G1 to S cell cycle control (Mus musculus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="G1 to S cell cycle control" Organism="Mus musculus" Last-Modified="10/17/2013"> <Comment Source="GenMAPP notes">Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.</Comment> <Comment Source="GenMAPP remarks"/> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;FOCUS_SPECIES=Homo%20sapiens&amp;ID=69615&amp;</Comment> <BiopaxRef>f5e</BiopaxRef> <Graphics BoardWidth="1378.6926666666666" BoardHeight="825.6067"/> <DataNode TextLabel="Cdk4" GraphId="d0c" Type="GeneProduct" GroupRef="db365"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdk4 | cyclin-dependent kinase 4"/> <Graphics CenterX="94.35913333333333" CenterY="143.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12567"/> </DataNode> <DataNode TextLabel="Cdk6" GraphId="c12" Type="GeneProduct" GroupRef="db365"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdk6 | cyclin-dependent kinase 6"/> <Graphics CenterX="94.35913333333333" CenterY="166.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12571"/> </DataNode> <DataNode TextLabel="Ccnd1" GraphId="fc6" Type="GeneProduct" GroupRef="ed54a"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ccnd1 | cyclin D1"/> <Graphics CenterX="234.35913333333335" CenterY="126.33333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12443"/> </DataNode> <DataNode TextLabel="Ccnd2" GraphId="ac0" Type="GeneProduct" GroupRef="ed54a"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ccnd2 | cyclin D2"/> <Graphics CenterX="234.35913333333335" CenterY="149.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12444"/> </DataNode> <DataNode TextLabel="Ccnd3" GraphId="a09" Type="GeneProduct" GroupRef="ed54a"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ccnd3 | cyclin D3"/> <Graphics CenterX="234.35913333333335" CenterY="173.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12445"/> </DataNode> <DataNode TextLabel="CyclinD" GraphId="fd5" Type="GeneProduct" GroupRef="a7d43"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CyclinD"/> <Graphics CenterX="170.35913333333335" CenterY="236.0" Width="56.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Cdk" GraphId="d58" Type="GeneProduct" GroupRef="a7d43"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdk"/> <Graphics CenterX="170.35913333333335" CenterY="256.0" Width="56.46666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Cdkn1a" GraphId="a30" Type="GeneProduct" GroupRef="f5bc9"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdkn1a | cyclin-dependent kinase inhibitor 1A (..."/> <Graphics CenterX="620.0258" CenterY="123.33333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12575"/> </DataNode> <DataNode TextLabel="Cdkn1b" GraphId="e3c" Type="GeneProduct" GroupRef="f5bc9"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdkn1b | cyclin-dependent kinase inhibitor 1B (..."/> <Graphics CenterX="620.0258" CenterY="96.66666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12576"/> </DataNode> <DataNode TextLabel="Cdk7" GraphId="a33" Type="GeneProduct" GroupRef="d3381"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdk7 | cyclin-dependent kinase 7 (homolog of Xe..."/> <Graphics CenterX="245.0258" CenterY="268.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12572"/> </DataNode> <DataNode TextLabel="Ccnh" GraphId="acb" Type="GeneProduct" GroupRef="d3381"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ccnh | cyclin H"/> <Graphics CenterX="245.0258" CenterY="288.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="66671"/> </DataNode> <DataNode TextLabel="CyclinD" GraphId="a61" Type="GeneProduct" GroupRef="dc679"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CyclinD"/> <Graphics CenterX="345.69246666666663" CenterY="235.0" Width="56.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Cdk" GraphId="ec3" Type="GeneProduct" GroupRef="dc679"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdk"/> <Graphics CenterX="345.69246666666663" CenterY="255.0" Width="56.46666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Rb" GraphId="b04" Type="GeneProduct" GroupRef="ffe"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Rb1"/> <Graphics CenterX="300.0258" CenterY="436.6666666666667" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="E2f" GraphId="f8b" Type="GeneProduct" GroupRef="ffe"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2f"/> <Graphics CenterX="300.0258" CenterY="456.6666666666667" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="E2f1" GraphId="b21" Type="GeneProduct" GroupRef="af9"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2f1 | E2F transcription factor 1"/> <Graphics CenterX="370.0258" CenterY="453.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="13555"/> </DataNode> <DataNode TextLabel="E2f2" GraphId="f15" Type="GeneProduct" GroupRef="af9"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2f2 | E2F transcription factor 2"/> <Graphics CenterX="370.0258" CenterY="493.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="242705"/> </DataNode> <DataNode TextLabel="E2f3" GraphId="a1b" Type="GeneProduct" GroupRef="af9"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2f3 | E2F transcription factor 3"/> <Graphics CenterX="370.0258" CenterY="533.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="13557"/> </DataNode> <DataNode TextLabel="Rbl1" GraphId="d60" Type="GeneProduct" GroupRef="b27"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Rbl1 | retinoblastoma-like 1 (p107)"/> <Graphics CenterX="456.69246666666663" CenterY="453.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="19650"/> </DataNode> <DataNode TextLabel="Rb1" GraphId="fcd" Type="GeneProduct" GroupRef="b27"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Rb1 | retinoblastoma 1"/> <Graphics CenterX="456.69246666666663" CenterY="433.