Point X="1972.0" Y="921.0" GraphId="e_96_c__0_1" GraphRef="e_96_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_REACTOME_110305">
    <Comment Source="Reactome summation">At the beginning of this reaction, 1 molecule of 'dNTP', 1 molecule of 'RPA heterotrimer', 1 molecule of 'PCNA homotrimer', 1 molecule of 'RFC Heteropentamer', 1 molecule of 'DNA Polymerase delta tetramer', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with dual incisions' are present. At the end of this reaction, 1 molecule of 'RPA heterotrimer', 1 molecule of 'PCNA homotrimer', 1 molecule of 'RFC Heteropentamer', 1 molecule of 'newly synthesized DNA fragment ', 1 molecule of 'DNA Polymerase delta tetramer', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with dual incisions' are present.&lt;br&gt;&lt;br&gt; This reaction takes place in the 'nucleus' and  is mediated by the 'delta DNA polymerase activity' of 'DNA Polymerase delta tetramer'.&lt;br&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1738.0" Y="1690.0" GraphId="e_110_0"/>
      <Point X="1541.0" Y="1573.0" GraphId="e_110_1"/>
      <Point X="1466.0" Y="1527.0" GraphId="e_110_2"/>
      <Anchor Position="0.0" GraphId="e_110_a_i"/>
      <Anchor Position="0.7225452313057592" GraphId="e_110_a_p"/>
      <Anchor Position="1.0" GraphId="e_110_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="689.0" Y="751.0" GraphId="e_110_i0_0" GraphRef="n18_REACTOME_68462" RelX="0.18691588785046728" RelY="1.3043478260869565"/>
      <Point X="1261.0" Y="1361.0" GraphId="e_110_i0_1"/>
      <Point X="1738.0" Y="1690.0" GraphId="e_110_i0_2" GraphRef="e_110_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1855.0" Y="842.0" GraphId="e_110_i1_0" GraphRef="n97_REACTOME_110303" RelX="1.0491803278688525" RelY="0.10666666666666667"/>
      <Point X="2197.0" Y="870.0" GraphId="e_110_i1_1"/>
      <Point X="2197.0" Y="1344.0" GraphId="e_110_i1_2"/>
      <Point X="1738.0" Y="1690.0" GraphId="e_110_i1_3" GraphRef="e_110_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_i2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="441.0" Y="1448.0" GraphId="e_110_i2_0" GraphRef="n44_REACTOME_68440" RelX="-0.078125" RelY="1.3043478260869565"/>
      <Point X="378.0" Y="1599.0" GraphId="e_110_i2_1"/>
      <Point X="664.0" Y="1776.0" GraphId="e_110_i2_2"/>
      <Point X="1322.0" Y="1719.0" GraphId="e_110_i2_3"/>
      <Point X="1738.0" Y="1690.0" GraphId="e_110_i2_4" GraphRef="e_110_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_i3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="950.0" Y="1594.0" GraphId="e_110_i3_0" GraphRef="n47_REACTOME_68436" RelX="1.0469798657718121" RelY="0.6428571428571429"/>
      <Point X="1738.0" Y="1690.0" GraphId="e_110_i3_1" GraphRef="e_110_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_i4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1770.0" Y="1708.0" GraphId="e_110_i4_0" GraphRef="n119_REACTOME_110300" RelX="-0.8372093023255814" RelY="-1.2173913043478262"/>
      <Point X="1738.0" Y="1690.0" GraphId="e_110_i4_1" GraphRef="e_110_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_i5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1499.0" Y="1622.0" GraphId="e_110_i5_0" GraphRef="n122_REACTOME_68450" RelX="0.984375" RelY="1.1578947368421053"/>
      <Point X="1738.0" Y="1690.0" GraphId="e_110_i5_1" GraphRef="e_110_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="688.0" Y="751.0" GraphId="e_110_o0_0" ArrowHead="Arrow"/>
      <Point X="1234.0" Y="1379.0" GraphId="e_110_o0_1" GraphRef="n18_REACTOME_68462" RelX="10.373831775700934" RelY="55.91304347826087"/>
      <Point X="1466.0" Y="1527.0" GraphId="e_110_o0_2" GraphRef="e_110_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1855.0" Y="848.0" GraphId="e_110_o1_0" ArrowHead="Arrow"/>
      <Point X="2149.0" Y="902.0" GraphId="e_110_o1_1"/>
      <Point X="2149.0" Y="1331.0" GraphId="e_110_o1_2"/>
      <Point X="1970.0" Y="1476.0" GraphId="e_110_o1_3" GraphRef="n97_REACTOME_110303" RelX="2.9344262295081966" RelY="17.013333333333332"/>
