Type III interferon signaling (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Type III interferon signaling" Author="Shamith Samarajiwa" Organism="Bos taurus"> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">The recently identified type III interferon group consists of three IFN-λ (lambda) genes encoding molecules called IFN-λ1, IFN-λ2 and IFN-λ3 (also called IL29, IL28A and IL28B respectively). These IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12).</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP2113_r70107 WP2113(70107)] with a 75.0% conversion rate.</Comment> <Graphics BoardWidth="1413.0" BoardHeight="1224.0" /> <DataNode TextLabel="IRF9" GraphId="fdbcc" Type="GeneProduct" GroupRef="dfa12"> <Comment Source="HomologyConvert">HomologyConvert: Multiple homologues found: En:ENSBTAG00000005816;En:ENSBTAG00000005815;</Comment> <Graphics CenterX="671.0" CenterY="546.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="IL28A" GraphId="eb7e9" Type="GeneProduct"> <Graphics CenterX="509.0" CenterY="152.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="IFNL1" GraphId="d26ec" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:282618</Comment> <Graphics CenterX="703.0" CenterY="97.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Ensembl" ID="ENSBTAG00000047691" /> </DataNode> <DataNode TextLabel="IL28B" GraphId="caf9d" Type="GeneProduct"> <Graphics CenterX="584.0" CenterY="118.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="JAK1" GraphId="e5c12" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716</Comment> <Graphics CenterX="581.0" CenterY="285.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Ensembl" ID="ENSBTAG00000003147" /> </DataNode> <DataNode TextLabel="IL10RB" GraphId="a02a0" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3588</Comment> <Graphics CenterX="676.0" CenterY="258.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Ensembl" ID="ENSBTAG00000019404" /> </DataNode> <DataNode TextLabel="TYK2" GraphId="c88d5" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7297</Comment> <Graphics CenterX="688.0" CenterY="283.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011698" /> </DataNode> <DataNode TextLabel="IFNLR1" GraphId="f78d0" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:163702</Comment> <Graphics CenterX="587.0" CenterY="257.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Ensembl" ID="ENSBTAG00000001101" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="eaf54" Type="GeneProduct" GroupRef="a1343"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Graphics CenterX="476.0" CenterY="513.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="STAT2" GraphId="c38be" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773</Comment> <Graphics CenterX="670.0" CenterY="463.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004380" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="bb515" Type="GeneProduct" GroupRef="a1343"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Graphics CenterX="474.0" CenterY="491.0" Width="80.0" Height="20.0" ZOrder="32773" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="b7ba1" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Graphics CenterX="672.0" CenterY="505.0" Width="80.0" Height="20.0" ZOrder="32774" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <Interaction GraphId="id79da6b86" GroupRef="dfa12"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="636.5" Y="345.0" GraphRef="ce6db" RelX="0.0" RelY="1.0" /> <Point X="671.75" Y="435.5" GraphRef="da410" RelX="0.0" 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GraphId="idce034040"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="584.0" Y="128.0" GraphRef="caf9d" RelX="0.0" RelY="1.0" /> <Point X="636.5" Y="208.5" GraphRef="ce6db" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="id7ddc5757"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="509.0" Y="162.0" GraphRef="eb7e9" RelX="0.0" RelY="1.0" /> <Point X="636.5" Y="208.5" GraphRef="ce6db" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="idff1e426a"> <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0"> <Point X="636.5" Y="345.0" GraphRef="ce6db" RelX="0.0" RelY="1.0" /> <Point X="479.75" Y="458.5" GraphRef="e22fd" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Label TextLabel="ISGF3 complex" GraphId="adca3" GroupRef="dfa12"> <Graphics CenterX="724.0" 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