DNA damage response (Sus scrofa)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://genmapp.org/GPML/2010a" Name="DNA damage response" Organism="Sus scrofa" License="CC BY 2.0"> <Comment Source="WikiPathways-description">This is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two central genes can be divides furthermore into their most important genes. In the ATM pathway are the most important genes TP53 and CHEK2 and on the other hand in the ATR pathway is this CHEK1. If it is not mentioned different, the processes take place in the cell cytoplasm. The goal of this first pathway is to give an overview of the most important gene products, processes and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arranged</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP707&amp;oldid=34441 WP707(r34441)] with a 61% conversion rate.</Comment> <BiopaxRef>efb</BiopaxRef> <Graphics BoardWidth="2004.2" BoardHeight="839.3"/> <DataNode TextLabel="GADD45A" GraphId="cda63" Type="GeneProduct" GroupRef="f92af"> <Graphics CenterX="832.0" CenterY="406.48333333333335" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="FAS" GraphId="cf525" Type="GeneProduct" GroupRef="c8bd3"> <Graphics CenterX="741.0" CenterY="99.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000010448"/> </DataNode> <DataNode TextLabel="PMAIP1" GraphId="c90dc" Type="GeneProduct" GroupRef="bcb51"> <Graphics CenterX="842.0" CenterY="120.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="RB1" GraphId="a35cb" Type="GeneProduct" GroupRef="edcc5"> <Graphics CenterX="917.0" CenterY="689.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000009401"/> </DataNode> <DataNode TextLabel="ATR" GraphId="a7c42" Type="GeneProduct"> <Graphics CenterX="1625.0" CenterY="276.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000011679"/> </DataNode> <DataNode TextLabel="CDK2" GraphId="a848a" Type="GeneProduct" GroupRef="a1373"> <Graphics CenterX="803.0" CenterY="547.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000000373"/> </DataNode> <DataNode TextLabel="CDKN1A" GraphId="a6028" Type="GeneProduct"> <Graphics CenterX="698.0" CenterY="303.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000001565"/> </DataNode> <DataNode TextLabel="FANCD2" GraphId="b969a" Type="GeneProduct"> <Graphics CenterX="1200.0" CenterY="354.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000011563"/> </DataNode> <DataNode TextLabel="CDK4" GraphId="df337" Type="GeneProduct" GroupRef="aad6d"> <Graphics CenterX="1037.0" CenterY="548.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000000445"/> </DataNode> <DataNode TextLabel="CASP9" GraphId="af3c9" Type="GeneProduct"> <Graphics CenterX="337.0" CenterY="218.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000003460"/> </DataNode> <DataNode TextLabel="CHEK2" GraphId="b87d6" Type="GeneProduct"> <Graphics CenterX="1111.0" CenterY="354.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="SMC1A" GraphId="df6f2" Type="GeneProduct"> <Graphics CenterX="1194.0" CenterY="424.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000012325"/> </DataNode> <DataNode TextLabel="CDC25A" GraphId="ff5a8" Type="GeneProduct"> <Graphics CenterX="1068.0" CenterY="482.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="SFN" GraphId="c1266" Type="GeneProduct"> <Graphics CenterX="888.0" CenterY="248.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000003562"/> </DataNode> <DataNode TextLabel="RAD9A" GraphId="f67a0" Type="GeneProduct" GroupRef="d3310"> <Graphics CenterX="1754.0" CenterY="374.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000012914"/> </DataNode> <DataNode TextLabel="ATM" GraphId="dde4a" Type="GeneProduct"> <Graphics CenterX="1155.0" CenterY="276.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000015007"/> </DataNode> <DataNode TextLabel="GADD45G" GraphId="af54e" Type="GeneProduct" GroupRef="daebd"> <Graphics CenterX="598.0" CenterY="223.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000009585"/> </DataNode> <DataNode TextLabel="RFC" GraphId="abe1f" Type="GeneProduct" GroupRef="bb98d"> <Graphics CenterX="1754.0" CenterY="424.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Caffeine" GraphId="d4c23" Type="Metabolite"> <Graphics CenterX="1366.0" CenterY="276.