      <Point X="1466.0" Y="1527.0" GraphId="e_110_o1_4" GraphRef="e_110_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_o2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="446.0" Y="1448.0" GraphId="e_110_o2_0" ArrowHead="Arrow"/>
      <Point X="447.0" Y="1585.0" GraphId="e_110_o2_1"/>
      <Point X="682.0" Y="1743.0" GraphId="e_110_o2_2" GraphRef="n44_REACTOME_68440" RelX="3.6875" RelY="26.956521739130434"/>
      <Point X="1466.0" Y="1527.0" GraphId="e_110_o2_3" GraphRef="e_110_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_o3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="950.0" Y="1577.0" GraphId="e_110_o3_0" ArrowHead="Arrow" GraphRef="n47_REACTOME_68436" RelX="1.0469798657718121" RelY="-0.5714285714285714"/>
      <Point X="1466.0" Y="1527.0" GraphId="e_110_o3_1" GraphRef="e_110_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_o4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1443.0" Y="1578.0" GraphId="e_110_o4_0" ArrowHead="Arrow" GraphRef="n122_REACTOME_68450" RelX="0.109375" RelY="-1.1578947368421053"/>
      <Point X="1466.0" Y="1527.0" GraphId="e_110_o4_1" GraphRef="e_110_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_o5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1340.0" Y="1502.0" GraphId="e_110_o5_0" ArrowHead="Arrow" GraphRef="n178_REACTOME_109964" RelX="1.0526315789473684" RelY="0.4528301886792453"/>
      <Point X="1466.0" Y="1527.0" GraphId="e_110_o5_1" GraphRef="e_110_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_110_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="1503.0" Y="1583.0" GraphId="e_110_c__0_0" GraphRef="n122_REACTOME_68450" RelX="1.046875" RelY="-0.8947368421052632"/>
      <Point X="1541.0" Y="1573.0" GraphId="e_110_c__0_1" GraphRef="e_110_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_135_REACTOME_109978">
    <Comment Source="Reactome summation">At the beginning of this reaction, 1 molecule of 'newly synthesized DNA fragment ', 1 molecule of 'DNA ligase I ', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with dual incisions' are present. At the end of this reaction, 1 molecule of 'repaired DNA template:nascent mRNA hybrid', and 1 molecule of 'DNA ligase I ' are present.&lt;br&gt;&lt;br&gt; This reaction takes place in the 'nucleus' and  is mediated by the 'DNA ligase activity' of 'DNA ligase I '.&lt;br&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1471.0" Y="618.0" GraphId="e_135_0"/>
      <Point X="1254.0" Y="618.0" GraphId="e_135_1"/>
      <Point X="1139.0" Y="618.0" GraphId="e_135_2"/>
      <Anchor Position="0.0" GraphId="e_135_a_i"/>
      <Anchor Position="0.6536144578313253" GraphId="e_135_a_p"/>
      <Anchor Position="1.0" GraphId="e_135_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_135_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1855.0" Y="813.0" GraphId="e_135_i0_0" GraphRef="n97_REACTOME_110303" RelX="1.0491803278688525" RelY="-0.6666666666666666"/>
      <Point X="1984.0" Y="761.0" GraphId="e_135_i0_1"/>
      <Point X="1885.0" Y="618.0" GraphId="e_135_i0_2"/>
      <Point X="1471.0" Y="618.0" GraphId="e_135_i0_3" GraphRef="e_135_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_135_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1011.0" Y="1244.0" GraphId="e_135_i1_0" GraphRef="n66_REACTOME_53787" RelX="0.17391304347826086" RelY="-1.2173913043478262"/>
      <Point X="1471.0" Y="618.0" GraphId="e_135_i1_1" GraphRef="e_135_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_135_i2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1516.0" Y="637.0" GraphId="e_135_i2_0" GraphRef="n182_REACTOME_109964" RelX="-0.8421052631578947" RelY="-1.0943396226415094"/>
      <Point X="1471.0" Y="618.0" GraphId="e_135_i2_1" GraphRef="e_135_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_135_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1005.0" Y="1244.0" GraphId="e_135_o0_0" ArrowHead="Arrow" GraphRef="n66_REACTOME_53787" RelX="0.043478260869565216" RelY="-1.2173913043478262"/>
