Quercetin and Nf-kB/ AP-1 induced cell apoptosis-delete (Homo sapiens)

<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://genmapp.org/GPML/2010a" Name="Quercetin and Nf-kB/ AP-1 induced cell apoptosis" Author="Chris Boye" Organism="Homo sapiens">
  <Graphics BoardWidth="2723.5714285714284" BoardHeight="1556.7619047619048" />
  <DataNode TextLabel="IKBKB" GraphId="a65ad" Type="GeneProduct">
    <Graphics CenterX="831.5422485810975" CenterY="204.57197633168653" Width="102.35000000000002" Height="39.90000000000002" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000104365" />
  </DataNode>
  <DataNode TextLabel="ACOX2" GraphId="d39eb" Type="GeneProduct">
    <Graphics CenterX="1317.4596108169903" CenterY="585.9664999612432" Width="84.5" Height="36.19999999999981" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000168306" />
  </DataNode>
  <DataNode TextLabel="NFKB1" GraphId="b7fb7" Type="GeneProduct">
    <Graphics CenterX="1089.5334985810935" CenterY="321.84947633168883" Width="107.44250000000001" Height="35.77999999999997" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000109320" />
  </DataNode>
  <DataNode TextLabel="IKBA_HUMAN" GraphId="da2f9" Type="Protein" GroupRef="ed99e">
    <Graphics CenterX="766.8372485810938" CenterY="321.64197633168624" Width="117.5" Height="38.5" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P25963" />
  </DataNode>
  <DataNode TextLabel="FOS" GraphId="ea043" Type="GeneProduct" GroupRef="a5732">
    <Graphics CenterX="1255.5117251249567" CenterY="288.5156047440893" Width="98.5" Height="33.5" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000170345" />
  </DataNode>
  <DataNode TextLabel="Prostaglandin H2" GraphId="cc355" Type="Metabolite">
    <Graphics CenterX="362.2629107981222" CenterY="328.6574446680081" Width="158.52582159624444" Height="24.685110663983778" ZOrder="32768" FontSize="14" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB01381" />
  </DataNode>
  <DataNode TextLabel="Arachidonic acid" GraphId="fcbc9" Type="Metabolite">
    <Graphics CenterX="362.7551553599768" CenterY="172.25981890093502" Width="182.48968928004638" Height="29.480362198129967" ZOrder="32768" FontSize="14" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB01043" />
  </DataNode>
  <DataNode TextLabel="Quercetin" GraphId="c9d3e" Type="Metabolite">
    <Graphics CenterX="1148.79761904762" CenterY="58.79761904761904" Width="591.9285714285713" Height="107.16666666666667" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB05794" />
  </DataNode>
  <DataNode TextLabel="Prostaglandin G2" GraphId="af617" Type="Metabolite">
    <Graphics CenterX="362.5833333333328" CenterY="256.89285714285734" Width="172.8333333333344" Height="26.214285714285325" ZOrder="32768" FontSize="14" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB03235" />
  </DataNode>
  <DataNode TextLabel="IKBA_HUMAN" GraphId="b6953" Type="Protein">
    <Graphics CenterX="826.2172485810934" CenterY="414.6219763316837" Width="69.29999999999993" Height="27.099999999999795" ZOrder="32774" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot/TrEMBL" ID="P25963" />
  </DataNode>
  <DataNode TextLabel="NOS1" GraphId="b3d1e" Type="GeneProduct">
    <Graphics CenterX="1066.3708155105114" CenterY="577.5352175567899" Width="84.5" Height="36.19999999999981" ZOrder="32780" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000089250" />
  </DataNode>
  <DataNode TextLabel="VEGFA" GraphId="fdd62" Type="GeneProduct">
    <Graphics CenterX="1067.4228765378366" CenterY="523.6384737649557" Width="84.5" Height="36.19999999999981" ZOrder="32781" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000112715" />
  </DataNode>
  <DataNode TextLabel="Angiogenesis" GraphId="afb7d" Type="Pathway">
    <Graphics CenterX="830.142485781166" CenterY="646.7374675837674" Width="222.06410622004321" Height="84.95176399502247" ZOrder="32783" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Carcinogenesis" GraphId="f9bcd" Type="Pathway">
    <Graphics CenterX="1278.7080396563163" CenterY="948.1107698135683" Width="253.12995970725373" Height="70.06424579899999" ZOrder="32784" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="NFKB1" GraphId="c30a8" Type="GeneProduct" GroupRef="ed99e">
    <Graphics CenterX="884.3372485810938" CenterY="321.64197633168624" Width="117.5" Height="38.5" ZOrder="32785" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000109320" />
