Phase I biotransformations, non P450 (Canis familiaris)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Phase I biotransformations, non P450" Last-Modified="2/20/2013" Organism="Canis familiaris"> <Comment Source="WikiPathways-description">This pathway lists several phase 1 biotransformations and their related enzymes. '''NOTE:''' This pathway is incomplete, reduction and oxidation enzymes are missing</Comment> <Comment Source="WikiPathways-category">Metabolic Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP136&amp;amp;oldid=29886 WP136(r29886)] with a 100% conversion rate.</Comment> <BiopaxRef>b69</BiopaxRef> <Graphics BoardWidth="625.0" BoardHeight="408.0"/> <DataNode TextLabel="NP_001003085.1" GraphId="f26" Type="GeneProduct" GroupRef="d23ac"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="NP_001003085.1"/> <Graphics CenterX="282.0" CenterY="94.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSCAFG00000009333"/> </DataNode> <DataNode TextLabel="ESD" GraphId="b38" Type="GeneProduct" GroupRef="d23ac"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ESD"/> <Graphics CenterX="282.0" CenterY="114.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSCAFG00000004473"/> </DataNode> <DataNode TextLabel="NP_001003969.1" GraphId="ac5" Type="GeneProduct" GroupRef="d23ac"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="NP_001003969.1"/> <Graphics CenterX="282.0" CenterY="134.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSCAFG00000009316"/> </DataNode> <DataNode TextLabel="CES2" GraphId="dd4" Type="GeneProduct" GroupRef="d23ac"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CES2"/> <Graphics CenterX="282.0" CenterY="173.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSCAFG00000020391"/> </DataNode> <DataNode TextLabel="LIPA" GraphId="b6f" Type="GeneProduct" GroupRef="d23ac"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LIPA"/> <Graphics CenterX="282.0" CenterY="154.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSCAFG00000015721"/> </DataNode> <DataNode TextLabel="PON1" GraphId="ff0" Type="GeneProduct" GroupRef="ee236"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PON1"/> <Graphics CenterX="265.0" CenterY="328.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSCAFG00000002114"/> </DataNode> <DataNode TextLabel="PON2_CANFA" GraphId="dfd" Type="GeneProduct" GroupRef="ee236"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PON2_CANFA"/> <Graphics CenterX="265.0" CenterY="348.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSCAFG00000002123"/> </DataNode> <DataNode TextLabel="PON3" GraphId="b76" Type="GeneProduct" GroupRef="ee236"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PON3"/> <Graphics CenterX="265.0" CenterY="368.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSCAFG00000002118"/> </DataNode> <DataNode TextLabel="amides" GraphId="bc7f3" Type="Metabolite" GroupRef="f9ad7"> <Graphics CenterX="478.0" CenterY="208.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="32988"/> </DataNode> <DataNode TextLabel="carboxylic acid esters" GraphId="c109a" Type="Metabolite" GroupRef="cff8d"> <Graphics CenterX="478.0" CenterY="184.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="thio esters" GraphId="b198c" Type="Metabolite" GroupRef="bb086"> <Graphics CenterX="478.0" CenterY="232.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Phosphoric acid esters" GraphId="db710" Type="Metabolite" GroupRef="cd78c"> <Graphics CenterX="478.0" CenterY="291.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="thio esters" GraphId="a1626" Type="Metabolite" GroupRef="b9ae8"> <Graphics CenterX="105.0" CenterY="233.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Phosphoric acid esters" GraphId="a1e36" Type="Metabolite"> <Graphics CenterX="105.0" CenterY="291.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="carboxylic acid esters" GraphId="b758e" Type="Metabolite" GroupRef="b9ae8"> <Graphics CenterX="105.0" CenterY="185.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="amides" GraphId="e744e" Type="Metabolite" GroupRef="b9ae8"> <Graphics CenterX="105.0" CenterY="209.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="32988"/> </DataNode> <Interaction GraphId="db646"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="205.00617931687952" Y="207.99935378864308" GraphRef="cae49" RelX="1.0" RelY="0.0"/> <Point X="397.5" Y="207.0" GraphRef="b0e4c" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> <Anchor Position="0.4" Shape="None" GraphId="c961d"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="af048"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="169.5" Y="291.0" GraphRef="a1e36" RelX="1.0" RelY="0.0"/> <Point X="405.5" Y="291.0" GraphRef="c28bd" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> <Anchor Position="0.4" Shape="None" GraphId="ca3c4"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ae21f"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="265.0" Y="310.0" GraphRef="aa661" RelX="0.0" RelY="-1.0"/> <Point X="263.9" Y="291.0" GraphRef="ca3c4" RelX="0.0" RelY="0.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d1dd6"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="282.0" Y="191.0" GraphRef="ab569" RelX="0.0" RelY="1.0"/> <Point X="282.0037075901277" Y="207.59961227318584" GraphRef="c961d" RelX="0.0" RelY="0.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Label TextLabel="OH" GraphId="db7" GroupRef="cff8d"> <Graphics CenterX="555.0" CenterY="182.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" Color="00ccff"/> </Label> <Label TextLabel="OH" GraphId="e68" GroupRef="f9ad7"> <Graphics CenterX="555.0" CenterY="208.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" Color="00ccff"/> </Label> <Label TextLabel="OH" GraphId="e3d" GroupRef="bb086"> <Graphics CenterX="555.0" CenterY="232.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" Color="00ccff"/> </Label> <Label TextLabel="Hydrolysis" GraphId="f6a"> <Graphics CenterX="282.0" CenterY="49.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="OH" GraphId="f1b" GroupRef="cd78c"> <Graphics CenterX="555.0" CenterY="291.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" Color="00ccff"/> </Label> <Shape GraphId="f37" GroupRef="b9ae8"> <Graphics CenterX="186.49827725542823" CenterY="206.4993537886431" Width="66.9982754184165" Height="21.006179533636843" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Brace" Rotation="1.5706526692754137"/> </Shape> <Group GroupId="b9ae8" GraphId="cae49"/> <Group GroupId="cff8d" GraphId="a21b3" GroupRef="a3c4f"/> <Group GroupId="f9ad7" GraphId="ac2ba" GroupRef="a3c4f"/> <Group GroupId="bb086" GraphId="e0819" GroupRef="a3c4f"/> <Group GroupId="cd78c" GraphId="c28bd"/> <Group GroupId="a3c4f" GraphId="b0e4c"/> <Group GroupId="d23ac" GraphId="ab569"/> <Group GroupId="ee236" GraphId="aa661"/> <InfoBox CenterX="0.0" CenterY="0.0"/> <Biopax> <bp:PublicationXref xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" rdf:id="b69"> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Casarett &amp;amp;amp; Doull's Essentials of Toxicology</bp:TITLE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2003</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Klaassen, C.D.</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Watkins III, J.B.</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

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