IL-2 signaling pathway (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="IL-2 Signaling Pathway" Organism="Bos taurus" License="Freely available under Creative Commons license"> <Comment Source="WikiPathways-description">IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at [http://www.netpath.org/netslim/IL_2_pathway.html NetSlim] database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP49_r78543 WP49(78543)] with a 98.0% conversion rate.</Comment> <Attribute Key="org.pathvisio.model.WindowHeight" Value="11190.0" /> <Attribute Key="org.pathvisio.model.WindowWidth" Value="15480.0" /> <Graphics BoardWidth="1098.0" BoardHeight="1448.0" /> <DataNode TextLabel="STAT5B" GraphId="fc7b3" Type="Protein" GroupRef="bd7b5"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MLLT7" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="444.75954000000024" CenterY="1288.0" Width="54.0" Height="20.0" ZOrder="-14" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010125" /> </DataNode> <DataNode TextLabel="STAT3" GraphId="e671e" Type="Protein" GroupRef="c670a"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="555.6666666666669" CenterY="1336.8333333333335" Width="56.0" Height="20.0" ZOrder="-12" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021523" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="b7da8" Type="Protein" GroupRef="d0f9c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="504.66666666666686" CenterY="1288.0" Width="54.0" Height="20.0" ZOrder="-10" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="MAPK1" GraphId="ae4fa" Type="Protein" GroupRef="af818"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="100.5" CenterY="1146.6666666666665" Width="53.00000000000002" Height="20.0" ZOrder="-8" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010312" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="d8d19" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="504.5000000000001" CenterY="876.0" Width="51.666666666666515" Height="20.0" ZOrder="-6" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="AKT1" GraphId="bd3e5" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="AKT1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="320.99999999999983" CenterY="912.6666666666665" Width="41.666666666666664" Height="20.0" ZOrder="-4" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000017636" /> </DataNode> <DataNode TextLabel="CBL" GraphId="f6f75" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:867</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TEC" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="187.66666666666652" CenterY="779.0" Width="40.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006817" /> </DataNode> <DataNode TextLabel="GAB2" GraphId="ab2ca" Type="Protein"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GAB2" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="231.99999999999972" CenterY="695.0" Width="43.333333333333336" Height="20.0" ZOrder="32770" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="MAP2K2" GraphId="ddece" Type="Protein" GroupRef="f008c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K2" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="100.33333333333303" CenterY="1079.6666666666665" Width="60.0" Height="20.0" ZOrder="32772" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000024450" /> </DataNode> <DataNode TextLabel="SHC1" GraphId="e81bd" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SHC1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="112.83333333333326" CenterY="625.0" Width="50.333333333333485" Height="20.0" ZOrder="32776" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000019838" /> </DataNode> <DataNode TextLabel="FYN" GraphId="d96bc" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SHC1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="237.0" CenterY="559.0" Width="34.0" Height="20.0" ZOrder="32778" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011851" /> </DataNode> <DataNode TextLabel="IL2" GraphId="c1e37" Type="Protein" GroupRef="fe675"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3558</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="378.3333333333336" CenterY="245.0" Width="33.333333333333336" Height="20.0" ZOrder="32780" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020883" /> </DataNode> <DataNode TextLabel="CRKL" GraphId="b3311" Type="Protein"> <Comment></Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK9" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="147.33333333333326" CenterY="858.3333333333334" Width="41.333333333333485" Height="19.333333333333258" ZOrder="32784" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000045548" /> </DataNode> <DataNode TextLabel="LCK" GraphId="a7625" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3932</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HCK" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="307.6666666666665" CenterY="659.8063993519645" Width="40.0" Height="20.0" ZOrder="32796" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000012695" /> </DataNode> <DataNode TextLabel="STAT5B" GraphId="d6dad" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT5B" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="444.3333333333336" CenterY="745.6666666666667" Width="57.333333333333485" Height="20.0" ZOrder="32798" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010125" /> </DataNode> <DataNode TextLabel="IL2RG" GraphId="aacc7" Type="Protein" GroupRef="fe675"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3561</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6ST" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="452.0" CenterY="407.0" Width="70.0" Height="20.0" ZOrder="32818" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007626" /> </DataNode> <DataNode TextLabel="RPS6" GraphId="b7974" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="320.3333333333335" CenterY="1163.0" Width="50.0" Height="20.0" ZOrder="32822" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000014449" /> </DataNode> <DataNode TextLabel="MYC" GraphId="dbbd3" Type="Rna"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="342.3333333333335" CenterY="1361.0" Width="50.0" Height="20.0" ZOrder="32822" FontName="SansSerif" FontStyle="Italic" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000008409" /> </DataNode> <DataNode TextLabel="BCL2" GraphId="f4d0f" Type="Rna"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="281.3333333333335" CenterY="1360.0" Width="50.0" Height="20.0" ZOrder="32822" FontName="SansSerif" FontStyle="Italic" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000019302" /> </DataNode> <DataNode TextLabel="JUN" GraphId="f0721" Type="Rna"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="129.33333333333348" CenterY="1347.0" Width="50.0" Height="20.0" ZOrder="32822" FontName="SansSerif" FontStyle="Italic" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004037" /> </DataNode> <DataNode TextLabel="CCND2" GraphId="c20d9" Type="Rna"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="496.00000000000034" CenterY="1407.0" Width="50.0" Height="20.0" ZOrder="32822" FontName="SansSerif" FontStyle="Italic" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016649" /> </DataNode> <DataNode