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="19645"/> </DataNode> <DataNode TextLabel="E2f4" GraphId="c68" Type="GeneProduct" GroupRef="af9"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2f4 | E2F transcription factor 4"/> <Graphics CenterX="370.0258" CenterY="433.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="104394"/> </DataNode> <DataNode TextLabel="E2f5" GraphId="b0a" Type="GeneProduct" GroupRef="af9"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2f5 | E2F transcription factor 5"/> <Graphics CenterX="370.0258" CenterY="473.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="13559"/> </DataNode> <DataNode TextLabel="E2f6" GraphId="faf" Type="GeneProduct" GroupRef="af9"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2f6 | E2F transcription factor 6"/> <Graphics CenterX="370.0258" CenterY="513.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="50496"/> </DataNode> <DataNode TextLabel="Rb" GraphId="efb" Type="GeneProduct" GroupRef="fde"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Rb1"/> <Graphics CenterX="122.35913333333333" CenterY="510.6666666666667" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="E2f" GraphId="e7b" Type="GeneProduct" GroupRef="f0f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2f"/> <Graphics CenterX="170.0258" CenterY="590.0" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="dp1" GraphId="d36" Type="GeneProduct" GroupRef="f0f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="dp1"/> <Graphics CenterX="170.0258" CenterY="610.0" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Tfdp1" GraphId="d9f" Type="GeneProduct" GroupRef="ef1"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Tfdp1 | transcription factor Dp 1"/> <Graphics CenterX="203.35913333333335" CenterY="460.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="21781"/> </DataNode> <DataNode TextLabel="Tfdp2" GraphId="aae" Type="GeneProduct" GroupRef="ef1"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Tfdp2 | transcription factor Dp 2"/> <Graphics CenterX="203.35913333333335" CenterY="480.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="211586"/> </DataNode> <DataNode TextLabel="Cdk2" GraphId="f98" Type="GeneProduct" GroupRef="bfb87"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdk2 | cyclin-dependent kinase 2"/> <Graphics CenterX="1143.3593333333333" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12566"/> </DataNode> <DataNode TextLabel="Ccne1" GraphId="a01" Type="GeneProduct" GroupRef="bfb87"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ccne1 | cyclin E1"/> <Graphics CenterX="1280.026" CenterY="140.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12447"/> </DataNode> <DataNode TextLabel="Ccne2" GraphId="a93" Type="GeneProduct" GroupRef="bfb87"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ccne2 | cyclin E2"/> <Graphics CenterX="1280.026" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12448"/> </DataNode> <DataNode TextLabel="Pole2" GraphId="c6e" Type="GeneProduct" GroupRef="c8c"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pole2 | polymerase (DNA directed) epsilon 2 (..."/> <Graphics CenterX="1006.6926666666666" CenterY="570.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="18974"/> </DataNode> <DataNode TextLabel="Pole" GraphId="bad" Type="GeneProduct" GroupRef="c8c"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pole | polymerase (DNA directed) epsilon"/> <Graphics CenterX="1006.6926666666666" CenterY="590.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="18973"/> </DataNode> <DataNode TextLabel="Cdc25a" GraphId="dd8" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdc25a | cell division cycle 25 homolog A (S. c..."/> <Graphics CenterX="1073.026" CenterY="319.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12530"/> </DataNode> <DataNode TextLabel="Wee1" GraphId="a2c" Type="GeneProduct" GroupRef="b5190"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Wee1 | wee 1 homolog (S. pombe)"/> <Graphics CenterX="1086.3593333333333" CenterY="210.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="22390"/> </DataNode> <DataNode TextLabel="Pkmyt1" GraphId="ed0" Type="GeneProduct" GroupRef="b5190"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pkmyt1 | protein kinase membrane associated t..."/> <Graphics CenterX="1086.3593333333333" CenterY="233.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="268930"/> </DataNode> <DataNode TextLabel="CyclinE" GraphId="f63" Type="GeneProduct" GroupRef="d3b32"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CyclinD"/> <Graphics CenterX="1173.3593333333333" CenterY="243.33333333333334" Width="56.46666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Cdk" GraphId="d3a" Type="GeneProduct" GroupRef="d3b32"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdk"/> <Graphics CenterX="1173.3593333333333" CenterY="263.3333333333333" Width="56.46666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CyclinE" GraphId="f6c" Type="GeneProduct" GroupRef="d2e83"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CyclinD"/> <Graphics CenterX="976.6926666666666" CenterY="243.0" Width="56.46666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Cdk" GraphId="e88" Type="GeneProduct" GroupRef="d2e83"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdk"/> <Graphics CenterX="976.6926666666666" CenterY="263.0" Width="56.46666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Cdc2a" GraphId="cc3" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdc2a | cell division cycle 2 homolog A (S. pom..."/> <Graphics CenterX="1106.6926666666666" CenterY="656.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12534"/> </DataNode> <DataNode TextLabel="Cdk4" GraphId="e54" Type="GeneProduct" GroupRef="a6e"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdk4 | cyclin-dependent kinase 4"/> <Graphics CenterX="1106.6926666666666" CenterY="683.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12567"/> </DataNode> <DataNode TextLabel="Cdk6" GraphId="beb" Type="GeneProduct" GroupRef="a6e"> 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