Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling (Mus musculus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling" Version="20160618" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">The signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth. The kinase Akt, or protein kinase B (PKB), is a central component in the pathway and is involved in both muscle synthesis, through mammalian target of rapmycin (mTOR) and glycogen synthase kinase 3B (GSK3B), and muscle degradation, through the transcription factors of the FoxO family. The pathway also involves several feedback loops such as the negative feedback of S6K, phosphorylated by mTORC1, which inhibits IRS, or the positive feedback of mTORC2, which is necessary to maximize the activation of Akt. A variety of other factors and pathways also influence the IGF1-Akt signaling pathway at various points. </Comment> <BiopaxRef>a03</BiopaxRef> <Graphics BoardWidth="1095.126050420168" BoardHeight="803.0566448801741"/> <DataNode TextLabel="IGF1" GraphId="f9c43" Type="GeneProduct"> <Graphics CenterX="546.0555555555555" CenterY="74.7037037037037" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000017427"/> </DataNode> <DataNode TextLabel="IGF1rec&#10;" GraphId="f5259" Type="GeneProduct"> <Graphics CenterX="546.0555555555555" CenterY="141.7037037037037" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000140443"/> </DataNode> <DataNode TextLabel="IRS1" GraphId="ceb96" Type="GeneProduct"> <Comment>not sure, because also 2, 3, 4</Comment> <Graphics CenterX="546.0555555555555" CenterY="203.7037037037037" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000169047"/> </DataNode> <DataNode TextLabel="PI3K" GraphId="a2d31" Type="GeneProduct"> <Comment>phosphatidlinositol 3-kinase</Comment> <Graphics CenterX="546.0555555555555" CenterY="266.7037037037037" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000105851"/> </DataNode> <DataNode TextLabel="PDK1" GraphId="dbe54" Type="GeneProduct"> <Graphics CenterX="546.0555555555555" CenterY="330.7037037037037" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000152256"/> </DataNode> <DataNode TextLabel="AKT1" GraphId="c0520" Type="GeneProduct"> <Graphics CenterX="546.0555555555555" CenterY="385.50420168067217" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000142208"/> </DataNode> <DataNode TextLabel="FoxO " GraphId="b2305" Type="GeneProduct"> <Comment>family of transcription factors </Comment> <Graphics CenterX="627.3055555555555" CenterY="457.4537037037037" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="MTOR" GraphId="e232e" Type="GeneProduct"> <Comment>effect of AKT on MTOR is indirect</Comment> <Comment>Part of two multiprotein complexes, TORC 1 and TORC 2</Comment> <Graphics CenterX="412.30555555555554" CenterY="453.25202303143476" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000198793"/> </DataNode> <DataNode TextLabel="MAFbx" GraphId="c7b3c" Type="GeneProduct"> <Comment>FBXO32/atrogin-1 </Comment> <Graphics CenterX="527.0555555555555" CenterY="536.6532835356364" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000156804"/> </DataNode> <DataNode TextLabel="MURF1&#10;" GraphId="cd260" Type="GeneProduct"> <Comment>TRIM63</Comment> <Graphics CenterX="734.4484126984153" CenterY="536.6532835356364" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000158022"/> </DataNode> <DataNode TextLabel="LC3" GraphId="c90fd" Type="GeneProduct"> <Graphics CenterX="626.6584967320262" CenterY="535.602863367569" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000101460"/> </DataNode> <DataNode TextLabel="GSK3B" GraphId="a169c" Type="GeneProduct"> <Graphics CenterX="702.7310924369748" CenterY="385.5042016806723" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000082701"/> </DataNode> <DataNode TextLabel="EIF2B2" GraphId="a5550" Type="GeneProduct"> <Graphics CenterX="824.5798319327731" CenterY="385.5042016806723" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000119718"/> </DataNode> <DataNode 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