PDGF pathway (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="PDGF Pathway" Organism="Bos taurus"> <Comment Source="WikiPathways-description">PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized to the chromosomes 7p22, 22q13, 4q31, and 11q22, respectively, and their expression is independently regulated. Two forms of the PDGF A-chain, containing 196 and 211 amino acid residues resulting from differential splicing of the transcript, are synthesized, dimerized, proteolytically processed in the Nterminus, and secreted from the cell as a ~30 kDa dimer. The PDGF B chain encoding 241 amino acid residues is dimerized, processed by additional proteolysis, and secreted as a 24 kDa dimer. The homodimers PDGF AA, BB, and the heterodimer AB contain three intrachain disulfide bonds made between the 1st </Comment> <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP2526_r96312 WP2526_96312] with a 90.0% conversion rate.</Comment> <Graphics BoardWidth="1625.4106059895714" BoardHeight="1171.943549882923" /> <DataNode TextLabel="GRB2" GraphId="a29c7" Type="Protein" GroupRef="ec31a"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P62993</Comment> <Graphics CenterX="807.3446721227585" CenterY="184.94886667833742" Width="42.98507462686574" Height="19.223520542781756" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004736" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="a8240" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P42224</Comment> <Graphics CenterX="622.4388892787503" CenterY="342.1493775791582" Width="49.41654357459356" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="STAT3" GraphId="ac0a0" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P40763</Comment> <Graphics CenterX="673.3663407469754" CenterY="368.0364807172311" Width="47.96602658788697" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021523" /> </DataNode> <DataNode TextLabel="NFkB" GraphId="b713e" Type="GeneProduct"> <Graphics CenterX="687.4876340484518" CenterY="713.1584612694329" Width="45.97250639774806" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="JUN" GraphId="b7458" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P05412</Comment> <Graphics CenterX="915.2775956165693" CenterY="873.3476657099354" Width="44.20168067226891" Height="37.31092436974787" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004037" /> </DataNode> <DataNode TextLabel="RASA1" GraphId="b8841" Type="GeneProduct" GroupRef="b4360"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000145715</Comment> <Graphics CenterX="720.0140198952583" CenterY="200.40828774379284" Width="67.27348362412408" Height="20.276039606235194" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009565" /> </DataNode> <DataNode TextLabel="PTPN11" GraphId="c148a" Type="GeneProduct" GroupRef="d7d95"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q06124</Comment> <Graphics CenterX="712.0681567281886" CenterY="171.6753164926957" Width="50.57521622540341" Height="30.80736740063698" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000002048" /> </DataNode> <DataNode TextLabel="SOS1" GraphId="c188e" Type="Protein" GroupRef="ec31a"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q07889</Comment> <Graphics CenterX="766.6806252256956" CenterY="185.06166491857516" Width="39.253731343283576" Height="19.129625149788367" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011643" /> </DataNode> <DataNode TextLabel="RAF1" GraphId="c7713" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P04049</Comment> <Graphics CenterX="869.8939808481532" CenterY="286.9666471239663" Width="47.352941176470644" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004514" /> </DataNode> <DataNode TextLabel="PDGFRB" GraphId="cf58b" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000113721</Comment> <Graphics CenterX="549.976366322009" CenterY="67.41211225997048" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000002804" /> </DataNode> <DataNode TextLabel="MAPK8" GraphId="d1d14" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P45983</Comment> <Graphics CenterX="1040.341464063904" CenterY="722.535195724027" Width="53.65546218487403" Height="35.21008403361357" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007876" /> </DataNode> <DataNode TextLabel="SHC1" GraphId="d4168" Type="Protein" GroupRef="ec31a"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P29353</Comment> <Graphics CenterX="786.0646230653695" CenterY="166.03561161929764" Width="38.50746268656712" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000019838" /> </DataNode> <DataNode TextLabel="MAPK3" GraphId="d4fa5" Type="GeneProduct" GroupRef="ce852"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5595</Comment> <Graphics CenterX="1266.6666666666697" CenterY="704.2735042735039" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016156" /> </DataNode> <DataNode TextLabel="MAP2K4" GraphId="d7869" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6416</Comment> <Graphics