  </DataNode>
  <DataNode TextLabel="JUN" GraphId="e9b91" Type="GeneProduct" GroupRef="a5732">
    <Graphics CenterX="1354.0117251249565" CenterY="288.5156047440893" Width="98.5" Height="33.5" ZOrder="32786" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000177606" />
  </DataNode>
  <DataNode TextLabel="MMP1" GraphId="f8256" Type="GeneProduct">
    <Graphics CenterX="1551.8960283731137" CenterY="524.5557842871368" Width="84.5" Height="36.19999999999981" ZOrder="32793" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000196611" />
  </DataNode>
  <DataNode TextLabel="Metastasis" GraphId="b2d86" Type="Pathway">
    <Graphics CenterX="1607.7507723565532" CenterY="946.7755911204762" Width="310.65853487215935" Height="78.57833529119421" ZOrder="32794" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="DNA damage" GraphId="de0af">
    <Graphics CenterX="2441.3722771871508" CenterY="252.21221476586254" Width="115.7380952380954" Height="59.54761904761904" ZOrder="32824" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="CYP2A6" GraphId="ee40d" Type="GeneProduct">
    <Comment>one of several possible phase 1 enzymes</Comment>
    <Graphics CenterX="2161.317993071606" CenterY="640.1178260264476" Width="94.28571428571422" Height="25.71428571428583" ZOrder="32825" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000255974" />
  </DataNode>
  <DataNode TextLabel="carcinogenic metabolite" GraphId="ab6fc" Type="Metabolite">
    <Graphics CenterX="2364.9060657025593" CenterY="384.0823128050852" Width="120.50000000000215" Height="50.023809523809405" ZOrder="32826" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="NFE2L2" GraphId="d06ca" Type="GeneProduct" GroupRef="cf591">
    <Graphics CenterX="1973.8621107186243" CenterY="336.11292406566434" Width="112.5" Height="41.5" ZOrder="32827" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000116044" />
  </DataNode>
  <DataNode TextLabel="KEAP1" GraphId="d2797" Type="GeneProduct" GroupRef="cf591">
    <Graphics CenterX="1861.3621107186239" CenterY="336.11292406566434" Width="112.5" Height="41.5" ZOrder="32828" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000079999" />
  </DataNode>
  <DataNode TextLabel="NFE2L2" GraphId="e67af" Type="GeneProduct">
    <Graphics CenterX="1953.996564500141" CenterY="481.12973078835216" Width="112.5" Height="41.5" ZOrder="32829" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000116044" />
  </DataNode>
  <DataNode TextLabel="NFE2L2" GraphId="dd341" Type="GeneProduct">
    <Graphics CenterX="1920.3775168810876" CenterY="606.7487784074012" Width="112.5" Height="41.5" ZOrder="32831" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl Human" ID="ENSG00000116044" />
  </DataNode>
  <DataNode TextLabel="small MAF" GraphId="a03df" Type="Protein">
    <Graphics CenterX="2013.496564500138" CenterY="606.7487784074012" Width="75.64285714285867" Height="41.5" ZOrder="32832" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Phase 2 enzyme&#xA;" GraphId="a9854" Type="Protein">
    <Graphics CenterX="2254.6513264049013" CenterY="640.3559212645329" Width="94.28571428571418" Height="25.238095238095184" ZOrder="32833" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="(Causes vasodilation;&#xA;inhibits platelet aggregation)" GraphId="a7f1b">
    <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
    <Graphics CenterX="108.31094372910326" CenterY="553.0336520063595" Width="205.98133156249992" Height="82.1820200000002" ZOrder="32836" FontSize="16" Valign="Middle" LineThickness="0.0" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Prostaglandin I2" GraphId="d5dc0" Type="Metabolite">
    <Graphics CenterX="124.56078990877809" CenterY="411.77815186726275" Width="164.97103602735842" Height="55.16979728638904" ZOrder="32858" FontSize="16" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB01335" />
  </DataNode>
  <DataNode TextLabel="Thromboxane A2" GraphId="ecf51" Type="Metabolite">
    <Graphics CenterX="621.2650365358573" CenterY="456.45929659578803" Width="155.72858783620296" Height="49.77498093749989" ZOrder="32859" FontSize="16" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB01452" />
  </DataNode>
  <DataNode TextLabel="(Causes vasoconstriction;&#xA;promotes platelet aggregation)" GraphId="f9ea2">
    <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
