YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="YAP1- and WWTR1 (TAZ)-stimulated gene expression" Data-Source="Reactome - http://www.reactome.org" Version="48" Author="D'Eustachio, P" Maintainer="D'Eustachio, P" Email="deustp01@nyumc.org" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&amp;FOCUS_SPECIES_ID=48887&amp;FOCUS_PATHWAY_ID=2032785</Comment> <BiopaxRef>c24</BiopaxRef> <BiopaxRef>a1c</BiopaxRef> <Attribute Key="reactome_id" Value="2032785" /> <Graphics BoardWidth="753.0" BoardHeight="1129.0" /> <DataNode TextLabel="YAP1" GraphId="bc69c" Type="Protein"> <Attribute Key="reactome_id" Value="1253322" /> <Graphics CenterX="213.5" CenterY="129.0" Width="39.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P46937" /> </DataNode> <DataNode TextLabel="WWTR1" GraphId="d8d8d" Type="Protein"> <Attribute Key="reactome_id" Value="1629775" /> <Graphics CenterX="216.5" CenterY="225.0" Width="53.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9GZV5" /> </DataNode> <DataNode TextLabel="TEAD" GraphId="df0c5" Type="Protein"> <Attribute Key="reactome_id" Value="2032773" /> <Graphics CenterX="253.5" CenterY="171.0" Width="41.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="REACT_119570" /> </DataNode> <DataNode TextLabel="TEAD:YAP1" GraphId="b0e20" Type="Complex"> <BiopaxRef>ec9</BiopaxRef> <Attribute Key="reactome_id" Value="2032772" /> <Graphics CenterX="417.5" CenterY="130.0" Width="75.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="REACT_119773" /> </DataNode> <DataNode TextLabel="YAP1 [nucleoplasm]" GraphId="e9b74" Type="Protein" GroupRef="c86fd"> <Attribute Key="reactome_id" Value="1253322" /> <Graphics CenterX="100.0" CenterY="549.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P46937" /> </DataNode> <DataNode TextLabel="TEAD1 [nucleoplasm]" GraphId="e60d6" Type="Protein" GroupRef="c86fd"> <Attribute Key="reactome_id" Value="2032774" /> <Graphics CenterX="100.0" CenterY="589.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P28347" /> </DataNode> <DataNode TextLabel="TEAD2 [nucleoplasm]" GraphId="ec880" Type="Protein" GroupRef="c86fd"> <Attribute Key="reactome_id" Value="2032763" /> <Graphics CenterX="100.0" CenterY="609.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15562" /> </DataNode> <DataNode TextLabel="TEAD3(1-435)&#xA;[nucleoplasm]" GraphId="a020d" Type="Protein" GroupRef="c86fd"> <Attribute Key="reactome_id" Value="2032767" /> <Graphics CenterX="100.0" CenterY="629.0" Width="100.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99594" /> </DataNode> <DataNode TextLabel="TEAD4 [nucleoplasm]" GraphId="b4bd7" Type="Protein" GroupRef="c86fd"> <Attribute Key="reactome_id" Value="2032780" /> <Graphics CenterX="100.0" CenterY="659.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q15561" /> </DataNode> <DataNode TextLabel="TEAD:WWTR1(TAZ)" GraphId="f6677" Type="Complex"> <BiopaxRef>ec9</BiopaxRef> <BiopaxRef>ee8</BiopaxRef> <Attribute Key="reactome_id" Value="2032762" /> <Graphics CenterX="417.0" CenterY="225.0" Width="120.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="REACT_120065" /> </DataNode> <DataNode TextLabel="TEAD1 [nucleoplasm]" GraphId="ba089" Type="Protein" GroupRef="c7557"> <Attribute Key="reactome_id" Value="2032774" /> <Graphics CenterX="100.0" CenterY="729.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P28347" /> </DataNode> <DataNode TextLabel="TEAD2 [nucleoplasm]" 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CenterY="1069.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q07869" /> </DataNode> <DataNode TextLabel="RXRA [nucleoplasm]" GraphId="e9f37" Type="Protein" GroupRef="bd54f"> <Attribute Key="reactome_id" Value="381319" /> <Graphics CenterX="240.0" CenterY="1089.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P19793" /> </DataNode> <Interaction GraphId="f2a61"> <Comment Source="Reactome">In the nucleus the YAP1 transcriptional coactivator can bind any one of the four TEAD transcription factors to form a complex. 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a1c"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20452772</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yorkie: the final destination of Hippo signaling.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oh H, Irvine KD.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ec9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19324876</bp:ID> <bp:DB 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</Pathway>

Return to YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens).