Eicosanoid synthesis (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Eicosanoid Synthesis" Organism="Homo sapiens"> <Comment Source="GenMAPP notes"></Comment> <Comment Source="GenMAPP remarks"></Comment> <Comment Source="WikiPathways-category">Metabolic Process</Comment> <Comment Source="WikiPathways-description">In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]. This pathway has been updated with information from Lipidmaps&gt;Eicosanoids [https://lipidmaps.org/resources/pathways/vanted.php]. Metabolites and proteins from this pathway have an rounded ractangle shape (where an oval shape indicates that the node only occures in the LipidMaps pathway). Reactions occurring in the lipidmaps pathways are coloured orange (where a dashed line indicates that the reaction only occures in the LipidMaps pathway). </Comment> <BiopaxRef>a1a</BiopaxRef> <Graphics BoardWidth="1140.7958314895225" BoardHeight="822.0197215777263" /> <DataNode TextLabel="ALOX5AP" GraphId="a08" Type="GeneProduct" GroupRef="ad2f8"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ALOX5AP | arachidonate 5-lipoxygenase-activatin..." /> <Graphics CenterX="688.2449617112557" CenterY="315.5413113426187" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="241" /> </DataNode> <DataNode TextLabel="5-HETE" GraphId="a0d" Type="Metabolite"> <Graphics CenterX="723.2002783388095" CenterY="474.54715069906456" Width="63.333333333333336" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="ff9900" /> <Xref Database="CAS" ID="70608-72-9" /> </DataNode> <DataNode 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