    <Graphics CenterX="631.0593505929914" CenterY="516.1596568710956" Width="234.83580749999985" Height="46.44613624999977" ZOrder="32861" FontSize="16" Valign="Middle" LineThickness="0.0" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Cell membrane phospholipids" GraphId="b43f7">
    <Graphics CenterX="362.4752624009845" CenterY="60.35611414949655" Width="232.78324437499987" Height="33.68332062500002" ZOrder="32864" FontSize="16" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="(Increases&#xA;vasoconstriction)" GraphId="b146d">
    <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
    <Graphics CenterX="364.128650739477" CenterY="528.9410385013252" Width="154.4300690624998" Height="54.10382562499967" ZOrder="32865" FontSize="16" Valign="Middle" LineThickness="0.0" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Prostaglandin F2a" GraphId="a55d5" Type="Metabolite">
    <Graphics CenterX="357.6199369884472" CenterY="470.58403210336525" Width="197.0186834292714" Height="50.27498093750011" ZOrder="32866" FontSize="16" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB01139" />
  </DataNode>
  <DataNode TextLabel="Prostaglandin D2" GraphId="ac7ad" Type="Metabolite">
    <Graphics CenterX="499.517425609929" CenterY="660.8082169686002" Width="153.51288020505183" Height="45.16985468749999" ZOrder="32867" FontSize="16" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB01403" />
  </DataNode>
  <DataNode TextLabel="Prostaglandin E2" GraphId="a8e97" Type="Metabolite">
    <Graphics CenterX="252.8136179188482" CenterY="665.5729855106222" Width="176.03968409780487" Height="66.33940702571277" ZOrder="32868" FontSize="16" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB01220" />
  </DataNode>
  <DataNode TextLabel="(Induces vasoconstriction&#xA;and secretion of IL-1 and IL-2)" GraphId="d64ef">
    <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
    <Graphics CenterX="379.49879925311484" CenterY="773.0966852618167" Width="225.09547384208116" Height="52.98423740853183" ZOrder="32869" FontSize="16" Valign="Middle" LineThickness="0.0" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="INFLAMMATION" GraphId="d0ba6">
    <Graphics CenterX="607.6276736401833" CenterY="984.0610498673753" Width="591.4183634375" Height="55.38010718749994" ZOrder="32870" FontSize="25" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <Line GraphId="e761c">
    <BiopaxRef>ff4</BiopaxRef>
    <BiopaxRef>c21</BiopaxRef>
    <Graphics ZOrder="-4" LineThickness="1.0">
      <Point X="252.8136179188482" Y="698.7426890234785" GraphRef="a8e97" RelX="0.0" RelY="1.0" />
      <Point X="311.9184919214333" Y="984.0610498673752" GraphRef="d0ba6" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="idcc7a10ef">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="882.7172485810975" Y="194.59697633168653" GraphRef="a65ad" RelX="1.0" RelY="-0.5" />
      <Point X="949.9172485810938" Y="195.1219763316865" ArrowHead="mim-catalysis" />
    </Graphics>
  </Line>
  <Line GraphId="id514deb37">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="831.5422485810975" Y="224.52197633168652" GraphRef="a65ad" RelX="0.0" RelY="1.0" />
      <Point X="831.2672485810937" Y="289.62197633168626" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="idef916c1c">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1021.9672485810935" Y="491.57197633168585" />
      <Point X="1275.0172485810938" Y="491.57197633168585" />
    </Graphics>
  </Line>
  <Line GraphId="ide8e51c45">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1189.9672485810938" Y="433.82197633168585" />
      <Point X="1189.9672485810938" Y="466.3719763316856" />
    </Graphics>
  </Line>
  <Line GraphId="id64b81f26">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1189.9672485810938" Y="433.82197633168585" />
      <Point X="1240.367248581094" Y="434.8719763316856" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line GraphId="ide2f8af03">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1317.4596108169903" Y="604.0664999612432" GraphRef="d39eb" RelX="0.0" RelY="1.0" />
      <Point X="903.3368553589332" Y="970.2160230705002" GraphRef="d0ba6" RelX="1.0" RelY="-0.5" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="id102303fa">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1025.1728765378366" Y="532.6884737649557" GraphRef="fdd62" RelX="-1.0" RelY="0.5" />
