Hepatocyte growth factor receptor signaling (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Hepatocyte growth factor receptor signaling" Organism="Bos taurus"> <Comment Source="WikiPathways-description">Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.</Comment> <Comment Source="GenMAPP notes"></Comment> <Comment Source="GenMAPP remarks">Converted to human by GenMAPP.org</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP313_r79946 WP313(79946)] with a 100.0% conversion rate.</Comment> <Graphics BoardWidth="964.1666666666667" BoardHeight="705.0" /> <DataNode TextLabel="FOS" GraphId="ffb" Type="GeneProduct" GroupRef="d658e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FOS | v-fos FBJ murine osteosarcoma viral oncog..." /> <Graphics CenterX="746.6666666666666" CenterY="406.6666666666667" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004322" /> </DataNode> <DataNode TextLabel="PTPN11" GraphId="f7a" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTPN11 | protein tyrosine phosphatase non-rece..." /> <Graphics CenterX="373.3333333333333" CenterY="143.33333333333334" Width="53.333333333333336" Height="20.0" ZOrder="32770" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000002048" /> </DataNode> <DataNode TextLabel="ELK1" GraphId="c92" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ELK1 | ELK1 member of ETS oncogene family" /> <Graphics CenterX="650.0" CenterY="460.0" Width="40.0" Height="20.0" ZOrder="32772" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000015817" /> </DataNode> <DataNode TextLabel="MAP4K1" GraphId="c3e" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11184</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP4K1 | mitogen-activated protein kinase kinas..." /> <Graphics CenterX="540.0" CenterY="243.33333333333334" Width="60.0" Height="20.0" ZOrder="32774" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021145" /> </DataNode> <DataNode TextLabel="PXN" GraphId="f8b" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5829</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PXN | paxillin" /> <Graphics CenterX="276.6666666666667" CenterY="163.33333333333334" Width="53.333333333333336" Height="20.0" ZOrder="32776" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000018108" /> </DataNode> <DataNode TextLabel="MAPK1" GraphId="cf0" Type="GeneProduct" GroupRef="de5d2"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK1 | mitogen-activated protein kinase 1" /> <Graphics CenterX="650.0" CenterY="326.6666666666667" Width="53.333333333333336" Height="20.0" ZOrder="32778" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010312" /> </DataNode> <DataNode TextLabel="PIK3CA" GraphId="d55" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PIK3CA | phosphoinositide-3-kinase catalytic ..." /> <Graphics CenterX="270.0" CenterY="220.0" Width="53.333333333333336" Height="20.0" ZOrder="32780" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009232" /> </DataNode> <DataNode TextLabel="PAK1" GraphId="d46" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PAK1 | p21/Cdc42/Rac1-activated kinase 1 (STE20..." /> <Graphics CenterX="133.33333333333334" CenterY="473.3333333333333" Width="40.0" Height="20.0" ZOrder="32782" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010191" /> </DataNode> <DataNode TextLabel="GRB2" GraphId="eb2" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2 | growth factor receptor-bound protein 2" /> <Graphics CenterX="326.6666666666667" CenterY="143.33333333333334" Width="40.0" Height="20.0" ZOrder="32784" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004736" /> </DataNode> <DataNode TextLabel="PXN" GraphId="aec" Type="GeneProduct" GroupRef="c1e29"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5829</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PXN | paxillin" /> <Graphics CenterX="83.33333333333333" CenterY="126.66666666666667" Width="53.333333333333336" Height="20.0" ZOrder="32786" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000018108" /> </DataNode> <DataNode TextLabel="MAPK8" GraphId="d51" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK8 | mitogen-activated protein kinase 8" /> <Graphics CenterX="543.3333333333334" CenterY="313.3333333333333" Width="80.0" Height="20.0" ZOrder="32788" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007876" /> </DataNode> <DataNode TextLabel="C-MET" GraphId="c41" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4233</Comment> <Graphics CenterX="306.6666666666667" CenterY="96.66666666666667" Width="40.0" Height="20.0" ZOrder="32790" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006161" /> </DataNode> <DataNode TextLabel="PTK2B" GraphId="c28" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2185</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTK2B | PTK2B protein tyrosine kinase 2 beta" /> <Graphics CenterX="310.0" CenterY="183.33333333333334" Width="46.666666666666664" Height="20.0" ZOrder="32792" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000005958" /> </DataNode> <DataNode TextLabel="JUN" GraphId="e66" Type="GeneProduct" GroupRef="d658e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JUN | v-jun sarcoma virus 17 oncogene homolog (..." /> <Graphics CenterX="746.6666666666666" CenterY="386.6666666666667" Width="40.0" Height="20.0" ZOrder="32794" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004037" /> </DataNode> <DataNode TextLabel="SRC" GraphId="c7d" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral ..." /> <Graphics CenterX="256.6666666666667" CenterY="193.33333333333334" Width="33.333333333333336" Height="20.0" ZOrder="32796" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000008938" /> </DataNode> <DataNode TextLabel="RAP1B" GraphId="a5c" Type="GeneProduct" GroupRef="d2132"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAP1B | RAP1B member of RAS oncogene family" /> <Graphics CenterX="453.3333333333333" CenterY="410.0" Width="53.333333333333336" Height="20.0" ZOrder="32798" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000008967" /> </DataNode> <DataNode TextLabel="CRKL" GraphId="da7" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CRKL | v-crk sarcoma virus CT10 oncogene homolo..." /> <Graphics CenterX="350.0" CenterY="313.3333333333333" Width="40.0" Height="20.0" ZOrder="32800" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000045548" /> </DataNode> <DataNode TextLabel="GAB1" GraphId="afd" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2549</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GAB1 | GRB2-associated binding protein 1" /> <Graphics CenterX="340.0" CenterY="163.33333333333334" Width="40.0" Height="20.0" ZOrder="32802" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000002813" /> </DataNode> <DataNode TextLabel="SRC" GraphId="a72" Type="GeneProduct" GroupRef="c1e29"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral ..." /> <Graphics CenterX="100.0" CenterY="166.66666666666666" Width="40.0" Height="20.0" ZOrder="32804" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000008938" /> </DataNode> <DataNode TextLabel="HRAS" GraphId="df3" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HRAS | v-Ha-ras Harvey rat sarcoma viral oncoge..." /> <Graphics CenterX="516.6666666666666" CenterY="110.0" Width="46.666666666666664" Height="20.0" ZOrder="32806" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000046644" /> </DataNode> <DataNode TextLabel="STAT3" GraphId="dad" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3 | signal transducer and activator of tran..." /> <Graphics CenterX="270.0" CenterY="360.0" Width="46.666666666666664" Height="20.0" ZOrder="32808" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021523" /> </DataNode> <DataNode TextLabel="CRK" GraphId="a8c" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CRK | v-crk sarcoma virus CT10 oncogene homolog..." /> <Graphics CenterX="450.0" CenterY="163.33333333333334" Width="40.0" Height="20.0" ZOrder="32810" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000005665" /> </DataNode> <DataNode TextLabel="PTEN" GraphId="b84" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5728</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTEN | phosphatase and tensin homolog (mutated ..." /> <Graphics CenterX="60.0" CenterY="306.6666666666667" Width="40.0" Height="20.0" ZOrder="32812" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009498" /> </DataNode> <DataNode TextLabel="MAP2K2" GraphId="bda" Type="GeneProduct" GroupRef="c7fcd"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K2 | mitogen-activated protein kinase kinas..." /> <Graphics CenterX="650.0" CenterY="206.66666666666666" Width="60.0" Height="20.0" ZOrder="32814" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000024450" /> </DataNode> <DataNode TextLabel="RAF1" GraphId="a5b" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAF1 | v-raf-1 murine leukemia viral oncogene h..." /> <Graphics CenterX="650.0" CenterY="136.66666666666666" Width="40.0" Height="20.0" ZOrder="32816" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000045748" /> </DataNode> <DataNode TextLabel="PTK2" GraphId="eaa" Type="GeneProduct" GroupRef="c1e29"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTK2 | PTK2 protein tyrosine kinase 2" /> <Graphics CenterX="116.66666666666667" CenterY="146.66666666666666" Width="40.0" Height="20.0" ZOrder="32818" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009578" /> </DataNode> <DataNode TextLabel="RAPGEF1" GraphId="a2a" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAPGEF1 | Rap guanine nucleotide exchange facto..." /> <Graphics CenterX="453.0" CenterY="313.3333333333333" Width="66.66666666666667" Height="20.0" ZOrder="32820" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020791" /> </DataNode> <DataNode TextLabel="RASA1" GraphId="c07" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RASA1 | RAS p21 protein activator (GTPase activ..." /> <Graphics CenterX="293.3333333333333" CenterY="203.33333333333334" Width="53.333333333333336" Height="20.0" ZOrder="32822" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009565" /> </DataNode> <DataNode TextLabel="MAPK3" GraphId="fdb" Type="GeneProduct" GroupRef="de5d2"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK3 | mitogen-activated protein kinase 3" /> <Graphics CenterX="650.0" CenterY="306.6666666666667" Width="53.333333333333336" Height="20.0" ZOrder="32824" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016156" /> </DataNode> <DataNode TextLabel="RAP1A" GraphId="ca6" Type="GeneProduct" GroupRef="d2132"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAP1A | RAP1A member of RAS oncogene family" /> <Graphics CenterX="453.3333333333333" CenterY="390.0" Width="53.333333333333336" Height="20.0" ZOrder="32826" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000014710" /> </DataNode> <DataNode TextLabel="MAP2K1" GraphId="c51" Type="GeneProduct" GroupRef="c7fcd"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K1 | mitogen-activated protein kinase kinas..." /> <Graphics CenterX="650.0" CenterY="186.66666666666666" Width="60.0" Height="20.0" ZOrder="32828" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000033983" /> </DataNode> <DataNode TextLabel="ITGB1" GraphId="f3b" Type="GeneProduct" GroupRef="c1e29"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ITGB1 | integrin beta 1 (fibronectin receptor..." /> <Graphics CenterX="83.33333333333333" CenterY="86.66666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32830" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000015910" /> </DataNode> <DataNode TextLabel="PTK2" GraphId="a77" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTK2 | PTK2 protein tyrosine kinase 2" /> <Graphics CenterX="236.66666666666666" CenterY="176.66666666666666" Width="40.0" Height="20.0" ZOrder="32832" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009578" /> </DataNode> <DataNode TextLabel="DOCK1" GraphId="f79" Type="GeneProduct"> <Comment Source="GenMAPP remarks">Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1793</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DOCK1 | dedicator of cytokinesis 1" /> <Graphics CenterX="353.3333333333333" CenterY="393.3333333333333" Width="53.333333333333336" Height="20.0" ZOrder="32834" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000031890" /> </DataNode> <DataNode TextLabel="HGF" GraphId="bb6" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3082</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HGF | hepatocyte growth factor (hepapoietin A; ..." /> <Graphics CenterX="306.6666666666667" CenterY="46.666666666666664" Width="33.333333333333336" Height="20.0" ZOrder="32836" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000017664" /> </DataNode> <DataNode TextLabel="PTK2B" GraphId="ac5" Type="GeneProduct" GroupRef="c1e29"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2185</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTK2B | PTK2B protein tyrosine kinase 2 beta" /> <Graphics CenterX="46.666666666666664" CenterY="146.66666666666666" Width="46.666666666666664" Height="20.0" ZOrder="32838" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000005958" /> </DataNode> <DataNode TextLabel="ITGA1" GraphId="c8a" Type="GeneProduct" GroupRef="c1e29"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3672</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ITGA1 | integrin alpha 1" /> <Graphics CenterX="83.33333333333333" CenterY="106.66666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32842" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016525" /> </DataNode> <DataNode TextLabel="SOS1" GraphId="e2a" Type="GeneProduct"> <Comment Source="GenMAPP remarks">Son of sevenless homolog 1 (Drosophila) (predicted)</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SOS1 | son of sevenless homolog 1 (Drosophila)" /> <Graphics CenterX="343.3333333333333" CenterY="123.33333333333333" Width="40.0" Height="20.0" ZOrder="32844" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011643" /> </DataNode> <State GraphRef="f8b" TextLabel="P" GraphId="f2f93"> <Graphics RelX="-0.602332979851534" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval" /> <Xref Database="" ID="" /> </State> <State GraphRef="c07" TextLabel="P" GraphId="b85ae"> <Graphics RelX="1.0" RelY="0.25768822905620253" Width="15.0" Height="15.0" ShapeType="Oval" /> <Xref Database="" ID="" /> </State> <State GraphRef="a77" TextLabel="P" GraphId="b75e5"> <Graphics RelX="-0.49628844114522686" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval" /> <Xref Database="" ID="" /> </State> <Interaction GraphId="ed8d0"> <Graphics ZOrder="-2" LineThickness="3.0" Color="cccccc"> <Point X="834.579831932773" Y="103.48739495798313" /> <Point X="10.0" Y="103.48739495798313" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ida5af703f"> <BiopaxRef>f69</BiopaxRef> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="306.66666666666663" Y="56.666666666666664" GraphRef="bb6" RelX="0.0" RelY="1.0" /> <Point X="306.6666666666667" Y="86.66666666666667" GraphRef="c41" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="d8888"> <Graphics ZOrder="12290" LineThickness="1.0"> <Point X="650.0" Y="344.6666666666667" GraphRef="f451e" RelX="0.0" RelY="1.0" /> <Point X="650.0" Y="450.0" 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