p38 MAPK signaling pathway (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="p38 MAPK signaling pathway" Organism="Bos taurus"> <Comment Source="WikiPathways-description">p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.</Comment> <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP400_r95117 WP400 (r95117)] with a 97.0% conversion rate.</Comment> <BiopaxRef>a09</BiopaxRef> <BiopaxRef>d07</BiopaxRef> <BiopaxRef>c22</BiopaxRef> <BiopaxRef>a36</BiopaxRef> <BiopaxRef>cae</BiopaxRef> <BiopaxRef>c41</BiopaxRef> <BiopaxRef>bb5</BiopaxRef> <BiopaxRef>f85</BiopaxRef> <Graphics BoardWidth="764.6666666666666" BoardHeight="873.0"/> <DataNode TextLabel="MAPKAPK2" GraphId="a00" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9261</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPKAPK2 | mitogen-activated protein kinase-act..."/> <Graphics CenterX="662.3333333333334" CenterY="570.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000038107"/> </DataNode> <DataNode TextLabel="GRB2" GraphId="a30" Type="GeneProduct" GroupRef="b85a4"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2885</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2 | growth factor receptor-bound protein 2"/> <Graphics CenterX="133.45913978494642" CenterY="227.01258064516125" Width="46.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004736"/> </DataNode> <DataNode TextLabel="TRAF2" GraphId="a3c" Type="GeneProduct" GroupRef="e6a4d"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7186</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TRAF2 | TNF receptor-associated factor 2"/> <Graphics CenterX="666.6666666666666" CenterY="220.0" Width="46.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000010497"/> </DataNode> <DataNode TextLabel="MAPKAPK5" GraphId="a3f" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8550</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPKAPK5 | mitogen-activated protein kinase-act..."/> <Graphics CenterX="523.3333333333333" CenterY="503.3333333333333" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009346"/> </DataNode> <DataNode TextLabel="HSPB1" GraphId="a76" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3315</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HSPB1 | heat shock 27kDa protein 1"/> <Graphics CenterX="629.3333333333334" CenterY="503.0" Width="53.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011969"/> </DataNode> <DataNode TextLabel="SHC1" GraphId="aa6" Type="GeneProduct" GroupRef="b85a4"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6464</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SHC1 | SHC (Src homology 2 domain containing) t..."/> <Graphics CenterX="136.2657258064516" CenterY="207.01258064516128" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019838"/> </DataNode> <DataNode TextLabel="MAP2K6" GraphId="ab1" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5608</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K6 | mitogen-activated protein kinase kinas..."/> <Graphics CenterX="363.3333333333333" CenterY="403.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000001609"/> </DataNode> <DataNode TextLabel="MAP3K9" GraphId="aba" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4293</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP3K9 | mitogen-activated protein kinase kinas..."/> <Graphics CenterX="323.3333333333333" CenterY="310.0" Width="93.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005700"/> </DataNode> <DataNode TextLabel="RAC1" GraphId="b32" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5879</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAC1 | ras-related C3 botulinum toxin substrate..."/> <Graphics CenterX="273.33333333333337" 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Width="53.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000046545"/> </DataNode> <DataNode TextLabel="ATF2" GraphId="b55" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1386</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATF2 | activating transcription factor 2"/> <Graphics CenterX="495.6666666666667" CenterY="684.6666666666666" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002295"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="b96" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1 | signal transducer and activator of tran..."/> <Graphics CenterX="186.66666666666666" CenterY="674.6666666666666" 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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">p38 MAPK signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000198</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c22"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10207619</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Making the connection: coupling of stress-activated 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