CenterX="1040.060725037387" CenterY="614.6817863303739" Width="57.85714285714297" Height="42.563025210083914" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000012103" /> </DataNode> <DataNode TextLabel="PLCG1" GraphId="d82bc" Type="GeneProduct" GroupRef="cea31"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000124181</Comment> <Graphics CenterX="713.9149780796612" CenterY="143.3548167980667" Width="55.2553315733569" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000017584" /> </DataNode> <DataNode TextLabel="PDGFA" GraphId="d941a" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5154</Comment> <Graphics CenterX="660.2710626065132" CenterY="61.10279447394987" Width="16.63157894736836" Height="63.79532163742684" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000014541" /> </DataNode> <DataNode TextLabel="MAPK1" GraphId="dded5" Type="GeneProduct" GroupRef="ce852"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5594</Comment> <Graphics CenterX="1266.6666666666697" CenterY="687.1794871794872" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010312" /> </DataNode> <DataNode TextLabel="MAP3K1" GraphId="e7616" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q13233</Comment> <Graphics CenterX="960.252462151823" CenterY="473.16412611556257" Width="54.70588235294113" Height="40.46218487394966" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000013790" /> </DataNode> <DataNode TextLabel="PDGFB" GraphId="e93e3" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5155</Comment> <Graphics CenterX="545.3428473421613" CenterY="30.114316116444222" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021697" /> </DataNode> <DataNode TextLabel="MAP2K1" GraphId="e97a4" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:Q02750</Comment> <Graphics CenterX="938.4693179597404" CenterY="350.56787831411674" Width="49.45378151260512" Height="38.361344537815185" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000033983" /> </DataNode> <DataNode TextLabel="HRAS" GraphId="f1bc5" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3265</Comment> <Graphics CenterX="941.2743098055205" CenterY="140.61403508771912" Width="44.093567251462034" Height="26.374269005847957" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000046644" /> </DataNode> <DataNode TextLabel="PDGFA" GraphId="eea7a" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5154</Comment> <BiopaxRef>c89</BiopaxRef> <BiopaxRef>b3a</BiopaxRef> <BiopaxRef>b2c</BiopaxRef> <BiopaxRef>a00</BiopaxRef> <BiopaxRef>f4a</BiopaxRef> <BiopaxRef>b74</BiopaxRef> <BiopaxRef>dd5</BiopaxRef> <BiopaxRef>c65</BiopaxRef> <BiopaxRef>dc2</BiopaxRef> <BiopaxRef>d53</BiopaxRef> <Graphics CenterX="637.2884266057393" CenterY="61.02174730146044" Width="16.63157894736836" Height="63.79532163742684" ZOrder="32777" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000014541" /> </DataNode> <DataNode TextLabel="NFkB" GraphId="cddfa" Type="GeneProduct"> <Graphics CenterX="578.8411541108077" CenterY="902.1289992720343" Width="45.97250639774806" Height="20.0" ZOrder="32778" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="ceee5" Type="Protein" GroupRef="d5783"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P42224</Comment> <Graphics CenterX="758.6036859325117" CenterY="363.34503159625393" Width="49.41654357459356" Height="20.0" ZOrder="32783" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="STAT3" GraphId="efacb" Type="Protein" GroupRef="d87e6"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P40763</Comment> <Graphics CenterX="718.4436310048392" CenterY="431.14635429257584" Width="47.96602658788697" Height="20.0" ZOrder="32784" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021523" /> </DataNode> <DataNode TextLabel="STAT3" GraphId="d2628" Type="Protein" GroupRef="fb8d4"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P40763</Comment> <Graphics CenterX="816.7800949139548" CenterY="550.4525208320601" Width="49.37806257067477" Height="20.0" ZOrder="32785" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021523" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="dafd5" Type="Protein" GroupRef="fb8d4"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P42224</Comment> <Graphics CenterX="816.8792109894545" CenterY="531.22356957652" Width="49.41654357459356" Height="20.0" ZOrder="32786" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="STAT3" GraphId="bd14b" Type="Protein" GroupRef="a2628"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P40763</Comment> <Graphics CenterX="756.2545901690492" CenterY="912.5675402836014" Width="49.37806257067477" Height="20.0" ZOrder="32800" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021523" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="fdd3f" Type="Protein" GroupRef="a2628"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P42224</Comment> <Graphics