Cancer prevention Q-delete (Homo sapiens)

<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://genmapp.org/GPML/2010a" Name="Cancer prevention Q" Author="Gisele Rojer" Organism="Homo sapiens">
  <Graphics BoardWidth="1254.0141407157694" BoardHeight="1095.75" />
  <DataNode TextLabel="Metastasis" GraphId="eb751" Type="GeneProduct">
    <Graphics CenterX="637.5238095238094" CenterY="366.5783362588563" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Prostaglandin E2" GraphId="b9132" Type="Metabolite">
    <Graphics CenterX="544.0952380952374" CenterY="833.9523809523808" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB01220" />
  </DataNode>
  <DataNode TextLabel="Metabolite" GraphId="f9962" Type="Metabolite">
    <Graphics CenterX="221.965614118426" CenterY="26.00375383368211" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="P55G" GraphId="f417a" Type="Protein">
    <Graphics CenterX="292.1656005685857" CenterY="208.85074626865674" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="Q92569" />
  </DataNode>
  <DataNode TextLabel="AP-1 complex&#xA;" GraphId="b4f8a" Type="GeneProduct">
    <Graphics CenterX="611.0342928216063" CenterY="272.78309523809526" Width="104.266879886283" Height="40.30099502487565" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="MMP9" GraphId="f56d1" Type="GeneProduct">
    <Graphics CenterX="886.0" CenterY="350.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000100985" />
  </DataNode>
  <DataNode TextLabel="VEGFA" GraphId="b55f6" Type="Protein">
    <BiopaxRef>bec</BiopaxRef>
    <Graphics CenterX="887.0" CenterY="441.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P15692" />
  </DataNode>
  <DataNode TextLabel="IKBKB" GraphId="cc65f" Type="GeneProduct">
    <Graphics CenterX="360.0" CenterY="458.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000104365" />
  </DataNode>
  <DataNode TextLabel="IKBA" GraphId="c4b13" Type="Protein" GroupRef="b4292">
    <Graphics CenterX="359.75" CenterY="543.25" Width="101.5" Height="23.5" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P25963" />
  </DataNode>
  <DataNode TextLabel="MMP1" GraphId="e8576" Type="Protein">
    <BiopaxRef>c73</BiopaxRef>
    <Graphics CenterX="886.75" CenterY="412.75" Width="80.5" Height="20.5" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P03956" />
  </DataNode>
  <DataNode TextLabel="GeneProduct" GraphId="ae33f" Type="GeneProduct">
    <Graphics CenterX="108.0" CenterY="530.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="TNF-a" GraphId="a362c" Type="Protein">
    <BiopaxRef>d91</BiopaxRef>
    <Graphics CenterX="354.28897912432853" CenterY="366.5783362588564" Width="80.0" Height="20.0" ZOrder="32769" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P01375" />
  </DataNode>
  <DataNode TextLabel="NFKB" GraphId="a2095" Type="Protein">
    <Graphics CenterX="334.5782470703125" CenterY="705.0" Width="80.0" Height="20.0" ZOrder="32771" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P19838" />
  </DataNode>
  <DataNode TextLabel="NOS2" GraphId="cf0fd" Type="GeneProduct">
    <Graphics CenterX="377.34999999999934" CenterY="894.6499999999999" Width="80.0" Height="22.0" ZOrder="32772" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="4843" />
  </DataNode>
  <DataNode TextLabel="COX2" GraphId="fb61c" Type="GeneProduct">
    <Graphics CenterX="376.2475000000003" CenterY="851.6524999999999" Width="81.0" Height="20.0" ZOrder="32773" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="4513" />
  </DataNode>
  <DataNode TextLabel="ICAM1" GraphId="df8e1" Type="Protein">
    <Graphics CenterX="504.80383795309024" CenterY="366.5783362588564" Width="80.0" Height="20.0" ZOrder="32774" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P05362" />
  </DataNode>
  <DataNode TextLabel="JNK1" GraphId="fe3a7" Type="Protein">
    <BiopaxRef>b46</BiopaxRef>
    <Graphics CenterX="177.17247581335306" CenterY="264.5737960666377" Width="80.0" Height="20.0" ZOrder="32775" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="C9JNK1" />
  </DataNode>
  <DataNode TextLabel="JUN" GraphId="aebba" Type="GeneProduct">
    <Graphics CenterX="297.32871276916404" CenterY="270.05626225851626" Width="80.0" Height="20.0" ZOrder="32776" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="3725" />
  </DataNode>
  <DataNode TextLabel="Nitric oxide" GraphId="cff5e" Type="Metabolite">
    <Graphics CenterX="465.82249999999954" CenterY="937.7174999999997" Width="80.0" Height="20.0" ZOrder="32777" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB03378" />
  </DataNode>
  <DataNode TextLabel="NFKB" GraphId="d4aac" Type="Protein">
    <Graphics CenterX="334.45648193359375" CenterY="817.0" Width="80.0" Height="24.0" ZOrder="32778" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P19838" />
  </DataNode>
  <DataNode TextLabel="P55" GraphId="c1eae" Type="Protein" GroupRef="fc4b4">
    <Graphics CenterX="431.7071783937473" CenterY="261.4385216773276" Width="80.0" Height="20.0" ZOrder="32779" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="Q92569" />
  </DataNode>
  <DataNode TextLabel="JUN" GraphId="d6f13" Type="GeneProduct" GroupRef="fc4b4">
    <Graphics CenterX="431.7071783937473" CenterY="282.4385216773276" Width="79.99999999999997" Height="20.000000000000004" ZOrder="32780" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="3725" />