      <Point X="1139.0" Y="618.0" GraphId="e_135_o0_1" GraphRef="e_135_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_135_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1116.0" Y="588.0" GraphId="e_135_o1_0" ArrowHead="Arrow" GraphRef="n136_REACTOME_110295" RelX="0.4" RelY="1.088235294117647"/>
      <Point X="1139.0" Y="618.0" GraphId="e_135_o1_1" GraphRef="e_135_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_135_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="1007.0" Y="1244.0" GraphId="e_135_c__0_0" GraphRef="n66_REACTOME_53787" RelX="0.08695652173913043" RelY="-1.2173913043478262"/>
      <Point X="1254.0" Y="618.0" GraphId="e_135_c__0_1" GraphRef="e_135_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_145_REACTOME_109980">
    <Comment Source="Reactome summation">At the beginning of this reaction, 1 molecule of 'Stalled Pol II in TC-NER', and 1 molecule of 'repaired DNA template:nascent mRNA hybrid' are present. At the end of this reaction, 1 molecule of 'Active Pol II complex with repaired DNA template:mRNA hybrid' is present.&lt;br&gt;&lt;br&gt; This reaction takes place in the 'nucleus'.&lt;br&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="2270.0" Y="550.0" GraphId="e_145_0"/>
      <Point X="2321.0" Y="551.0" GraphId="e_145_1"/>
      <Point X="2358.0" Y="551.0" GraphId="e_145_2" GraphRef="n146_REACTOME_110296" RelX="-1.0420168067226891" RelY="-0.024096385542168676" ArrowHead="Arrow"/>
      <Anchor Position="0.0" GraphId="e_145_a_i"/>
      <Anchor Position="0.5795922869109378" GraphId="e_145_a_p"/>
    </Graphics>
  </Line>
  <Line GraphId="e_145_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1876.0" Y="1363.0" GraphId="e_145_i0_0" GraphRef="n89_REACTOME_110294" RelX="1.0588235294117647" RelY="-0.05263157894736842"/>
      <Point X="2270.0" Y="1363.0" GraphId="e_145_i0_1"/>
      <Point X="2270.0" Y="550.0" GraphId="e_145_i0_2" GraphRef="e_145_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_145_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1154.0" Y="550.0" GraphId="e_145_i1_0" GraphRef="n136_REACTOME_110295" RelX="1.0608695652173914" RelY="-0.029411764705882353"/>
      <Point X="2270.0" Y="550.0" GraphId="e_145_i1_1" GraphRef="e_145_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_REACTOME_110306">
    <Comment Source="Reactome summation">At the beginning of this reaction, 1 molecule of 'dNTP', 1 molecule of 'RPA heterotrimer', 1 molecule of 'PCNA homotrimer', 1 molecule of 'RFC Heteropentamer', 1 molecule of 'DNA polymerase epsilon', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with dual incisions' are present. At the end of this reaction, 1 molecule of 'RPA heterotrimer', 1 molecule of 'PCNA homotrimer', 1 molecule of 'RFC Heteropentamer', 1 molecule of 'newly synthesized DNA fragment ', 1 molecule of 'DNA polymerase epsilon', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with dual incisions' are present.&lt;br&gt;&lt;br&gt; This reaction takes place in the 'nucleus' and  is mediated by the 'DNA-directed DNA polymerase activity' of 'DNA polymerase epsilon'.&lt;br&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="783.0" Y="1839.0" GraphId="e_159_0"/>
      <Point X="99.0" Y="1795.0" GraphId="e_159_1"/>
      <Point X="90.0" Y="750.0" GraphId="e_159_2"/>
      <Anchor Position="0.0" GraphId="e_159_a_i"/>
      <Anchor Position="0.3960893142618899" GraphId="e_159_a_p"/>
      <Anchor Position="1.0" GraphId="e_159_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="623.0" Y="734.0" GraphId="e_159_i0_0" GraphRef="n18_REACTOME_68462" RelX="-1.0467289719626167" RelY="-0.17391304347826086"/>
      <Point X="34.0" Y="721.0" GraphId="e_159_i0_1"/>
      <Point X="37.0" Y="1839.0" GraphId="e_159_i0_2"/>
      <Point X="783.0" Y="1839.0" GraphId="e_159_i0_3" GraphRef="e_159_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1855.0" Y="832.0" GraphId="e_159_i1_0" GraphRef="n97_REACTOME_110303" RelX="1.0491803278688525" RelY="-0.16"/>
      <Point X="2245.0" Y="798.0" GraphId="e_159_i1_1"/>