CenterX="756.3537062445487" CenterY="893.3385890280608" Width="49.41654357459356" Height="20.0" ZOrder="32801" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="JAK1" GraphId="b8298" Type="Protein" GroupRef="b25c2"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P23458</Comment> <Graphics CenterX="676.6302749513349" CenterY="248.68493911430653" Width="43.06715063520869" Height="20.0" ZOrder="32810" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000003147" /> </DataNode> <DataNode TextLabel="Cyclic AMP&#xA;(cAMP)" GraphId="cbdf4" Type="Metabolite"> <Graphics CenterX="1448.5945257414332" CenterY="663.6880546370187" Width="63.01963439404206" Height="35.727826675693706" ZOrder="32832" FontSize="10" Valign="Middle" 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<Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P00403</Comment> <Graphics CenterX="1343.963751202572" CenterY="456.9698661563478" Width="42.937500396530865" Height="20.0" ZOrder="32836" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000043556" /> </DataNode> <DataNode TextLabel="PIP2[4',5']" GraphId="d1003" Type="Metabolite"> <Graphics CenterX="1277.131853697329" CenterY="136.77959949404263" Width="62.97667020148447" Height="17.542005340279598" ZOrder="32837" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="LIPID MAPS" ID="LMGP08010003" /> </DataNode> <DataNode TextLabel="Ca2+" GraphId="e2e76" Type="Metabolite"> <Graphics CenterX="1442.3647965937973" CenterY="35.72378138847861" Width="42.0" Height="20.0" ZOrder="32838" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="Phospholipid&#xA;(containing arachidonic acid)" GraphId="bf4f4" Type="Metabolite"> <Graphics CenterX="1230.3018069429559" CenterY="318.9188679539103" Width="143.31632653061246" Height="32.95918367346961" ZOrder="32839" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16247" /> </DataNode> <DataNode TextLabel="PLA2G4A" GraphId="aa8c7" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000116711</Comment> <Graphics CenterX="1387.3316212383443" CenterY="348.0440251257846" Width="65.05077860528097" Height="28.95734597156399" ZOrder="32840" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000013298" /> </DataNode> <DataNode TextLabel="Cell proliferation" GraphId="f9a51" Type="Pathway"> <Graphics CenterX="1400.5611405342156" CenterY="835.2214496085646" Width="111.71293161814498" Height="27.603249830738076" ZOrder="32841" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="&#xA;Ca&#xA;&#xA;c&#xA;h&#xA;a&#xA;n&#xA;n&#xA;e&#xA;l" GraphId="f3727" Type="Protein"> <Graphics CenterX="1390.8502400602822" CenterY="126.04131693350254" Width="24.0" Height="118.0" ZOrder="32842" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="[Ca2+]i" GraphId="d597f" Type="Metabolite"> <Graphics CenterX="1434.7615467630574" CenterY="261.7021158502255" Width="42.0" Height="20.0" ZOrder="32843" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="Arachidonic acid" GraphId="f08b4" Type="Metabolite"> <Graphics CenterX="1230.3018069429495" CenterY="385.0362148926864" Width="93.10204081632833" Height="21.112244897959613" ZOrder="32845" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB01043" /> </DataNode> <DataNode TextLabel="ELK1" GraphId="fb4f9" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P19419</Comment> <Graphics CenterX="1035.4668078119828" CenterY="917.2272294675781" Width="42.35216308745703" Height="27.571973233737253" ZOrder="32849" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000015817" /> </DataNode> <DataNode TextLabel="FOS" GraphId="e8d70" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P01100</Comment> <Graphics CenterX="977.1797707749465" CenterY="923.7550072453562" Width="42.35216308745703" Height="27.571973233737253" ZOrder="32850" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004322" /> </DataNode> <DataNode TextLabel="SRF" GraphId="be021" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P11831</Comment> <Graphics CenterX="1099.448289293464" CenterY="914.0790813194305" 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Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29101" /> </DataNode> <DataNode TextLabel="PIK3R1" GraphId="e8254" Type="Protein" GroupRef="b39f9"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P27986</Comment> <Graphics CenterX="582.3004318530307" CenterY="198.35816621288683" Width="54.6202472782972" Height="30.578724219049608" ZOrder="32858" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010989" /> </DataNode> <DataNode TextLabel="SRC" GraphId="fde06" Type="Protein" GroupRef="ff7b7"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = S:P12931</Comment> <Graphics CenterX="583.1278661917005" CenterY="159.36843004754036" Width="54.6202472782972" Height="30.578724219049608" ZOrder="32862" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000008938" /> </DataNode> <DataNode TextLabel="TIAM1" GraphId="e6678" Type="Protein"> <Comment 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