TextLabel="IL2RA" GraphId="aaeaa" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134460</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="432.00000000000034" CenterY="1408.0" Width="50.0" Height="20.0" ZOrder="32822" FontName="SansSerif" FontStyle="Italic" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020892" /> </DataNode> <DataNode TextLabel="FOS" GraphId="eb0d4" Type="Rna"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="69.33333333333348" CenterY="1347.0" Width="50.0" Height="20.0" ZOrder="32822" FontName="SansSerif" FontStyle="Italic" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004322" /> </DataNode> <DataNode TextLabel="IL2RA" GraphId="ce87a" Type="Protein" GroupRef="fe675"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134460</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6ST" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="300.0" CenterY="407.0" Width="76.0" Height="20.0" ZOrder="32832" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020892" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="dce3a" Type="Protein" GroupRef="d0f9c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="504.33333333333337" CenterY="1268.6666666666667" Width="54.0" Height="20.0" ZOrder="32834" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="MAPT" GraphId="dd415" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4137</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPT" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="320.99999999999983" CenterY="990.0" Width="46.666666666666664" Height="20.0" ZOrder="32836" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000017512" /> </DataNode> <DataNode TextLabel="SOS1" GraphId="c89bf" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SOS1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="99.99999999999994" CenterY="858.0" Width="43.333333333333336" Height="20.0" ZOrder="32840" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011643" /> </DataNode> <DataNode TextLabel="RAF1" GraphId="d7a9c" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAF1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="100.00000000000028" CenterY="989.6666666666665" Width="41.666666666666664" Height="20.0" ZOrder="32860" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000045748" /> </DataNode> <DataNode TextLabel="MAP2K1" GraphId="b6079" Type="Protein" GroupRef="f008c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="100.66666666666697" CenterY="1056.6666666666665" Width="60.0" Height="20.0" ZOrder="32868" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000033983" /> </DataNode> <DataNode TextLabel="IL2RB" GraphId="bad8b" Type="Protein" GroupRef="fe675"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3560</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6R" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="377.5" CenterY="407.0" Width="77.0" Height="20.0" ZOrder="32876" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016345" /> </DataNode> <DataNode TextLabel="STAT3" GraphId="ea4b4" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="601.8333333333335" CenterY="802.0" Width="66.33333333333303" Height="20.0" ZOrder="32886" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021523" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="e6a2e" Type="Protein" GroupRef="c670a"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="555.6666666666669" CenterY="1315.0" Width="56.000000000000014" Height="20.0" ZOrder="32892" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="CISH" GraphId="c6c46" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1154</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="681.3333333333328" CenterY="665.0" Width="60.0" Height="20.0" ZOrder="32896" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000022622" /> </DataNode> <DataNode TextLabel="FOXO3" GraphId="dd83c" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2309</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FOXO3A" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="221.66666666666669" CenterY="913.1030494216614" Width="61.842893333333336" Height="20.0" ZOrder="32903" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011234" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="ad218" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="504.33333333333337" CenterY="818.6666666666667" Width="50.0" Height="20.0" ZOrder="32908" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="GRB2" GraphId="db5db" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="99.99999999999983" CenterY="779.0" Width="46.666666666666664" Height="20.0" ZOrder="32918" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004736" /> </DataNode> <DataNode TextLabel="JAK3" GraphId="dba31" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3718</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK2" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="618.833333333333" CenterY="624.9999999999999" Width="57.0" Height="20.0" ZOrder="32920" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020904" /> </DataNode> <DataNode TextLabel="MAPK3" GraphId="b11ca" Type="Protein" GroupRef="af818"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="100.73426666666683" CenterY="1168.6666666666665" Width="52.53146666666629" Height="20.0" ZOrder="32928" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016156" /> </DataNode> <DataNode TextLabel="STAT3" GraphId="ed41b" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="601.6666666666663" CenterY="876.0" Width="54.0" Height="20.0" ZOrder="32931" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021523" /> </DataNode> <DataNode TextLabel="PTK2B" GraphId="c88ee" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2185</Comment> <Attribute 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Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RPS6KB1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="321.33333333333337" CenterY="1079.0" Width="67.16199999999999" Height="20.0" ZOrder="32952" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016851" /> </DataNode> <DataNode TextLabel="RPS6KB2" GraphId="b8363" Type="Protein" GroupRef="f090d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6199</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RPS6KB1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="320.5" CenterY="1102.0" Width="67.0" Height="20.0" ZOrder="32954" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009175" /> </DataNode> <DataNode TextLabel="JAK1" GraphId="ddbe6" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK1" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="396.3333333333335" CenterY="625.0" Width="58.0" Height="20.0" ZOrder="32960" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000003147" /> </DataNode> <DataNode TextLabel="STAT5A" GraphId="cbcf2" Type="Protein" GroupRef="bd7b5"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3" /> <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value="" /> <Graphics CenterX="444.66666666666686" CenterY="1268.0" Width="54.0" Height="20.0" ZOrder="32964" 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