      <Point X="830.142485781166" Y="604.2615855862562" GraphRef="afb7d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="id40de190e">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="825.5872485810938" Y="352.89197633168624" GraphRef="ceb1d" RelX="0.0" RelY="1.0" />
      <Point X="826.2172485810934" Y="401.0719763316838" GraphRef="b6953" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="idc90b1b17">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1089.5334985810935" Y="339.7394763316888" GraphRef="b7fb7" RelX="0.0" RelY="1.0" />
      <Point X="1089.5672485810933" Y="443.17197633168394" GraphRef="d8636" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="id3fcc5c1">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1516.5872485810944" Y="431.89197633168556" />
      <Point X="1570.5872485810935" Y="432.89197633168556" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line GraphId="id88bfdb81">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="955.0872485810938" Y="321.64197633168624" GraphRef="ceb1d" RelX="1.0" RelY="0.0" />
      <Point X="1035.8122485810934" Y="321.84947633168883" GraphRef="b7fb7" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="idd140daf2">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1360.0117251249567" Y="317.2656047440893" GraphRef="f57a5" RelX="0.5" RelY="1.0" />
      <Point X="1415.187248581094" Y="442.3244763316832" GraphRef="bf76f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="ide8e97792">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1109.6728765378366" Y="532.6884737649557" GraphRef="fdd62" RelX="1.0" RelY="0.5" />
      <Point X="1278.708039656316" Y="913.0786469140683" GraphRef="f9bcd" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="id5ae1971e">
    <BiopaxRef>b17</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="2161.317993071606" Y="627.2606831693047" GraphRef="ee40d" RelX="0.0" RelY="-1.0" />
      <Point X="2162.7721247242253" Y="70.82931062028538" GraphRef="d907f" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="ide3f3d14b">
    <BiopaxRef>b17</BiopaxRef>
    <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0">
      <Point X="2184.8894216430344" Y="627.2606831693047" GraphRef="ee40d" RelX="0.5" RelY="-1.0" />
      <Point X="2334.781065702559" Y="409.0942175669899" GraphRef="ab6fc" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="id72fca9eb">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="2499.2413248061985" Y="267.0991195277673" GraphRef="de0af" RelX="1.0" RelY="0.5" />
      <Point X="1278.0468750000002" Y="1145.9765625" />
    </Graphics>
  </Line>
  <Line GraphId="id1e6f33e4">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1278.0468750000002" Y="1145.15625" />
      <Point X="1278.708039656316" Y="983.1428927130682" GraphRef="f9bcd" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="id3640f85f">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1148.79761904762" Y="112.38095238095238" GraphRef="c9d3e" RelX="0.0" RelY="1.0" />
      <Point X="1249.5117251249567" Y="222.21560474408977" GraphRef="f57a5" RelX="-0.5" RelY="-1.0" ArrowHead="TBar" />
    </Graphics>
  </Line>
  <Line GraphId="f9b57">
    <Graphics ZOrder="32771" LineThickness="1.0">
      <Point X="860.8672485810933" Y="414.6219763316837" GraphRef="b6953" RelX="1.0" RelY="0.0" />
      <Point X="934.8372485810938" Y="414.69197633168574" ArrowHead="mim-catalysis" />
    </Graphics>
  </Line>
  <Line GraphId="ecdbd">
    <Graphics ZOrder="32778" LineThickness="1.0">
      <Point X="1023.5422485810935" Y="468.4719763316855" />
      <Point X="1273.4422485810937" Y="467.42197633168576" />
    </Graphics>
  </Line>
  <Line GraphId="bafc7">
    <Graphics ZOrder="32787" LineThickness="1.0">
      <Point X="1347.5872485810942" Y="490.72447633168554" />
      <Point X="1600.6372485810937" Y="490.72447633168554" />
    </Graphics>
  </Line>
  <Line GraphId="c6b09">
    <Graphics ZOrder="32788" LineThickness="1.0">
      <Point X="1516.5872485810944" Y="432.97447633168554" />
      <Point X="1516.5872485810944" Y="465.52447633168526" />
    </Graphics>
  </Line>
  <Line GraphId="a8f93">
    <Graphics ZOrder="32790" LineThickness="1.0">
      <Point X="1349.1622485810942" Y="467.6244763316856" />
      <Point X="1599.0622485810939" Y="466.57447633168545" />
    </Graphics>
  </Line>
  <Line GraphId="acab9">
    <BiopaxRef>f0c</BiopaxRef>
    <Graphics ZOrder="32801" LineThickness="1.0">
      <Point X="1444.7619047619055" Y="85.58928571428572" GraphRef="c9d3e" RelX="1.0" RelY="0.5" />