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="00cccc"/> <Xref Database="Chemspider" ID="2424"/> </DataNode> <DataNode TextLabel="CCND1" GraphId="ace9b" Type="GeneProduct" GroupRef="aad6d"> <Graphics CenterX="935.0" CenterY="548.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="RPA2" GraphId="ccdd5" Type="GeneProduct"> <Graphics CenterX="1754.0" CenterY="196.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000003583"/> </DataNode> <DataNode TextLabel="CDKN1B" GraphId="ab4a3" Type="GeneProduct"> <Graphics CenterX="977.0" CenterY="299.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="TLK2" GraphId="bd01f" Type="GeneProduct" GroupRef="a5395"> <Graphics CenterX="1479.0" CenterY="420.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000017301"/> </DataNode> <DataNode TextLabel="c-Myc" GraphId="e86b6" Type="GeneProduct"> <Graphics CenterX="996.0" CenterY="445.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CYCS" GraphId="df713" Type="GeneProduct"> <Graphics CenterX="374.0" CenterY="99.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CCNB1" GraphId="fcb39" Type="GeneProduct" GroupRef="fd657"> <Graphics CenterX="711.0" CenterY="341.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="BBC3" GraphId="e6f34" Type="GeneProduct" GroupRef="bcb51"> <Graphics CenterX="842.0" CenterY="100.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="GADD45B" GraphId="a3789" Type="GeneProduct" GroupRef="daebd"> <Graphics CenterX="598.0" CenterY="201.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="SESN1" GraphId="de74b" Type="GeneProduct" GroupRef="daebd"> <Graphics CenterX="679.0" CenterY="223.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000004390"/> </DataNode> <DataNode TextLabel="BID" GraphId="adae8" Type="GeneProduct"> <Graphics CenterX="513.0" CenterY="120.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000000769"/> </DataNode> <DataNode TextLabel="E2F1" GraphId="def85" Type="GeneProduct" GroupRef="edcc5"> <Graphics CenterX="917.0" CenterY="711.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000007268"/> </DataNode> <DataNode TextLabel="TP53AIP1" GraphId="acb7b" Type="GeneProduct" GroupRef="bcb51"> <Graphics CenterX="842.0" CenterY="79.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="RB1" GraphId="c9e7c" Type="GeneProduct"> <Graphics CenterX="1114.0" CenterY="710.4833333333333" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000009401"/> </DataNode> <DataNode TextLabel="CDK6" GraphId="da396" Type="GeneProduct" GroupRef="aad6d"> <Graphics CenterX="1037.0" CenterY="589.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000015318"/> </DataNode> <DataNode TextLabel="E2F1" GraphId="ea834" Type="GeneProduct"> <Graphics CenterX="1114.0" CenterY="666.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000007268"/> </DataNode> <DataNode TextLabel="CHEK1" GraphId="ac4da" Type="GeneProduct"> <Graphics CenterX="1625.0" CenterY="354.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="TLK1" GraphId="bdb9e" Type="GeneProduct" GroupRef="a5395"> <Graphics CenterX="1479.0" CenterY="399.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000015944"/> </DataNode> <DataNode TextLabel="TP53" GraphId="e15c3" Type="GeneProduct"> <Graphics CenterX="864.0" CenterY="345.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000017950"/> </DataNode> <DataNode TextLabel="Estradiol" GraphId="a606d" Type="Metabolite"> <Graphics CenterX="946.0" CenterY="371.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="00cccc"/> <Xref Database="ChEBI" ID="16469"/> </DataNode> <DataNode TextLabel="CCNB3" GraphId="e5cf1" Type="GeneProduct" GroupRef="fd657"> <Graphics CenterX="711.0" CenterY="385.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000012307"/> </DataNode> <DataNode TextLabel="CCNE2" GraphId="d4237" Type="GeneProduct" GroupRef="a1373"> <Graphics CenterX="803.0" CenterY="590.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000006095"/> </DataNode> <DataNode TextLabel="BAX" GraphId="d99a6" Type="GeneProduct" GroupRef="bcb51"> <Graphics CenterX="842.0" CenterY="141.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000003144"/> </DataNode> <DataNode TextLabel="CDK1" GraphId="f107a" Type="GeneProduct"> <Graphics CenterX="718.0" CenterY="456.