  </DataNode>
  <DataNode TextLabel="AP-1" GraphId="b7d29" Type="GeneProduct">
    <BiopaxRef>b46</BiopaxRef>
    <Graphics CenterX="824.6334399431415" CenterY="253.15049751243782" Width="61.26687988628305" Height="40.30099502487565" ZOrder="32781" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="ICAM1" GraphId="ada39" Type="Protein">
    <Graphics CenterX="886.0" CenterY="289.0" Width="80.0" Height="20.0" ZOrder="32782" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P05362" />
  </DataNode>
  <DataNode TextLabel="AP-1 &#xA;" GraphId="c06ac" Type="GeneProduct">
    <Graphics CenterX="474.1334399431415" CenterY="196.15049751243782" Width="104.266879886283" Height="40.30099502487565" ZOrder="32783" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="COX2" GraphId="a0f30" Type="GeneProduct">
    <Graphics CenterX="886.0" CenterY="324.0" Width="81.0" Height="20.0" ZOrder="32784" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="4513" />
  </DataNode>
  <DataNode TextLabel="MMP2" GraphId="cdb5b" Type="GeneProduct">
    <BiopaxRef>a86</BiopaxRef>
    <Graphics CenterX="886.0" CenterY="382.0" Width="80.0" Height="20.0" ZOrder="32785" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000087245" />
  </DataNode>
  <DataNode TextLabel="IKBB" GraphId="f6b3a" Type="Protein" GroupRef="b4292">
    <Graphics CenterX="357.75" CenterY="566.75" Width="101.5" Height="23.5" ZOrder="32786" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="Q15653" />
  </DataNode>
  <DataNode TextLabel="NFKB" GraphId="bdf2f" Type="Protein" GroupRef="b4292">
    <Graphics CenterX="356.0" CenterY="590.0" Width="80.0" Height="20.0" ZOrder="32787" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P19838" />
  </DataNode>
  <DataNode TextLabel="IKBA" GraphId="d07fd" Type="Protein">
    <Graphics CenterX="485.75" CenterY="563.75" Width="101.5" Height="23.5" ZOrder="32788" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P25963" />
  </DataNode>
  <Line>
    <BiopaxRef>ec0</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="ff3333">
      <Point X="253.71428571428578" Y="366.5783362588564" GraphRef="d39c6" RelX="1.0" RelY="0.0" />
      <Point X="314.28897912432853" Y="366.5783362588564" GraphRef="a362c" RelX="-1.0" RelY="0.0" ArrowHead="mim-inhibition" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="3.0">
      <Point X="334.0" Y="718.0" />
      <Point X="334.45648193359375" Y="805.0" GraphRef="d4aac" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="3.0">
      <Point X="268.4564971923828" Y="831.0" />
      <Point X="454.0" Y="832.0" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="400.0" Y="829.0" />
      <Point X="401.0" Y="816.5" />
      <Point X="412.0" Y="804.0" />
      <Point X="423.0" Y="804.0" />
      <Point X="443.0" Y="804.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="417.34999999999934" Y="894.6499999999999" GraphRef="cf0fd" RelX="1.0" RelY="0.0" />
      <Point X="439.8499999999999" Y="886.4" />
      <Point X="476.2000000000004" Y="878.1500000000001" GraphRef="d950d" RelX="-1.0" RelY="0.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="416.7475000000003" Y="851.6524999999999" GraphRef="fb61c" RelX="1.0" RelY="0.0" />
      <Point X="439.8499999999999" Y="864.90125" />
      <Point X="476.2000000000004" Y="878.1500000000001" GraphRef="d950d" RelX="-1.0" RelY="0.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="387.35" Y="908.5923809523811" />
      <Point X="425.82249999999954" Y="937.7174999999997" GraphRef="cff5e" RelX="-1.0" RelY="0.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="507.52250000000004" Y="938.51" />
      <Point X="551.9500000000004" Y="887.4000000000001" GraphRef="d950d" RelX="0.0" RelY="1.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <BiopaxRef>b46</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="392.9047619047619" Y="366.51942334314055" />
      <Point X="464.80383795309024" Y="366.5783362588564" GraphRef="df8e1" RelX="-1.0" RelY="0.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
      <Point X="536.7142857142857" Y="366.1717702164747" />
      <Point X="597.5238095238094" Y="366.5783362588563" GraphRef="eb751" RelX="-1.0" RelY="0.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="445.82249999999954" Y="947.7174999999997" GraphRef="cff5e" RelX="-0.5" RelY="1.0" />
      <Point X="335.7475000000003" Y="851.6524999999999" GraphRef="fb61c" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="412.95238095238096" Y="848.047619047619" />
      <Point X="504.0952380952374" Y="833.9523809523808" GraphRef="b9132" RelX="-1.0" RelY="0.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="540.5714285714286" Y="842.3333333333333" />
      <Point X="553.3500000000005" Y="860.9000000000001" GraphRef="fb16a" RelX="0.0" RelY="-1.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <BiopaxRef>b46</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="ff3333">
      <Point X="178.31627576403702" Y="344.60056858564326" />
      <Point X="177.17247581335306" Y="274.5737960666377" GraphRef="fe3a7" RelX="0.0" RelY="1.0" ArrowHead="mim-inhibition" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="215.40653873489703" Y="266.42004264392324" />
      <Point X="255.91826581378825" Y="266.42004264392324" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="338.3631840796021" Y="272.10589907604833" />