      <Point X="1917.612110718624" Y="303.36292406566434" GraphRef="c5785" RelX="0.0" RelY="-1.0" ArrowHead="TBar" />
    </Graphics>
  </Line>
  <Line GraphId="b8f94">
    <BiopaxRef>f0c</BiopaxRef>
    <Graphics ZOrder="32802" LineThickness="1.0">
      <Point X="1973.8621107186243" Y="356.86292406566434" GraphRef="d06ca" RelX="0.0" RelY="1.0" />
      <Point X="1953.996564500141" Y="460.37973078835216" GraphRef="e67af" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="a3a44">
    <BiopaxRef>f0c</BiopaxRef>
    <Graphics ZOrder="32803" LineThickness="1.0">
      <Point X="1444.7619047619055" Y="58.797619047619044" GraphRef="c9d3e" RelX="1.0" RelY="0.0" />
      <Point X="1973.8621107186243" Y="315.36292406566434" GraphRef="d06ca" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="a1fe3">
    <BiopaxRef>b17</BiopaxRef>
    <Graphics ZOrder="32805" LineThickness="1.0">
      <Point X="1444.7619047619055" Y="32.00595238095237" GraphRef="c9d3e" RelX="1.0" RelY="-0.5" />
      <Point X="2135.742362819463" Y="46.06740585838048" GraphRef="d907f" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="c604c">
    <BiopaxRef>f0c</BiopaxRef>
    <Graphics ZOrder="32806" LineThickness="1.0">
      <Point X="1953.996564500141" Y="501.87973078835216" GraphRef="e67af" RelX="0.0" RelY="1.0" />
      <Point X="1948.5025168810876" Y="585.9987784074012" GraphRef="dd341" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="c98fa">
    <BiopaxRef>f0c</BiopaxRef>
    <Graphics ZOrder="32807" LineThickness="1.0">
      <Point X="1296.7797619047628" Y="112.38095238095238" GraphRef="c9d3e" RelX="0.5" RelY="1.0" />
      <Point X="1805.1121107186239" Y="325.73792406566434" GraphRef="d2797" RelX="-1.0" RelY="-0.5" ArrowHead="TBar" />
    </Graphics>
  </Line>
  <Line GraphId="f4a5e">
    <Graphics ZOrder="32808" LineThickness="1.0">
      <Point X="2243.8614104385115" Y="58.44835823933293" GraphRef="d907f" RelX="1.0" RelY="0.5" />
      <Point X="2412.437753377627" Y="222.43840524205302" GraphRef="de0af" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="ba97a">
    <Graphics ZOrder="32809" LineThickness="1.0">
      <Point X="1830.3656121191846" Y="627.2606831693056" />
      <Point X="2113.2227549763297" Y="627.2606831693056" />
    </Graphics>
  </Line>
  <Line GraphId="cb8fe">
    <BiopaxRef>b17</BiopaxRef>
    <Graphics ZOrder="32812" LineThickness="1.0">
      <Point X="2395.0310657025598" Y="359.0704080431805" GraphRef="ab6fc" RelX="0.5" RelY="-1.0" />
      <Point X="2441.3722771871508" Y="281.98602428967206" GraphRef="de0af" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="e2cea">
    <BiopaxRef>b17</BiopaxRef>
    <Graphics ZOrder="32813" LineThickness="1.0">
      <Point X="2254.6513264049017" Y="627.7368736454853" GraphRef="a9854" RelX="0.0" RelY="-1.0" />
      <Point X="2189.801886628987" Y="70.82931062028538" GraphRef="d907f" RelX="0.0" RelY="1.0" ArrowHead="TBar" />
    </Graphics>
  </Line>
  <Line GraphId="dac2c">
    <Graphics ZOrder="32830" LineThickness="1.0">
      <Point X="1830.3656121191846" Y="652.4987784074007" />
      <Point X="2113.2227549763297" Y="652.4987784074007" />
    </Graphics>
  </Line>
  <Line GraphId="e7ae3">
    <BiopaxRef>f2a</BiopaxRef>
    <Graphics ZOrder="32837" LineThickness="1.0">
      <Point X="852.8333333333344" Y="58.797619047619044" GraphRef="c9d3e" RelX="-1.0" RelY="0.0" />
      <Point X="503.0" Y="120.0" GraphRef="c58ad" RelX="1.0" RelY="0.0" ArrowHead="mim-inhibition" />
    </Graphics>
  </Line>
  <Line GraphId="f2df1">
    <Graphics ZOrder="32839" LineThickness="1.0">
      <Point X="362.2629107981222" Y="341.0" GraphRef="cc355" RelX="0.0" RelY="1.0" />
      <Point X="357.6199369884472" Y="445.4465416346152" GraphRef="a55d5" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="da220">
    <BiopaxRef>ff4</BiopaxRef>
    <BiopaxRef>c21</BiopaxRef>
    <Graphics ZOrder="32840" LineThickness="1.0">
      <Point X="621.2650365358573" Y="481.346787064538" />
      <Point X="607.6276736401833" Y="956.3709962736252" GraphRef="d0ba6" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="dccab">
    <BiopaxRef>ff4</BiopaxRef>
    <BiopaxRef>c21</BiopaxRef>
    <Graphics ZOrder="32841" LineThickness="1.0">
      <Point X="441.52582159624444" Y="334.82872233400406" GraphRef="cc355" RelX="1.0" RelY="0.5" />
      <Point X="499.517425609929" Y="638.2232896248502" GraphRef="ac7ad" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="b3941">