      <Point X="2249.0" Y="1835.0" GraphId="e_159_i1_2"/>
      <Point X="783.0" Y="1839.0" GraphId="e_159_i1_3" GraphRef="e_159_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_i2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="492.0" Y="1448.0" GraphId="e_159_i2_0" GraphRef="n44_REACTOME_68440" RelX="0.71875" RelY="1.3043478260869565"/>
      <Point X="673.0" Y="1489.0" GraphId="e_159_i2_1"/>
      <Point X="783.0" Y="1839.0" GraphId="e_159_i2_2" GraphRef="e_159_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_i3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="564.0" Y="1536.0" GraphId="e_159_i3_0" GraphRef="n45_REACTOME_68483" RelX="0.34" RelY="1.12"/>
      <Point X="783.0" Y="1839.0" GraphId="e_159_i3_1" GraphRef="e_159_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_i4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="867.0" Y="1602.0" GraphId="e_159_i4_0" GraphRef="n47_REACTOME_68436" RelX="-0.06711409395973154" RelY="1.2142857142857142"/>
      <Point X="783.0" Y="1839.0" GraphId="e_159_i4_1" GraphRef="e_159_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_i5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="717.0" Y="1808.0" GraphId="e_159_i5_0" GraphRef="n169_REACTOME_110300" RelX="1.1627906976744187" RelY="0.782608695652174"/>
      <Point X="783.0" Y="1839.0" GraphId="e_159_i5_1" GraphRef="e_159_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_o0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="623.0" Y="737.0" GraphId="e_159_o0_0" ArrowHead="Arrow" GraphRef="n18_REACTOME_68462" RelX="-1.0467289719626167" RelY="0.08695652173913043"/>
      <Point X="90.0" Y="750.0" GraphId="e_159_o0_1" GraphRef="e_159_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_o1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1776.0" Y="798.0" GraphId="e_159_o1_0" ArrowHead="Arrow"/>
      <Point X="1661.0" Y="504.0" GraphId="e_159_o1_1"/>
      <Point X="492.0" Y="504.0" GraphId="e_159_o1_2" GraphRef="n97_REACTOME_110303" RelX="-21.295081967213115" RelY="-8.906666666666666"/>
      <Point X="90.0" Y="750.0" GraphId="e_159_o1_3" GraphRef="e_159_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_o2">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="420.0" Y="1448.0" GraphId="e_159_o2_0" ArrowHead="Arrow"/>
      <Point X="230.0" Y="1531.0" GraphId="e_159_o2_1" GraphRef="n44_REACTOME_68440" RelX="-3.375" RelY="8.521739130434783"/>
      <Point X="90.0" Y="750.0" GraphId="e_159_o2_2" GraphRef="e_159_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_o3">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="494.0" Y="1523.0" GraphId="e_159_o3_0" ArrowHead="Arrow"/>
      <Point X="175.0" Y="1621.0" GraphId="e_159_o3_1" GraphRef="n45_REACTOME_68483" RelX="-7.44" RelY="4.52"/>
      <Point X="90.0" Y="750.0" GraphId="e_159_o3_2" GraphRef="e_159_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_o4">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="858.0" Y="1568.0" GraphId="e_159_o4_0" ArrowHead="Arrow" GraphRef="n47_REACTOME_68436" RelX="-0.18791946308724833" RelY="-1.2142857142857142"/>
      <Point X="90.0" Y="750.0" GraphId="e_159_o4_1" GraphRef="e_159_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_o5">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="211.0" Y="983.0" GraphId="e_159_o5_0" ArrowHead="Arrow" GraphRef="n170_REACTOME_109964" RelX="-0.21052631578947367" RelY="-1.0943396226415094"/>
      <Point X="90.0" Y="750.0" GraphId="e_159_o5_1" GraphRef="e_159_a_o"/>
    </Graphics>
  </Line>
  <Line GraphId="e_159_c__0">
    <Graphics LineStyle="Broken" Color="000000" ConnectorType="Segmented">
      <Point X="507.0" Y="1536.0" GraphId="e_159_c__0_0" GraphRef="n45_REACTOME_68483" RelX="-0.8" RelY="1.12"/>
      <Point X="99.0" Y="1795.0" GraphId="e_159_c__0_1" GraphRef="e_159_a_p" ArrowHead="Line"/>
    </Graphics>
  </Line>
  <Line GraphId="e_192_REACTOME_109955">
