Insulin Signaling (Pan troglodytes)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://genmapp.org/GPML/2010a" Name="Insulin Signaling" Organism="Pan troglodytes" Last-Modified="5/9/2012"> <Comment Source="WikiPathways-description">Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP481&amp;oldid=45380 WP481(r45380)] with a 87% conversion rate.</Comment> <BiopaxRef>b27</BiopaxRef> <BiopaxRef>d3b</BiopaxRef> <Graphics BoardWidth="1397.5213675213677" BoardHeight="1120.0"/> <DataNode TextLabel="INSR" GraphId="c27" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="INSR | insulin receptor"/> <Graphics CenterX="616.6666666666666" CenterY="103.33333333333333" Width="113.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="455650"/> </DataNode> <DataNode TextLabel="IGF1R" GraphId="d20" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IGF1R | insulin-like growth factor 1 receptor"/> <Graphics CenterX="763.3333333333334" CenterY="103.33333333333333" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="453676"/> </DataNode> <DataNode TextLabel="IRS1" GraphId="a45" Type="GeneProduct" GroupRef="bef8f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRS1 | insulin receptor substrate 1"/> <Graphics CenterX="631.9644723092998" CenterY="205.68443051201686" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="459985"/> </DataNode> <DataNode TextLabel="LOC473846" GraphId="c8c" Type="GeneProduct" GroupRef="bef8f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRS4 | insulin receptor substrate 4"/> <Graphics CenterX="631.9644723092998" CenterY="265.68443051201695" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="473846"/> </DataNode> <DataNode TextLabel="PIK3CA" GraphId="fa4" 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