    <Graphics ZOrder="32842" LineThickness="1.0">
      <Point X="283.0" Y="328.6574446680081" GraphRef="cc355" RelX="-1.0" RelY="0.0" />
      <Point X="125.0520883533656" Y="383.4087450721158" />
    </Graphics>
  </Line>
  <Line GraphId="efbdf">
    <BiopaxRef>ff4</BiopaxRef>
    <Graphics ZOrder="32843" LineThickness="1.0">
      <Point X="357.6199369884472" Y="495.7215225721153" GraphRef="a55d5" RelX="0.0" RelY="1.0" />
      <Point X="459.7730827808083" Y="956.3709962736252" GraphRef="d0ba6" RelX="-0.5" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="ef66b">
    <BiopaxRef>ff4</BiopaxRef>
    <BiopaxRef>c21</BiopaxRef>
    <Graphics ZOrder="32845" LineThickness="1.0">
      <Point X="362.7551553599768" Y="187.0" GraphRef="fcbc9" RelX="0.0" RelY="1.0" />
      <Point X="362.5833333333328" Y="243.78571428571468" GraphRef="af617" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="a60b2">
    <Graphics ZOrder="32846" LineThickness="1.0">
      <Point X="322.6314553990611" Y="341.0" GraphRef="cc355" RelX="-0.5" RelY="1.0" />
      <Point X="250.12768147836567" Y="420.420910384616" />
    </Graphics>
  </Line>
  <Line GraphId="cef54">
    <BiopaxRef>ff4</BiopaxRef>
    <Graphics ZOrder="32847" LineThickness="1.0">
      <Point X="362.5833333333328" Y="270.0" GraphRef="af617" RelX="0.0" RelY="1.0" />
      <Point X="362.2629107981222" Y="316.3148893360162" GraphRef="cc355" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="a2a3e">
    <Graphics ZOrder="32848" LineThickness="1.0">
      <Point X="441.52582159624444" Y="328.6574446680081" GraphRef="cc355" RelX="1.0" RelY="0.0" />
      <Point X="570.4743536658655" Y="383.4087450721158" />
    </Graphics>
  </Line>
  <Line GraphId="d1ec9">
    <BiopaxRef>ff4</BiopaxRef>
    <Graphics ZOrder="32849" LineThickness="1.0">
      <Point X="251.4039630408658" Y="420.420910384616" />
      <Point X="252.8136179188482" Y="632.4032819977658" GraphRef="a8e97" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="dc15b">
    <BiopaxRef>ff4</BiopaxRef>
    <Graphics ZOrder="32850" LineThickness="1.0">
      <Point X="499.517425609929" Y="683.3931443123502" GraphRef="ac7ad" RelX="0.0" RelY="1.0" />
      <Point X="459.7730827808083" Y="956.3709962736252" GraphRef="d0ba6" RelX="-0.5" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="ebafd">
    <BiopaxRef>f88</BiopaxRef>
    <BiopaxRef>ff4</BiopaxRef>
    <Graphics ZOrder="32851" LineThickness="1.0">
      <Point X="362.4752624009845" Y="77.19777446199656" GraphRef="b43f7" RelX="0.0" RelY="1.0" />
      <Point X="362.7551553599768" Y="157.51963780187003" GraphRef="fcbc9" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="eaf1d">
    <BiopaxRef>ff4</BiopaxRef>
    <Graphics ZOrder="32852" LineThickness="1.0">
      <Point X="570.4743536658655" Y="384.6850266346159" />
      <Point X="621.2650365358573" Y="431.5718061270381" GraphRef="ecf51" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="cfb3f">
    <BiopaxRef>ff4</BiopaxRef>
    <BiopaxRef>c21</BiopaxRef>
    <Graphics ZOrder="32854" LineThickness="1.0">
      <Point X="125.48614614898203" Y="384.9600732880943" />
      <Point X="124.56078990877809" Y="384.19325322406826" GraphRef="d5dc0" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Line GraphId="id83b9a976">
    <Graphics ZOrder="32871" LineThickness="1.0">
      <Point X="1551.8960283731137" Y="542.6557842871367" GraphRef="f8256" RelX="0.0" RelY="1.0" />
      <Point X="1685.415406074593" Y="907.4864234748791" GraphRef="b2d86" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="db5fc">
    <Graphics ZOrder="32872" LineThickness="1.0">
      <Point X="2115.235294117649" Y="594.6470588235313" />
      <Point X="2169.2352941176487" Y="595.6470588235313" ArrowHead="mim-conversion" />
    </Graphics>
  </Line>
  <Line GraphId="f0ce0">
    <Graphics ZOrder="32873" LineThickness="1.0">
      <Point X="2115.235294117649" Y="595.7295588235313" />
      <Point X="2115.235294117649" Y="628.279558823531" />
    </Graphics>
  </Line>
  <Line GraphId="idf174d5e5">
    <Graphics ZOrder="32874" LineThickness="1.0">
      <Point X="1000.8154761904772" Y="112.38095238095238" GraphRef="c9d3e" RelX="-0.5" RelY="1.0" />
      <Point X="831.5422485810975" Y="184.62197633168654" GraphRef="a65ad" RelX="0.0" RelY="-1.0" ArrowHead="TBar" />
    </Graphics>
  </Line>
  <Line GraphId="idbb0f4d64">
    <Graphics ZOrder="32875" LineThickness="1.0">