    <Comment Source="Reactome summation">At the beginning of this reaction, 1 molecule of 'ERCC1, DNA excision repair protein', and 1 molecule of 'XPF protein' are present. At the end of this reaction, 1 molecule of 'ERCC1:XPF complex' is present.&lt;br&gt;&lt;br&gt; This reaction takes place in the 'nucleus'.&lt;br&gt;</Comment>
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1584.0" Y="752.0" GraphId="e_192_0"/>
      <Point X="1520.0" Y="753.0" GraphId="e_192_1"/>
      <Point X="1478.0" Y="760.0" GraphId="e_192_2" GraphRef="n28_REACTOME_109943" RelX="1.0789473684210527" RelY="-0.3684210526315789" ArrowHead="Arrow"/>
      <Anchor Position="0.0" GraphId="e_192_a_i"/>
      <Anchor Position="0.6005209087790956" GraphId="e_192_a_p"/>
    </Graphics>
  </Line>
  <Line GraphId="e_192_i0">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1575.0" Y="762.0" GraphId="e_192_i0_0" GraphRef="n193_REACTOME_54427" RelX="0.125" RelY="-1.1851851851851851"/>
      <Point X="1584.0" Y="752.0" GraphId="e_192_i0_1" GraphRef="e_192_a_i"/>
    </Graphics>
  </Line>
  <Line GraphId="e_192_i1">
    <Graphics LineStyle="Solid" Color="000000" ConnectorType="Segmented">
      <Point X="1657.0" Y="752.0" GraphId="e_192_i1_0" GraphRef="n194_REACTOME_67445" RelX="-1.0769230769230769" RelY="0.0"/>
      <Point X="1584.0" Y="752.0" GraphId="e_192_i1_1" GraphRef="e_192_a_i"/>
    </Graphics>
  </Line>
  <Label GraphId="comp_text_9" GroupRef="group_comp_9" TextLabel="nucleoplasm">
    <Graphics Color="000000" CenterX="138.0" CenterY="1942.5" Width="92.0" Height="33.0" Valign="Middle" FontSize="12"/>
  </Label>
  <Shape GraphId="comp_9" GroupRef="group_comp_9">
    <Graphics Color="000000" CenterX="1278.0" CenterY="1193.0" Width="2548.0" Height="1592.0" Valign="Middle" ShapeType="Rectangle" LineThickness="2.0"/>
  </Shape>
  <InfoBox CenterX="3872.5" CenterY="6350.0"/>
  <Biopax>
    <bp:publicationXref xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" rdf:ID="lit_110555" rdf:id="lit_110555">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11900249</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pubmed</bp:DB>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#int">2002</bp:YEAR>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">How nucleotide excision repair protects against cancer.</bp:TITLE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Friedberg, EC</bp:AUTHORS>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Rev Cancer 1:22-33</bp:SOURCE>
    </bp:publicationXref>
    <bp:publicationXref xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" rdf:ID="lit_110556" rdf:id="lit_110556">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">14599765</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pubmed</bp:DB>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#int">2003</bp:YEAR>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mechanisms of human DNA repair: an update.</bp:TITLE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Christmann, M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tomicic, MT</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Roos, WP</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kaina, B</bp:AUTHORS>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Toxicology 193:3-34</bp:SOURCE>
    </bp:publicationXref>
    <bp:publicationXref xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" rdf:ID="lit_110557" rdf:id="lit_110557">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10583946</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pubmed</bp:DB>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1999</bp:YEAR>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Quality control by DNA repair</bp:TITLE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lindahl, T</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wood, RD</bp:AUTHORS>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Science 286:1897-905</bp:SOURCE>
    </bp:publicationXref>