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000010214"/> </DataNode> <DataNode TextLabel="CDC25C" GraphId="f456b" Type="GeneProduct"> <Graphics CenterX="1539.0" CenterY="531.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000014329"/> </DataNode> <DataNode TextLabel="CCNE1" GraphId="e598e" Type="GeneProduct" GroupRef="a1373"> <Graphics CenterX="803.0" CenterY="569.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000002855"/> </DataNode> <DataNode TextLabel="CASP8" GraphId="d81c9" Type="GeneProduct"> <Graphics CenterX="634.0" CenterY="120.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000016106"/> </DataNode> <DataNode TextLabel="RAD17" GraphId="abca1" Type="GeneProduct" GroupRef="bb98d"> <Graphics CenterX="1754.0" CenterY="445.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000016960"/> </DataNode> <DataNode TextLabel="CCND2" GraphId="b2eb2" Type="GeneProduct" GroupRef="aad6d"> <Graphics CenterX="935.0" CenterY="568.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000000727"/> </DataNode> <DataNode TextLabel="PRKDC" GraphId="d7209" Type="GeneProduct"> <Graphics CenterX="947.0" CenterY="411.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000006274"/> </DataNode> <DataNode TextLabel="RRM2B" GraphId="ece52" Type="GeneProduct" GroupRef="daebd"> <Graphics CenterX="679.0" CenterY="180.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000006058"/> </DataNode> <DataNode TextLabel="DDB2" GraphId="c7f52" Type="GeneProduct" GroupRef="daebd"> <Graphics CenterX="679.0" CenterY="201.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000013243"/> </DataNode> <DataNode TextLabel="RAD50" GraphId="e84b2" Type="GeneProduct" GroupRef="f1382"> <Graphics CenterX="993.0" CenterY="209.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000014280"/> </DataNode> <DataNode TextLabel="GADD45B" GraphId="c6556" Type="GeneProduct" GroupRef="f92af"> <Graphics CenterX="832.0" CenterY="427.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="ATRIP" GraphId="f488e" Type="GeneProduct"> <Graphics CenterX="1754.0" CenterY="237.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CCND3" GraphId="a947d" Type="GeneProduct" GroupRef="aad6d"> <Graphics CenterX="935.0" CenterY="589.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000001632"/> </DataNode> <DataNode TextLabel="CDK5" GraphId="baf31" Type="GeneProduct" GroupRef="aad6d"> <Graphics CenterX="1037.0" CenterY="569.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="NBN" GraphId="b7bdf" Type="GeneProduct" GroupRef="f1382"> <Graphics CenterX="993.0" CenterY="230.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="GADD45A" GraphId="aa8a3" Type="GeneProduct" GroupRef="daebd"> <Graphics CenterX="598.0" CenterY="180.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="BRCA1" GraphId="c2a35" Type="GeneProduct"> <Graphics CenterX="1318.0" CenterY="342.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CASP3" GraphId="d9b7f" Type="GeneProduct"> <Graphics CenterX="337.0" CenterY="262.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000015783"/> </DataNode> <DataNode TextLabel="MRE11" GraphId="f2df4" Type="GeneProduct" GroupRef="f1382"> <Graphics CenterX="993.0" CenterY="251.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="HUS1" GraphId="e4be3" Type="GeneProduct" GroupRef="d3310"> <Graphics CenterX="1754.0" CenterY="333.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode 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GroupRef="c8bd3"> <Graphics CenterX="741.0" CenterY="141.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="APAF1" GraphId="a1a1f" Type="GeneProduct"> <Graphics CenterX="284.0" CenterY="98.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000000884"/> </DataNode> <DataNode TextLabel="PML" GraphId="b4c86" Type="GeneProduct"> <Graphics CenterX="1035.0" CenterY="411.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CCNB2" GraphId="a1ae8" Type="GeneProduct" GroupRef="fd657"> <Graphics CenterX="711.0" CenterY="363.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl Pig" ID="ENSSSCG00000004588"/> </DataNode> <DataNode TextLabel="RAD1" GraphId="d4e5e" Type="GeneProduct" GroupRef="d3310"> <Graphics 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