      <Point X="1066.3708155105114" Y="595.6352175567898" GraphRef="b3d1e" RelX="0.0" RelY="1.0" />
      <Point X="755.4822644995583" Y="956.3709962736252" GraphRef="d0ba6" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="id6ba4ea74">
    <Graphics ZOrder="32887" LineStyle="Broken" LineThickness="1.0">
      <Point X="1173.6097613648633" Y="493.13609041500195" />
      <Point X="1317.4596108169903" Y="567.8664999612433" GraphRef="d39eb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="id884dca54">
    <Graphics ZOrder="32888" LineStyle="Broken" LineThickness="1.0">
      <Point X="1476.5864017564697" Y="491.811539430587" />
      <Point X="1317.4596108169903" Y="567.8664999612433" GraphRef="d39eb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
  </Line>
  <Line GraphId="f7f11">
    <BiopaxRef>ff4</BiopaxRef>
    <Graphics ZOrder="32889" LineThickness="1.0">
      <Point X="124.56078990877809" Y="439.36305051045724" GraphRef="d5dc0" RelX="0.0" RelY="1.0" />
      <Point X="311.9184919214333" Y="997.9060766642502" GraphRef="d0ba6" RelX="-1.0" RelY="0.5" ArrowHead="mim-binding" />
    </Graphics>
  </Line>
  <Label TextLabel="Phosphorylated" GraphId="c9d2d">
    <Graphics CenterX="922.5672485810932" CenterY="184.57197633168633" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="AP-1 transcription factor complex" GraphId="bb185" GroupRef="a5732">
    <Graphics CenterX="1298.7617251249567" CenterY="244.21560474408977" Width="166.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="E-box" GraphId="fb0a6">
    <Graphics CenterX="1089.662248581094" CenterY="479.2669763316859" Width="74.64999999999964" Height="22.050000000000004" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" />
  </Label>
  <Label TextLabel="it was not possbile to add a further article without pubmed id" GraphId="ede28">
    <Graphics CenterX="2138.7301587301495" CenterY="701.0317460317439" Width="233.01587301587313" Height="60.793650793650826" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="a87b9">
    <Graphics CenterX="844.6955238118015" CenterY="260.80876750172075" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="Phosphorylated" GraphId="a527c">
    <Graphics CenterX="898.9672485810951" CenterY="400.07197633168676" Width="80.0" Height="20.0" ZOrder="32773" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="Gene box" GraphId="e1ade">
    <Graphics CenterX="1227.0622485810936" CenterY="479.8169763316847" Width="74.64999999999964" Height="22.050000000000004" ZOrder="32795" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" />
  </Label>
  <Label TextLabel="E-box" GraphId="d6bc9">
    <Graphics CenterX="1414.1872485810943" CenterY="478.46697633168526" Width="74.49999999999955" Height="22.549999999999482" ZOrder="32796" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" />
  </Label>
  <Label TextLabel="Gene box&#xA;" GraphId="e9d95">
    <Graphics CenterX="1553.237248581093" CenterY="478.966976331685" Width="71.5" Height="25.64999999999932" ZOrder="32797" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" />
  </Label>
  <Label TextLabel="Apoptosis" GraphId="e2f6b">
    <BiopaxRef>b17</BiopaxRef>
    <Graphics CenterX="2646.9047619047624" CenterY="1460.8095238095236" Width="74.28571428571377" Height="57.619047619047414" ZOrder="32817" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="induces malformation" GraphId="a45b7">
    <BiopaxRef>f0c</BiopaxRef>
    <Graphics CenterX="1689.0164057699799" CenterY="301.3400482486704" Width="142.0" Height="20.0" ZOrder="32818" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="inhibits dimerization" GraphId="f13c4">
    <BiopaxRef>b17</BiopaxRef>
    <Graphics CenterX="1815.698945452451" CenterY="276.0225879312108" Width="99.04761904761904" Height="20.0" ZOrder="32820" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="inhibition of ubiquitination" GraphId="a97e8">
    <BiopaxRef>f0c</BiopaxRef>
    <Graphics CenterX="1707.4370406906162" CenterY="134.84798475660742" Width="141.0" Height="20.0" ZOrder="32821" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="8" GraphId="bd75d">
    <Comment>SIMULTANEOUS ACTION OF THE FLAVONOID QUERCETIN ON
CYTOCHROME P450 (CYP) 1A2, CYP2A6, N-ACETYLTRANSFERASE
AND XANTHINE OXIDASE ACTIVITY IN HEALTHY VOLUNTEERS.
Yao Chen, Peng Xiao, Dong-Sheng Ou-Yang, Lan Fan, Dong Guo, Yi-Nan Wang,
Yang Han, Jiang-Hua Tu, Gan Zhou, Yuan-Fei Huang and Hong-Hao Zhou.
Clinical and Experimental Pharmacology and Physiology</Comment>
    <Graphics CenterX="2150.048151801724" CenterY="669.800365708984" Width="20.952380952380523" Height="20.0" ZOrder="32822" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="Cell cycle arrest" GraphId="fc75b">
    <BiopaxRef>b17</BiopaxRef>
    <Graphics CenterX="2643.8095238095243" CenterY="1470.5714285714294" Width="99.52380952380895" Height="53.333333333333556" ZOrder="32834" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="Malignancy" GraphId="dc35f">
    <BiopaxRef>b17</BiopaxRef>
    <Graphics CenterX="2643.571428571429" CenterY="1495.095238095238" Width="67.619047619047" Height="63.33333333333371" ZOrder="32835" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="d8e00">
    <Graphics CenterX="969.7758177651526" CenterY="145.90354314197992" Width="80.0" Height="20.0" ZOrder="32876" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="fe7dc">
    <Graphics CenterX="1221.834914529623" CenterY="163.96480687824354" Width="80.0" Height="20.0" ZOrder="32877" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="a55a5">
    <Graphics CenterX="1093.7587364667647" CenterY="390.56020848581977" Width="80.0" Height="20.0" ZOrder="32878" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="dd04c">
    <Graphics CenterX="998.3714533980841" CenterY="326.02906135520175" Width="80.0" Height="20.0" ZOrder="32879" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="afb8b">
    <Graphics CenterX="839.6321275942626" CenterY="378.7798283474591" Width="80.0" Height="20.0" ZOrder="32880" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="d5c99">
    <Graphics CenterX="1398.8502345334634" CenterY="392.8542816441843" Width="80.0" Height="20.0" ZOrder="32881" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="e3fd7">
    <Graphics CenterX="951.5546377281066" CenterY="556.7855118237769" Width="80.0" Height="20.0" ZOrder="32882" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="b35a5">
    <Graphics CenterX="1019.7882923010486" CenterY="725.7222672137627" Width="80.0" Height="21.82014181333892" ZOrder="32883" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="d6fb1">
    <Graphics CenterX="1160.4763704423497" CenterY="830.5015117157961" Width="80.0" Height="20.0" ZOrder="32884" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="c9d40">
    <Graphics CenterX="1241.684037900873" CenterY="822.6322076449621" Width="80.0" Height="20.0" ZOrder="32885" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="4" GraphId="dc933">
    <Graphics CenterX="1629.57887917072" CenterY="781.7577295468454" Width="80.0" Height="20.0" ZOrder="32886" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Shape TextLabel="Nf-kB" GraphId="d8636">
    <Graphics CenterX="1089.5672485810933" CenterY="455.2969763316837" Width="72.69999999999992" Height="24.249999999999545" ZOrder="32779" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape TextLabel="AP-1" GraphId="bf76f">
    <Graphics CenterX="1415.187248581094" CenterY="454.44947633168294" Width="72.69999999999992" Height="24.249999999999545" ZOrder="32791" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape TextLabel="ARE" GraphId="e66b3">
    <Graphics CenterX="1959.6394216429933" CenterY="639.6416355502578" Width="200.50000000000034" Height="24.761904761904738" ZOrder="32815" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape TextLabel="ROS" GraphId="d907f">
    <Graphics CenterX="2189.801886628987" CenterY="46.06740585838048" Width="108.11904761904839" Height="49.5238095238098" ZOrder="32816" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape TextLabel="Phospholipase A2 &#xA;(PLA2)&#xA;" GraphId="c58ad">
    <Graphics CenterX="434.07265598471815" CenterY="120.0" Width="137.8546880305637" Height="44.0" ZOrder="32855" FontSize="13" Valign="Middle" ShapeType="Oval" Rotation="0.0" />
  </Shape>
  <Shape TextLabel="Cox1/Cox2&#xA;" GraphId="dbf59">
    <Graphics CenterX="409.50308199746917" CenterY="214.59934486002547" Width="88.99383600506167" Height="30.801310279949064" ZOrder="32856" FontSize="13" Valign="Middle" ShapeType="Oval" Rotation="0.0" />
  </Shape>
  <Group GroupId="ed99e" GraphId="ceb1d" Style="Complex" />
  <Group GroupId="a5732" GraphId="f57a5" Style="Complex" />
  <Group GroupId="cf591" GraphId="c5785" Style="Complex" />
  <InfoBox CenterX="0.0" CenterY="0.0" />
  <Biopax>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f88">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21508345</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandins and inflammation.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arterioscler Thromb Vasc Biol</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21508345</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandins and inflammation.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arterioscler Thromb Vasc Biol</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ricciotti E</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FitzGerald GA</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ff4">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11729303</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandins and leukotrienes: advances in eicosanoid biology.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Science</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR>
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11729303</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandins and leukotrienes: advances in eicosanoid biology.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Science</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Funk CD</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c21">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21508345</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandins and inflammation.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arterioscler Thromb Vasc Biol</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ricciotti E</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FitzGerald GA</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f2a">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11993721</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A2.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandins Leukot Essent Fatty Acids</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim HR</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pham HT</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ziboh VA</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ea0">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Journal of Food Composition and Analysis</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ala Y.Issa</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Suresh R.Volate</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Micheal J. Wargovich</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b17">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">www.sciencedirect.com                                                                                                                                                                                                                                                                                                                              www.sciencedirect.com</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Journal of food composition and analysis</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Journal of food composition and analysis</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ala Y. Issaa</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Suresh R. Volatea</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Michael J. Wargovich</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f0c">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17462537</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Free Radic Biol Med</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tanigawa S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fujii M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hou DX</bp:AUTHORS>
    </bp:PublicationXref>
  </Biopax>
</Pathway>