      <Point X="386.7071783937473" Y="272.9385216773276" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="306.38024164889845" Y="217.37953091684437" />
      <Point X="355.42075337597737" Y="272.10589907604833" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="477.8075" Y="271.5075" />
      <Point X="558.9008528784648" Y="272.78309523809526" GraphRef="b4f8a" RelX="-1.0" RelY="0.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <BiopaxRef>d91</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="3.0">
      <Point X="764.0" Y="274.0" />
      <Point X="922.0" Y="275.0" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="663.0" Y="271.0" />
      <Point X="736.0" Y="272.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="882.0" Y="271.0" />
      <Point X="885.0" Y="251.5" />
      <Point X="894.5" Y="232.0" />
      <Point X="904.0" Y="232.0" />
      <Point X="938.0" Y="232.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="497.0" Y="219.0" />
      <Point X="526.0" Y="273.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="846.0" Y="350.0" GraphRef="f56d1" RelX="-1.0" RelY="0.0" />
      <Point X="677.5238095238094" Y="366.5783362588563" GraphRef="eb751" RelX="1.0" RelY="0.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="846.0" Y="382.0" GraphRef="cdb5b" RelX="-1.0" RelY="0.0" />
      <Point X="677.5238095238094" Y="366.5783362588563" GraphRef="eb751" RelX="1.0" RelY="0.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="926.5" Y="324.0" GraphRef="a0f30" RelX="1.0" RelY="0.0" />
      <Point X="1113.0" Y="601.075" />
      <Point X="627.7000000000004" Y="878.1500000000001" GraphRef="d950d" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="846.0" Y="288.0" />
      <Point X="677.0" Y="355.0" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="887.0" Y="451.0" GraphRef="b55f6" RelX="0.0" RelY="1.0" />
      <Point X="886.0" Y="668.5" GraphRef="b65ca" RelX="0.0" RelY="-1.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="886.0" Y="691.0" GraphRef="b65ca" RelX="0.0" RelY="1.0" />
      <Point X="886.0" Y="723.5" GraphRef="d6424" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="637.5238095238094" Y="376.5783362588563" GraphRef="eb751" RelX="0.0" RelY="1.0" />
      <Point X="782.75" Y="735.75" GraphRef="d6424" RelX="-1.0" RelY="0.0" ArrowHead="mim-modification" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="846.0" Y="415.0" />
      <Point X="677.5238095238094" Y="366.5783362588563" GraphRef="eb751" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="332.0" Y="611.0" />
      <Point X="333.0" Y="696.0" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="423.0" Y="539.0" />
      <Point X="460.375" Y="552.0" GraphRef="d07fd" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="33ff33">
      <Point X="534.0" Y="564.0" />
      <Point X="560.0" Y="564.0" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="351.0" Y="380.0" />
      <Point X="352.0" Y="447.0" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="357.0" Y="471.0" />
      <Point X="357.0" Y="516.0" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line GraphId="ff07e">
    <Graphics ZOrder="32789" LineThickness="1.0" Color="33ff33">
      <Point X="400.0" Y="458.0" />
      <Point X="426.0" Y="458.0" />
    </Graphics>
  </Line>
  <Label TextLabel="Quercetin" GraphId="af650">
    <Graphics CenterX="181.71428571428578" CenterY="366.5783362588563" Width="152.0" Height="34.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="20" Valign="Middle" />
  </Label>
  <Label TextLabel="Inflammation&#xA;" GraphId="c95f8" GroupRef="ada66">
    <Graphics CenterX="553.3500000000005" CenterY="878.45" Width="158.0" Height="18.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" Color="ff6666" />
  </Label>
  <Label TextLabel="Angiogenesis" GraphId="cc46e">
    <Graphics CenterX="885.0" CenterY="681.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" Color="ff0033" />
  </Label>
  <Label TextLabel="Tumor growth/spread" GraphId="b46ad">
    <Graphics CenterX="888.5" CenterY="737.0" Width="103.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" Color="ff3333" />
  </Label>
  <Label TextLabel="P" GraphId="a291d">
    <Graphics CenterX="560.5" CenterY="564.0" Width="29.0" Height="42.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="P" GraphId="d0caf">
    <Graphics CenterX="426.5" CenterY="458.0" Width="29.0" Height="42.0" ZOrder="32791" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Shape GraphId="d39c6">
    <Graphics CenterX="181.46428571428578" CenterY="366.5783362588564" Width="144.5" Height="40.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape GraphId="d950d" GroupRef="ada66">
    <Graphics CenterX="551.9500000000004" CenterY="878.1500000000001" Width="151.5" Height="18.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="ff6666" Rotation="0.0" />
  </Shape>
  <Shape GraphId="e9154">
    <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Nucleus" />
    <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
    <Graphics CenterX="360.69100923951623" CenterY="843.5616560056859" Width="203.0586353944567" Height="227.22352523098786" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" />
  </Shape>
  <Shape GraphId="ed5d6">
    <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Nucleus" />
