Vitamin B1 (thiamin) biosynthesis and salvage pathway (Zea mays)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Vitamin B1 (thiamin) biosynthesis and salvage pathway" Version="20121025" Author="Pankaj Jaiswal" Organism="Zea mays"> <Comment Source="WikiPathways-description">Thiamin, in its active form thiamin diphosphate (ThDP), is the cofactor for transketolases, decarboxylases, and other enzymes that make or break C-C bonds. Thiamin contains pyrimidine and thiazole moieties, which are synthesized separately in plastids and then coupled together in plastids to yield thiamin monophosphate (ThMP) (Goyer, 2010; Rapala-Kozik, 2011). The next steps are (in unknown order) export from the plastid and hydrolysis to thiamin (Goyer, 2010). Thiamin then is converted to ThDP in the cytosol. A remarkable feature of the pathway is that the thiazole synthesis protein Thi4 uses itself as sulphur donor for thiazole formation and undergoes only a single turnover (Chatterjee et al., 2011). This makes thiazole energetically very costly to produce, and puts a high premium on salvaging thiazole moieties from ThDP breakdown. Biosynthesis and metabolism of thiamin and it’s various derivatives (mono-, di- , tri- phosphates) and degradation products in plants (or other organisms) are far from being elucidated. This diagram is an attempt to capture the current state of the field</Comment> <Comment Source="WikiPathways-category">Metabolic Process</Comment> <BiopaxRef>f6f</BiopaxRef> <BiopaxRef>db1</BiopaxRef> <BiopaxRef>e26</BiopaxRef> <Graphics BoardWidth="2923.231290427627" BoardHeight="2957.4802259887" /> <DataNode TextLabel="5-aminoimidazole ribotide" GraphId="ab226" Type="Metabolite"> <Graphics CenterX="439.5414073195948" CenterY="217.65106605119746" Width="245.50986246833185" Height="39.21623731319855" ZOrder="32768" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="28843" /> </DataNode> <DataNode TextLabel="(4-amino-2-methylpyrimidin-5-yl)methyl phosphate" GraphId="b5d38" Type="Metabolite"> <Graphics CenterX="439.5414073195951" CenterY="404.20335666299496" Width="334.49074074074105" Height="28.300788412175052" ZOrder="32768" FontSize="15" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="15422" /> </DataNode> <DataNode TextLabel="hydroxymethylpyrimidine phosphate synthase (HMPPS)" GraphId="a8c50" Type="GeneProduct" GroupRef="d4e7d"> <Graphics CenterX="282.21382111269963" CenterY="312.0826870320999" Width="257.98212005108564" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Glycine" GraphId="d533c" Type="Metabolite"> <Graphics CenterX="989.0758534629841" CenterY="246.52122453540838" Width="69.91258919470215" Height="35.96457696228152" ZOrder="32768" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="ATP" GraphId="ba86b" Type="Metabolite"> <Graphics CenterX="326.93955546774436" CenterY="443.7426397579715" Width="61.5" Height="22.5" ZOrder="32768" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="thiamine diphosphate transporter" GraphId="f7a93" Type="Protein"> <Graphics CenterX="909.0803266013033" CenterY="1601.692321117637" Width="325.65805797447956" Height="53.96534653465369" ZOrder="32768" FontSize="20" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="UNKNOWN" GraphId="f17af" Type="Metabolite"> <Graphics CenterX="780.1984993516932" CenterY="1468.2759466156742" Width="160.03975153359988" Height="37.78664963270285" ZOrder="32768" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="NUDIX hydrolase" GraphId="e122e" Type="GeneProduct" GroupRef="bd05b"> <Graphics CenterX="581.1793595999543" CenterY="1427.5317815816315" Width="188.48349351063916" Height="30.36090705844443" ZOrder="32768" FontSize="20" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="GRMZM2G027663" GraphId="aef11" Type="GeneProduct" GroupRef="d4e7d"> <Graphics CenterX="290.59967320261427" CenterY="347.24455337690637" Width="190.04248366013098" Height="33.179738562091416" ZOrder="32768" FontSize="20" Valign="Middle" /> <Xref Database="Gramene Maize" ID="GRMZM2G027663" /> </DataNode> <DataNode