Metastatic brain tumor (Homo sapiens)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://genmapp.org/GPML/2010a" Name="Metastatic brain tumor" Author="devi" Organism="Homo sapiens"> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">Interaction between microRNAs (miRNAs) and abnormal methylation to control metastasis. Tumor growth and metastasis formation through down regulation of their oncogenic targets such as MYC ,E2F3 and cyclin –dependent kinase(CDK6). </Comment> <Graphics BoardWidth="573.1951219512194" BoardHeight="435.8210498818186" /> <Line GraphId="ide9346f58"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="140.45599151643688" Y="80.90111346765642" GraphRef="be17f" RelX="1.0" RelY="0.0" /> <Point X="237.87910922587469" Y="76.81044538706259" GraphRef="b88e6" RelX="-1.0" RelY="0.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="idd573b1f6"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="444.3679745493105" Y="101.21977730646871" GraphRef="f2157" RelX="-1.0" RelY="-0.5" /> <Point X="321.8791092258747" Y="76.81044538706259" GraphRef="b88e6" RelX="1.0" RelY="0.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="idea615a9c"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="350.0137857900321" Y="142.60299575821847" GraphRef="b9ac6" RelX="1.0" RelY="-0.5" /> <Point X="444.3679745493105" Y="107.96977730646871" GraphRef="f2157" RelX="-1.0" RelY="0.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id7a88703e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="421.2370523902868" Y="227.11078976402416" GraphRef="e097e" RelX="-1.0" RelY="0.0" /> <Point X="395.10101010101" Y="227.00505050505052" GraphRef="ed889" RelX="1.0" RelY="0.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id81bdc5b0"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="287.0137857900321" Y="169.22799575821847" GraphRef="b9ac6" RelX="0.0" RelY="1.0" /> <Point X="270.9093319194062" Y="205.56044538706254" GraphRef="df8db" RelX="0.0" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id52771ce1"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="255.6593319194062" Y="228.06044538706254" GraphRef="df8db" RelX="-0.5" RelY="1.0" /> <Point X="225.59477730646861" Y="270.03022269353124" GraphRef="eaaa9" RelX="0.5" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id66145239"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="270.9093319194062" Y="228.06044538706254" GraphRef="df8db" RelX="0.0" RelY="1.0" /> <Point X="272.75" Y="268.5000000000001" GraphRef="c88b3" RelX="0.0" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id887eef25"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="286.1593319194062" Y="228.06044538706254" GraphRef="df8db" RelX="0.5" RelY="1.0" /> <Point X="313.9436638388123" Y="271.1511134676565" GraphRef="ea7c4" RelX="-0.5" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="idde203126"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="266.9917815482503" Y="309.2582184517497" GraphRef="bc7cd" RelX="-0.5" RelY="-1.0" /> <Point X="263.125" Y="281.5482502651113" GraphRef="c88b3" RelX="-0.5" RelY="1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id11f13a9"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="282.375" Y="281.5482502651113" GraphRef="c88b3" RelX="0.5" RelY="1.0" /> <Point X="281.7417815482503" Y="309.2582184517497" GraphRef="bc7cd" RelX="0.0" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id4785ab5a"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="102.45599151643688" Y="90.65111346765642" GraphRef="be17f" RelX="0.0" RelY="1.0" /> <Point X="108.40933191940614" Y="141.34888653234364" GraphRef="cd5e8" RelX="0.0" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id54882f2f"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="121.45599151643688" Y="90.65111346765642" GraphRef="be17f" RelX="0.5" RelY="1.0" /> <Point X="144.74999999999994" Y="141.40933191940613" GraphRef="d060b" RelX="-0.5" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id400aeb70"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="144.74999999999994" Y="163.40933191940613" GraphRef="d060b" RelX="-0.5" RelY="1.0" /> <Point X="139.28844114528096" Y="205.53022269353136" GraphRef="ec39b" RelX="0.5" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="ida07644a2"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="108.40933191940614" Y="158.34888653234364" GraphRef="cd5e8" RelX="0.0" RelY="1.0" /> <Point X="109.28844114528096" Y="205.53022269353136" GraphRef="ec39b" RelX="-0.5" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="idf3c6767"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="83.45599151643688" Y="90.65111346765642" GraphRef="be17f" RelX="-0.5" RelY="1.0" /> <Point X="87.22242841993628" Y="268.0604453870627" GraphRef="e2b9f" RelX="-0.5" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id1bd0da03"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="113.72242841993628" Y="291.0604453870627" GraphRef="e2b9f" RelX="0.5" RelY="1.0" /> <Point X="247.5030064664935" Y="373.6440106232267" GraphRef="d40bf" RelX="-1.0" RelY="-0.5" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="idc11bf4b5"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="281.7417815482503" Y="334.7582184517497" GraphRef="bc7cd" RelX="0.0" RelY="1.0" /> <Point