    <bp:publicationXref xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" rdf:ID="lit_68474" rdf:id="lit_68474">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">9405441</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pubmed</bp:DB>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1998</bp:YEAR>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon.</bp:TITLE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li, Y</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Asahara, H</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Patel, VS</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhou, S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Linn, S</bp:AUTHORS>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem 272:32337-44</bp:SOURCE>
    </bp:publicationXref>
    <bp:publicationXref xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" rdf:ID="lit_110564" rdf:id="lit_110564">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11511374</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pubmed</bp:DB>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#int">2001</bp:YEAR>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sequential assembly of the nucleotide excision repair factors in vivo.</bp:TITLE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Volker, M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MonÃ©, MJ</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Karmakar, P</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">van Hoffen, A</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schul, W</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vermeulen, W</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hoeijmakers, JH</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">van Driel, R</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">van Zeeland, AA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mullenders, LH</bp:AUTHORS>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Cell 8:213-24</bp:SOURCE>
    </bp:publicationXref>
    <bp:publicationXref xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" rdf:ID="lit_110738" rdf:id="lit_110738">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10526214</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pubmed</bp:DB>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1999</bp:YEAR>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Protein complexes in nucleotide excision repair.</bp:TITLE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AraÃºjo, SJ</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wood, RD</bp:AUTHORS>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mutat Res 435:23-33</bp:SOURCE>
    </bp:publicationXref>
    <bp:publicationXref xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" rdf:ID="lit_110739" rdf:id="lit_110739">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10214908</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pubmed</bp:DB>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1999</bp:YEAR>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DNA damage recognition during nucleotide excision repair in mammalian cells.</bp:TITLE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wood, RD</bp:AUTHORS>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie 81:39-44</bp:SOURCE>
    </bp:publicationXref>
    <bp:publicationXref xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" rdf:ID="lit_113805" rdf:id="lit_113805">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11313499</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pubmed</bp:DB>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#int">2001</bp:YEAR>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.</bp:TITLE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gnatt, AL</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cramer, P</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fu, J</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bushnell, DA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kornberg, RD</bp:AUTHORS>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Science 292:1876-82</bp:SOURCE>
    </bp:publicationXref>
  </Biopax>
</Pathway>