TextLabel="(4-amino-2-methylpyrimidin-5-yl)methyl diphosphate" GraphId="c184a" Type="Metabolite"> <Graphics CenterX="439.54140731959535" CenterY="650.3484092798768" Width="347.2222222222227" Height="20.0" ZOrder="32772" FontSize="15" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="16761" /> </DataNode> <DataNode TextLabel="hydroxymethylpyrimidine phosphate kinase ThiD" GraphId="cf9e1" Type="GeneProduct" GroupRef="e8814"> <Graphics CenterX="285.33462230228326" CenterY="536.650656661867" Width="261.2393681652491" Height="24.53851153266551" ZOrder="32773" FontSize="12" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="2.7.4.7" /> </DataNode> <DataNode TextLabel="NAD" GraphId="cba0b" Type="Metabolite"> <Graphics CenterX="851.9732000934467" CenterY="225.27756404550678" Width="80.0" Height="20.0" ZOrder="32776" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="13389" /> </DataNode> <DataNode TextLabel="adenylated thiazole carboxylate" GraphId="e1584" Type="Metabolite"> <Graphics CenterX="853.3145554677427" CenterY="437.24484817766887" Width="274.30555555555657" Height="24.024114949722502" ZOrder="32777" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="thiazole biosynthetic enzyme (Thi4)" GraphId="c6ade" Type="GeneProduct" GroupRef="fb274"> <Graphics CenterX="1023.2800217483556" CenterY="312.85489751999853" Width="269.3290807093754" Height="24.412173866435907" ZOrder="32778" FontSize="15" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="4-methyl-5-(2-hydroxyethyl)-thiazole phosphate (HET-P)" GraphId="c2a82" Type="Metabolite"> <Graphics CenterX="854.4697777338713" CenterY="585.7639716312179" Width="372.9395554677429" Height="20.0" ZOrder="32781" FontSize="15" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="hydrolase?" 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See also http://pathway.gramene.org/MAIZE/NEW-IMAGE?type=ENZYME&amp;object=GBWI-76117-MONOMER</Comment> <Comment>Type your comment here</Comment> <Graphics CenterX="1499.7566769073194" CenterY="365.8450597070413" Width="348.06560876804997" Height="27.627198652721972" ZOrder="32856" FontSize="15" Valign="Middle" /> <Xref Database="MaizeGDB" ID="GRMZM2G057140" /> </DataNode> <DataNode TextLabel="thiamine diphosphate" GraphId="fa5a4" Type="Metabolite"> <Graphics CenterX="1712.2947097768101" CenterY="756.5799873517277" Width="229.82488154419354" Height="41.9099752061546" ZOrder="32859" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="9532" /> </DataNode> <DataNode TextLabel="Phosphoric acid" GraphId="b8d32" Type="Metabolite"> <Graphics CenterX="1865.0893677071715" CenterY="423.4647418356616" Width="187.821264585657" Height="32.02047230717267" ZOrder="32860" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="26078" /> </DataNode> <DataNode TextLabel="Water" GraphId="eeae1" Type="Metabolite"> <Graphics CenterX="1798.0774841160705" CenterY="329.04254284537484" Width="85.84503176785893" Height="34.683146449204756" ZOrder="32861" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="15377" /> </DataNode> <DataNode TextLabel="thiamine pyrophosphokinase (TPPK))" GraphId="be51b" Type="GeneProduct" GroupRef="cfd90"> <Graphics CenterX="1539.57581643741" CenterY="604.4395642760774" Width="259.0638625319435" Height="32.91104144748195" ZOrder="32863" FontSize="15" Valign="Middle" /> <Xref Database="Enzyme Nomenclature" ID="2.7.6.2" /> </DataNode> <DataNode TextLabel="ATP/GTP" GraphId="daadb" Type="Metabolite"> <Graphics CenterX="1824.286509491774" CenterY="574.0399494569396" Width="110.37938018028932" Height="32.409768351911424" ZOrder="32865" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="AMP/GMP" GraphId="e5f22" Type="Metabolite"> <Graphics CenterX="1830.1088591982746" CenterY="702.2671640206097" Width="111.82560369638195" Height="29.002118343824122" ZOrder="32866" FontSize="20" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="thiamine degradation products transporter (?)" 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