X="281.82887792074274" Y="364.60834537271614" GraphRef="d40bf" RelX="0.0" RelY="-1.0" ArrowHead="TBar" /> </Graphics> </Line> <Line GraphId="id6b5e1390"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="279.8791092258747" Y="88.06044538706259" GraphRef="b88e6" RelX="0.0" RelY="1.0" /> <Point X="287.0137857900321" Y="133.72799575821847" GraphRef="b9ac6" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line GraphId="id5781dac0"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="154.28844114528096" Y="215.03022269353136" GraphRef="ec39b" RelX="1.0" RelY="0.0" /> <Point X="240.4093319194062" Y="216.81044538706254" GraphRef="df8db" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line GraphId="ide6e2d0cb"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="207.84477730646861" Y="282.53022269353124" GraphRef="eaaa9" RelX="-0.5" RelY="1.0" /> <Point X="264.6659421936181" Y="364.60834537271614" GraphRef="d40bf" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line GraphId="id93b27aa6"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="337.1936638388123" Y="287.6511134676565" GraphRef="ea7c4" RelX="0.5" RelY="1.0" /> <Point X="298.9918136478674" Y="364.60834537271614" GraphRef="d40bf" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> </Line> <Line GraphId="id992ac51f"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="382.47601010101" Y="239.50505050505052" GraphRef="ed889" RelX="0.5" RelY="1.0" /> <Point X="316.154749374992" Y="373.6440106232267" GraphRef="d40bf" RelX="1.0" RelY="-0.5" ArrowHead="Arrow" /> </Graphics> </Line> <Line GraphId="ide92d1813"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="357.22601010101" Y="214.50505050505052" GraphRef="ed889" RelX="-0.5" RelY="-1.0" /> <Point X="318.5137857900321" Y="169.22799575821847" GraphRef="b9ac6" RelX="0.5" RelY="1.0" ArrowHead="Arrow" /> </Graphics> </Line> <Shape TextLabel="DNMTs" GraphId="b88e6"> <Graphics CenterX="279.8791092258747" CenterY="76.81044538706259" Width="84.0" Height="22.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0" /> </Shape> <Shape TextLabel="miR-29" GraphId="be17f"> <Graphics CenterX="102.45599151643687" CenterY="80.90111346765642" Width="76.0" Height="19.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="CpG hypermethylation" GraphId="b9ac6"> <Graphics CenterX="287.0137857900321" CenterY="151.47799575821847" Width="126.0" Height="35.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0" /> </Shape> <Shape TextLabel="miR-148" GraphId="f2157"> <Graphics CenterX="473.3679745493105" CenterY="107.96977730646871" Width="58.0" Height="27.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="miR-34" GraphId="df8db"> <Graphics CenterX="270.9093319194062" CenterY="216.81044538706254" Width="61.0" Height="22.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="E2H2" GraphId="ed889"> <Graphics CenterX="369.85101010101" CenterY="227.00505050505052" Width="50.5" Height="25.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="miR-101" GraphId="e097e"> <Graphics CenterX="456.9870523902868" CenterY="227.11078976402416" Width="71.5" Height="28.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="CDC42" GraphId="cd5e8"> <Graphics CenterX="108.40933191940614" CenterY="149.84888653234364" Width="34.0" Height="17.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="P85a" GraphId="d060b"> <Graphics CenterX="155.49999999999994" CenterY="152.40933191940613" Width="43.0" Height="22.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="p53" GraphId="ec39b"> <Graphics CenterX="124.28844114528096" CenterY="215.03022269353136" Width="60.0" Height="19.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="TTP" GraphId="e2b9f"> <Graphics CenterX="100.47242841993628" CenterY="279.5604453870627" Width="53.0" Height="23.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="CDK6" GraphId="eaaa9"> <Graphics CenterX="216.71977730646861" CenterY="276.28022269353124" Width="35.5" Height="12.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="MYC" GraphId="c88b3"> <Graphics CenterX="272.75" CenterY="275.0241251325557" Width="38.5" Height="13.048250265111228" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="E2F3" GraphId="ea7c4"> <Graphics CenterX="325.5686638388123" CenterY="279.4011134676565" Width="46.5" Height="16.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="let-7" GraphId="bc7cd"> <Graphics CenterX="281.7417815482503" CenterY="322.0082184517497" Width="59.0" Height="25.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Rotation="0.0" /> </Shape> <Shape TextLabel="Metastasis" GraphId="d40bf"> <Graphics CenterX="281.8288779207427" CenterY="382.67967587373715" Width="67.88701076968499" Height="34.61784875847435" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.022593094571613324" /> </Shape> <InfoBox CenterX="0.0" CenterY="0.0" /> </Pathway>

• Template:AuthorInfo
• Template:CheckAvailable (protected)
• Template:PathwayPage:History
• Template:PathwayPage:Xrefs

Return to Metastatic brain tumor (Homo sapiens).