    <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
    <Graphics CenterX="984.9234347602522" CenterY="301.68897377592407" Width="478.1814119110344" Height="392.2145383357366" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" LineThickness="3.0" Color="c0c0c0" Rotation="6.2823327924671055" />
  </Shape>
  <Shape GraphId="b65ca">
    <Graphics CenterX="886.0" CenterY="679.75" Width="121.0" Height="22.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="ff3333" Rotation="0.0" />
  </Shape>
  <Shape GraphId="d6424">
    <Graphics CenterX="886.0" CenterY="735.75" Width="206.5" Height="24.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="ff0033" Rotation="0.0" />
  </Shape>
  <Shape GraphId="ddebd">
    <Graphics CenterX="559.25" CenterY="562.75" Width="13.5" Height="16.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Color="33ff33" Rotation="0.0" />
  </Shape>
  <Shape GraphId="e748b">
    <Graphics CenterX="425.25" CenterY="456.75" Width="13.5" Height="16.5" ZOrder="32790" FontSize="10" Valign="Middle" ShapeType="Oval" Color="33ff33" Rotation="0.0" />
  </Shape>
  <Group GroupId="ada66" GraphId="fb16a" Style="Group" />
  <Group GroupId="b4292" GraphId="ddd8c" Style="Complex" />
  <Group GroupId="fc4b4" Style="Complex" />
  <InfoBox CenterX="0.0" CenterY="0.0" />
  <Biopax>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ec0">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16522772</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Clin Vaccine Immunol</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nair MP</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mahajan S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reynolds JL</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Aalinkeel R</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nair H</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schwartz SA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kandaswami C</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bec">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20804812</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Food Chem Toxicol</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oh SJ</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim O</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee JS</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim JA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim MR</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Choi HS</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shim JH</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kang KW</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim YC</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d91">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of phytochemicals in inhibition of cancer and inflammation: new directions and perspectives.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR>
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of phytochemicals in inhibition of cancer and inflammation: new directions and perspectives.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Journal of foood composition and analysis</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of phytochemicals in inhibition of cancer and inflammation: new directions and perspectives.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Journal of foood composition and analysis</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ala Y. Issa</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Suresh R. Volate</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Micheal J. Wargovich</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a86">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16645725</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3).</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Cell Biochem</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vijayababu MR</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arunkumar A</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kanagaraj P</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Venkataraman P</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Krishnamoorthy G</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arunakaran J</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b46">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10484327</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Am J Physiol</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1999</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kobuchi H</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Roy S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sen CK</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nguyen HG</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Packer L</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c73">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11414687</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arch Biochem Biophys</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Song L</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xu M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lopes-Virella MF</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huang Y</bp:AUTHORS>
    </bp:PublicationXref>
  </Biopax>
</Pathway>